Problem solving treatment and group psychoeducation for depression: multicentre randomised controlled trial
Open accessAbstract
OBJECTIVES: To determine the acceptability of two psychological interventions for depressed adults in the community and their effect on caseness, symptoms, and subjective function. DESIGN: A pragmatic multicentre randomised controlled trial, stratified by centre. SETTING: Nine urban and rural communities in Finland, Republic of Ireland, Norway, Spain, and the United Kingdom. PARTICIPANTS: 452 participants aged 18 to 65, identified through a community survey with depressive or adjustment disorders according to the international classification of diseases, 10th revision or Diagnostic and Statistical Manual of Mental Disorders, fourth edition. INTERVENTIONS: Six individual sessions of problem solving treatment (n=128), eight group sessions of the course on prevention of depression (n=108), and controls (n=189). MAIN OUTCOME MEASURES: Completion rates for each intervention, diagnosis of depression, and depressive symptoms and subjective function. RESULTS: 63% of participants assigned to problem solving and 44% assigned to prevention of depression completed their intervention. The proportion of problem solving participants depressed at six months was 17% less than that for controls, giving a number needed to treat of 6; the mean difference in Beck depression inventory score was -2. 63 (95% confidence interval -4.95 to -0.32), and there were significant improvements in SF-36 scores. For depression prevention, the difference in proportions of depressed participants was 14% (number needed to treat of 7); the mean difference in Beck depression inventory score was -1.50 (-4.16 to 1.17), and there were significant improvements in SF-36 scores. Such differences were not observed at 12 months. Neither specific diagnosis nor treatment with antidepressants affected outcome. CONCLUSIONS: When offered to adults with depressive disorders in the community, problem solving treatment was more acceptable than the course on prevention of depression. Both interventions reduced caseness and improved subjective function.
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- Findingown data
At six months, the mean difference in Beck depression inventory score between problem solving and controls was -2.63 (95% confidence interval -4.95 to -0.32).
“the mean difference in Beck depression inventory score was -2.63 (95% confidence interval -4.95 to -0.32)”
Quote in the paperSubstantial claim - Findingown data
At 12 months, there were no differences between the three treatment arms in diagnosis of depression.
“At 12 months there were no differences between the three treatment arms.”
- Also stated in: § Abstract Objectives To determine the acceptability of two psychological interventions for depressed adults in the community and their effect on caseness, symptoms, and subjective function.Design A pragmatic multicentre randomised controlled trial, stratified by centre.Setting Nine urban and rural communities in Finland, Republic of Ireland, Norway, Spain, and the United Kingdom.Participants 452 participants aged 18 to 65, identified through a community survey with depressive or adjustment disorders according to the international classification of diseases, 10th revision or Diagnostic and Statistical Manual of Mental Disorders, fourth edition.Interventions Six individual sessions of problem solving treatment (n = 128), eight group sessions of the course on prevention of depression (n = 108), and controls (n = 189). Main outcome measures Completion rates for each intervention, diagnosis of depression, and depressive symptoms and subjective function.Results 63% of participants assigned to problem solving and 44% assigned to prevention of depression completed their intervention.The proportion of problem solving participants depressed at six months was 17% less than that for controls, giving a number needed to treat of 6; the mean difference in Beck depression inventory score was -2.63 (95% confidence interval -4.95 to -0.32), and there were significant improvements in SF-36 scores.For depression prevention, the difference in proportions of depressed participants was 14% (number needed to treat of 7); the mean difference in Beck depression inventory score was -1.50 (-4.16 to 1.17), and there were significant improvements in SF-36 scores.Such differences were not observed at 12 months.Neither specific diagnosis nor treatment with antidepressants affected outcome.Conclusions When offered to adults with depressive disorders in the community, problem solving treatment was more acceptable than the course on prevention of depression.Both interventions reduced caseness and improved subjective function. · plain
“Such differences were not observed at 12 months.”
Quote in the paperSubstantial claim - Also stated in: § Abstract Objectives To determine the acceptability of two psychological interventions for depressed adults in the community and their effect on caseness, symptoms, and subjective function.Design A pragmatic multicentre randomised controlled trial, stratified by centre.Setting Nine urban and rural communities in Finland, Republic of Ireland, Norway, Spain, and the United Kingdom.Participants 452 participants aged 18 to 65, identified through a community survey with depressive or adjustment disorders according to the international classification of diseases, 10th revision or Diagnostic and Statistical Manual of Mental Disorders, fourth edition.Interventions Six individual sessions of problem solving treatment (n = 128), eight group sessions of the course on prevention of depression (n = 108), and controls (n = 189). Main outcome measures Completion rates for each intervention, diagnosis of depression, and depressive symptoms and subjective function.Results 63% of participants assigned to problem solving and 44% assigned to prevention of depression completed their intervention.The proportion of problem solving participants depressed at six months was 17% less than that for controls, giving a number needed to treat of 6; the mean difference in Beck depression inventory score was -2.63 (95% confidence interval -4.95 to -0.32), and there were significant improvements in SF-36 scores.For depression prevention, the difference in proportions of depressed participants was 14% (number needed to treat of 7); the mean difference in Beck depression inventory score was -1.50 (-4.16 to 1.17), and there were significant improvements in SF-36 scores.Such differences were not observed at 12 months.Neither specific diagnosis nor treatment with antidepressants affected outcome.Conclusions When offered to adults with depressive disorders in the community, problem solving treatment was more acceptable than the course on prevention of depression.Both interventions reduced caseness and improved subjective function. · plain
- Findingown data
44% of participants assigned to prevention of depression completed their intervention.
“63% of participants assigned to problem solving and 44% assigned to prevention of depression completed their intervention.”
Quote in the paperSubstantial claim - Findingown data
At six months, prevention of depression had significant improvements in SF-36 scores.
“and there were significant improvements in SF-36 scores.”
- Also stated in: § Depressive symptoms and subjective function · plain
“prevention of depression had a significant effect on the SF-36 scores but not on the Beck depression inventory score”
Quote in the paperSubstantial claim - Also stated in: § Depressive symptoms and subjective function · plain
- Findingown data
63% of participants assigned to problem solving completed their intervention.
“63% of participants assigned to problem solving and 44% assigned to prevention of depression completed their intervention.”
Quote in the paperSubstantial claim
- Findingown data
At six months, problem solving had significant improvements in SF-36 scores.
“there were significant improvements in SF-36 scores.”
- Also stated in: § Depressive symptoms and subjective function · plain
“at six months problem solving had a significant effect on the score on the Beck depression inventory and all three SF-36 scores”
Quote in the paperSubstantial claim - Also stated in: § Depressive symptoms and subjective function · plain
- Findingown data
At six months, the mean difference in Beck depression inventory score between prevention of depression and controls was -1.50 (95% confidence interval -4.16 to 1.17).
“the mean difference in Beck depression inventory score was -1.50 (-4.16 to 1.17)”
Quote in the paperSubstantial claim - Findingown data
No significant differences were found in mean scores on the Beck depression inventory between participants completing or refusing to take part in an intervention.
“No significant differences were found in mean scores on the Beck depression inventory between participants completing or refusing to take part in an intervention.”
Quote in the paperNot a substantial claim - Findingown data
Ignoring drop-outs does not significantly bias estimates of treatment effects.
“Ignoring drop-outs does not significantly bias estimates of treatment effects.”
Quote in the paperSubstantial claim - Findingown data
Course on prevention of depression improves subjective social functioning at 6 months compared to controls.
“Depression prevention | SF-36 (social function) ‡ | 8.66 (0.07 to 17.25) | 0.048 | 2.36 (-6.10 to 10.83) | 0.584”
Quote in the paperSubstantial claim - Findingnone given
Problem solving treatment seems more acceptable than the course on prevention of depression to depressed people in community settings.
“Problem solving treatment seems more acceptable than the course on prevention of depression to depressed people in community settings”
Quote in the paperNot a substantial claim - Findingown data
There was evidence of a residual advantage from problem solving treatment in two domains of subjective function at 12 months.
“although there was evidence of a residual advantage from the problem solving treatment in two domains of subjective function.”
Quote in the paperNot a substantial claim - Findingown data
At 12 months, no significant effects were retained in either treatment arm.
“By 12 months no significant effects were retained in either treatment arm”
Quote in the paperSubstantial claim - Findingnone given
It is feasible to undertake psychological interventions for depressive disorders in the context of community based surveys in a range of urban and rural settings across Europe.
“It is feasible to undertake psychological interventions for depressive disorders in the context of community based surveys in a range of urban and rural settings across Europe”
Quote in the paperSubstantial claim - Findingown data
Participants who were randomised to problem solving were significantly more likely than those randomised to prevention of depression to complete the intervention.
“Participants who were randomised to problem solving were significantly more likely than those who were randomised to prevention of depression to complete the intervention ( 2 = 7.61, df = 1, P = 0.006).”
Quote in the paperNot a substantial claim - Findingown data
Problem solving treatment improves subjective social functioning at 6 months compared to controls.
“Problem solving | SF-36 (social function) ‡ | 9.57 (2.12 to 17.02) | 0.012 | 6.96 (-0.74 to 14.59) | 0.077”
Quote in the paperSubstantial claim - Findingown data
At 12 months, there was evidence of a residual effect of problem solving on SF-36 domains of mental role and social function.
“At 12 months there was evidence of a residual effect of problem solving on SF-36 domains of mental role and social function.”
Quote in the paperSubstantial claim - Findingcitation
The positive outcomes for the course on prevention of depression at six months were less substantial than those in the studies cited earlier.
“The positive outcomes for the course on prevention of depression at six months were less substantial than those in the studies cited earlier.[14][15][16]”
Quote in the paperNot a substantial claim0 of 3 sources checked- cites [14] 14. Cuijpers P. A psychoeducational approach to the treatment of depression: a meta-analysis of Lewinsohn's 'coping with depression' course. Behav Ther 1998;29:521-33.
Not checked in the free run.
- cites [15] 15. Muñoz R, Ying Y, Bernal G, Perez-Stable E, Sorensen J, Hargreaves W, et al. Prevention of depression with primary care patients: a randomized controlled trial. Am J Community Psychol 1995;23:199-222.
Not checked in the free run.
- cites [16] 16. Wells K, Sherbourne C, Schoenbaum M, Duan N, Meredith L, Unutzer J, et al. Impact of disseminating quality improvement programs for depres- sion in managed primary care: a randomized controlled trial. JAMA 2000;283:212-20.
Not checked in the free run.
- Findingown data
Factors such as treatment allocation and the acceptability of the treatment offered influenced drop-out rates.
“It was clear, however, that factors such as treatment allocation and the acceptability of the treatment offered influenced drop-out rates.”
Quote in the paperSubstantial claim - Findingown data
Problem solving treatment reduces the severity of depressive disorders at 6 months compared to controls.
“Problem solving | Beck depression inventory* | -2.63 (-4.95 to -0.32) | 0.026 | -1.00 (-3.31 to 1.31) | 0.398”
Quote in the paperSubstantial claim - Findingown data
Problem solving treatment improves subjective mental functioning at 6 months compared to controls.
“Problem solving | SF-36 (mental health) § | 7.59 (2.26 to 12.92) | 0.005 | 4.14 (-0.99 to 9.28) | 0.114”
Quote in the paperSubstantial claim - Interpretationown data
Problem solving treatment was more acceptable than the course on prevention of depression when offered to adults with depressive disorders in the community.
“problem solving treatment was more acceptable than the course on prevention of depression.”
- Also stated in: § Implications · hedged
“Our results indicate that problem solving was more acceptable than the course on prevention of depression when offered to people identified with depression in the community through a random sampling procedure.”
Quote in the paperSubstantial claim - Also stated in: § Implications · hedged
- Study design and conductown data
No significant differences were found in follow up rates between the three trial groups at either six or 12 months.
“No significant differences were found in follow up rates between the three trial groups at either six or 12 months.”
Quote in the paperNot a substantial claim - Interpretationown data
Participants assigned to problem solving were less likely to report depressive symptoms.
“Participants assigned to problem solving were less likely to report depressive symptoms.”
Quote in the paperSubstantial claim - Interpretationcitation
Nondoctors can deliver the problem solving intervention effectively.
“We confirm that nondoctors can deliver the problem solving intervention effectively 11”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [11] 11. Mynors-Wallis L, Gath D, Day A, Baker F. Randomised controlled trial of problem solving treatment, antidepressant medication, and combined treatment for major depression in primary care. BMJ 2000;320:26-30.
Not checked in the free run.
- Interpretationcitation
The benefits of problem solving at six months are comparable with previous studies in primary care.
“The benefits of problem solving at six months are comparable with previous studies in primary care, 10 11”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [10] 10. Mynors-Wallis L, Gath D, Lloyd-Thomas A, Tomlinson D. Randomised controlled trial comparing problem solving treatment with amitriptyline and placebo for major depression in primary care. BMJ 1995;310:441-5.
Not checked in the free run.
- cites [11] 11. Mynors-Wallis L, Gath D, Day A, Baker F. Randomised controlled trial of problem solving treatment, antidepressant medication, and combined treatment for major depression in primary care. BMJ 2000;320:26-30.
Not checked in the free run.
- Study design and conductnone given
The number of participants recruited fell far short of those planned in the original sample size calculations.
“The number of participants recruited fell far short of those planned in the original sample size calculations”
Quote in the paperSubstantial claim - Study design and conductreasoning
The corresponding power for comparing individual therapies with the controls (i.e. using 100 patients per group) is about 60%.
“The corresponding power for comparing individual therapies with the controls (i.e. using 100 patients per group) is about 60%.”
Quote in the paperNot a substantial claim - Study design and conductreasoning
It was not possible to conceal group allocation from either investigators or participants at follow up.
“Given the nature of the intervention, it was not possible to conceal group allocation from either investigators or participants at follow up.”
Quote in the paperNot a substantial claim - Study design and conductown data
There were significant differences between the nine centres in the proportions of participants reinterviewed at six months and 12 months.
“There were significant differences between the nine centres in the proportions of participants reinterviewed at six months ( 2 = 17.52, df = 8, P = 0.025) and 12 months ( 2 = 21.47,df = 8, P = 0.006).”
Quote in the paperNot a substantial claim - Study design and conductnone given
Not all patients provided follow up information.
“Not all patients provided follow up information.”
Quote in the paperSubstantial claim - Study design and conductreasoning
The trial has about 85% power to detect a difference between treatment and control groups of 2.5 (8 SD) points on the Beck depression inventory with Student's t test.
“These sample sizes are sufficient to have about 85% power to detect a difference between treatment and control groups of 2.5 (8 SD) points on the Beck depression inventory with Student's t test.”
Quote in the paperSubstantial claim - Study design and conductown data
Participants who completed were more likely to take part in follow up interviews at both six and 12 months.
“Participants who completed were more likely to take part in follow up interviews: differences were significant at follow up at both six months ( 2 = 52.71df = 3, P < 0.001) and 12 months ( 2 = 30.78,df = 3, P < 0.001).”
Quote in the paperNot a substantial claim - Study design and conductreasoning
Our data have limited power to differentiate the effects of the two forms of therapy.
“Our data have limited power to differentiate the effects of the two forms of therapy.”
Quote in the paperSubstantial claim
- May combine two claims. 19
- The quote only partly states this claim. 2
- Classified as probably not a substantial claim. 20
May combine two claims.
Findingown dataAt six months, the proportion of problem solving participants depressed was 17% less than that for controls, giving a number needed to treat of 6.
“The proportion of problem solving participants depressed at six months was 17% less than that for controls, giving a number needed to treat of 6”
- Also stated in: § Diagnosis of depression · plain
“At six months there was a 17% difference in the proportions of cases between participants assigned to problem solving and controls, giving a number needed to treat of 6”
Quote in the paperSubstantial claim- Also stated in: § Diagnosis of depression · plain
May combine two claims.
Findingown dataAt six months, the difference in proportions of depressed participants between prevention of depression and controls was 14%, giving a number needed to treat of 7.
“For depression prevention, the difference in proportions of depressed participants was 14% (number needed to treat of 7)”
- Also stated in: § Diagnosis of depression · plain
“a 14% difference between participants assigned to prevention of depression and controls, giving a number needed to treat of 7”
Quote in the paperSubstantial claim- Also stated in: § Diagnosis of depression · plain
May combine two claims.
Findingown dataNeither specific diagnosis nor treatment with antidepressants affected outcome.
“Neither specific diagnosis nor treatment with antidepressants affected outcome.”
- Also stated in: § Implications · plain
“These differences were unrelated to diagnostic category or concurrent treatment with antidepressants.”
Quote in the paperNot a substantial claim- Also stated in: § Implications · plain
The quote only partly states this claim.
Findingown dataCourse on prevention of depression improves subjective mental functioning at 6 months compared to controls.
“Depression prevention | SF-36 (mental health) § | 6.95 (0.76 to 13.14) | 0.028 | -3.25 (-8.47 to 1.97) | 0.223”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataOf 394 participants with available data, 102 (26%) reported currently taking antidepressants.
“Of 394 participants with available data, 102 (26%) reported currently taking antidepressants.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingnone givenMen and single people were least likely to complete.
“Men and single people were least likely to complete.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S1 (asserted). The quote only partly states this claim.
Findingown dataCourse on prevention of depression reduces the severity of depressive disorders at 6 months compared to controls.
“Total for depression | 32/78 (41) | 44/80 (55) | 14 ‡ | 43/72 (60) | 44/83 (53) | -7 §”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataThe probability of providing a follow up interview decreased with increasing baseline score on the Beck depression inventory at 12 months (P=0.047).
“From a logistic regression analysis for the whole sample the probability of providing a follow up interview decreased with increasing baseline score on the Beck depression inventory: at six months = -0.017(0.013 SE); P = 0.203 and at 12 months = -0.025(0.013 SE), P = 0.047.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
FindingcitationThose who responded to the survey were more likely to be female and older than non-responders.
“Those who responded to the survey were more likely to be female and older than non-responders: the sex difference was significant at three sites.23”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [23] 23. Ayuso-Mateos J, Vazquez-Barquero J, Dowrick C, Lehtinen V, Dalgard O, Casey P, et al. Depressive disorders in Europe: prevalence figures from the ODIN study. Br J Psychiatry 2000 (in press).
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
Findingown dataOverall, 452 people were identified as cases through the survey phase of the ODIN project.
“Overall, 452 people were identified as cases through the survey phase of the project of the outcomes of depression international network.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataOverall, 317 (74%) participants took part in follow up interviews at six months and 301 (71%) at 12 months.
“Overall, 317 (74%) participants took part in follow up interviews at six months and 301 (71%) at 12 months (figure).”
Quote in the paperNot a substantial claimMay combine two claims.
Interpretationown dataBoth interventions reduced caseness and improved subjective function.
“Both interventions reduced caseness and improved subjective function.”
- Also stated in: § Implications · plain
“Outcomes at six months were positive for both treatment arms, with results consistent across most measures.”
Quote in the paperSubstantial claim- Also stated in: § Implications · plain
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationProblem solving treatment is as effective as pharmacotherapy for major depression in primary care.
“It is as effective as pharmacotherapy for major depression in primary care 10 11”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [10] 10. Mynors-Wallis L, Gath D, Lloyd-Thomas A, Tomlinson D. Randomised controlled trial comparing problem solving treatment with amitriptyline and placebo for major depression in primary care. BMJ 1995;310:441-5.
Not checked in the free run.
- cites [11] 11. Mynors-Wallis L, Gath D, Day A, Baker F. Randomised controlled trial of problem solving treatment, antidepressant medication, and combined treatment for major depression in primary care. BMJ 2000;320:26-30.
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationPsychoeducation has been used in healthcare and community settings and seems effective in prevention and quality improvement programmes in US primary care.
“Psychoeducation has been used in healthcare and community settings and seems effective in prevention and quality improvement programmes in US primary care.[14][15][16]”
Quote in the paperNot a substantial claim0 of 3 sources checked- cites [14] 14. Cuijpers P. A psychoeducational approach to the treatment of depression: a meta-analysis of Lewinsohn's 'coping with depression' course. Behav Ther 1998;29:521-33.
Not checked in the free run.
- cites [15] 15. Muñoz R, Ying Y, Bernal G, Perez-Stable E, Sorensen J, Hargreaves W, et al. Prevention of depression with primary care patients: a randomized controlled trial. Am J Community Psychol 1995;23:199-222.
Not checked in the free run.
- cites [16] 16. Wells K, Sherbourne C, Schoenbaum M, Duan N, Meredith L, Unutzer J, et al. Impact of disseminating quality improvement programs for depres- sion in managed primary care: a randomized controlled trial. JAMA 2000;283:212-20.
Not checked in the free run.
May combine two claims.
Study design and conductown dataRandomisation and assessment were correctly undertaken for 425 people, with 26 people recruited in Dublin excluded post hoc from the analysis after discovery of a breach in protocol, and one participant with a psychotic condition excluded from the Norwegian sample.
“Randomisation and assessment were correctly undertaken for 425 people-26 people recruited in Dublin were excluded post hoc from the analysis, after discovery of a breach in protocol by a former member of the Irish research team, and one participant with a psychotic condition was excluded from the Norwegian sample (figure).”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationProblem solving treatment involves six individual sessions and less than four hours' therapist time.
“The treatment involves six individual sessions-less than four hours' therapist time 9 -and is easily taught to a range of health professionals.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [9] 9. Hawton K, Kirk J. Problem-solving. In: Hawton K, Salkovskis PM, Kirk JW, Clark DM, eds. Cognitive behaviour therapy for psychiatric problems: a practi- cal guide. Oxford: Oxford Medical, 1989:406-27.
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationProblem solving treatment is easily taught to a range of health professionals.
“The treatment involves six individual sessions-less than four hours' therapist time 9 -and is easily taught to a range of health professionals.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [9] 9. Hawton K, Kirk J. Problem-solving. In: Hawton K, Salkovskis PM, Kirk JW, Clark DM, eds. Cognitive behaviour therapy for psychiatric problems: a practi- cal guide. Oxford: Oxford Medical, 1989:406-27.
Not checked in the free run.
Classified as probably not a substantial claim.
Study design and conductreasoningIt is essential in estimating and testing treatment effects that the analysis involves stratification by centre to ensure that each intervention group is being compared with its own control.
“It is essential, therefore, in estimating and testing treatment effects that the analysis involves stratification by centre to ensure that each intervention group is being compared with its own control.”
Quote in the paperSubstantial claimMay combine two claims.
Interpretationown dataProblem solving treatment and the course on prevention of depression improve subjective mental and social functioning.
“Both problem solving treatment and the course on prevention of depression reduce the severity and duration of depressive disorders and improve subjective mental and social functioning”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
InterpretationcitationDifferential recruitment between centres reflected differences in the prevalence of depressive disorders in the populations surveyed during the first phase of the ODIN project.
“Differential recruitment between centres reflected differences in the prevalence of depressive disorders in the populations surveyed during the first phase of the outcomes of depression international network.23”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [23] 23. Ayuso-Mateos J, Vazquez-Barquero J, Dowrick C, Lehtinen V, Dalgard O, Casey P, et al. Depressive disorders in Europe: prevalence figures from the ODIN study. Br J Psychiatry 2000 (in press).
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductnone givenEthical approval was obtained according to local protocols.
“Ethical approval was obtained according to local protocols.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim. May combine two claims.
Study design and conductnone givenRelevant baseline scores, age, and treatment with antidepressants were used as covariates, and treatment group, centre, and diagnostic group were treated as qualitative factors.
“Relevant baseline scores, age, and treatment with antidepressants were used as covariates, and treatment group, centre, and diagnostic group were treated as qualitative factors.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductcitationDetails of survey methods, including translation, training, and quality control procedures, have been published.
“Details of our survey methods, including translation, training, and quality control procedures, have been published.8”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [8] 8. Dowrick C, Casey P, Dalgard O, Hosman C, Lehtinen V, Vazquez- Barquero J-L, et al. Outcomes of Depression International Network (ODIN): background, methods and field trials. Br J Psychiatry 1998;172:359-63.
Not checked in the free run.
Classified as probably not a substantial claim.
Study design and conductnone givenAt each study site the unit of randomisation was the participant.
“At each study site the unit of randomisation was the participant.”
Quote in the paperSubstantial claimMay combine two claims.
Study design and conductown dataThere were no significant differences in diagnosis or antidepressant receipt between the study sites or the intervention arms.
“There were no significant differences in diagnosis or antidepressant receipt between the study sites or the intervention arms.”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductnone givenOur methods of analysis allowed us to account for the effects of conducting a set of linked trials in different centres but not for the possible constituents of centre effects.
“Our methods of analysis allowed us to account for the effects of conducting a set of linked trials in different centres but not for the possible constituents of centre effects.”
Quote in the paperNot a substantial claimMay combine two claims.
Interpretationown dataCompared with controls, participants assigned to problem solving and the course on prevention of depression were less likely to remain cases of depression and more likely to report improved subjective mental and social functioning.
“Compared with the controls, participants who were assigned to problem solving and the course on prevention of depression were less likely to remain cases of depression and more likely to report improved subjective mental and social functioning.”
Quote in the paperSubstantial claimClassified as probably not a substantial claim.
Study design and conductreasoningGiven the uncertainty of outcome from a study based outside healthcare settings, we made no assumptions concerning the difference in efficacy of problem solving and prevention of depression.
“Given the uncertainty of outcome from a study based outside healthcare settings, we made no assumptions concerning the difference in efficacy of problem solving and prevention of depression.”
Quote in the paperSubstantial claimMay combine two claims.
Study design and conductnone givenThe design of the trial is complex, involving nine treatment centres, only one of which used both interventions.
“The design of the trial is complex, involving nine treatment centres, only one of which used both interventions.”
Quote in the paperSubstantial claimMay combine two claims.
Interpretationown dataProblem solving treatment and the course on prevention of depression reduce the severity and duration of depressive disorders.
“This is because they reduce severity and duration of depressive disorders and improve subjective mental and social functioning.”
Quote in the paperSubstantial claimClassified as probably not a substantial claim.
Study design and conductown dataCases were randomly allocated to one of the trial groups.
“Cases were randomly allocated to one of the trial groups.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductown dataAllocation schedules were generated by random number tables and administered by staff not in contact with the participants.
“Allocation schedules were generated by random number tables and administered by staff not in contact with the participants.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
Study design and conductreasoningAll analyses were carried out by intention to treat but with alternative approaches to dealing with the effects of drop-outs.
“All analyses were carried out by intention to treat but with alternative approaches to dealing with the effects of drop-outs.”
Quote in the paperSubstantial claimMay combine two claims.
InterpretationreasoningProblem solving treatment and the course on prevention of depression are effective interventions for people with depressive conditions in urban and rural community settings.
“Problem solving treatment and the course on prevention of depression may be recommended as effective interventions for people with depressive conditions in urban and rural community settings.”
Quote in the paperSubstantial claim
The paper relies on this without support.
Problem solving treatment has not yet been tested in community settings.
“but has not yet been tested in community settings.”
The paper relies on this without support.
The ODIN study is the first international multicentre randomised controlled trial of psychological interventions for depression undertaken among the general population.
“The outcomes of depression international network is the first international multicentre randomised controlled trial of psychological interventions for depression undertaken among the general population.”
The paper relies on this without support.
The ODIN trial is the largest trial to date of problem solving treatment and the largest and most rigorously designed trial of the course on prevention of depression.
“It is the largest trial to date of problem solving treatment and the largest and most rigorously designed trial of the course on prevention of depression.”
The authors state this as an assumption.
In the complete case analysis, data are missing completely at random.
“analysis of available data (complete case analysis) assumed that data are missing completely at random.22”
The authors state this as an assumption.
In the weighted analysis, data are missing at random.
“The second approach therefore assumed that data were missing at random, involving calculation of adjustment weights to compensate for missing values.22”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The largest trial (Dowrick et al. 2000) had sufficient power only to detect a differential effect size of d = 0.42, and the average study with 52 patients had enough power only to find a differential effect size of d = 0.79.
“The largest trial (Dowrick et al. 2000) had sufficient power only to detect a differential effect size of d = 0.42, and the average study with 52 patients had enough power only to find a differential effect size of d = 0.79.”
From The Role of Common Factors in Psychotherapy Outcomes (2019) · cites this paper as Dowrick et al. 2000
The Implications section identifies Dowrick et al. as the largest trial to date of problem-solving treatment. Statistical methods discusses the trial’s sample size and power, but does not give a detectable differential effect size of d = 0.42. The paper also does not address an average study of 52 patients or d = 0.79. Page numbers are unavailable in our copy. (LLM, conf=0.82)
Experimental — accuracy not yet measuredCases were randomly assigned to one of three trial groups: individual problem-solving treatment, group depression prevention course, or treatment as usual, to optimize comparability across groups.
“cases were randomly assigned to one of three trial groups, receiving either six individual sessions of individual problem-solving treatment, eight sessions of a group depression prevention course, or treatment as usual (controls).”
From The role of personality disorder in 'difficult to reach' patients with depression: Findings from the ODIN study (2007) · cites this paper as [8]
The Study design section says cases were randomly allocated to trial groups, and the Abstract lists six individual problem-solving sessions, eight group depression-prevention sessions, and controls. The paper describes the controls as receiving “no intervention,” not “treatment as usual.” It does not explicitly give optimizing comparability as the reason for random assignment. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Centre 5 twelve-month difference has the wrong sign
MinorThe reported treatment and control percentages are 51% and 50%, respectively. Their treatment-minus-control difference is +1 percentage point, not −1.
Reported -1 · recomputed 1
“| 5 Depression prevention | 9/17 (53) | 18/31 (58) | 5 | 8/16 (50) | 18/35 (51) | -1 |”
Centre 1 has more six-month control outcomes than interviews
MinorTable 3 records 17 control interviews at six months in centre 1, whereas table 5 uses 19 controls as the denominator for that centre's six-month outcome.
“| 1 Problem solving | 8/19 (42) | 11/19 (58) | 16 | 9/17 (53) | 11/16 (69) | 16 |”
“| 1 | Finland | Urban | Problem solving | 24 | 17 | 17 | 23 | 19 | 16 |”
Centre 2 has conflicting twelve-month treatment counts
MinorTable 3 records 21 treatment interviews at 12 months for centre 2, while table 5 uses 22 as the denominator for its outcome.
“| 2 Problem solving | 12/20 (60) | 20/24 (83) | 23 | 13/20 (65) | 13/22 (59) | -6 |”
“| 2 | Finland | Rural | Problem solving | 22 | 20 | 20 | 28 | 24 | 21 |”
Centre 7 twelve-month treatment percentage is miscalculated
MinorEleven of 17 participants is approximately 65%, rather than the reported 68%.
Reported 68 · recomputed 64.705882
“| 7 Problem solving | 2/6 (33) | 8/15 (53) | 20 | 5/7 (71) | 11/17 (68) | -7 |”
Depression-prevention refusal percentage is understated
MinorTable 4 reports 32 refusals among 108 people offered depression prevention. That is about 29.6%, which rounds to 30%, not 29%.
Reported 29 · recomputed 29.62963
“| | No (%) depression | 108 | 32 (29) | 14 (13) | 14 (13) | 48 (44) |”
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- Authors
- Dowrick, C., Dunn, G., Ayuso-Mateos, J. L., Dalgard, O. S., Page, H., Lehtinen, V., Casey, P., Wilkinson, C., Vazquez-Barquero, J. L., & Wilkinson, G.
- Affiliations
- University of Liverpool (GB)
- University of Manchester (GB)
- University of Oslo (NO)
- University College Dublin (IE)
- University of Wales (GB)
- Corresponding author
- Dowrick, C.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2000-12-09
- Volume
- 321
- Issue
- 7274
- Pages
- 1450-1450
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- PMC
- PMC27549
- OpenAlex
- W2140850139
- Semantic Scholar
- d35ffc1457dd92e337553867ff670dcf31bef458
- Cited by
- 228
- References
- 27
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 6 · 2023: 3 · 2022: 5 · 2020: 2 · 2019: 8 · 2018: 6 · 2017: 1 · 2016: 10 · 2015: 12 · 2014: 8 · 2013: 12 · 2012: 10
- FWCI
- 9.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BMJ (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- problem-solving therapy, group psychoeducation, depression prevention, depression, adjustment disorder, community mental health, treatment acceptability, treatment completion, depressive symptoms, number needed to treat, antidepressant treatment
- MeSH terms
- Adolescent, Adult, Aged, Depressive Disorder, Europe, Humans, Middle Aged, Patient Education as Topic, Problem Solving, Psychotherapy, Treatment Outcome, Patient Satisfaction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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