The role of dopamine in the nucleus accumbens and striatum during sexual behavior in the female rat
Open accessAbstract
Dopamine in dialysate from the nucleus accumbens (NAcc) increases during sexual and feeding behavior and after administration of drugs of abuse, even those that do not directly activate dopaminergic systems (e.g., morphine or nicotine). These findings and others have led to hypotheses that propose that dopamine is rewarding, predicts that reinforcement will occur, or attributes incentive salience. Examining increases in dopamine in NAcc or striatum during sexual behavior in female rats provides a unique situation to study these relations. This is because, for the female rat, sexual behavior is associated with an increase in NAcc dopamine and conditioned place preference only under certain testing conditions. This experiment was conducted to determine what factors are important for the increase in dopamine in dialysate from NAcc and striatum during sexual behavior in female rats. The factors considered were the number of contacts by the male, the timing of contacts by the male, or the ability of the female to control contacts by the male. The results indicate that increased NAcc dopamine is dependent on the timing of copulatory stimuli, independent of whether the female rat is actively engaged in regulating this timing. For the striatum, the timing of copulatory behavior influences the magnitude of the increase in dopamine in dialysate, but other factors are also involved. We conclude that increased extracellular dopamine in the NAcc and striatum conveys qualitative or interpretive information about the rewarding value of stimuli. Sexual behavior in the female rat is proposed as a model to determine the role of dopamine in motivated behavior.
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Dopaminergic release within the nucleus accumbens only appears to occur when females copulate according to their pacing preferences.
“Dopaminergic release within the nucleus accumbens only appears to occur when females copulate according to their pacing preferences (Becker et al., 2001, Jenkins and Becker, 2003a, Mermelstein and Becker, 1995).”
From Oxytocin, motivation and the role of dopamine (2014) · cites this paper as Becker et al., 2001
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- Authors
- Becker, J. B., Rudick, C. N., & Jenkins, W. J.
- Affiliations
- University of Michigan (US)
- ORCID
- Becker, Jill B.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2001-05-01
- Volume
- 21
- Issue
- 9
- Pages
- 3236-3241
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6762549
- OpenAlex
- W1721700897
- Cited by
- 206
- References
- 21
- Citations by year
- 2026: 3 · 2025: 4 · 2023: 1 · 2022: 9 · 2021: 3 · 2020: 7 · 2019: 7 · 2018: 8 · 2017: 4 · 2016: 6 · 2015: 7 · 2014: 7 · 2013: 10 · 2012: 13
- FWCI
- 5.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (9816673)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- dopamine, nucleus accumbens, striatum, female sexual behavior, mating behavior, extracellular dopamine, reward, incentive salience, conditioned place preference, motivated behavior, female rats
- MeSH terms
- Animals, Chromatography, High Pressure Liquid, Corpus Striatum, Dopamine, Estradiol, Extracellular Space, Female, Homovanillic Acid, Male, Motivation, Nucleus Accumbens, Ovariectomy, Periodicity, Progesterone, Reaction Time, Sexual Behavior, Animal, 3,4-Dihydroxyphenylacetic Acid, Microdialysis, Rats, Long-Evans, Rats
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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