Cited by 771Cellular transport and secretionAutophagy in Disease and TherapyUbiquitin and proteasome pathways

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Biogenesis and Function of Multivesicular Bodies

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Piper, Robert C., Katzmann, David J.·2007·Annual Review of Cell and Developmental Biology

DOI 10.1146/annurev.cellbio.23.090506.123319PMC PMC2911632

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Abstract

The two major cellular sites for membrane protein degradation are the proteasome and the lysosome. Ubiquitin attachment is a sorting signal for both degradation routes. For lysosomal degradation, ubiquitination triggers the sorting of cargo proteins into the lumen of late endosomal multivesicular bodies (MVBs)/endosomes. MVB formation occurs when a portion of the limiting membrane of an endosome invaginates and buds into its own lumen. Intralumenal vesicles are degraded when MVBs fuse to lysosomes. The proper delivery of proteins to the MVB interior relies on specific ubiquitination of cargo, recognition and sorting of ubiquitinated cargo to endosomal subdomains, and the formation and scission of cargo-filled intralumenal vesicles. Over the past five years, a number of proteins that may directly participate in these aspects of MVB function and biogenesis have been identified. However, major questions remain as to exactly what these proteins do at the molecular level and how they may accomplish these tasks.

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THE UBIQUITIN SYSTEM
Hershko, A., & Ciechanover, A. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.425 · Cited by 8,840
Global analysis of protein localization in budding yeast
Huh, W.-K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., & O'Shea, E. K. (2003) · Nature · doi:10.1038/nature02026 · Cited by 4,248 · cited 1×
“Although loss of Sna3 does not cause a sorting defect, other Sna3-like candidates exist among other polytopic membrane proteins that localize to the vacuolar lumen and exhibit no known function (Huh et al. 2003).”
Background
Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor
Pan, B., & Johnstone, R. M. (1983) · Cell · doi:10.1016/0092-8674(83)90040-5 · Cited by 2,042
Proteomic Analysis of Dendritic Cell-Derived Exosomes: A Secreted Subcellular Compartment Distinct from Apoptotic Vesicles
Théry, C., Boussac, M., Véron, P., Ricciardi‐Castagnoli, P., Raposo, G., Garin, J., & Amigorena, S. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7309 · Cited by 1,564
Activated Platelets Release Two Types of Membrane Vesicles: Microvesicles by Surface Shedding and Exosomes Derived From Exocytosis of Multivesicular Bodies and -Granules
Heijnen, H. F. G., Schiel, A. E., Fijnheer, R., Geuze, H. J., & Sixma, J. J. (1999) · Blood · doi:10.1182/blood.v94.11.3791 · Cited by 1,488
Ubiquitin-Dependent Sorting into the Multivesicular Body Pathway Requires the Function of a Conserved Endosomal Protein Sorting Complex, ESCRT-I
Katzmann, D. J., Babst, M., & Emr, S. D. (2001) · Cell · doi:10.1016/s0092-8674(01)00434-2 · Cited by 1,473
Self-citation
Selective Enrichment of Tetraspan Proteins on the Internal Vesicles of Multivesicular Endosomes and on Exosomes Secreted by Human B-lymphocytes
Escola, J.-M., Kleijmeer, M. J., Stoorvogel, W., Griffith, J. M., Yoshie, O., & Geuze, H. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.32.20121 · Cited by 1,228
Receptor downregulation and multivesicular-body sorting
Katzmann, D. J., Odorizzi, G., & Emr, S. D. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm973 · Cited by 1,201
Self-citation
Regulation of Membrane Protein Transport by Ubiquitin and Ubiquitin-Binding Proteins
Hicke, L., & Dunn, R. (2003) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.19.110701.154617 · Cited by 1,131
Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells
Gillooly, D. J., Morrow, I. C., Lindsay, M., Gould, R., Bryant, N. J., Gaullier, J., Parton, R. G., & Stenmark, H. (2000) · The EMBO Journal · doi:10.1093/emboj/19.17.4577 · Cited by 1,031
A SMALL PARTICULATE COMPONENT OF THE CYTOPLASM
Palade, G. E. (1955) · The Journal of Cell Biology · doi:10.1083/jcb.1.1.59 · Cited by 1,014
Exosomes: A Common Pathway for a Specialized Function
van Niel, G., Porto-Carreiro, I., Simoes, S., & Raposo, G. (2006) · The Journal of Biochemistry · doi:10.1093/jb/mvj128 · Cited by 922
Proteomic and Biochemical Analyses of Human B Cell-derived Exosomes
Wubbolts, R., Leckie, R. S., Veenhuizen, P. T. M., Schwarzmann, G., Möbius, W., Hoernschemeyer, J., Slot, J.-W., Geuze, H. J., & Stoorvogel, W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207550200 · Cited by 886
Escrt-III
Babst, M., Katzmann, D. J., Estepa, E. J., Meerloo, T., & Emr, S. D. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00220-4 · Cited by 865
Self-citation
Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants.
Raymond, C. K., Howald-Stevenson, I., Vater, C. A., & Stevens, T. H. (1992) · Molecular Biology of the Cell · doi:10.1091/mbc.3.12.1389 · Cited by 840
The Protein Network of HIV Budding
von Schwedler, U. K., Stuchell‐Brereton, M. D., Müller, B., Ward, D. M., Chung, H.-Y., Morita, E., Wang, H. E., Davis, T., He, G.-P., Cimbora, D. M., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00714-1 · Cited by 835
Tetraspanin Proteins Mediate Cellular Penetration, Invasion, and Fusion Events and Define a Novel Type of Membrane Microdomain
Hemler, M. E. (2003) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.19.111301.153609 · Cited by 831
A lipid associated with the antiphospholipid syndrome regulates endosome structure and function
Kobayashi, T., Stang, E., Fang, K. S., de Moerloose, P., Parton, R. G., & Gruenberg, J. (1998) · Nature · doi:10.1038/32440 · Cited by 787
The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function
Babst, M., Wendland, B., Estepa, E. J., & Emr, S. D. (1998) · The EMBO Journal · doi:10.1093/emboj/17.11.2982 · Cited by 770
Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation
Haglund, K., Sigismund, S., Polo, S., Szymkiewicz, I., Di Fiore, P. P., & Dikic, I. (2003) · Nature Cell Biology · doi:10.1038/ncb983 · Cited by 715
Role of LBPA and Alix in Multivesicular Liposome Formation and Endosome Organization
Matsuo, H., Chevallier, J., Mayran, N., Le Blanc, I., Ferguson, C., Fauré, J., Blanc, N. S., Matile, S., Dubochet, J., Sadoul, R., et al. (2004) · Science · doi:10.1126/science.1092425 · Cited by 705
Endosome-Associated Complex, ESCRT-II, Recruits Transport Machinery for Protein Sorting at the Multivesicular Body
Babst, M., Katzmann, D. J., Snyder, W. B., Wendland, B., & Emr, S. D. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00219-8 · Cited by 662
Self-citation
Exosome lipidomics unravels lipid sorting at the level of multivesicular bodies
Subra, C., Laulagnier, K., Perret, B., & Record, M. (2006) · Biochimie · doi:10.1016/j.biochi.2006.10.014 · Cited by 660
Fab1p PtdIns(3)P 5-Kinase Function Essential for Protein Sorting in the Multivesicular Body
Odorizzi, G., Babst, M., & Emr, S. D. (1998) · Cell · doi:10.1016/s0092-8674(00)81707-9 · Cited by 656
Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes
Raiborg, C., Bache, K. G., Gillooly, D. J., Madshus, I. H., Stang, E., & Stenmark, H. (2002) · Nature Cell Biology · doi:10.1038/ncb791 · Cited by 652
Membrane transport in the endocytic pathway
Grüenberg, J., & Maxfield, F. R. (1995) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(95)80013-1 · Cited by 645
Ubiquitin-binding domains
Hurley, J. H., Lee, S., & Prag, G. (2006) · Biochemical Journal · doi:10.1042/bj20061138 · Cited by 614
RETROVIRUS BUDDING
Morita, E., & Sundquist, W. I. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.102350 · Cited by 594
Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane
Booth, A. M., Fang, Y., Fallon, J. K., Yang, J.-M., Hildreth, J. E. K., & Gould, S. J. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200508014 · Cited by 562
Direct visualization of the binding and internalization of a ferritin conjugate of epidermal growth factor in human carcinoma cells A-431.
Haigler, H. T., McKanna, J. A., & Cohen, S. (1979) · The Journal of Cell Biology · doi:10.1083/jcb.81.2.382 · Cited by 526
Protein sorting into multivesicular endosomes
Raiborg, C., Rusten, T. E., & Stenmark, H. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00080-2 · Cited by 500
Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes
Bache, K. G., Brech, A., Mehlum, A., & Stenmark, H. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302131 · Cited by 465
PRINCIPLES OF LYSOSOMAL MEMBRANE DIGESTION: Stimulation of Sphingolipid Degradation by Sphingolipid Activator Proteins and Anionic Lysosomal Lipids
Kolter, T., & Sandhoff, K. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.122303.120013 · Cited by 464
Vps27 recruits ESCRT machinery to endosomes during MVB sorting
Katzmann, D. J., Stefan, C. J., Babst, M., & Emr, S. D. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302136 · Cited by 455
Self-citation
Recycling Compartments and the Internal Vesicles of Multivesicular Bodies Harbor Most of the Cholesterol Found in the Endocytic Pathway
Möbius, W., van Donselaar, E. G., Ohno‐Iwashita, Y., Shimada, Y., Heijnen, H. F. G., Slot, J. W., & Geuze, H. J. (2003) · Traffic · doi:10.1034/j.1600-0854.2003.00072.x · Cited by 453
Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body
Felder, S., Miller, K., Moehren, G., Ullrich, A., Schlessinger, J., & Hopkins, C. R. (1990) · Cell · doi:10.1016/0092-8674(90)90474-s · Cited by 445
Sorting of membrane components from endosomes and subsequent recycling to the cell surface occurs by a bulk flow process
Mayor, S., Presley, J. F., & Maxfield, F. R. (1993) · The Journal of cell biology · doi:10.1083/jcb.121.6.1257 · Cited by 436
Separation and Characterization of Late Endosomal Membrane Domains
Kobayashi, T., Beuchat, M.-H., Chevallier, J., Makino, A., Mayran, N., Escola, J.-M., Lebrand, C., Cosson, P., Kobayashi, T., & Gruenberg, J. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202838200 · Cited by 409
Accumulation of Major Histocompatibility Complex Class II Molecules in Mast Cell Secretory Granules and Their Release upon Degranulation
Raposo, G., Tenza, D., Mecheri, S., Péronet, R., Bonnerot, C., & Desaymard, C. (1997) · Molecular Biology of the Cell · doi:10.1091/mbc.8.12.2631 · Cited by 406
Hrs Regulates Endosome Membrane Invagination and Tyrosine Kinase Receptor Signaling in Drosophila
Lloyd, T. E., Atkinson, R., Wu, M. N., Zhou, Y., Pennetta, G., & Bellen, H. J. (2002) · Cell · doi:10.1016/s0092-8674(02)00611-6 · Cited by 401
Mammalian Tumor Susceptibility Gene 101 (TSG101) and the Yeast Homologue, Vps23p, Both Function in Late Endosomal Trafficking
Babst, M., Odorizzi, G., Estepa, E. J., & Emr, S. D. (2000) · Traffic · doi:10.1034/j.1600-0854.2000.010307.x · Cited by 396
An Electron Microscope Study of the Rat Ovum
Sotelo, J. R., & Porter, K. R. (1959) · The Journal of Cell Biology · doi:10.1083/jcb.5.2.327 · Cited by 388
Ubiquitination and proteasomal activity is required for transport of the EGF receptor to inner membranes of multivesicular bodies
Longva, K. E., Blystad, F. D., Stang, E., Larsen, A. M., Johannessen, L. E., & Madshus, I. H. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200106056 · Cited by 385
VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae.
Piper, R. C., Cooper, A. A., Yang, H., & Stevens, T. H. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.131.3.603 · Cited by 382
Self-citation
EGF stimulates annexin 1‐dependent inward vesiculation in a multivesicular endosome subpopulation
White, I. J., Bailey, L. M., Aghakhani, M. R., Moss, S. E., & Futter, C. E. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600759 · Cited by 380
AMSH is an endosome-associated ubiquitin isopeptidase
McCullough, J., Clague, M. J., & Urbé, S. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200401141 · Cited by 369
Epidermal growth factor: morphological demonstration of binding, internalization, and lysosomal association in human fibroblasts.
Görden, P., Carpentier, J. L., Cohen, S., & Orci, L. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.10.5025 · Cited by 351
Proteomic Analysis of Exosomes Secreted by Human Mesothelioma Cells
Hegmans, J. P., Bard, M. P. L., Hemmes, A., Luider, T. M., Kleijmeer, M. J., Prins, J., Zitvogel, L., Burgers, S. A., Hoogsteden, H. C., & Lambrecht, B. N. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63739-x · Cited by 350
The E3 Ubiquitin Ligase AIP4 Mediates Ubiquitination and Sorting of the G Protein-Coupled Receptor CXCR4
Marchese, A., Raiborg, C., Santini, F., Keen, J. H., Stenmark, H., & Benovic, J. L. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00321-6 · Cited by 349
The Vps27p–Hse1p complex binds ubiquitin and mediates endosomal protein sorting
Bilodeau, P. S., Urbanowski, J. L., Winistorfer, S. C., & Piper, R. C. (2002) · Nature Cell Biology · doi:10.1038/ncb815 · Cited by 341
Self-citation
Endosome-to-cytosol transport of viral nucleocapsids
Blanc, I., Luyet, P., Pons, V., Ferguson, C., Emans, N., Petiot, A., Mayran, N., Demaurex, N., Fauré, J., Sadoul, R., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1269 · Cited by 336
Sorting of proteins into multivesicular bodies: ubiquitin‐dependent and ‐independent targeting
Reggiori, F., & Pelham, H. R. B. (2001) · The EMBO Journal · doi:10.1093/emboj/20.18.5176 · Cited by 324
Bilayered Clathrin Coats on Endosomal Vacuoles Are Involved in Protein Sorting toward Lysosomes
Sachse, M., Urbé, S., Oorschot, V., Strous, G. J., & Klumperman, J. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-10-0525 · Cited by 321
Regulation of ubiquitin-binding proteins by monoubiquitination
Hoeller, D., Crosetto, N., Blagoev, B., Raiborg, C., Tikkanen, R., Wagner, S., Kowanetz, K., Breitling, R., Mann, M., Stenmark, H., et al. (2006) · Nature Cell Biology · doi:10.1038/ncb1354 · Cited by 320
β-Amyloid Accumulation Impairs Multivesicular Body Sorting by Inhibiting the Ubiquitin-Proteasome System
Almeida, C. G., Takahashi, R. H., & Gouras, G. K. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5078-05.2006 · Cited by 316
TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation
Lu, Q., Hope, L. W., Brasch, M., Reinhard, C., & Cohen, S. N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0932599100 · Cited by 301
The Doa4 Deubiquitinating Enzyme Is Functionally Linked to the Vacuolar Protein-sorting and Endocytic Pathways
Amerik, A. Y., Nowak, J. A., Swaminathan, S., & Hochstrasser, M. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.10.3365 · Cited by 298
Proprotein convertase cleavage liberates a fibrillogenic fragment of a resident glycoprotein to initiate melanosome biogenesis
Berson, J. F., Theos, A. C., Harper, D. C., Tenza, D., Raposo, G., & Marks, M. S. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302072 · Cited by 288
The Tetraspanin CD63/lamp3 Cycles between Endocytic and Secretory Compartments in Human Endothelial Cells
Kobayashi, T., Vischer, U. M., Rosnoblet, C., Lebrand, C., Lindsay, M. R., Parton, R. G., Kruithof, E. K. O., & Gruenberg, J. E. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.5.1829 · Cited by 283
Multilamellar endosome-like compartment accumulates in the yeast vps28 vacuolar protein sorting mutant.
Rieder, S., Banta, L. M., Köhrer, K., McCaffery, J. M., & Emr, S. D. (1996) · Molecular Biology of the Cell · doi:10.1091/mbc.7.6.985 · Cited by 280
A lumenal domain-dependent pathway for sorting to intralumenal vesicles of multivesicular endosomes involved in organelle morphogenesis
Theos, A. C., Truschel, S. T., Tenza, D., Hurbain, I., Harper, D. C., Berson, J. F., Thomas, P. C., Raposo, G., & Marks, M. S. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.01.012 · Cited by 263
Surface expression of MHC class II in dendritic cells is controlled by regulated ubiquitination
Shin, J., Ebersold, M. W., Pypaert, M., Delamarre, L., Hartley, A., & Mellman, I. (2006) · Nature · doi:10.1038/nature05261 · Cited by 262
Mapping of tetraspanin-enriched microdomains that can function as gateways for HIV-1
Nydegger, S., Khurana, S., Krementsov, D. N., Foti, M., & Thali, M. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200508165 · Cited by 257
Distinct Roles for Tsg101 and Hrs in Multivesicular Body Formation and Inward Vesiculation
Razi, M., & Futter, C. E. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-11-1054 · Cited by 255
Structural Basis for Budding by the ESCRT-III Factor CHMP3
Muzioł, T. M., Pineda‐Molina, E., Ravelli, R. B. G., Zamborlini, A., Usami, Y., Göttlinger, H. G., & Weissenhorn, W. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.03.013 · Cited by 253
ATPase-defective Mammalian VPS4 Localizes to Aberrant Endosomes and Impairs Cholesterol Trafficking
Bishop, N. E., & Woodman, P. G. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.1.227 · Cited by 249
ESCRT-II, an Endosome-Associated Complex Required for Protein Sorting
Teo, H., Perišić, O., González, B., & Williams, R. L. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.09.003 · Cited by 249
Human VPS34 is required for internal vesicle formation within multivesicular endosomes
Futter, C. E., Collinson, L., Backer, J., & Hopkins, C. R. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200108152 · Cited by 248
Ubiquitin interactions of NZF zinc fingers
Alam, S. L., Sun, J., Payne, M., Welch, B. D., Blake, B. K., Davis, D. R., Meyer, H. H., Emr, S. D., & Sundquist, W. I. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600114 · Cited by 248
ESCRT-I Core and ESCRT-II GLUE Domain Structures Reveal Role for GLUE in Linking to ESCRT-I and Membranes
Teo, H., Gill, D. J., Sun, J., Perisic, O., Veprintsev, D. B., Vallis, Y., Emr, S. D., & Williams, R. L. (2006) · Cell · doi:10.1016/j.cell.2006.01.047 · Cited by 242
The Ubiquitin Isopeptidase UBPY Regulates Endosomal Ubiquitin Dynamics and Is Essential for Receptor Down-regulation
Row, P. E., Prior, I. A., McCullough, J., Clague, M. J., & Urbé, S. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512615200 · Cited by 239
Endosomal and non-endosomal functions of ESCRT proteins
Slagsvold, T., Pattni, K., Malerød, L., & Stenmark, H. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.04.004 · Cited by 238
bicoid RNA localization requires specific binding of an endosomal sorting complex
Irion, U., & Johnston, D. S. (2007) · Nature · doi:10.1038/nature05503 · Cited by 236
A physical and functional link between cholesterol and tetraspanins
Charrin, S., Manié, S. N., Thiele, C., Billard, M., Gerlier, D., Boucheix, C., & Rubinstein, E. (2003) · European Journal of Immunology · doi:10.1002/eji.200323884 · Cited by 232
Structural and mechanistic studies of VPS4 proteins
Scott, A., Chung, H.-Y., Gonciarz-Swiatek, M., Hill, G. C., Whitby, F. G., Gaspar, J., Holton, J. M., Viswanathan, R., Ghaffarian, S., Hill, C. P., et al. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600818 · Cited by 225
Ubiquitin Recognition by the Human TSG101 Protein
Sundquist, W. I., Schubert, H. L., Kelly, B. N., Hill, G. C., Holton, J. M., & Hill, C. P. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00129-7 · Cited by 223
Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway
Abrami, L., Lindsay, M. R., Parton, R. G., Leppla, S. H., & van der Goot, F. G. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200312072 · Cited by 219
Degradation of AP2 During Reticulocyte Maturation Enhances Binding of Hsc70 and Alix to a Common Site on TfR for Sorting into Exosomes
Géminard, C., Gassart, A. D., Blanc, L., & Vidal, M. (2004) · Traffic · doi:10.1111/j.1600-0854.2004.0167.x · Cited by 217
Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis
Komada, M., & Soriano, P. (1999) · Genes & Development · doi:10.1101/gad.13.11.1475 · Cited by 209
Bro1 coordinates deubiquitination in the multivesicular body pathway by recruiting Doa4 to endosomes
Luhtala, N., & Odorizzi, G. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200403139 · Cited by 207
Hrs Interacts with Sorting Nexin 1 and Regulates Degradation of Epidermal Growth Factor Receptor
Chin, L., Raynor, M., Wei, X., Chen, H.-Q., & Li, L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m004129200 · Cited by 199
Protein–Protein Interactions of ESCRT Complexes in the Yeast Saccharomyces cerevisiae
Bowers, K., Lottridge, J. M., Helliwell, S. B., Goldthwaite, L. M., Luzio, J. P., & Stevens, T. H. (2004) · Traffic · doi:10.1111/j.1600-0854.2004.00169.x · Cited by 198
Molecular mechanisms of coupled monoubiquitination
Woelk, T., Oldrini, B., Maspero, E., Confalonieri, S., Cavallaro, E. C., Fiore, P. P. D., & Polo, S. (2006) · Nature Cell Biology · doi:10.1038/ncb1484 · Cited by 198
Interactions of GGA3 with the ubiquitin sorting machinery
Puertollano, R., & Bonifacino, J. S. (2004) · Nature Cell Biology · doi:10.1038/ncb1106 · Cited by 196
The multiple personalities of Alix
Odorizzi, G. (2006) · Journal of Cell Science · doi:10.1242/jcs.03072 · Cited by 195
Dendritic Cells Regulate Exposure of MHC Class II at Their Plasma Membrane by Oligoubiquitination
van Niel, G., Wubbolts, R., ten Broeke, T., Buschow, S. I., OSSENDORP, F. A., Melief, C. J. M., Raposo, G., van Balkom, B. W. M., & Stoorvogel, W. (2006) · Immunity · doi:10.1016/j.immuni.2006.11.001 · Cited by 195
Vps27-Hse1 and ESCRT-I complexes cooperate to increase efficiency of sorting ubiquitinated proteins at the endosome
Bilodeau, P. S., Winistorfer, S. C., Kearney, W. R., Robertson, A. D., & Piper, R. C. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200305007 · Cited by 193
Self-citation
Exploring the ESCRTing machinery in eukaryotes
Ibl, V., & Hauser, M. (2006) · Trends in Plant Science · doi:10.1016/j.tplants.2006.01.008 · Cited by 191
The Mouse SKD1, a Homologue of Yeast Vps4p, Is Required for Normal Endosomal Trafficking and Morphology in Mammalian Cells
Yoshimori, T., Yamagata, F., Yamamoto, A., Mizushima, N., Kabeya, Y., Nara, A., Miwako, I., Ohashi, M., Ohsumi, M., & Ohsumi, Y. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.2.747 · Cited by 190
Control of MHC class II antigen presentation in dendritic cells: a balance between creative and destructive forces
Villadangos, J., Schnorrer, P., & Wilson, N. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00317.x · Cited by 189
TSG101/Mammalian VPS23 and Mammalian VPS28 Interact Directly and Are Recruited to VPS4-induced Endosomes
Bishop, N., & Woodman, P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009863200 · Cited by 187
Exosomes contain ubiquitinated proteins
Buschow, S. I., Liefhebber, J. M. P., Wubbolts, R., & Stoorvogel, W. (2005) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2005.08.005 · Cited by 185
Aggregation reroutes molecules from a recycling to a vesicle-mediated secretion pathway during reticulocyte maturation
Vidal, M., Mangeat, P. H., & Hoekstra, D. (1997) · Journal of Cell Science · doi:10.1242/jcs.110.16.1867 · Cited by 184
Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A
Scott, A., Gaspar, J., Stuchell‐Brereton, M. D., Alam, S. L., Skalicky, J. J., & Sundquist, W. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502165102 · Cited by 183
Depletion of TSG101 forms a mammalian `Class E' compartment: a multicisternal early endosome with multiple sorting defects
Doyotte, A., Russell, M. R. G., Hopkins, C. R., & Woodman, P. G. (2005) · Journal of Cell Science · doi:10.1242/jcs.02421 · Cited by 175
Multivesicular Body-ESCRT Components Function in pH Response Regulation in Saccharomyces cerevisiae and Candida albicans
Xu, W., Smith, F. J., Subaran, R. L., & Mitchell, A. P. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-08-0666 · Cited by 168
Degradation of Endocytosed Epidermal Growth Factor and Virally Ubiquitinated Major Histocompatibility Complex Class I Is Independent of Mammalian ESCRTII
Bowers, K., Piper, S. C., Edeling, M. A., Gray, S. R., Owen, D. J., Lehner, P. J., & Luzio, J. P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m508632200 · Cited by 166
The ESCRT-III Subunit hVps24 Is Required for Degradation but Not Silencing of the Epidermal Growth Factor Receptor
Bache, K. G., Stuffers, S., Malerød, L., Slagsvold, T., Raiborg, C., Lechardeur, D., Wälchli, S., Lukács, G. L., Brech, A., & Stenmark, H. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-10-0915 · Cited by 166
Human ESCRT-II Complex and Its Role in Human Immunodeficiency Virus Type 1 Release
Langelier, C., von Schwedler, U. K., Fisher, R. D., De Domenico, I., White, P. L., Hill, C. P., Kaplan, J., Ward, D., & Sundquist, W. I. (2006) · Journal of Virology · doi:10.1128/jvi.01049-06 · Cited by 166
Interaction of the Mammalian Endosomal Sorting Complex Required for Transport (ESCRT) III Protein hSnf7-1 with Itself, Membranes, and the AAA+ ATPase SKD1
Lin, Y., Kimpler, L. A., Naismith, T. V., Lauer, J. M., & Hanson, P. I. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413968200 · Cited by 160
A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control
Li, L., Liao, J., Ruland, J., Mak, T. W., & Cohen, S. N. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1619 · Cited by 159
A systematic analysis of human CHMP protein interactions: Additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex
Tsang, H. T. H., Connell, J. W., Brown, S. E., Thompson, A., Reid, E., & Sanderson, C. M. (2006) · Genomics · doi:10.1016/j.ygeno.2006.04.003 · Cited by 156
Flat clathrin coats on endosomes mediate degradative protein sorting by scaffolding Hrs in dynamic microdomains
Raiborg, C., Wesche, J., Malerød, L., & Stenmark, H. (2006) · Journal of Cell Science · doi:10.1242/jcs.02978 · Cited by 155
Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1
Azmi, I. F., Davies, B. A., Dimaano, C., Payne, J. A., Eckert, D. M., Babst, M., & Katzmann, D. J. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200508166 · Cited by 155
Self-citation
Nedd4.1-mediated ubiquitination and subsequent recruitment of Tsg101 ensure HTLV-1 Gag trafficking towards the multivesicular body pathway prior to virus budding
Blot, V., Perugi, F., Gay, B., Prévost, M., Briant, L., Tangy, F., Abriel, H., Staub, O., Dokhélar, M., & Pique, C. (2004) · Journal of Cell Science · doi:10.1242/jcs.01095 · Cited by 154
Ubiquitin Sorts Proteins into the Intralumenal Degradative Compartment of the Late‐Endosome/Vacuole
Urbanowski, J. L., & Piper, R. C. (2001) · Traffic · doi:10.1034/j.1600-0854.2001.20905.x · Cited by 151
Self-citation
Structural insight into the ESCRT‐I/‐II link and its role in MVB trafficking
Gill, D. J., Teo, H., Sun, J., Perišić, O., Veprintsev, D. B., Emr, S. D., & Williams, R. L. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601501 · Cited by 150
Multivesicular bodies in HEp-2 cells are maturing endosomes.
van Deurs, B., Holm, P. K., Kayser, L., Sandvig, K., & Hansen, S. H. (1993) · PubMed · Cited by 150
Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus buddingPreprint
Amit, I., Yakir, L., Katz, M., Zwang, Y., Marmor, M. D., Citri, A., Shtiegman, K., Alroy, I., Tuvia, S., Reiss, Y., et al. (2004) · Genes & Development · doi:10.1101/gad.294904 · Cited by 148
Phosphoinositide signaling and turnover: PtdIns(3)P, a regulator of membrane traffic, is transported to the vacuole and degraded by a process that requires lumenal vacuolar hydrolase activities
Wurmser, A. E., & Emr, S. D. (1998) · The EMBO Journal · doi:10.1093/emboj/17.17.4930 · Cited by 148
Intracellular Trafficking of Interleukin-1 Receptor I Requires Tollip
Brissoni, B., Agostini, L., Kropf, M., Martinon, F., Swoboda, V., Lippens, S., Everett, H., Aebi, N., Janssens, S., Meylan, E., et al. (2006) · Current Biology · doi:10.1016/j.cub.2006.09.062 · Cited by 148
Endosomal compartmentalization in three dimensions: Implications for membrane fusion
Murk, J., Humbel, B. M., Ziese, U., Griffith, J. M., Posthuma, G., Slot, J. W., Koster, A. J., Verkleij, A. J., Geuze, H. J., & Kleijmeer, M. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2232379100 · Cited by 145
Cholesterol contributes to the organization of tetraspanin-enriched microdomains and to CD81-dependent infection by malaria sporozoites
Silvie, O., Charrin, S., Billard, M., Franetich, J., Clark, K. L., van Gemert, G., Sauerwein, R. W., Dautry, F., Boucheix, C., Mazier, D., et al. (2006) · Journal of Cell Science · doi:10.1242/jcs.02911 · Cited by 138
Spongiform Neurodegeneration-associated E3 Ligase Mahogunin Ubiquitylates TSG101 and Regulates Endosomal Trafficking
Kim, B. Y., Olzmann, J. A., Barsh, G. S., Chin, L., & Li, L. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-09-0787 · Cited by 137
Structural Insights into Endosomal Sorting Complex Required for Transport (ESCRT-I) Recognition of Ubiquitinated Proteins
Teo, H., Veprintsev, D. B., & Williams, R. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400023200 · Cited by 137
CART: An Hrs/Actinin-4/BERP/Myosin V Protein Complex Required for Efficient Receptor Recycling
Yan, Q., Sun, W., Kujala, P., Lotfi, Y., Vida, T. A., & Bean, A. J. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-11-1014 · Cited by 131
Rapid Ca 2+ -dependent decrease of protein ubiquitination at synapses
Chen, H., Polo, S., Fiore, P. P. D., & Camilli, P. V. D. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2136625100 · Cited by 121
A Deubiquitinating Enzyme UBPY Regulates the Level of Protein Ubiquitination on Endosomes
Mizuno, E., Kobayashi, K., Yamamoto, A., Kitamura, N., & Komada, M. (2006) · Traffic · doi:10.1111/j.1600-0854.2006.00452.x · Cited by 120
Proteasome Inhibitors Block a Late Step in Lysosomal Transport of Selected Membrane but not Soluble Proteins
van Kerkhof, P., dos Santos, C. M. A., Sachse, M., Klumperman, J., Bu, G., & Strous, G. J. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.8.2556 · Cited by 114
VESICLE FUSION AND FORMATION AT THE SURFACE OF PINOCYTIC VACUOLES IN MACROPHAGES
Hirsch, J. G., Fedorko, M. E., & Cohn, Z. A. (1968) · The Journal of Cell Biology · doi:10.1083/jcb.38.3.629 · Cited by 113
Involvement of the Ubiquitin/Proteasome System in Sorting of the Interleukin 2 Receptor β Chain to Late Endocytic Compartments
Rocca, A., Lamaze, C., Subtil, A., & Dautry‐Varsat, A. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.5.1293 · Cited by 113
Evidence of Cholesterol Accumulated in High Curvature Regions: Implication to the Curvature Elastic Energy for Lipid Mixtures
Wang, W., Yang, L., & Huang, H. W. (2007) · Biophysical Journal · doi:10.1529/biophysj.106.097923 · Cited by 110
Endosomal Dynamics of Met Determine Signaling Output
Hammond, D. E., Carter, S., McCullough, J., Urbé, S., Woude, G. V., & Clague, M. J. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-09-0578 · Cited by 103
Tetraspanin CD82 controls the association of cholesterol-dependent microdomains with the actin cytoskeleton in T lymphocytes: relevance to co-stimulation
Delaguillaumie, A., Harriague, J., Kohanna, S., Bismuth, G., Rubinstein, E., Seigneuret, M., & Conjeaud, H. (2004) · Journal of Cell Science · doi:10.1242/jcs.01380 · Cited by 103
Isolation and characterization of multivesicular bodies from rat hepatocytes: an organelle distinct from secretory vesicles of the Golgi apparatus.
Hornick, C. A., Hamilton, R. L., Spaziani, E., Enders, G. H., & Havel, R. J. (1985) · The Journal of Cell Biology · doi:10.1083/jcb.100.5.1558 · Cited by 102
Hrs regulates early endosome fusion by inhibiting formation of an endosomal SNARE complex
Sun, W., Yan, Q., Vida, T. A., & Bean, A. J. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302083 · Cited by 94
Biogenesis of transport intermediates in the endocytic pathway
Gu, F., & Gruenberg, J. E. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00561-x · Cited by 92
Vta1p and Vps46p regulate the membrane association and ATPase activity of Vps4p at the yeast multivesicular body
Lottridge, J. M., Flannery, A. R., Vincelli, J. L., & Stevens, T. H. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601712103 · Cited by 89
Interactions of TOM1L1 with the Multivesicular Body Sorting Machinery
Puertollano, R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m412481200 · Cited by 80
Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain
Alam, S. L., Langelier, C., Whitby, F. G., Koirala, S., Robinson, H. H., Hill, C. P., & Sundquist, W. I. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1160 · Cited by 80
Membrane transport: Ubiquitylation in endosomal sorting
Dupré‐Crochet, S., Volland, C., & Haguenauer‐Tsapis, R. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00558-9 · Cited by 79
Efficient Cargo Sorting by ESCRT-I and the Subsequent Release of ESCRT-I from Multivesicular Bodies Requires the Subunit Mvb12
Curtiss, M., Jones, C. B., & Babst, M. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-07-0588 · Cited by 77
Targeting of AMSH to Endosomes Is Required for Epidermal Growth Factor Receptor Degradation
Ma, Y. M., Boucrot, E., Villén, J., Affar, E. B., Gygi, S. P., Göttlinger, H. G., & Kirchhausen, T. L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611635200 · Cited by 77
Peripherin/rds Influences Membrane Vesicle Morphology
Wrigley, J. D. J., Ahmed, T., Nevett, C. L., & Findlay, J. B. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c900853199 · Cited by 76
Characterization of Vta1p, a Class E Vps Protein in Saccharomyces cerevisiae
Shiflett, S. L., Ward, D. M., Huynh, D., Vaughn, M. B., Simmons, J. C., & Kaplan, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312669200 · Cited by 75
Direct Binding to Rsp5 Mediates Ubiquitin-independent Sorting of Sna3 via the Multivesicular Body Pathway
McNatt, M. W., McKittrick, I., West, M., & Odorizzi, G. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-08-0663 · Cited by 74
Effects of deficiencies of STAMs and Hrs, mammalian class E Vps proteins, on receptor downregulation
Kanazawa, C., Morita, E., Yamada, M., Ishii, N., Miura, S., Asao, H., Yoshimori, T., & Sugamura, K. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.08.078 · Cited by 68
Hse1, a Component of the Yeast Hrs-STAM Ubiquitin-sorting Complex, Associates with Ubiquitin Peptidases and a Ligase to Control Sorting Efficiency into Multivesicular Bodies
Ren, J., Kee, Y., Huibregtse, J. M., & Piper, R. C. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-06-0557 · Cited by 66
Self-citation
Snf7p, a Component of the ESCRT-III Protein Complex, Is an Upstream Member of the RIM101 Pathway in Candida albicans
Kullas, A. L., Li, M., & Davis, D. A. (2004) · Eukaryotic Cell · doi:10.1128/ec.3.6.1609-1618.2004 · Cited by 65
Recruitment of clathrin onto endosomes by the Tom1–Tollip complex
Katoh, Y., Imakagura, H., Futatsumori, M., & Nakayama, K. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.12.156 · Cited by 64
Characterization of Multiple Multivesicular Body Sorting Determinants within Sna3: A Role for the Ubiquitin Ligase Rsp5
Oestreich, A. J., Aboian, M., Lee, J. R. E., Azmi, I. F., Payne, J. A., Issaka, R. B., Davies, B. A., & Katzmann, D. J. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-08-0680 · Cited by 64
Self-citation
ATPase-deficient hVPS4 impairs formation of internal endosomal vesicles and stabilizes bilayered clathrin coats on endosomal vacuoles
Sachse, M., Strous, G. J., & Klumperman, J. (2004) · Journal of Cell Science · doi:10.1242/jcs.00998 · Cited by 63
AAA ATPases regulate membrane association of yeast oxysterol binding proteins and sterol metabolism
Wang, P., Zhang, Y., Li, H., Chieu, H. K., Munn, A. L., & Yang, H. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600764 · Cited by 63
The GAT Domains of Clathrin-associated GGA Proteins Have Two Ubiquitin Binding Motifs
Bilodeau, P. S., Winistorfer, S. C., Allaman, M. M., Surendhran, K., Kearney, W. R., Robertson, A. D., & Piper, R. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406654200 · Cited by 59
Self-citation
Old lysosomes, new tricks: MHC II dynamics in DCs
CHOW, A., & Mellman, I. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.11.008 · Cited by 55
Structural basis of ubiquitin recognition by mammalian Eap45 GLUE domain
Hirano, S., Suzuki, N., Slagsvold, T., Kawasaki, M., Trambaiolo, D. M., Kato, R., Stenmark, H., & Soichi Wakatsuki, A. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1163 · Cited by 55
Mvb12 Is a Novel Member of ESCRT-I Involved in Cargo Selection by the Multivesicular Body Pathway
Oestreich, A. J., Davies, B. A., Payne, J. A., & Katzmann, D. J. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-07-0601 · Cited by 53
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A Mutation indVps28Reveals a Link between a Subunit of the Endosomal Sorting Complex Required for Transport-I Complex and the Actin Cytoskeleton inDrosophila
Sevrioukov, E. A., Moghrabi, N. N., Kuhn, M., & Krämer, H. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-11-1013 · Cited by 50
The Plasmodium falciparum Vps4 homolog mediates multivesicular body formation
Yang, M., Coppens, I., Wormsley, S., Baevova, P., Hoppe, H. C., & Joiner, K. A. (2004) · Journal of Cell Science · doi:10.1242/jcs.01237 · Cited by 47
Hepatocyte Growth Factor-regulated Tyrosine Kinase Substrate (HRS) Interacts with PELP1 and Activates MAPK
Rayala, S. K., den Hollander, P., Balasenthil, S., Molli, P. R., Bean, A. J., Vadlamudi, R. K., Wang, R., & Kumar, R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510368200 · Cited by 45
Formation of multivesicular endosomes in Dictyostelium
Marchetti, A., Mercanti, V., Cornillon, S., Alibaud, L., Charette, S. J., & Cosson, P. (2004) · Journal of Cell Science · doi:10.1242/jcs.01524 · Cited by 30
Monoubiquitylation of GGA3 by hVPS18 regulates its ubiquitin-binding ability
Yogosawa, S., Kawasaki, M., Wakatsuki, S., Kominami, E., Shiba, Y., Nakayama, K., Kohsaka, S., & Akazawa, C. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.09.013 · Cited by 26
Both clathrin-positive and -negative coats are involved in endosomal sorting of the EGF receptor
Myromslien, F. D., Grøvdal, L. M., Raiborg, C., Stenmark, H., Madshus, I. H., & Stang, E. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.06.004 · Cited by 22
Ubiquitin, lysosomes and neurodegenerative diseases
Mayer, R. J., László, L., MIDDLETON, A., Landon, M., Hope, J., & Lowe, J. S. (1992) · Biochemical Society Transactions · doi:10.1042/bst0200645 · Cited by 7

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van Deurs B, 1993, Eur. J. Cell Biol., 61, 208

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Authors: Piper, R. C., & Katzmann, D. J.
Affiliations: University of Iowa (US)
Mayo Clinic (US)
ORCID: Piper, Robert C.
Katzmann, David J.
Venue: Annual Review of Cell and Developmental Biology
Publisher: Annual Reviews
Published: 2007-11-01
Volume: 23
Issue: 1
Pages: 519-547
ISSN: 1081-0706 (ISSN-L)
1530-8995
DOI: 10.1146/annurev.cellbio.23.090506.123319
PMC: PMC2911632
OpenAlex: W2109691647
Cited by: 771
References: 154
Citations by year: 2026: 23 · 2025: 34 · 2024: 55 · 2023: 39 · 2022: 51 · 2021: 49 · 2020: 48 · 2019: 54 · 2018: 46 · 2017: 36 · 2016: 28 · 2015: 37 · 2014: 26 · 2013: 34 · 2012: 38
FWCI: 3.06
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Annual Review of Cell and Developmental Biology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (R01GM58202, R01GM73024, R01GM073024, R01GM058202)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Keywords: multivesicular bodies, endosomes, membrane protein degradation, ubiquitination, lysosomal degradation, proteasome, intralumenal vesicles, endosomal sorting, cargo sorting, membrane fission
MeSH terms: Animals, Humans, Lysosomes, Protein Conformation, Proteins, Endosomes, Protein Transport, Protein Sorting Signals, Ubiquitin, Lipid Metabolism, Ubiquitination

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Biogenesis and Function of Multivesicular Bodies

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