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Interleukin-10
Abstract
In the three years since its discovery, the pleiotropic cytokine interleukin-10 (IL-10) has been implicated as an important regulator of the functions of lymphoid and myeloid cells. IL-10's ability to block activation of cytokine synthesis and several accessory cell functions of macrophage renders this cytokine a potent suppressor of the effector functions of macrophages, T cells, and NK cells. In addition, IL-10 likely contributes to regulating proliferation and differentiation of B cells, mast cells, and thymocytes. The Epstein-Barr virus genome encodes a homolog of IL-10 (BCFR1, viral IL-10, vIL-10) which shares many of the cellular cytokine's biological activities and may therefore play a role in the host-virus interaction. This article reviews current studies of IL-10's biological activities and discusses its possible roles in regulation of immune responses.
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Metadata
- Authors
- Moore, K.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 1993-01-01
- Volume
- 11
- Issue
- 1
- Pages
- 165-190
- ISSN
- 0732-0582 (ISSN-L)
- OpenAlex
- W4231581694
- Cited by
- 1,884
- References
- 0
- FWCI
- 36.57
- Type
- journal article
- Language
- en
- Open access
- closed
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