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The Glial Nature of Embryonic and Adult Neural Stem Cells
Open accessAbstract
Glial cells were long considered end products of neural differentiation, specialized supportive cells with an origin very different from that of neurons. New studies have shown that some glial cells—radial glia (RG) in development and specific subpopulations of astrocytes in adult mammals—function as primary progenitors or neural stem cells (NSCs). This is a fundamental departure from classical views separating neuronal and glial lineages early in development. Direct visualization of the behavior of NSCs and lineage-tracing studies reveal how neuronal lineages emerge. In development and in the adult brain, many neurons and glial cells are not the direct progeny of NSCs, but instead originate from transit amplifying, or intermediate, progenitor cells (IPCs). Within NSCs and IPCs, genetic programs unfold for generating the extraordinary diversity of cell types in the central nervous system. The timing in development and location of NSCs, a property tightly linked to their neuroepithelial origin, appear to be the key determinants of the types of neurons generated. Identification of NSCs and IPCs is critical to understand brain development and adult neurogenesis and to develop new strategies for brain repair.
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“GFAP is also expressed by progenitor cells15 and its expression depends on developmental stages16,17.”
From Reactive astrocyte nomenclature, definitions, and future directions (2021) · cites this paper as [15]
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In the citing paper
“In particular, and by taking advantage of Btg2 and Tubb3 expression, our group has generated a combinatorial, double-reporter mouse line in which RFP and or GFP expression allowed the isolation specifically of PP, DP and N based on their endogenous fluorescence (RFP-, RFP+ and GFP+, respectively) (31).”
From MicroRNA profiling of mouse cortical progenitors and neurons reveals miR-486-5p as a regulator of neurogenesis (2020) · cites this paper as [31]
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“Unsurprisingly, when analyzing the expression pattern of the host genes of switch miRNAs (data retrieved from ( 31)), we found a high degree of overlap in their differential expression within different cell populations (Figure 3).”
From MicroRNA profiling of mouse cortical progenitors and neurons reveals miR-486-5p as a regulator of neurogenesis (2020) · cites this paper as [31]
Experimental — accuracy not yet measuredIn the citing paper
“There is evidence of neurogenesis from adult neural stem cells deriving from the subventricular zone (SVZ) and the subgranular zone (SGZ) of the hippocampal dentate gyrus, that can give rise to neurons, oligodendrocytes and astrocytes [107,108].”
From Ageing, Cellular Senescence and Neurodegenerative Disease (2018) · cites this paper as [108]
In the citing paper
“The predicted progenitors expressed proliferation (Mki67) and known markers (Pax6, Rspo2/3, Wnt5a/3a/1, Fabp7, clusters 7 and 8 in Figure 2A,B S2B; STAR Methods), previously reported for precursors of ependymal cells and cortical neurons (Kriegstein and Alvarez-Buylla, 2009), with Wnt1 having the most specific expression (Figure S2G).”
From A cellular and spatial map of the choroid plexus across brain ventricles and ages (2021) · cites this paper as Kriegstein and Alvarez-Buylla, 2009
In the citing paper
“In embryos, subsets of glial cells expressed markers of neural progenitor/stem-like cells (e.g. Pax6, Nes, Sox2, Rspo2/3) or of oligodendrocyte precursor cells (OPCs, e.g. Olig1, Olig2) (Kriegstein and Alvarez-Buylla, 2009) (Figure 2A, S2A,B).”
From A cellular and spatial map of the choroid plexus across brain ventricles and ages (2021) · cites this paper as Kriegstein and Alvarez-Buylla, 2009
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“Validation and use of this mouse line revealed to be very powerful in the identification of several new genes and biological processes regulating cortical development (31).”
From MicroRNA profiling of mouse cortical progenitors and neurons reveals miR-486-5p as a regulator of neurogenesis (2020) · cites this paper as [31]
In the citing paper
“our group previously concluded that a transient up-or down-regulation specifically in DP compared to both their PP progenitors and N progeny (on-and off-switch transcripts, respectively) represented a hallmark of functional commitment to the neurogenic lineage (31,36).”
From MicroRNA profiling of mouse cortical progenitors and neurons reveals miR-486-5p as a regulator of neurogenesis (2020) · cites this paper as [31]
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Citations
Cites
Neurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369
Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 4,786
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898
Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats
Altman, J., & Das, G. D. (1965) · Journal of Comparative Neurology · doi:10.1002/cne.901240303 · Cited by 3,592
More hippocampal neurons in adult mice living in an enriched environment
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1997) · Nature · doi:10.1038/386493a0 · Cited by 3,586
Specification of Cerebral Cortical Areas
Rakic, P. (1988) · Science · doi:10.1126/science.3291116 · Cited by 3,127 · cited 1×
“Astrocytes may retain fundamental properties and positional information linked to the original array of RG in the developing brain (Rakic 1988).”
BackgroundMechanisms and Functional Implications of Adult Neurogenesis
Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007
Running enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904
Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
Monje, M. L., Toda, H., & Palmer, T. D. (2003) · Science · doi:10.1126/science.1088417 · Cited by 2,426
Research works printed but not linked: 7
- 10.1016/S0092-8674(00)80783-7 · DOI · Paper page
- Hajós F, 1981, Acta Morphol. Acad. Sci. Hung., 29, 361
- Magini J, 1888, Arch. Ital. Biol., 10, 384
- Miyata T, 2008, Dev. Growth Differ., 50, S105
- Retzius G, 1894, Biol. Unters., 6, 1
- Smart IH, 1973, J. Anat., 116, 67
- 10.1523/JNEUROSCI.18-20-08331.1998 · DOI
Cited by
Sorted by citations
Items 101–200 of 1,011
Baldwin, K. T., Murai, K. K., & Khakh, B. S. (2023) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.09.006 · Cited by 237
Suzuki, S. C., Bleckert, A., Williams, P. R., Takechi, M., Kawamura, S., & Wong, R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303551110 · Cited by 226
How many neurons do you have? Some dogmas of quantitative neuroscience under revision
Lent, R., Azevedo, F. A. C., Andrade-Moraes, C. H., & de Oliveira-Pinto, A. V. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07923.x · Cited by 233
Astrocyte glutamine synthetase: pivotal in health and disease
Rose, C. F., Verkhratsky, A., & Parpura, V. (2013) · Biochemical Society Transactions · doi:10.1042/bst20130237 · Cited by 224
SOX2 Reprograms Resident Astrocytes into Neural Progenitors in the Adult Brain
Niu, W., Zang, T., Smith, D. K., Vue, T. Y., Zou, Y., Bachoo, R. M., Johnson, J. E. B., & Zhang, C. (2015) · Stem Cell Reports · doi:10.1016/j.stemcr.2015.03.006 · Cited by 232
An astroglial basis of major depressive disorder? An overview
Wang, Q., Jie, W., Liu, J., Yang, J., & Gao, T. (2017) · Glia · doi:10.1002/glia.23143 · Cited by 222
Chromatin Remodeling BAF (SWI/SNF) Complexes in Neural Development and Disorders
Sokpor, G., Xie, Y., Rosenbusch, J., & Tuoc, T. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00243 · Cited by 230
Preferential electrical coupling regulates neocortical lineage-dependent microcircuit assembly
Yu, Y.-C., He, S., Chen, S., Fu, Y., Brown, K. N., Yao, X.-H., Ma, J., Gao, K. P., Sosinsky, G. E., Huang, K., et al. (2012) · Nature · doi:10.1038/nature10958 · Cited by 219
Götz, M., Sirko, S., Beckers, J., & Irmler, M. (2015) · Glia · doi:10.1002/glia.22850 · Cited by 237
Glial Development: The Crossroads of Regeneration and Repair in the CNS
Gallo, V., & Deneen, B. (2014) · Neuron · doi:10.1016/j.neuron.2014.06.010 · Cited by 232
Adult Lineage-Restricted CNS Progenitors Specify Distinct Glioblastoma Subtypes
Llaguno, S. R. A., Wang, Z., Sun, D., Chen, J., Xu, J., Kim, E., Hatanpaa, K. J., Raisanen, J. M., Burns, D. K., Johnson, J. E. B., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.09.007 · Cited by 231
Neurogenesis at the Brain–Cerebrospinal Fluid Interface
Lehtinen, M. K., & Walsh, C. A. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154026 · Cited by 230
Kelava, I., Reillo, I., Murayama, A. Y., Kalinka, A. T., Stenzel, D., Tomančák, P., Matsuzaki, F., Lebrand, C., Sasaki, E., Schwamborn, J. C., et al. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr301 · Cited by 217
Amplification of progenitors in the mammalian telencephalon includes a new radial glial cell type
Pilz, G.-A., Shitamukai, A., Reillo, I., Pacary, E., Schwausch, J., Stahl, R., Ninkovic, J., Snippert, H. J. G., Clevers, H. C., Godinho, L., et al. (2013) · Nature Communications · doi:10.1038/ncomms3125 · Cited by 229
It Takes a Village: Constructing the Neurogenic Niche
Bjornsson, C. S., Apostolopoulou, M., Tian, Y. I., & Temple, S. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.01.010 · Cited by 228
Neural stem cell therapies and hypoxic-ischemic brain injury
Huang, L., & Zhang, L. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.05.004 · Cited by 209
Orchestrating transcriptional control of adult neurogenesisPreprint
Hsieh, J. (2012) · Genes & Development · doi:10.1101/gad.187336.112 · Cited by 218
Weng, Q., Wang, J., Wang, J., He, D., Cheng, Z., Zhang, F., Verma, R., Xu, L., Dong, X., Liao, Y., et al. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.03.006 · Cited by 206
Souza, B. S. D. F., Sampaio, G. L. D. A., Pereira, C. S., Campos, G. S., Sardi, S. I., de Freitas, L. A. R., Figueira, C. P., Paredes, B. D., Nonaka, C. K. V., Azevedo, C. M., et al. (2016) · Scientific Reports · doi:10.1038/srep39775 · Cited by 204
A Quantitative Framework to Evaluate Modeling of Cortical Development by Neural Stem Cells
Stein, J. L., de la Torre-Ubieta, L., Tian, Y., Parikshak, N. N., Hernández, I. A., Marchetto, M. C., Baker, D. K., Lu, D., Hinman, C. R., Lowe, J. K., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.035 · Cited by 201
The Adult Human Brain Harbors Multipotent Perivascular Mesenchymal Stem Cells
Paul, G., Özen, Í., Christophersen, N. S., Reinbothe, T. M., Bengzon, J., Visse, E., Jansson, K., Dannaeus, K., Henriques-Oliveira, C., Roybon, L., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035577 · Cited by 206
Long, J. M., Ray, B., & Lahiri, D. K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.366336 · Cited by 198
A mosaic world: puzzles revealed by adult neural stem cell heterogeneity
Chaker, Z., Codega, P., & Doetsch, F. (2016) · WIREs Developmental Biology · doi:10.1002/wdev.248 · Cited by 198
Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis
Lange, C. M., Garcίa, M. T., Decimo, I., Bifari, F., Eelen, G., Quaegebeur, A., Boon, R., Zhao, H., Boeckx, B., Chang, J., et al. (2016) · The EMBO Journal · doi:10.15252/embj.201592372 · Cited by 198
Shao, Q., Herrlinger, S. A., Yang, S., Lai, F., Moore, J. M., Brindley, M. A., & Chen, J.-F. (2016) · Development · doi:10.1242/dev.143768 · Cited by 203
Yuzwa, S. A., Borrett, M. J., Innes, B. T., Voronova, A., Ketela, T., Kaplan, D. R., Bader, G. D., & Miller, F. D. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.12.017 · Cited by 205
Migaud, M., Batailler, M., Segura, S., Duittoz, A. H., Franceschini, I., & Pillon, D. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07521.x · Cited by 210
Rothenaigner, I., Krecsmarik, M., Hayes, J. A., Bahn, B., Lepier, A., Fortin, G., Götz, M., Jagasia, R., & Bally‐Cuif, L. (2011) · Development · doi:10.1242/dev.058156 · Cited by 202
Human Models Are Needed for Studying Human Neurodevelopmental Disorders
Zhao, X., & Bhattacharyya, A. (2018) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2018.10.009 · Cited by 192
Midbrain dopaminergic neurons: A review of the molecular circuitry that regulates their development
Hegarty, S. V., Sullivan, A. M., & O’Keeffe, G. W. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.04.014 · Cited by 190
Diotel, N., Charlier, T. D., d’Hellencourt, C. L., Couret, D., Trudeau, V. L., Cano‐Nicolau, J., Meilhac, O., Kah, O., & Pellegrini, E. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00084 · Cited by 199
Molecular Control of Neurogenesis: A View from the Mammalian Cerebral CortexPreprint
Martynoga, B., Drechsel, D., & Guillemot, F. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008359 · Cited by 214
Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy
Basak, O., Krieger, T. G., Muraro, M. J., Wiebrands, K., Stange, D. E., Frias-Aldeguer, J., Rivron, N. C., van de Wetering, M., van Es, J. H., van Oudenaarden, A., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1715911114 · Cited by 186
Nagashima, M., Barthel, L. K., & Raymond, P. A. (2013) · Development · doi:10.1242/dev.090738 · Cited by 186
Ascl1 Coordinately Regulates Gene Expression and the Chromatin Landscape during Neurogenesis
Raposo, A. A. S. F., Vasconcelos, F. F., Drechsel, D., Marie, C., Johnston, C., Dolle, D. D., Bithell, A., Gillotin, S., van den Berg, D. L. C., Ettwiller, L. M., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.02.025 · Cited by 193
Cytosine-5 RNA Methylation Regulates Neural Stem Cell Differentiation and Motility
Flores, J. V., Cordero-Espinoza, L., Oeztuerk-Winder, F., Andersson-Rolf, A., Selmi, T., Blanco, S., Tailor, J. K., Dietmann, S., & Frye, M. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.11.014 · Cited by 186
Hu, D. J.-K., Baffet, A. D., Nayak, T., Akhmanova, A. S., Doye, V., & Vallee, R. B. (2013) · Cell · doi:10.1016/j.cell.2013.08.024 · Cited by 185
Functional Cell Types in Taste Buds Have Distinct Longevities
Perea‐Martinez, I., Nagai, T., & Chaudhari, N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053399 · Cited by 184
Gargiulo, G., Cesaroni, M., Serresi, M., de Vries, N., Hulsman, D., Bruggeman, S. W., Lancini, C., & van Lohuizen, M. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.03.030 · Cited by 176
Effects of inflammation on stem cells: together they strive?
Kızıl, Ç., Kyritsis, N., & Brand, M. (2015) · EMBO Reports · doi:10.15252/embr.201439702 · Cited by 190
Cortical neurogenesis in the absence of centrioles
Insolera, R., Bazzi, H., Shao, W., Anderson, K. V., & Shi, S. (2014) · Nature Neuroscience · doi:10.1038/nn.3831 · Cited by 189
Glial cells in adult neurogenesis
Morrens, J., Broeck, W. V. D., & Kempermann, G. (2011) · Glia · doi:10.1002/glia.21247 · Cited by 187
Adult neural stem cells stake their ground
Lim, D. A., & Álvarez-Buylla, A. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.08.006 · Cited by 191
Direct Neuronal Reprogramming: Achievements, Hurdles, and New Roads to Success
Gascón, S., Masserdotti, G., Russo, G. L., & Götz, M. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.06.011 · Cited by 183
Sueda, R., Imayoshi, I., Harima, Y., & Kageyama, R. (2019) · Genes & Development · doi:10.1101/gad.323196.118 · Cited by 184
Adult neurogenesis and neurodegenerative diseases: A systems biology perspective
Horgusluoglu, E., Nudelman, K., Nho, K., & Saykin, A. J. (2017) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32429 · Cited by 174
Bustamante-Barrientos, F. A., Méndez-Ruette, M., Ortloff, A., Luz‐Crawford, P., Rivera, F. J., Figueroa, C. D., Molina, L., & Bátiz, L. F. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.636176 · Cited by 180
Adult neurogenesis in mammals – a theme with many variations
Bonfanti, L., & Peretto, P. M. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07832.x · Cited by 177
Molecular and cellular dynamics of the developing human neocortex
Wang, L., Wang, C., Moriano, J., Chen, S., Zuo, G., Cebrián‐Silla, A., Zhang, S., Mukhtar, T., Wang, S., Song, M., et al. (2025) · Nature · doi:10.1038/s41586-024-08351-7 · Cited by 179
Self-citationMEK Is a Key Regulator of Gliogenesis in the Developing Brain
Li, X., Newbern, J. M., Wu, Y., Morgan-Smith, M., Zhong, J., Charron, J., & Snider, W. D. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.031 · Cited by 174
BMP-Smad 1/5/8 signalling in the development of the nervous system
Hegarty, S. V., O’Keeffe, G. W., & Sullivan, A. M. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.07.002 · Cited by 176
Oligodendrogenesis in the subventricular zone and the role of epidermal growth factor
González-Pérez, Ó., & Álvarez-Buylla, A. (2011) · Brain Research Reviews · doi:10.1016/j.brainresrev.2011.01.001 · Cited by 176
Adult neurogenesis in the mammalian dentate gyrus
Abbott, L. C., & Nigussie, F. (2019) · Anatomia Histologia Embryologia · doi:10.1111/ahe.12496 · Cited by 183
Dopaminergic Neurons and Brain Reward Pathways
Luo, S. X., & Huang, E. J. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.09.023 · Cited by 170
FIP200 is required for maintenance and differentiation of postnatal neural stem cells
Wang, C., Liang, C.-C., Bian, Z. C., Zhu, Y., & Guan, J.-L. (2013) · Nature Neuroscience · doi:10.1038/nn.3365 · Cited by 169
Postiglione, M. P., Jüschke, C., Xie, Y., Haas, G. A., Charalambous, C., & Knoblich, J. A. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.022 · Cited by 178
Human neural stem cells alleviate Alzheimer-like pathology in a mouse model
Lee, I.-S., Jung, K., Kim, I., Lee, H.-J., Kim, M., Yun, S., Hwang, K., Shin, J. E., & Park, K. I. (2015) · Molecular Neurodegeneration · doi:10.1186/s13024-015-0035-6 · Cited by 170
Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesisPreprint
Calvo, C.-F., Fontaine, R. H., Soueid, J., Tammela, T., Makinen, T., Alfaro-Cervello, C., Bonnaud, F., Miguez, A., Benhaim, L., Xu, Y., et al. (2011) · Genes & Development · doi:10.1101/gad.615311 · Cited by 175
Schwann Cell Precursors; Multipotent Glial Cells in Embryonic Nerves
Jessen, K. R., & Mirsky, R. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00069 · Cited by 167
Role of mTOR Complexes in Neurogenesis
Licausi, F., & Hartman, N. W. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051544 · Cited by 172
Wnt your brain be inflamed? Yes, it Wnt!
Marchetti, B., & Pluchino, S. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.12.001 · Cited by 167
Astrocytes and the TGF-β1 Pathway in the Healthy and Diseased Brain: a Double-Edged Sword
Diniz, L. P., Matias, I. C. P., Siqueira, M., Stipursky, J., & Gomes, F. C. A. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1396-y · Cited by 169
An Adaptive Threshold in Mammalian Neocortical Evolution
Lewitus, É., Kelava, I., Kalinka, A. T., Tomančák, P., & Huttner, W. Β. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1002000 · Cited by 169
Neural stem cell niches: Roles for the hyaluronan-based extracellular matrix
Preston, M. (2011) · Frontiers in Bioscience-Scholar · doi:10.2741/218 · Cited by 160
Direct reprogramming of human astrocytes into neural stem cells and neurons
Corti, S. P., Nizzardo, M., Simone, C., Falcone, M., Donadoni, C., Salani, S., Rizzo, F., Nardini, M., Riboldi, G. M., Magri, F., et al. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.02.040 · Cited by 165
Live-imaging of astrocyte morphogenesis and function in zebrafish neural circuits
Chen, J., Poskanzer, K. E., Freeman, M. R., & Monk, K. R. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0703-x · Cited by 166
Adult neural stem cells and their niche: a dynamic duo during homeostasis, regeneration, and aging
Silva-Vargas, V., Crouch, E. E., & Doetsch, F. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.09.004 · Cited by 157
Chen, F., & LoTurco, J. J. (2012) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2012.03.016 · Cited by 157
Astrogliopathology in neurological, neurodevelopmental and psychiatric disorders
Verkhratsky, A., & Parpura, V. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.03.025 · Cited by 162
Continuous live imaging of adult neural stem cell division and lineage progression in vitro
Costa, M. R., Ortega, F., Brill, M. S., Beckervordersandforth, R., Petrone, C., Schroeder, T., Götz, M., & Berninger, B. (2011) · Development · doi:10.1242/dev.061663 · Cited by 157
Pioneering Axons Regulate Neuronal Polarization in the Developing Cerebral Cortex
Namba, T., Kibe, Y., Funahashi, Y., Nakamuta, S., Takano, T., Ueno, T., Shimada, A., Kozawa, S., Okamoto, M., Shimoda, Y., et al. (2014) · Neuron · doi:10.1016/j.neuron.2013.12.015 · Cited by 163
Exosomes as Novel Regulators of Adult Neurogenic Niches
Bátiz, L. F., Castro, M. A., Burgos, P. V., Velásquez, Z. D., Muñoz, R. I., Lafourcade, C., Troncoso-Escudero, P., & Wyneken, Ú. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00501 · Cited by 164
Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration
García-Revilla, J., Boza-Serrano, A., Espinosa-Oliva, A. M., Soto, M. S., Deierborg, T., Ruiz, R., de Pablos, R. M., Burguillos, M. A., & Venero, J. L. (2022) · Cell Death & Disease · doi:10.1038/s41419-022-05058-3 · Cited by 156
Comparative aspects of adult neural stem cell activity in vertebrates
Grandel, H., & Brand, M. (2012) · Development Genes and Evolution · doi:10.1007/s00427-012-0425-5 · Cited by 166
Jurisch‐Yaksi, N., Yaksi, E., & Kızıl, Ç. (2020) · Glia · doi:10.1002/glia.23849 · Cited by 174
Adhesion molecules in the stem cell niche – more than just staying in shape?
Marthiens, V., Kazanis, I., Moss, L., Long, K. R., & ffrench‐Constant, C. (2010) · Journal of Cell Science · doi:10.1242/jcs.054312 · Cited by 164
Chen, J.-F., Zhang, Y., Wilde, J. J., Hansen, K. C., Lai, F., & Niswander, L. A. (2014) · Nature Communications · doi:10.1038/ncomms4885 · Cited by 163
Immunoadolescence: Neuroimmune development and adolescent behavior
Brenhouse, H. C., & Schwarz, J. M. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.035 · Cited by 163
Endogenous neural stem cell responses to stroke and spinal cord injury
Grégoire, C., Goldenstein, B., Floriddia, E. M., Barnabé‐Heider, F., & Fernandes, K. J. L. (2015) · Glia · doi:10.1002/glia.22851 · Cited by 156
Predicting stem cell fate changes by differential cell cycle progression patterns
Roccio, M., Schmitter, D., Knobloch, M., Okawa, Y., Sage, D., & Lütolf, M. P. (2012) · Development · doi:10.1242/dev.086215 · Cited by 165
Wang, Y., Kim, E., Wang, X., Novitch, B. G., Yoshikawa, K., Chang, L.-S., & Zhu, Y. (2012) · Cell · doi:10.1016/j.cell.2012.06.034 · Cited by 151
Bao, H., Asrican, B., Li, W., Gu, B., Wen, Z., Lim, S.-A., Haniff, I., Ramakrishnan, C., Deisseroth, K., Philpot, B., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.10.003 · Cited by 151
LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche
Gajera, C. R., Emich, H., Lioubinski, O., Christ, A., Beckervordersandforth, R., Yoshikawa, K., Bachmann, S., Christensen, E., Götz, M., Kempermann, G., et al. (2010) · Journal of Cell Science · doi:10.1242/jcs.065912 · Cited by 151
Axonal Control of the Adult Neural Stem Cell Niche
Tong, C. K., Chen, J., Cebrián‐Silla, A., Mirzadeh, Z., Obernier, K., Guinto, C. D., Tecott, L. H., García‐Verdugo, J. M., Kriegstein, A. R., & Álvarez-Buylla, A. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.01.014 · Cited by 148
Self-citationGlia as a Link between Neuroinflammation and Neuropathic Pain
Jha, M. K., Jeon, S., & Suk, K. (2012) · Immune Network · doi:10.4110/in.2012.12.2.41 · Cited by 148
Born this way: Hippocampal neurogenesis across the lifespan
Kozareva, D. A., Cryan, J. F., & Nolan, Y. M. (2019) · Aging Cell · doi:10.1111/acel.13007 · Cited by 155
TGF-β Family Signaling in Embryonic and Somatic Stem-Cell Renewal and DifferentiationPreprint
Mullen, A. C., & Wrana, J. L. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022186 · Cited by 149
Non-neuronal cells in amyotrophic lateral sclerosis — from pathogenesis to biomarkers
Vahsen, B. F., Gray, E., Thompson, A. G., Ansorge, O., Anthony, D. C., Cowley, S. A., Talbot, K., & Turner, M. R. (2021) · Nature Reviews Neurology · doi:10.1038/s41582-021-00487-8 · Cited by 147
Verkhratsky, A., Rodriguez, J. J., & Steardo, L. (2013) · The Neuroscientist · doi:10.1177/1073858413510208 · Cited by 147
Perinatal Interactions between the Microbiome, Immunity, and Neurodevelopment
Pronovost, G. N., & Hsiao, E. Y. (2019) · Immunity · doi:10.1016/j.immuni.2018.11.016 · Cited by 150
Nelson, B. R., Ueki, Y., Reardon, S., Karl, M., Georgi, S. A., Hartman, B. H., Lamba, D. A., & Reh, T. A. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022817 · Cited by 148
Generation of subtype-specific neurons from postnatal astroglia of the mouse cerebral cortex
Heinrich, C., Gascón, S., Masserdotti, G., Lepier, A., Sánchez, R., Simon‐Ebert, T., Schroeder, T., Götz, M., & Berninger, B. (2011) · Nature Protocols · doi:10.1038/nprot.2010.188 · Cited by 151
Gorovets, D. J., Kannan, K. S., Shen, R., Kastenhuber, E. R., Islamdoust, N., Campos, C., Pentsova, E. I., Heguy, A., Jhanwar, S. C., Mellinghoff, I. K., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-2977 · Cited by 145
Papadimitriou, C., Celikkaya, H., Cosacak, M. I., Mashkaryan, V., Bray, L., Bhattarai, P., Brandt, K., Hollak, H., Chen, X., He, S., et al. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.06.005 · Cited by 143
Glial Cell Development and Function in ZebrafishPreprint
Lyons, D. A., & Talbot, W. S. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020586 · Cited by 163
Dong, Z., Yang, N., Yeo, S., Chitnis, A. B., & Guo, S. (2012) · Neuron · doi:10.1016/j.neuron.2012.01.031 · Cited by 154
Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune functionPreprint
Akay, L. A., Effenberger, A. H., & Tsai, L. (2021) · Genes & Development · doi:10.1101/gad.344218.120 · Cited by 150
Brain size and limits to adult neurogenesis
Paredes, M. F., Sorrells, S. F., García‐Verdugo, J. M., & Álvarez-Buylla, A. (2015) · The Journal of Comparative Neurology · doi:10.1002/cne.23896 · Cited by 148
Oxygen sensing by the carotid body: mechanisms and role in adaptation to hypoxia
López‐Barneo, J., González‐Rodríguez, P., Gao, L., Fernández-Agüera, M. C., Pardal, R., & Ortega‐Sáenz, P. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00265.2015 · Cited by 144
Paez-Gonzalez, P., Asrican, B., Rodriguez, E., & Kuo, C. T. (2014) · Nature Neuroscience · doi:10.1038/nn.3734 · Cited by 140
Metadata
- Authors
- Kriegstein, A., & Alvarez-Buylla, A.
- Affiliations
- University of California, San Francisco (US)
- The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Departments of Neurology, Neurological Surgery, and School of Medicine, University of California, San Francisco, California 94143-0525;,
- ORCID
- Kriegstein, Arnold
- Venue
- Annual Review of Neuroscience
- Publisher
- Annual Reviews
- Published
- 2009-06-01
- Volume
- 32
- Issue
- 1
- Pages
- 149-184
- ISSN
- 0147-006X (ISSN-L)
- 1545-4126
- PMC
- PMC3086722
- OpenAlex
- W2172266256
- Cited by
- 2,475
- References
- 263
- Citations by year
- 2026: 87 · 2025: 141 · 2024: 138 · 2023: 131 · 2022: 133 · 2021: 168 · 2020: 162 · 2019: 147 · 2018: 166 · 2017: 155 · 2016: 162 · 2015: 129 · 2014: 167 · 2013: 172 · 2012: 155
- FWCI
- 12.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS035710, R01NS028478, R01NS021223)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- neural stem cells, radial glia, astrocytes, intermediate progenitor cells, transit amplifying cells, neuronal lineage, neuroepithelium, adult neurogenesis, brain development, lineage tracing, brain repair
- MeSH terms
- Animals, Cell Differentiation, Central Nervous System, Humans, Neuroglia, Neurons, Stem Cells, Gene Expression Regulation, Developmental, Cell Lineage, Adult Stem Cells, Neurogenesis
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