Cited by 60Nutrition and Health in AgingMuscle Physiology and DisordersDialysis and Renal Disease Management

Myokines as possible therapeutic targets in cancer cachexia

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Manole, Emilia, Ceafalan, Laura C., Popescu, Bogdan O., Dumitru, Carmen, Bastian, Alexandra E.·2018·Journal of Immunology Research

Abstract

Cachexia is an extremely serious syndrome which occurs in most patients with different cancers, and it is characterized by systemic inflammation, a negative protein and energy balance, and involuntary loss of body mass. This syndrome has a dramatic impact on the patient's quality of life, and it is also associated with a low response to chemotherapy leading to a decrease in survival. Despite this, cachexia is still underestimated and often untreated. New research is needed in this area to understand this complex phenomenon and ultimately find treatment methods and therapeutic targets. The skeletal muscle can act as an endocrine organ. Signaling between muscles and other systems is done through myokines, cytokines, and proteins produced and released by myocytes. In this review, we would like to draw attention to some of the most important myokines that could have potential as biomarkers and therapeutic targets: myostatin, irisin, myonectin, decorin, fibroblast growth factor 21, interleukin-6, interleukin-8, and interleukin-15.

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Crossref · 10.1155/2018/8260742

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  • A few mechanistic studies have demonstrated a potential role of other myokines, including Oncostatin M, irisin, and SPARC in the suppression of breast and colon cancer growth.

    “A few mechanistic studies have demonstrated a potential role of other myokines, including Oncostatin M, irisin, and SPARC in the suppression of breast and colon cancer growth (41, 224-227).”

    From Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020) · cites this paper as [227]

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Authors
Manole, E., Ceafalan, L. C., Popescu, B. O., Dumitru, C., & Bastian, A. E.
Affiliations
  • Spitalul Clinic Colentina (RO)
  • Carol Davila University of Medicine and Pharmacy (RO)
Corresponding author
Manole, Emilia
Venue
Journal of Immunology Research
Publisher
Wiley
Published
2018-10-22
Volume
2018
Pages
1-9
ISSN
  • 2314-7156 (ISSN-L)
  • 2314-8861
OpenAlex
W2896464059
Cited by
60
References
99
Citations by year
2026: 3 · 2025: 5 · 2024: 8 · 2023: 7 · 2022: 9 · 2021: 6 · 2020: 15 · 2019: 6
FWCI
0.89
Type
journal article
Language
en
Open access
Locations
  • Journal of Immunology Research (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • REGMED (PN-III-P1-1.2-PCCDI-2017-0782, PN-III-P1-1.2-PCCDI-2017-0341)
  • PATHDERM (PN-III-P1-1.2-PCCDI-2017-0782, PN-III-P1-1.2-PCCDI-2017-0341)
Topics
  • Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Nephrology › Dialysis and Renal Disease Management
Keywords
cancer cachexia, myokines, therapeutic target, skeletal muscle endocrine function, myostatin, irisin, myonectin, decorin, FGF21, interleukin-6, interleukin-8, IL-15, systemic inflammation, biomarkers
MeSH terms
Animals, Biological Therapy, Cachexia, Humans, Interleukins, Neoplasms, Weight Loss, Muscle, Skeletal, Paracrine Communication, Muscle Cells, Intercellular Signaling Peptides and Proteins, Molecular Targeted Therapy

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