Cited by 359Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

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Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins

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Lumeng, Carey N., Deyoung, Stephanie M., Saltiel, Alan R.·2007·American Journal of Physiology-Endocrinology and Metabolism

DOI 10.1152/ajpendo.00284.2006PMC PMC3888778

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Abstract

Obesity leads to a proinflammatory state with immune responses that include infiltration of adipose tissue with macrophages. These macrophages are believed to alter insulin sensitivity in adipocytes, but the mechanisms that underlie this effect have not been characterized. We have explored the interaction between macrophages and adipocytes in the context of both indirect and direct coculture. Macrophage-secreted factors blocked insulin action in adipocytes via downregulation of GLUT4 and IRS-1, leading to a decrease in Akt phosphorylation and impaired insulin-stimulated GLUT4 translocation to the plasma membrane. GLUT1 was upregulated with a concomitant increase in basal glucose uptake. These changes recapitulate those seen in adipose tissue from insulin-resistant humans and animal models. TNF-alpha-neutralizing antibodies partially reversed the insulin resistance produced by macrophage-conditioned media. Peritoneal macrophages and macrophage-enriched stromal vascular cells from adipose tissue also attenuated responsiveness to insulin in a manner correlating with inflammatory cytokine secretion. Adipose tissue macrophages from obese mice have an F4/80(+)CD11b(+)CD68(+)CD14(-) phenotype and form long cellular extensions in culture. Peritoneal macrophages take on similar characteristics in direct coculture with adipocytes and induce proinflammatory cytokines, suggesting that macrophage activation state is influenced by contact with adipocytes. Thus both indirect/secreted and direct/cell contact-mediated factors derived from macrophages influence insulin sensitivity in adipocytes.

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Authors: Lumeng, C. N., Deyoung, S. M., & Saltiel, A. R.
Affiliations: University of Michigan (US)
ORCID: Lumeng, Carey N.
Saltiel, Alan R.
Venue: American Journal of Physiology-Endocrinology and Metabolism
Publisher: American Physiological Society
Published: 2007-01
Volume: 292
Issue: 1
Pages: E166-E174
ISSN: 0193-1849 (ISSN-L)
1522-1555
DOI: 10.1152/ajpendo.00284.2006
PMC: PMC3888778
OpenAlex: W2086073611
Cited by: 359
References: 68
Citations by year: 2026: 8 · 2025: 11 · 2024: 7 · 2023: 11 · 2022: 13 · 2021: 19 · 2020: 22 · 2019: 13 · 2018: 14 · 2017: 28 · 2016: 19 · 2015: 19 · 2014: 31 · 2013: 28 · 2012: 25
FWCI: 11.23
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK 60591, R01DK060591, K08DK078851)
National Institute of Child Health and Human Development
Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD007513)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: macrophages, adipocytes, insulin resistance, GLUT4, IRS-1, Akt phosphorylation, GLUT1, glucose transport, TNF-α, adipose tissue inflammation, obesity, macrophage activation, stromal vascular cells, inflammatory cytokines
MeSH terms: Adipose Tissue, Animals, Cells, Cultured, Insulin, Insulin Resistance, Macrophages, Male, Mice, Inbred C57BL, Tumor Necrosis Factor-alpha, Signal Transduction, Culture Media, Conditioned, Stromal Cells, Adipocytes, Coculture Techniques, Protein Transport, 3T3-L1 Cells, Glucose Transport Proteins, Facilitative, Glucose Transporter Type 4, Mice

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Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins

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