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Cited by 190Muscle metabolism and nutritionMuscle Physiology and DisordersCardiovascular and exercise physiology

The DOI matches its Crossref record; 59 of the 60 references it cites were found in a registry or an index.

Whey and casein labeled with l-[1-13C]leucine and muscle protein synthesis: effect of resistance exercise and protein ingestion

Reitelseder, Søren, Agergaard, Jakob, Doessing, Simon, Helmark, Ida C., Lund, Peter, Kristensen, Niels B., Frystyk, Jan, Flyvbjerg, Allan, Schjerling, Peter, van Hall, Gerrit, Kjaer, Michael, Holm, Lars·2011·American Journal of Physiology-Endocrinology and Metabolism
DOI 10.1152/ajpendo.00513.2010
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Abstract

Muscle protein turnover following resistance exercise and amino acid availability are relatively well described. By contrast, the beneficial effects of different sources of intact proteins in relation to exercise need further investigation. Our objective was to compare muscle anabolic responses to a single bolus intake of whey or casein after performance of heavy resistance exercise. Young male individuals were randomly assigned to participate in two protein trials ( n = 9) or one control trial ( n = 8). Infusion of l-[1-13 C]leucine was carried out, and either whey, casein (0.3 g/kg lean body mass), or a noncaloric control drink was ingested immediately after exercise. l-[1-13 C]leucine-labeled whey and casein were used while muscle protein synthesis (MPS) was assessed. Blood and muscle tissue samples were collected to measure systemic hormone and amino acid concentrations, tracer enrichments, and myofibrillar protein synthesis. Western blots were used to investigate the Akt signaling pathway. Plasma insulin and branched-chain amino acid concentrations increased to a greater extent after ingestion of whey compared with casein. Myofibrillar protein synthesis was equally increased 1–6 h postexercise after whey and casein intake, both of which were higher compared with control ( P < 0.05). Phosphorylation of Akt and p70 S6K was increased after exercise and protein intake ( P < 0.05), but no differences were observed between the types of protein except for total 4E-BP1, which was higher after whey intake than after casein intake ( P < 0.05). In conclusion, whey and casein intake immediately after resistance exercise results in an overall equal MPS response despite temporal differences in insulin and amino acid concentrations and 4E-BP1.

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Crossref · 10.1152/ajpendo.00513.2010

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Research works printed but not linked: 3

  1. Bergström J, 1962, Scand J Clin Lab Invest, 14, 1, 10.3109/00365516209075148 · DOI
  2. Evans WJ, 1982, Med Sci Sports Exerc, 14, 101
  3. World Health Organization, 2007, Protein and Amino Acid Requirements in Human Nutrition: Report of a Joint WHO/FAO/UNU Expert Consultation

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Metadata

Authors
Reitelseder, S., Agergaard, J., Doessing, S., Helmark, I. C., Lund, P., Kristensen, N. B., Frystyk, J., Flyvbjerg, A., Schjerling, P., van Hall, G., Kjaer, M., & Holm, L.
Affiliations
  • University of Copenhagen (DK)
  • Aarhus University (DK)
  • Aarhus University Hospital (DK)
  • Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery M, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen;
Corresponding author
Reitelseder, Søren
ORCID
Venue
American Journal of Physiology-Endocrinology and Metabolism
Publisher
American Physiological Society
Published
2011-01
Volume
300
Issue
1
Pages
E231-E242
ISSN
  • 0193-1849 (ISSN-L)
  • 1522-1555
DOI
10.1152/ajpendo.00513.2010
OpenAlex
W2113426840
Cited by
190
References
60
Citations by year
2025: 5 · 2024: 3 · 2023: 7 · 2022: 10 · 2021: 9 · 2020: 14 · 2019: 19 · 2018: 16 · 2017: 13 · 2016: 24 · 2015: 17 · 2014: 13 · 2013: 17 · 2012: 15
FWCI
5.60
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
Funders
  • Heising-Simons Foundation
  • Hidradenitis Suppurativa Foundation
  • Mejeribrugets ForskningsFond
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords
whey protein, casein, muscle protein synthesis, resistance training, myofibrillar protein synthesis, Akt signaling, p70S6K, 4E-BP1, insulin, branched-chain amino acids, leucine tracer, protein turnover
MeSH terms
Whey Proteins, Adult, Amino Acids, Carbon Isotopes, Caseins, Dietary Proteins, Food, Formulated, Humans, Insulin, Leucine, Male, Milk Proteins, Muscle Proteins, Myofibrils, Phosphoproteins, Phosphorylation, Signal Transduction, Single-Blind Method, Cell Cycle Proteins, Ribosomal Protein S6 Kinases, 70-kDa, Adaptor Proteins, Signal Transducing, Proto-Oncogene Proteins c-akt, Resistance Training

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