The DOI matches its Crossref record; 133 of the 133 references it cites were found in a registry or an index.
Adiposity signals and food reward: expanding the CNS roles of insulin and leptin
Abstract
The hormones insulin and leptin have been proposed to act in the central nervous system (CNS) as adiposity signals as part of a theoretical negative feedback loop that senses the caloric stores of an animal and orchestrates adjustments in energy balance and food intake. Much research has provided support for both the existence of such a feedback loop and the specific roles that insulin and leptin may play. Most studies have focused on hypothalamic sites, which historically are implicated in the regulation of energy balance, and on the brain stem, which is a target for neural and humoral signals relating to ingestive acts. More recent lines of research, including studies from our lab, suggest that in addition to these CNS sites, brain reward circuitry may be a target for insulin and leptin action. These studies are reviewed together here with the goals of providing a historical overview of the findings that have substantiated the originally hypothesized negative feedback model and of opening up new lines of investigation that will build on these findings and allow further refinement of the model of adiposity signal/CNS feedback loop. The understanding of how motivational circuitry and its endocrine or neuroendocrine modulation contributes to normal energy balance regulation should expand possibilities for future therapeutic approaches to obesity and may lead to important insights into mental illnesses such as substance abuse or eating disorders.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“After the initial demonstration that leptin and insulin injections directly into this brain area suppressed expression of food-conditioned place preference ([61](#B61))”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [61]
Citations
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127
The Continuing Epidemics of Obesity and Diabetes in the United States
Mokdad, A. H. (2001) · JAMA · doi:10.1001/jama.286.10.1195 · Cited by 2,730
Getting formal with dopamine and reward
Schultz, W. (2002) · Neuron · doi:10.1016/s0896-6273(02)00967-4 · Cited by 2,574
The Spread of the Obesity Epidemic in the United States, 1991-1998
Mokdad, A. H. (1999) · JAMA · doi:10.1001/jama.282.16.1519 · Cited by 2,384
Role of Brain Insulin Receptor in Control of Body Weight and Reproduction
Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235
Wise, R. A., & Rompre, P.-P. (1989) · Annual Review of Psychology · doi:10.1146/annurev.ps.40.020189.001203 · Cited by 1,968
Food reward: brain substrates of wanting and liking
Berridge, K. C. (1996) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00033-b · Cited by 1,901
The Neuroscience of Natural Rewards: Relevance to Addictive Drugs
Kelley, A. E., & Berridge, K. C. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03306.2002 · Cited by 1,505
NEUROPEPTIDE Y AND HUMAN PANCREATIC POLYPEPTIDE STIMULATE FEEDING BEHAVIOR IN RATS
Clark, J. T., Kalra, P. S., Crowley, W. R., & Kalra, S. P. (1984) · Endocrinology · doi:10.1210/endo-115-1-427 · Cited by 1,276
Research works printed but not linked: 6
- Carvalheira JBC, 2002, Diabetes, 51, 41
- 10.1002/(SICI)1096-9861(19980615)395:4<535::AID-CNE9>3.0.CO;2-2 · DOI
- Giddings SJ, 1985, Diabetologia, 27, 343
- Schwartz MW, 1992, Endocr Rev, 13, 387
- Smith GP., 1995, Prog Psychobiol Physiol Psychol, 16, 83
- Smith GP, 1979, Prog Psychobiol Physiol Psychol, 8, 179
Cited by
Sorted by citations
Central nervous system control of food intake and body weight
Morton, G. J., Cummings, D. E., Baskin, D. G., Barsh, G. S., & Schwartz, M. W. (2006) · Nature · doi:10.1038/nature05026 · Cited by 2,503
Stress, eating and the reward system
Adam, T. C., & Epel, E. S. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.04.011 · Cited by 1,732
Mechanisms of leptin action and leptin resistance.
Myers, M. G., Cowley, M. A., & Münzberg, H. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100707 · Cited by 1,074
Abizaid, A., Liu, Z.-W., Andrews, Z. B., Shanabrough, M., Borok, E., Elsworth, J. D., Roth, R. H., Sleeman, M. W., Picciotto, M. R., Tschöp, M. H., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29867 · Cited by 984
Leptin Receptor Signaling in Midbrain Dopamine Neurons Regulates Feeding
Hommel, J. D., Trinko, R., Sears, R. M., Georgescu, D., Liu, Z.-W., Gao, X.-B., Thurmon, J. J., Marinelli, M., & DiLeone, R. J. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.023 · Cited by 902
Stress-induced obesity and the emotional nervous system
Dallman, M. F. (2010) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2009.10.004 · Cited by 814
Neurobiology of food intake in health and disease
Morton, G. J., Meek, T. H., & Schwartz, M. W. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3745 · Cited by 748
The Brain, Appetite, and Obesity
Berthoud, H., & Morrison, C. D. (2007) · Annual Review of Psychology · doi:10.1146/annurev.psych.59.103006.093551 · Cited by 699
The role of insulin receptor signaling in the brain
Plum, L., Schubert, M., & Brüning, J. C. (2005) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2005.01.008 · Cited by 604
Brain abnormalities in human obesity: A voxel-based morphometric study
Pannacciulli, N., Del Parigi, A., Chen, K., Le, D. S. N. T., Reiman, E. M., & Tataranni, P. A. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.01.047 · Cited by 523
Metabolic and hedonic drives in the neural control of appetite: who is the boss?
Berthoud, H. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.09.004 · Cited by 543
Is dopamine a physiologically relevant mediator of feeding behavior?
Palmiter, R. D. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.06.004 · Cited by 469
Food Reward in the Absence of Taste Receptor Signaling
de Araujo, I. E., Oliveira-Maia, A. J., Sotnikova, T. D., Gainetdinov, R. R., Caron, M. G., Nicolelis, M. A. L., & Simon, S. A. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.032 · Cited by 431
Minireview: Glucocorticoids—Food Intake, Abdominal Obesity, and Wealthy Nations in 2004
Dallman, M. F., la Fleur, S. E., Pecoraro, N. C., Gómez-Oliver, F., Houshyar, H., & Akana, S. F. (2004) · Endocrinology · doi:10.1210/en.2004-0037 · Cited by 413
Naleid, A. M., Grace, M. K., Cummings, D. E., & Levine, A. S. (2005) · Peptides · doi:10.1016/j.peptides.2005.04.025 · Cited by 409
Upadhyay, J., Farr, O. M., Perakakis, N., Ghaly, W., & Mantzoros, C. S. (2017) · Medical Clinics of North America · doi:10.1016/j.mcna.2017.08.004 · Cited by 425
Agorastos, A., Pervanidou, P., Chrousos, G. P., & Baker, D. G. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00118 · Cited by 385
“GCs, as the end-effectors of the HPA axis, stimulate appetite (277), alter insulin and leptin secretion and target tissue effects by increasing body weight through the orexigenic and food reward effect of the hypothalamic feeding signal NPY (278, 279) [an effect inhibited by leptin and insulin (280)].”
BackgroundIdentifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis
Elmquist, J. K., Coppari, R., Balthasar, N., Ichinose, M., & Lowell, B. B. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20786 · Cited by 406
Food reinforcement and eating: A multilevel analysis.
Epstein, L. H., Leddy, J. J., Temple, J. L., & Faith, M. S. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.5.884 · Cited by 405
Neurobiology of Feeding and Energy Expenditure
Gao, Q., & Horvath, T. L. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094324 · Cited by 346
Central and Peripheral Regulation of Food Intake and Physical Activity: Pathways and Genes
Lenard, N. R., & Berthoud, H. (2008) · Obesity · doi:10.1038/oby.2008.511 · Cited by 338
Olfaction Under Metabolic Influences
Palouzier‐Paulignan, B., Lacroix, M. C., Aimé, P., Baly, C., Caillol, M., Congar, P., Julliard, A., Tucker, K. R., & Fadool, D. A. (2012) · Chemical Senses · doi:10.1093/chemse/bjs059 · Cited by 339
Metabolic consequences of stress during childhood and adolescence
Pervanidou, P., & Chrousos, G. P. (2012) · Metabolism · doi:10.1016/j.metabol.2011.10.005 · Cited by 316
Ahima, R. S., & Osei, S. Y. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.02.014 · Cited by 332
Fructose: Metabolic, Hedonic, and Societal Parallels with Ethanol
Lustig, R. H. (2010) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2010.06.008 · Cited by 317
Hyperinsulinemia in Obesity, Inflammation, and Cancer
Zhang, A. M. Y., Wellberg, E. A., Kopp, J. L., & Johnson, J. D. (2021) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2020.0250 · Cited by 344
Morrison, C. D., Pistell, P. J., Ingram, D. K., Johnson, W. D., Liu, Y., Fernandez‐Kim, S. O., White, C. L., Purpera, M. N., Uranga, R. M., Bruce‐Keller, A. J., et al. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06865.x · Cited by 300
Interactions between the “cognitive” and “metabolic” brain in the control of food intake
Berthoud, H. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.12.016 · Cited by 289
Zheng, H., Lenard, N. R., Shin, A. C., & Berthoud, H. R. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.65 · Cited by 286
Adipokines: a link between obesity and dementia?
Kiliaan, A. J., Arnoldussen, I. A. C., & Gustafson, D. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70085-7 · Cited by 290
Food reward, hyperphagia, and obesity
Berthoud, H.-R., Lenard, N. R., & Shin, A. C. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00028.2011 · Cited by 275
Cephalic phase responses and appetite
Smeets, P. A. M., Erkner, A., & de Graaf, C. (2010) · Nutrition Reviews · doi:10.1111/j.1753-4887.2010.00334.x · Cited by 263
Stress, Endocrine Physiology and Pathophysiology -- Endotext
DeGroot, L. J., Chrousos, G. P., Dungan, K., Grossman, A. B., Jm, H., Koch, C., Korbonits, M., McLachlan, R., New, M., Purnell, J. Q., et al. (2000) · Europe PMC (PubMed Central) · Cited by 260
Fast Food, Central Nervous System Insulin Resistance, and Obesity
ISGANAITIS, E. M., & Lustig, R. H. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000186208.06964.91 · Cited by 262
Mind versus metabolism in the control of food intake and energy balance
Berthoud, H. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.04.034 · Cited by 259
Insulin and its evolving partnership with leptin in the hypothalamic control of energy homeostasis
Niswender, K. D., Baskin, D. G., & Schwartz, M. W. (2004) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2004.07.009 · Cited by 267
Advances in understanding the interrelations between leptin resistance and obesity
Pan, H., Guo, J., & Su, Z. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.04.003 · Cited by 257
The impact of gut hormones on the neural circuit of appetite and satiety: A systematic review
Zanchi, D., Depoorter, A., Egloff, L., Haller, S., Mählmann, L., Lang, U. E., Drewe, J., Beglinger, C., Schmidt, A., & Borgwardt, S. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.06.013 · Cited by 244
Appetite regulation and weight control: the role of gut hormones
Perry, B., & Wang, Y. (2012) · Nutrition and Diabetes · doi:10.1038/nutd.2011.21 · Cited by 229
Control of energy homeostasis by insulin and leptin: Targeting the arcuate nucleus and beyond
Könner, A. C., Klöckener, T., & Brüning, J. C. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.03.027 · Cited by 230
Insulin, leptin, and food reward: update 2008
Figlewicz, D. P., & Benoit, S. C. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90725.2008 · Cited by 205
Self-citationNeural control of appetite: cross-talk between homeostatic and non-homeostatic systems
Berthoud, H. (2004) · Appetite · doi:10.1016/j.appet.2004.04.009 · Cited by 194
Central nervous system regulation of eating: Insights from human brain imaging
Farr, O. M., Li, C. R., & Mantzoros, C. S. (2016) · Metabolism · doi:10.1016/j.metabol.2016.02.002 · Cited by 201
Stockhorst, U., de Fries, D., Steingrüber, H.-J., & Scherbaum, W. A. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.07.022 · Cited by 191
Molecular and neural mediators of leptin action
Robertson, S., Leinninger, G. M., & Myers, M. G. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.04.005 · Cited by 195
Metabolic hormones, dopamine circuits, and feeding
Narayanan, N. S., Guarnieri, D. J., & Dileone, R. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.10.004 · Cited by 182
Hedonic and incentive signals for body weight control
Egecioglu, E., Skibicka, K. P., Hansson, C., Álvarez-Crespo, M., Friberg, P. A., Jerlhag, E., Engel, J. A., & Dickson, S. L. (2011) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-011-9166-4 · Cited by 192
Intraventricular Insulin and Leptin Reverse Place Preference Conditioned With High-Fat Diet in Rats.
Figlewicz, D. P., Bennett, J. L., Evans, S. B., Kaiyala, K. J., Sipols, A. J., & Benoit, S. C. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.3.479 · Cited by 172
Self-citationElman, I., Borsook, D., & Lukas, S. E. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301051 · Cited by 169
Intraventricular insulin and leptin decrease sucrose self-administration in rats
Figlewicz, D. P., Bennett, J. L., Naleid, A. M., Davis, C. D., & Grimm, J. W. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.07.023 · Cited by 170
Self-citationLeptin Regulates Energy Balance and Motivation Through Action at Distinct Neural Circuits
Davis, J. F., Choi, D. L., Schurdak, J. D., Fitzgerald, M. F., Clegg, D. J., Lipton, J. W., Figlewicz, D. P., & Benoit, S. C. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.08.028 · Cited by 169
Self-citationNutrient Selection in the Absence of Taste Receptor Signaling
Ren, X., Ferreira, J. G. P., Zhou, L.-W., Shammah‐Lagnado, S. J., Yeckel, C. W., & de Araújo, I. E. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5749-09.2010 · Cited by 162
Lustig, R. H. (2006) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0220 · Cited by 162
Stress and obesity/metabolic syndrome in childhood and adolescence
Pervanidou, P., & Chrousos, G. P. (2011) · International Journal of Pediatric Obesity · doi:10.3109/17477166.2011.615996 · Cited by 163
Neuronal control of energy homeostasis
Gao, Q., & Horváth, T. L. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.11.063 · Cited by 160
Ghitza, U. E., Gray, S. M., Epstein, D. H., Rice, K. C., & Shaham, Y. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300964 · Cited by 154
Shin, A. C., Zheng, H., & Berthoud, H. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.02.010 · Cited by 153
Modulation of food reward by adiposity signals
Figlewicz, D. P., Naleid, A. M., & Sipols, A. J. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2006.10.008 · Cited by 149
Self-citationChoice of Lard, But Not Total Lard Calories, Damps Adrenocorticotropin Responses to Restraint
la Fleur, S. E., Houshyar, H., Roy, M., & Dallman, M. F. (2005) · Endocrinology · doi:10.1210/en.2004-1603 · Cited by 148
K. Garber, A., & H. Lustig, R. (2011) · Current Drug Abuse Reviewse · doi:10.2174/1874473711104030146 · Cited by 143
Vucetic, Z., & Reyes, T. M. (2010) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.77 · Cited by 145
The gut–brain dopamine axis: a regulatory system for caloric intake
de Araujo, I. E., Ferreira, J. G., Tellez, L. A., Ren, X., & Yeckel, C. W. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.02.026 · Cited by 140
Roche, J. R., Blache, D., Kay, J. K., Miller, D. R., Sheahan, A. J., & Miller, D. W. (2008) · Nutrition Research Reviews · doi:10.1017/s0954422408138744 · Cited by 154
Neural Systems Controlling the Drive to Eat: Mind Versus Metabolism
Zheng, H., & Berthoud, H.-R. (2008) · Physiology · doi:10.1152/physiol.00047.2007 · Cited by 131
South, T., & Huang, X. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9483-x · Cited by 129
Diabetes, lipids, and adipocyte secretagogues
Faraj, M., Lu, H. L., & Cianflone, K. (2004) · Biochemistry and Cell Biology · doi:10.1139/o03-078 · Cited by 128
Modulation of taste responsiveness and food preference by obesity and weight loss
Berthoud, H.-R., & Zheng, H. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.04.004 · Cited by 123
Obesity – A neuropsychological disease? Systematic review and neuropsychological model
Jauch‐Chara, K., & Oltmanns, K. M. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.12.001 · Cited by 136
Neuroendocrinology of reward in anorexia nervosa and bulimia nervosa: Beyond leptin and ghrelin
Berner, L. A., Brown, T. A., Lavender, J. M., Lopez, E., Wierenga, C. E., & Kaye, W. H. (2018) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.10.018 · Cited by 133
Thoughts for Food: Brain Mechanisms and Peripheral Energy Balance
Abizaid, A. B., Gao, Q., & Horváth, T. L. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.025 · Cited by 122
Naef, L., Srivastava, L. K., Gratton, A. P., Hendrickson, H. P., Owens, S. M., & Walker, C. (2007) · Psychopharmacology · doi:10.1007/s00213-007-1008-4 · Cited by 119
Eating for pleasure or calories
Zheng, H., & Berthoud, H. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.10.011 · Cited by 121
Regulation of fat intake in the absence of flavour signalling
Ferreira, J. G. P., Téllez, L. A., Ren, X., Yeckel, C. W., & de Araújo, I. E. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.218289 · Cited by 116
Figlewicz, D. P., Bennett, J. L., Aliakbari, S., Zavosh, A., & Sipols, A. J. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90334.2008 · Cited by 115
Self-citation(Still) longing for food: Insulin reactivity modulates response to food pictures
Kroemer, N. B., Krebs, L., Kobiella, A., Grimm, O., Vollstädt‐Klein, S., Wolfensteller, U., Kling, R., Bidlingmaier, M., Zimmermann, U. S., & Smolka, M. N. (2012) · Human Brain Mapping · doi:10.1002/hbm.22071 · Cited by 111
Energy regulatory signals and food reward
Figlewicz, D. P., & Sipols, A. J. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.03.002 · Cited by 116
Self-citationModulation of the mesolimbic dopamine system by leptin
Opland, D. M., Leinninger, G. M., & Myers (2010) · Brain Research · doi:10.1016/j.brainres.2010.04.028 · Cited by 111
Psychological and Neurobiological Correlates of Food Addiction
Kalon, E., Hong, J., Tobin, C. T., & Schulte, T. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.06.003 · Cited by 117
Higgs, S., Spetter, M. S., Thomas, J. M., Rotshtein, P., Lee, M. D., Hallschmid, M., & Dourish, C. T. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117736917 · Cited by 108
Distribution of insulin receptor substrate-2 in brain areas involved in energy homeostasis
Pardini, A. W., Hồng, N. T., Figlewicz, D. P., Baskin, D. G., Williams, D. L., Kim, F., & Schwartz, M. W. (2006) · Brain Research · doi:10.1016/j.brainres.2006.06.109 · Cited by 101
Self-citationNew Twist on Neuronal Insulin Receptor Signaling in Health, Disease, and Therapeutics
Wada, A., Yokoo, H., Yanagita, T., & Kobayashi, H. (2005) · Journal of Pharmacological Sciences · doi:10.1254/jphs.crj05006x · Cited by 95
Li, Y., South, T., Han, M., Chen, J., Wang, R., & Huang, X. (2009) · Brain Research · doi:10.1016/j.brainres.2009.02.075 · Cited by 83
Glucagon-like peptide 1 in the pathophysiology and pharmacotherapy of clinical obesity
Anandhakrishnan, A., & Korbonits, M. (2016) · World Journal of Diabetes · doi:10.4239/wjd.v7.i20.572 · Cited by 83
Pannacciulli, N., Le, D. S. N. T., Chen, K., Reiman, E. M., & Krakoff, J. A. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.11.019 · Cited by 80
Eat, sleep, repeat – endocrine regulation of behavioural circadian rhythms
Koop, S., & Oster, H. (2021) · FEBS Journal · doi:10.1111/febs.16109 · Cited by 75
Appetite Regulatory Neuropeptides are Expressed in the Sheep Hypothalamus Before Birth
Mühlhäusler, B. S., McMillen, I. C., Rouzaud, G., Findlay, P. A., Marrocco, E. M., Rhind, S. M., & Adam, C. L. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2004.01197.x · Cited by 67
Atypical antipsychotics and the neural regulation of food intake and peripheral metabolism
Teff, K. L., & Kim, S. F. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.05.033 · Cited by 70
Food reward functions as affected by obesity and bariatric surgery
Shin, A. C., & Berthoud, H. R. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.147 · Cited by 68
Stress and Obesity as Risk Factors in Cardiovascular Diseases: A Neuroimmune Perspective
Ippoliti, F., Canitano, N., & Businaro, R. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9432-6 · Cited by 63
Thermogenic and metabolic antiobesity drugs: rationale and opportunities
Clapham, J. C., & Arch, J. R. S. (2007) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2006.00608.x · Cited by 60
Pregnancy and the endocrine regulation of the baroreceptor reflex
Brooks, V. L., Dampney, R. A. L., & Heesch, C. M. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00059.2010 · Cited by 58
Effects of in utero conditions on adult feeding preferences
Portella, A. K., Kajantie, E., Hovi, P., Desai, M., Ross, M. G., Goldani, M. Z., Roseboom, T. J., & Silveira, P. P. (2012) · Journal of Developmental Origins of Health and Disease · doi:10.1017/s2040174412000062 · Cited by 61
LRb signals act within a distributed network of leptin‐responsive neurones to mediate leptin action
Leinninger, G. M., & Myers, M. G. (2008) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01784.x · Cited by 56
Metabolic Imprinting by Maternal Protein Malnourishment Impairs Vagal Activity in Adult Rats
de Oliveira, J. C., Scomparin, D. X., Andreazzi, A. E., Branco, R. C. S., Martins, A. G., Gravena, C., Grassiolli, S., Rinaldi, W., Barbosa, F. B., & Mathias, P. C. D. F. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02095.x · Cited by 55
Alzheimer's Disease Promotion by Obesity: Induced Mechanisms—Molecular Links and Perspectives
Businaro, R., Ippoliti, F., Ricci, S., Canitano, N., & Fuso, A. (2012) · Current Gerontology and Geriatrics Research · doi:10.1155/2012/986823 · Cited by 57
Neurobiology of Nutrition and Obesity
Morrison, C. D., & Berthoud, H. (2007) · Nutrition Reviews · doi:10.1301/nr.2007.dec.517-534 · Cited by 71
Insulin actions in the mesolimbic dopamine system
Liu, S., & Borgland, S. L. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.113006 · Cited by 52
Leptin in Energy Balance and Reward: Two Faces of the Same Coin?
Cota, D., Barrera, J. G., & Seeley, R. J. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.009 · Cited by 53
Leptin and its cardiovascular effects: Focus on angiogenesis
Khazaei, M., & Tahergorabi, Z. (2015) · Advanced Biomedical Research · doi:10.4103/2277-9175.156526 · Cited by 54
Costs of pair-bonding and paternal care in male prairie voles (Microtus ochrogaster)
Campbell, J. C., Laugero, K. D., Westerhuyzen, J. A. V., Hostetler, C. M., Cohen, J. D., & Bales, K. L. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.06.014 · Cited by 51
Metadata
- Authors
- Figlewicz, D. P.
- Affiliations
- University of Washington (US)
- Corresponding author
- Figlewicz, Dianne P.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2003-04-01
- Volume
- 284
- Issue
- 4
- Pages
- R882-R892
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2126649488
- Cited by
- 221
- References
- 132
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 9 · 2020: 2 · 2019: 11 · 2018: 4 · 2017: 7 · 2016: 7 · 2015: 6 · 2014: 12 · 2013: 7 · 2012: 13
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 40963, R01DK040963)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- insulin, leptin, adiposity signals, food reward, central nervous system, energy balance, negative feedback loop, hypothalamus, brainstem, reward systems, food intake regulation, obesity, substance abuse, eating disorders
- MeSH terms
- Animals, Central Nervous System, Energy Metabolism, Feeding Behavior, Humans, Insulin, Leptin, Feedback, Physiological
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
