A heartfelt response: oxytocin effects on response to social stress in men and women
Open accessAbstract
Background Animal research indicates that oxytocin is involved in social behavior, stress regulation, and positive physiologic adaptation. This study examines whether oxytocin enhances adaptive responses to social stress and compares effects between men and women.Methods Hypotheses were tested with a placebo-controlled, double-blind experiment. Social stress was induced. Changes in cardiovascular reactivity, affect, and behavior were assessed.Results Participants given oxytocin, relative to placebo, responded to social stress with a challenge orientation characterized by a benign pattern of cardiovascular reactivity. Gender differences emerged. Men given oxytocin reported less negative affect and had greater vagal rebound, while women given oxytocin reported more anger and had better math performance following social stress.Discussion Findings indicate oxytocin stimulates an approach-oriented cardiovascular profile during social stress, suggesting mechanisms by which oxytocin might improve physical health. However, before considering oxytocin as therapeutic or uniformly enhancing health, greater understanding of possible gender differences in effects is needed.
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Intranasally administered and naturally secreted oxytocin increases HF-HRV in humans.
“intranasally administered and naturally secreted oxytocin increases HF-HRV in humans27–30.”
From Voluntary upregulation of heart rate variability through biofeedback is improved by mental contemplative training (2019) · cites this paper as [28]
The Methods (section 2.4; page unavailable) define the measured HRV index as high-frequency power. The Results (section 3.2; page unavailable) report greater vagal rebound after social stress in participants given intranasal oxytocin than in those given placebo, but no effect on HRV during the stress task. The study did not test whether naturally secreted oxytocin increases HF-HRV, and its finding is specific to recovery after social stress. (LLM, conf=0.90)
Experimental — accuracy not yet measuredIntranasal administration of oxytocin has been found to increase HF-HRV in humans.
“intranasal administration of oxytocin has been found to increase HF-HRV in humans27–30”
From Voluntary upregulation of heart rate variability through biofeedback is improved by mental contemplative training (2019) · cites this paper as [28]
The Methods (§2.4; page unavailable) define RSA using high-frequency HRV power, and the Results (§3.2; page unavailable) report greater vagal rebound after social stress in participants given intranasal oxytocin than in those given placebo. The finding is limited to post-stress recovery: the paper reports no effect on RSA during the stress task, so it does not establish an increase in HF-HRV generally. (LLM, conf=0.88)
Experimental — accuracy not yet measuredSex differences in behavioral or brain responses were found after manipulations of the OXT brain system in voles and after intranasal OXT application in humans.
“Sex differences in behavioral or brain responses were also found after manipulations of the OXT brain system in voles (Insel & Hulihan, 1995) and after intranasal OXT application in humans (Kubzansky et al., 2012; Lische et al., 2012).”
From Sex-specific modulation of juvenile social play by vasopressin (2013) · cites this paper as Kubzansky et al., 2012
Men given intranasal OT reported less negative affect.
“women given intranasal OT reported more distress and anger in response to a social stress test, while men given OT reported less negative affect (Kubzansky et al., 2012).”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Kubzansky et al., 2012
Women given intranasal OT reported more distress and anger in response to a social stress test.
“women given intranasal OT reported more distress and anger in response to a social stress test, while men given OT reported less negative affect (Kubzansky et al., 2012).”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Kubzansky et al., 2012
Oxytocin administration may modulate glucocorticoid and autonomic stress reactivity, dampen anxiety and neural threat processing, and beneficially impact socioemotional processes and prosocial behavior.
“Accumulating evidence from studies in animals and in healthy and psychiatric human populations shows that oxytocin administration may modulate glucocorticoid (16) and autonomic stress reactivity (17), dampen anxiety and neural threat processing (18,19), and beneficially impact socioemotional processes and prosocial behavior (20,21) [but see also (22,23) for seemingly nonprosocial effects].”
From Intranasal Oxytocin to Prevent Posttraumatic Stress Disorder Symptoms: A Randomized Controlled Trial in Emergency Department Patients (2017) · cites this paper as [17]
Factors such as gender, attachment style, and early parental experiences appear to moderate the effects of intranasal oxytocin on several outcome measures.
“Factors such as gender [48], attachment style [49], and early parental experiences [50] appear to moderate the effects of intranasal oxytocin on several outcome measures [51,52].”
From Efficacy of oxytocin administration early after psychotrauma in preventing the development of PTSD: study protocol of a randomized controlled trial (2014) · cites this paper as [48]
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Feng, C., Lori, A., Waldman, I. D., Binder, E. B., Haroon, E., & Rilling, J. K. (2015) · Genes, Brain and Behavior · doi:10.1111/gbb.12234 · Cited by 94 · see citing works
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Sex-dependent neural effect of oxytocin during subliminal processing of negative emotion faces.
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Feeser, M., Fan, Y., Weigand, A., Hahn, A., Gärtner, M., Böker, H., Grimm, S., & Bajbouj, M. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.12.015 · Cited by 74 · see citing works
Antisocial oxytocin: Complex effects on social behavior
Beery, A. K. (2015) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2015.11.006 · Cited by 74 · see citing works
Gender moderates the effect of oxytocin on social judgments
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The impact of oxytocin on stress: the role of sex
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Circuits for social learning: a unified model and application to autism spectrum disorder
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Oxytocin and vasopressin modulate risk-taking
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Plasma oxytocin is modulated by mental training, but does not mediate its stress-buffering effect
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Shared Reality Can Reduce Stressor Reactivity
Goldring, M. R., Pinelli, F., Bolger, N., & Higgins, E. T. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.853750 · Cited by 11 · see citing works
- Authors
- Kubzansky, L. D., Mendes, W. B., Appleton, A. A., Block, J., & Adler, G. K.
- Affiliations
- Harvard University (US)
- University of California, San Francisco (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Kubzansky, Laura D.
- Venue
- Biological Psychology
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 90
- Issue
- 1
- Pages
- 1-9
- ISSN
- 0301-0511 (ISSN-L)
- PMC
- PMC3327158
- OpenAlex
- W2108489413
- Cited by
- 142
- References
- 72
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 8 · 2023: 5 · 2022: 4 · 2021: 8 · 2020: 16 · 2019: 28 · 2018: 6 · 2017: 10 · 2016: 8 · 2015: 15 · 2014: 12 · 2013: 9 · 2012: 4
- FWCI
- 19.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (1R21AG030632-01A2)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, social stress, cardiovascular reactivity, gender differences, negative affect, anger, mathematics achievement, stress adaptation, social behavior
- MeSH terms
- Adult, Analysis of Variance, Cardiovascular System, Double-Blind Method, Estradiol, Female, Humans, Male, Middle Aged, Oxytocin, Saliva, Sex Factors, Social Behavior, Stress, Psychological
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