Cited by 282Neuroscience and Neural EngineeringNeural dynamics and brain functionAnalog and Mixed-Signal Circuit Design

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Polytrodes: High-Density Silicon Electrode Arrays for Large-Scale Multiunit Recording

Blanche, Timothy J., Spacek, Martin A., Hetke, Jamille F., Swindale, Nicholas V.·2005·Journal of Neurophysiology

DOI 10.1152/jn.01023.2004

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Abstract

We developed a variety of 54-channel high-density silicon electrode arrays (polytrodes) designed to record from large numbers of neurons spanning millimeters of brain. In cat visual cortex, it was possible to make simultaneous recordings from >100 well-isolated neurons. Using standard clustering methods, polytrodes provide a quality of single-unit isolation that surpasses that attainable with tetrodes. Guidelines for successful in vivo recording and precise electrode positioning are described. We also describe a high-bandwidth continuous data-acquisition system designed specifically for polytrodes and an automated impedance meter for testing polytrode site integrity. Despite having smaller interconnect pitches than earlier silicon-based electrodes of this type, these polytrodes have negligible channel crosstalk, comparable reliability, and low site impedances and are capable of making high-fidelity multiunit recordings with minimal tissue damage. The relatively benign nature of planar electrode arrays is evident both histologically and in experiments where the polytrode was repeatedly advanced and retracted hundreds of microns over periods of many hours. It was possible to maintain stable recordings from active neurons adjacent to the polytrode without change in their absolute positions, neurophysiological or receptive field properties.

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Authors: Blanche, T. J., Spacek, M. A., Hetke, J. F., & Swindale, N. V.
Affiliations: University of British Columbia (CA)
ORCID: Spacek, Martin A.
Swindale, Nicholas V.
Venue: Journal of Neurophysiology
Publisher: American Physiological Society
Published: 2005-05
Volume: 93
Issue: 5
Pages: 2987-3000
ISSN: 0022-3077 (ISSN-L)
1522-1598
DOI: 10.1152/jn.01023.2004
OpenAlex: W2141361751
Cited by: 282
References: 74
Citations by year: 2026: 2 · 2025: 11 · 2024: 6 · 2023: 10 · 2022: 10 · 2021: 12 · 2020: 14 · 2019: 23 · 2018: 18 · 2017: 18 · 2016: 27 · 2015: 20 · 2014: 18 · 2013: 19 · 2012: 11
FWCI: 1.41
Type: journal article
Language: en
Open access: closed
Locations: Journal of Neurophysiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p41rr009754-09)
National Center for Research Resources (P41-RR09754)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Physical Sciences › Engineering › Electrical and Electronic Engineering › Analog and Mixed-Signal Circuit Design
Keywords: multi-unit recording, cat visual cortex, electrode placement, impedance measurement, crosstalk, planar electrodes, tetrodes, receptive fields
MeSH terms: Action Potentials, Animals, Brain Mapping, Carbocyanines, Cats, Computer Simulation, Densitometry, Electric Conductivity, Electric Stimulation, Electrodes, Implanted, Electrophysiology, Evoked Potentials, Microelectrodes, Neurons, Online Systems, Research Design, Silicon, Time, Visual Cortex, Electric Impedance, Rats

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Polytrodes: High-Density Silicon Electrode Arrays for Large-Scale Multiunit Recording

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