Implantable microscale neural interfaces
Abstract
Implantable neural microsystems provide an interface to the nervous system, giving cellular resolution to physiological processes unattainable today with non-invasive methods. Such implantable microelectrode arrays are being developed to simultaneously sample signals at many points in the tissue, providing insight into processes such as movement control, memory formation, and perception. These electrode arrays have been microfabricated on a variety of substrates, including silicon, using both surface and bulk micromachining techniques, and more recently, polymers. Current approaches to achieving a stable long-term tissue interface focus on engineering the surface properties of the implant, including coatings that discourage protein adsorption or release bioactive molecules. The implementation of a wireless interface requires consideration of the necessary data flow, amplification, signal processing, and packaging. In future, the realization of a fully implantable neural microsystem will contribute to both diagnostic and therapeutic applications, such as a neuroprosthetic interface to restore motor functions in paralyzed patients.
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Incorporating eluting anti-inflammatory chemicals released in surrounding tissue post-implantation is an additional method of reducing the foreign body response.
“An additional method of reducing the foreign body response is to incorporate eluting chemicals such as anti-inflammatory agents which are released in the surrounding tissue post-implantation (Cheung 2007).”
From Peripheral nerve bionic interface: a review of electrodes (2019) · cites this paper as Cheung 2007
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Thukral, A., Ershad, F., Enan, N., Rao, Z., & Yu, C. (2018) · IEEE Nanotechnology Magazine · doi:10.1109/mnano.2017.2781290 · Cited by 19 · see citing works
The Pursuit of Chronically Reliable Neural Interfaces: A Materials Perspective
Guo, L. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00599 · Cited by 19 · see citing works
- Authors
- Cheung, K. C.
- Affiliations
- University of British Columbia (CA)
- Corresponding author
- Cheung, Karen C.
- ORCID
- Cheung, Karen C.
- Venue
- Biomedical Microdevices
- Published
- 2007-01-25
- Volume
- 9
- Issue
- 6
- Pages
- 923-938
- ISSN
- 1387-2176 (ISSN-L)
- 1572-8781
- OpenAlex
- W2020923214
- Cited by
- 202
- References
- 100
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 3 · 2023: 7 · 2022: 7 · 2021: 10 · 2020: 7 · 2019: 17 · 2018: 12 · 2017: 15 · 2016: 11 · 2015: 7 · 2014: 19 · 2013: 18 · 2012: 11
- FWCI
- 4.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Biomedical Microdevices (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Analog and Mixed-Signal Circuit Design
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Advanced MEMS and NEMS Technologies
- Keywords
- implantable neural interfaces, microelectrode arrays, neural recording, microfabrication, silicon substrate, polymer substrates, surface modification, protein adsorption, wireless neural interface, neuroprosthetics
- MeSH terms
- Animals, Electric Stimulation, Electrodes, Implanted, Electric Stimulation Therapy, Humans, Microelectrodes, Neurons, Prosthesis Design, Prostheses and Implants, Microfluidic Analytical Techniques
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