Distinct Effects of Calorie Restriction and Resveratrol on Diet-Induced Obesity and Fatty Liver Formation
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The potential of resveratrol to mimic beneficial effects of calorie restriction (CR) was investigated. We compared the effects of both CR (70% of ad libitum energy intake) or resveratrol (2 g/kg or 4 g/kg food) on high-fat diet-induced obesity and fatty liver formation in C57Bl/6J mice, and we examined their effects on calorimetry, metabolic performance, and the expressions of inflammatory genes and SIRT proteins. We found that resveratrol with 4 g/kg dose partially prevented hepatic steatosis and hepatocyte ballooning and induced skeletal muscle SIRT1 and SIRT4 expression while other examined parameter were unaffected by resveratrol. In contrast, CR provided superior protection against diet-induced obesity and fatty liver formation as compared to resveratrol, and the effects were associated with increased physical activity and ameliorated adipose tissue inflammation. CR increased expressions of SIRT3 in metabolically important tissues, suggesting that the beneficial effects of CR are mediated, at least in part, via SIRT3-dependent pathways.
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Reduced intake of energy compared to normal needs by 30% in obese rats increased the expression of SIRT3 in the liver and muscles.
“Reduced intake of energy compared to normal needs by 30% in obese rats increased the expression of SIRT3 in the liver and muscles (Tauriainen et al. 2011).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Tauriainen et al. 2011
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- Authors
- Tauriainen, E., Luostarinen, M., Martonen, E., Finckenberg, P., Kovalainen, M., Huotari, A., Herzig, K.-H., Lecklin, A., & Mervaala, E.
- Affiliations
- University of Helsinki (FI)
- University of Eastern Finland (FI)
- Kuopio University Hospital (FI)
- Corresponding author
- Mervaala, Eero
- Venue
- Journal of Nutrition and Metabolism
- Publisher
- Wiley
- Published
- 2011
- Volume
- 2011
- Pages
- 1-10
- ISSN
- 2090-0724 (ISSN-L)
- 2090-0732
- PMC
- PMC3184417
- OpenAlex
- W2065306327
- Cited by
- 81
- References
- 44
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 9 · 2021: 3 · 2020: 3 · 2019: 6 · 2018: 6 · 2017: 7 · 2016: 8 · 2015: 3 · 2014: 12 · 2013: 8 · 2012: 6
- FWCI
- 3.96
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Nutrition and Metabolism (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Foundation for Nutrition Research
- The Finnish Funding Agency for Technology and Innovation
- Suomen Akatemia
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Keywords
- caloric restriction, resveratrol, diet-induced obesity, hepatic steatosis, SIRT3, SIRT1, SIRT4, adipose tissue inflammation, physical activity, high-fat diet, hepatocyte ballooning, C57BL/6J mice
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