Cited by 81Sirtuins and Resveratrol in MedicineDiet, Metabolism, and DiseaseDietary Effects on Health

Distinct Effects of Calorie Restriction and Resveratrol on Diet-Induced Obesity and Fatty Liver Formation

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Tauriainen, Eveliina, Luostarinen, Mira, Martonen, Essi, Finckenberg, Piet, Kovalainen, Miia, Huotari, Anne, Herzig, Karl-Heinz, Lecklin, Anne +1 more·2011·Journal of Nutrition and Metabolism

Abstract

The potential of resveratrol to mimic beneficial effects of calorie restriction (CR) was investigated. We compared the effects of both CR (70% of ad libitum energy intake) or resveratrol (2 g/kg or 4 g/kg food) on high-fat diet-induced obesity and fatty liver formation in C57Bl/6J mice, and we examined their effects on calorimetry, metabolic performance, and the expressions of inflammatory genes and SIRT proteins. We found that resveratrol with 4 g/kg dose partially prevented hepatic steatosis and hepatocyte ballooning and induced skeletal muscle SIRT1 and SIRT4 expression while other examined parameter were unaffected by resveratrol. In contrast, CR provided superior protection against diet-induced obesity and fatty liver formation as compared to resveratrol, and the effects were associated with increased physical activity and ameliorated adipose tissue inflammation. CR increased expressions of SIRT3 in metabolically important tissues, suggesting that the beneficial effects of CR are mediated, at least in part, via SIRT3-dependent pathways.

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Authors
Tauriainen, E., Luostarinen, M., Martonen, E., Finckenberg, P., Kovalainen, M., Huotari, A., Herzig, K.-H., Lecklin, A., & Mervaala, E.
Affiliations
  • University of Helsinki (FI)
  • University of Eastern Finland (FI)
  • Kuopio University Hospital (FI)
Corresponding author
Mervaala, Eero
Venue
Journal of Nutrition and Metabolism
Publisher
Wiley
Published
2011
Volume
2011
Pages
1-10
ISSN
  • 2090-0724 (ISSN-L)
  • 2090-0732
OpenAlex
W2065306327
Cited by
81
References
44
Citations by year
2026: 2 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 9 · 2021: 3 · 2020: 3 · 2019: 6 · 2018: 6 · 2017: 7 · 2016: 8 · 2015: 3 · 2014: 12 · 2013: 8 · 2012: 6
FWCI
3.96
Type
journal article
Language
en
Open access
Locations
  • Journal of Nutrition and Metabolism (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Foundation for Nutrition Research
  • The Finnish Funding Agency for Technology and Innovation
  • Suomen Akatemia
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
Keywords
caloric restriction, resveratrol, diet-induced obesity, hepatic steatosis, SIRT3, SIRT1, SIRT4, adipose tissue inflammation, physical activity, high-fat diet, hepatocyte ballooning, C57BL/6J mice

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