The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis
Open accessAbstract
Background. Growth hormone (GH) and insulin-like growth factor (IGF-1) are fundamental in skeletal growth during puberty and bone health throughout life. GH increases tissue formation by acting directly and indirectly on target cells; IGF-1 is a critical mediator of bone growth. Clinical studies reporting the use of GH and IGF-1 in osteoporosis and fracture healing are outlined.Methods. A Pubmed search revealed 39 clinical studies reporting the effects of GH and IGF-1 administration on bone metabolism in osteopenic and osteoporotic human subjects and on bone healing in operated patients with normal GH secretion. Eighteen clinical studies considered the effect with GH treatment, fourteen studies reported the clinical effects with IGF-1 administration, and seven related to the GH/IGF-1 effect on bone healing.Results. Both GH and IGF-1 administration significantly increased bone resorption and bone formation in the most studies. GH/IGF-1 administration in patients with hip or tibial fractures resulted in increased bone healing, rapid clinical improvements. Some conflicting results were evidenced.Conclusions. GH and IGF-1 therapy has a significant anabolic effect. GH administration for the treatment of osteoporosis and bone fractures may greatly improve clinical outcome. GH interacts with sex steroids in the anabolic process. GH resistance process is considered.
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“Masters athletes require protein intakes higher than the RDA (between 1.2 and 1.6 up to 2.2 g/kg body mass/day) through its support for muscle mass and function [201], but also via the increase in circulating hormones and growth factors, such as IGF-1, which have an anabolic effect on bone [222].”
From Nutrition for Older Athletes: Focus on Sex-Differences (2021) · cites this paper as [222]
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Citations
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Metadata
- Authors
- Locatelli, V., & Bianchi, V. E.
- Venue
- International Journal of Endocrinology
- Publisher
- Hindawi Limited
- Published
- 2014
- Volume
- 2014
- Pages
- 1-25
- ISSN
- 1687-8337 (ISSN-L)
- 1687-8345
- OpenAlex
- W2038682678
- Cited by
- 307
- References
- 27
- FWCI
- 11.25
- Type
- journal article
- Language
- en
- Open access
- gold
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