Probiotic Enhancement of Antioxidant Capacity and Alterations of Gut Microbiota Composition in 6-Hydroxydopamin-Induced Parkinson’s Disease Rats
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Oxidative stress plays a key role in the degeneration of dopaminergic neurons in Parkinson’s disease (PD), which may be aggravated by concomitant PD-associated gut dysbiosis. Probiotics and prebiotics are therapeutically relevant to these conditions due to their antioxidant, anti-inflammatory, and gut microbiome modulation properties. However, the mechanisms by which probiotic/prebiotic supplementation affects antioxidant capacity and the gut microbiome in PD remains poorly characterized. In this study, we assessed the effects of a Lactobacillus salivarius AP-32 probiotic, a prebiotic (dried AP-32 culture medium supernatant), and a probiotic/prebiotic cocktail in rats with unilateral 6-hydroxydopamine (6-OHDA)-induced PD. The neuroprotective effects and levels of oxidative stress were evaluated after eight weeks of daily supplementation. Fecal microbiota composition was analyzed by fecal 16S rRNA gene sequencing. The supplements were associated with direct increases in host antioxidant enzyme activities and short-chain fatty acid production, protected dopaminergic neurons, and improved motor functions. The supplements also altered the fecal microbiota composition, and some specifically enriched commensal taxa correlated positively with superoxide dismutase, glutathione peroxidase, and catalase activity, indicating supplementation also promotes antioxidant activity via an indirect pathway. Therefore, L. salivarius AP-32 supplementation enhanced the activity of host antioxidant enzymes via direct and indirect modes of action in rats with 6-OHDA-induced PD.
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Probiotic administration helped repair 6-OHDA-induced motor deficits by enhancing mitochondrial function in PD rats.
“probiotic administration helped repair 6-OHDA-induced motor deficits by enhancing mitochondrial function in PD rats [79]”
From Healthy Human Fecal Microbiota Transplantation into Mice Attenuates MPTP-Induced Neurotoxicity <i>via</i> AMPK/SOD2 Pathway (2023) · cites this paper as [79]
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Advice to People with Parkinson’s in My Clinic: Probiotics and Prebiotics
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The role of gut-derived short-chain fatty acids in Parkinson's disease
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Probiotic: A Gut Microbiota-Based Therapeutic Approaches for the Treatment of Parkinson’s Disease
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- Authors
- Tsao, S.-P., Nurrahma, B. A., Kumar, R., Wu, C.-H., Yeh, T.-H., Chiu, C.-C., Lee, Y.-P., Liao, Y.-C., Huang, C.-H., Yeh, Y.-T., & Huang, H.-Y.
- Affiliations
- Taipei Medical University (TW)
- Taipei Medical University Hospital (TW)
- Chang Gung University of Science and Technology (TW)
- Kaohsiung Medical University (TW)
- Fooyin University (TW)
- Corresponding author
- Huang, Hui-Yu
- ORCID
- Venue
- Antioxidants
- Publisher
- MDPI AG
- Published
- 2021-11-17
- Volume
- 10
- Issue
- 11
- Pages
- 1823
- ISSN
- 2076-3921 (ISSN-L)
- PMC
- PMC8615185
- OpenAlex
- W3211533091
- Cited by
- 79
- References
- 84
- Citations by year
- 2026: 10 · 2025: 25 · 2024: 17 · 2023: 13 · 2022: 14
- FWCI
- 5.26
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Antioxidants (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Bioflag Biotech Co., Ltd (A-109-065)
- Ministry of Science and Technology, Taiwan (MOST109-2410-H-038-016-MY3, MOST109-2320-B-038-058-MY3)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- Parkinson's disease, probiotics, prebiotics, gut microbiota, 6-hydroxydopamine, oxidative stress, antioxidant enzymes, short-chain fatty acids, dopaminergic neuroprotection, neuroprotection, motor function, gut-brain axis
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