The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Oxidative Stress, Prooxidants, and Antioxidants: The Interplay
Open accessAbstract
Oxidative stress is a normal phenomenon in the body. Under normal conditions, the physiologically important intracellular levels of reactive oxygen species (ROS) are maintained at low levels by various enzyme systems participating in the in vivo redox homeostasis. Therefore, oxidative stress can also be viewed as an imbalance between the prooxidants and antioxidants in the body. For the last two decades, oxidative stress has been one of the most burning topics among the biological researchers all over the world. Several reasons can be assigned to justify its importance: knowledge about reactive oxygen and nitrogen species production and metabolism; identification of biomarkers for oxidative damage; evidence relating manifestation of chronic and some acute health problems to oxidative stress; identification of various dietary antioxidants present in plant foods as bioactive molecules; and so on. This review discusses the importance of oxidative stress in the body growth and development as well as proteomic and genomic evidences of its relationship with disease development, incidence of malignancies and autoimmune disorders, increased susceptibility to bacterial, viral, and parasitic diseases, and an interplay with prooxidants and antioxidants for maintaining a sound health, which would be helpful in enhancing the knowledge of any biochemist, pathophysiologist, or medical personnel regarding this important issue.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Free radicals, metals and antioxidants in oxidative stress-induced cancer
Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M., & Mazur, M. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2005.12.009 · Cited by 6,680
NF-κB: a key role in inflammatory diseases
Tak, P. P., & Firestein, G. S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11830 · Cited by 3,918
Uttara, B., Singh, A., Zamboni, P., & Mahajan, R. (2009) · Current Neuropharmacology · doi:10.2174/157015909787602823 · Cited by 3,378
Oxidative stress and neurodegeneration: where are we now?
Halliwell, B. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03907.x · Cited by 2,614
The Pecking Order of Free Radicals and Antioxidants: Lipid Peroxidation, α-Tocopherol, and Ascorbate
Buettner, G. R. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1074 · Cited by 2,417
Halliwell, B., & Whiteman, M. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705776 · Cited by 2,238
Nathan, C., & Shiloh, M. U. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.16.8841 · Cited by 1,469
Generation of reactive oxygen species by the mitochondrial electron transport chain
Liu, Y., Fiskum, G., & Schubert, D. (2002) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2002.00744.x · Cited by 1,260
Aubert, G., & Lansdorp, P. M. (2008) · Physiological Reviews · doi:10.1152/physrev.00026.2007 · Cited by 1,188
Kregel, K. C., & Zhang, H. J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00327.2006 · Cited by 883
Cited by
Kurutas, E. B. (2015) · Nutrition Journal · doi:10.1186/s12937-016-0186-5 · Cited by 2,152
Oxidative Stress in Neurodegenerative Diseases
Simonian, N. A., & Coyle, J. T. (1996) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.36.040196.000503 · Cited by 1,377
ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age‐Related Diseases
Davalli, P., Mitic, T., Caporali, A., Lauriola, A., & D’Arca, D. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/3565127 · Cited by 1,059
ROS and Autophagy: Interactions and Molecular Regulatory Mechanisms
Li, L., Tan, J., Miao, Y., Lei, P., & Zhang, Q. (2015) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0166-x · Cited by 876
Oxidative Stress in Neurodegenerative Diseases
Niedzielska, E., Smaga, I., Gawlik, M., Moniczewski, A., Stankowicz, P., Pera, J., & Filip, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9337-5 · Cited by 800
Neag, M. A., Mocan, A., Echeverría, J., Pop, R. M., Bocsan, C. I., Crişan, G., & Buzoianu, A. D. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00557 · Cited by 562
Edible insects: an alternative of nutritional, functional and bioactive compounds.
Jantzen da Silva Lucas, A., Menegon de Oliveira, L., da Rocha, M., & Prentice, C. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2019.126022 · Cited by 412
Vitamin C, Aging and Alzheimer’s Disease
Monacelli, F., Acquarone, E., Giannotti, C., Borghi, R., & Nencioni, A. (2017) · Nutrients · doi:10.3390/nu9070670 · Cited by 243
“A pro-oxidant or antioxidant effect of AA mainly relies on the concentration gradient and redox state of a cell [106].”
BackgroundDietary strategies implicated in the prevention and treatment of metabolic syndrome
De la Iglesia, R., Loria-Kohen, V., Zulet, M., Martinez, J., Reglero, G., & Ramirez de Molina, A. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17111877 · Cited by 168
Ezzat Abd El-Hack, M., Alagawany, M., Ragab Farag, M., Tiwari, R., Karthik, K., Dhama, K., Zorriehzahra, J., & Adel, M. (2016) · Journal of Essential Oil Research · doi:10.1080/10412905.2016.1153002 · Cited by 166
Self-citationMalongane, F., McGaw, L. J., & Mudau, F. N. (2017) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.8472 · Cited by 161
Resveratrol, human health and winemaking perspectives
Pastor, R. F., Restani, P., Di Lorenzo, C., Orgiu, F., Teissedre, P.-L., Stockley, C., Ruf, J. C., Quini, C. I., Garcìa Tejedor, N., Gargantini, R., et al. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1400517 · Cited by 123
Varadharaj, S., Kelly, O. J., Khayat, R. N., Kumar, P. S., Ahmed, N., & Zweier, J. L. (2017) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00064 · Cited by 101
Oxidation, glycation and glycoxidation—The vicious cycle and lung cancer
Ahmad, S., Khan, M. Y., Rafi, Z., Khan, H., Siddiqui, Z., Rehman, S., Shahab, U., Khan, M. S., Saeed, M., Alouffi, S., et al. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.10.005 · Cited by 91
Sun, A., Hu, D., He, X., Ji, X., Li, T., Wei, X., & Qian, Z. (2022) · NPG Asia Materials · doi:10.1038/s41427-022-00434-z · Cited by 74
The impact of tobacco chemicals and nicotine on placental development
Suter, M. A., & Aagaard, K. M. (2020) · Prenatal Diagnosis · doi:10.1002/pd.5660 · Cited by 70
Antioxidant Production in Dunaliella
Roy, U. K., Nielsen, B. V., & Milledge, J. J. (2021) · Applied Sciences · doi:10.3390/app11093959 · Cited by 51
Potential effects of metformin in DNA BER system based on oxidative status in type 2 diabetes
Dogan Turacli, I., Candar, T., Yuksel, E. B., Kalay, S., Oguz, A. K., & Demirtas, S. (2018) · Biochimie · doi:10.1016/j.biochi.2018.08.002 · Cited by 46
Grandi, C., & D’Ovidio, M. C. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17041357 · Cited by 46
El-Hack, M. E. A., Mahgoub, S. A., Alagawany, M., & Dhama, K. (2015) · International Journal of Pharmacology · doi:10.3923/ijp.2015.689.696 · Cited by 45
Self-citationRecent advances of tanshinone in regulating autophagy for medicinal research
Wu, S., Zhao, K., Wang, J., Liu, N., Nie, K., Qi, L., & Xia, L. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1059360 · Cited by 32
Ayaz, A., Zaman, W., Radák, Z., & Gu, Y. (2024) · Antioxidants · doi:10.3390/antiox13040437 · Cited by 26
Nirmal, S., Olatunde, O. O., Medhe, S., Vitti, S., Khemtong, C., & Nirmal, N. P. (2023) · Current Nutrition Reports · doi:10.1007/s13668-023-00500-0 · Cited by 22
Jungert, A., & Frank, J. (2021) · Antioxidants · doi:10.3390/antiox10030448 · Cited by 9
Salem, M. A., El-Gameel, S. M., Kamel, M. S., Elsamman, E. M., & Ramadan, R. M. (2025) · Parasites & Vectors · doi:10.1186/s13071-025-06970-1 · Cited by 5
“In response to this imbalance, the host activates various antioxidant defenses; however, if ROS production overwhelms these systems, oxidative stress occurs [11].”
Metadata
- Authors
- Rahal, A., Kumar, A., Singh, V., Yadav, B., Tiwari, R., Chakraborty, S., & Dhama, K.
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2014
- Volume
- 2014
- Pages
- 1-19
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- OpenAlex
- W2082221119
- Cited by
- 1,706
- References
- 19
- FWCI
- 57.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
