Saliva-Based Biosensors: Noninvasive Monitoring Tool for Clinical Diagnostics

ELECTRODE SYSTEMS FOR CONTINUOUS MONITORING IN CARDIOVASCULAR SURGERY

Clark, L. C., & Lyons, C. (1962) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1962.tb13623.x · Cited by 3,945

Salivary alpha-amylase as a non-invasive biomarker for the sympathetic nervous system: Current state of research

Nater, U. M., & Rohleder, N. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.01.014 · Cited by 1,370

Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection

Bayerdörffer, E., Rudolph, B., Neubauer, A., Thiede, C., Lehn, N., Eidt, S., Stolte, M., & M. Group (1995) · The Lancet · doi:10.1016/s0140-6736(95)90113-2 · Cited by 956

T he D iagnostic A pplications of S aliva — A R eview

Kaufman, E., & Lamster, I. B. (2002) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/154411130201300209 · Cited by 887

Synthesis of a cortisol–biotin conjugate and evaluation as a tracer in an immunoassay for salivary cortisol measurement

Dressendörfer, R. A., Kirschbaum, C., Rohde, W., Stahl, F., & Strasburger, C. J. (1992) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(92)90294-s · Cited by 882

Saliva specimen: A new laboratory tool for diagnostic and basic investigation

Chiappin, S., Antonelli, G., Gatti, R., & De Palo, E. F. (2007) · Clinica Chimica Acta · doi:10.1016/j.cca.2007.04.011 · Cited by 828

Salivary cortisol: a better measure of adrenal cortical function than serum cortisol

Vining, R. F., McGinley, R. A., Maksvytis, J. J., & Ho, K. Y. (1983) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/000456328302000601 · Cited by 684

Human salivary alpha-amylase reactivity in a psychosocial stress paradigm

Nater, U. M., Rohleder, N., Gaab, J., Berger, S., Jud, A., Kirschbaum, C., & Ehlert, U. (2005) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2004.09.009 · Cited by 618

Recent advances in ZnO nanostructures and thin films for biosensor applications: Review

Arya, S. K., Saha, S., Ramı́rez-Vick, J. E., Gupta, V., Bhansali, S., & Singh, S. P. (2012) · Analytica Chimica Acta · doi:10.1016/j.aca.2012.05.048 · Cited by 579

Review: The physiology of saliva and transfer of drugs into saliva.

Aps, J., & Martens, L. (2005) · Forensic Science International · doi:10.1016/j.forsciint.2004.10.026 · Cited by 559

Saliva: an emerging biofluid for early detection of diseases.

Lee, Y. H., & Wong, D. T. (2009) · PubMed · Cited by 481

Anaerobic Threshold: The Concept and Methods of Measurement

Svedahl, K., & MacIntosh, B. R. (2003) · Canadian Journal of Applied Physiology · doi:10.1139/h03-023 · Cited by 467

Interleukin 6 and Interleukin 8 as Potential Biomarkers for Oral Cavity and Oropharyngeal Squamous Cell Carcinoma

John, M. A. R. S., Li, Y., Zhou, X. C., Denny, P., Ho, C., Montemagno, C. D., Shi, W., Qi, F., Wu, B. M., Sinha, U. K., et al. (2004) · Archives of Otolaryngology - Head and Neck Surgery · doi:10.1001/archotol.130.8.929 · Cited by 424

Non-invasive mouthguard biosensor for continuous salivary monitoring of metabolites

Kim, J., Valdés-Ramírez, G., Bandodkar, A. J., Jia, W., Martinez, A. G., Ramírez, J., Mercier, P., & Wang, J. (2014) · The Analyst · doi:10.1039/c3an02359a · Cited by 367

Salivary cortisol determined by enzyme immunoassay is preferable to serum total cortisol for assessment of dynamic hypothalamic–pituitary–adrenal axis activity

Gozansky, W. S., Lynn, J. S., Laudenslager, M. L., & Kohrt, W. M. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02349.x · Cited by 356

Salivary Transcriptomic Biomarkers for Detection of Resectable Pancreatic Cancer

Zhang, L., Farrell, J. J., Zhou, H., Elashoff, D. A., Akin, D., Park, N., Chia, D., & Wong, D. T. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.11.010 · Cited by 342

Salivary α-Amylase: Role in Dental Plaque and Caries Formation

Scannapieco, F. A., Torres, G., & Levine, M. J. (1993) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/10454411930040030701 · Cited by 272

Do Salivary Antibodies Reliably Reflect Both Mucosal and Systemic Immunity?

Brandtzæg, P. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1384.012 · Cited by 263

Electrochemical Sensor for Multiplex Biomarkers Detection

Fang, W., Patel, P. S., Liao, W., Chaudhry, K., Zhang, L., Arellano-Garcia, M. E., Hu, S., Elashoff, D. A., Zhou, H., Shukla, S. N., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0050 · Cited by 257

Nano-bio-chips for high performance multiplexed protein detection: Determinations of cancer biomarkers in serum and saliva using quantum dot bioconjugate labels

Jokerst, J. V., Raamanathan, A., Christodoulides, N. J., Floriano, P. N., Pollard, A. A., Simmons, G. W., Wong, J., Gage, C. L., Furmaga, W. B., Redding, S. W., et al. (2009) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2009.05.026 · Cited by 253

Performance evaluation of salivary amylase activity monitor

Yamaguchi, M., Kanemori, T., Kanemaru, M., Takai, N., Mizuno, Y., & Yoshida, H. (2004) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2004.02.012 · Cited by 234

Salivary cortisol reflects serum cortisol: analysis of circadian profiles.

Dorn, L. D., Lucke, J. F., Loucks, T. L., & Berga, S. L. (2007) · Annals of Clinical Biochemistry: International Journal of Laboratory Medicine · doi:10.1258/000456307780480954 · Cited by 228

Concomitant Analysis of Salivary Tumor Markers—A New Diagnostic Tool for Oral Cancer

Nagler, R. M., Bahar, G., Shpitzer, T., & Feinmesser, R. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2412 · Cited by 217

Noninvasive Blood Glucose Monitoring

Klonoff, D. C. (1997) · Diabetes Care · doi:10.2337/diacare.20.3.433 · Cited by 213

The Passage of Tissue Fluid into the Clinically Healthy Gingival Pocket

Brill, N., & Krasse, B. (1958) · Acta Odontologica Scandinavica · doi:10.3109/00016355809064110 · Cited by 199

Intercollegiate soccer: Saliva cortisol and testosterone are elevated during competition, and testosterone is related to status and social connectedness with teammates

EDWARDS, D., WETZEL, K., & WYNER, D. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.09.007 · Cited by 196

Hand-held monitor of sympathetic nervous system using salivary amylase activity and its validation by driver fatigue assessment

Yamaguchi, M., Deguchi, M., Wakasugi, J., Ono, S., Takai, N., Higashi, T., & Mizuno, Y. (2006) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2005.03.014 · Cited by 195

Helicobacter pylori infection and gastric cancer

Matysiak‐Budnik, T., & Mégraud, F. (2006) · European Journal of Cancer · doi:10.1016/j.ejca.2006.01.020 · Cited by 189

Detection of Cortisol in Saliva with a Flow-Filtered, Portable Surface Plasmon Resonance Biosensor System

Stevens, R. C., Soelberg, S. D., Near, S., & Furlong, C. E. (2008) · Analytical Chemistry · doi:10.1021/ac800892h · Cited by 179

The presence of soluble c-erbB-2 in saliva and serum among women with breast carcinoma: a preliminary study.

Streckfus, C. F., Bigler, L. R., Dellinger, T. M., Dai, X., Kingman, A., & Thigpen, J. T. (2000) · PubMed · Cited by 174

Structural and functional salivary disorders in type 2 diabetic patients.

Cardá, C., Mosquera-Lloreda, N., Salom, L., de Ferraris, M. E. G., & Peydró, A. (2006) · PubMed · Cited by 171

A Comparison of Ghrelin, Glucose, Alpha-amylase and Protein Levels in Saliva from Diabetics

Aydın, S. (2007) · BMB Reports · doi:10.5483/bmbrep.2007.40.1.029 · Cited by 170

Progress and recent advances in phosphate sensors: A review

al, A. T. L., & Adeloju, S. B. O. (2013) · Talanta · doi:10.1016/j.talanta.2013.03.031 · Cited by 164

Small Molecule Immunosensing Using Surface Plasmon Resonance

Mitchell, J. S. (2010) · Sensors · doi:10.3390/s100807323 · Cited by 164

Development of transcriptomic biomarker signature in human saliva to detect lung cancer

Zhang, L., Xiao, H., Zhou, H., Santiago, S., Lee, J. M., Garon, E. B., Yang, J., Brinkmann, O., Yan, X., Akin, D., et al. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1027-0 · Cited by 162

A Preliminary Study of CA15-3, c-erbB-2, Epidermal Growth Factor Receptor, Cathepsin-D, and p53 in Saliva Among Women with Breast Carcinoma

Streckfus, C. F., Bigler, L. R., Tucci, M. A., & Thigpen, J. T. (2000) · Cancer Investigation · doi:10.3109/07357900009038240 · Cited by 161

Proteomic identification of salivary transferrin as a biomarker for early detection of oral cancer

Jou, Y.-J., Lin, C.-D., Lai, C., Chen, C.-H., Kao, J., Chen, S., Tsai, M.-H., Huang, S., & Lin, C.-W. (2010) · Analytica Chimica Acta · doi:10.1016/j.aca.2010.09.030 · Cited by 159

Estimation of salivary glucose, salivary amylase, salivary total protein and salivary flow rate in diabetics in India

Panchbhai, A. S., Degwekar, S. S., & Bhowte, R. (2010) · Journal of Oral Science · doi:10.2334/josnusd.52.359 · Cited by 152

Saturation of human saliva with respect to calcium salts

Larsen, M., & Pearce, E. I. F. (2003) · Archives of Oral Biology · doi:10.1016/s0003-9969(03)00007-4 · Cited by 150

Soluble CD44 Is a Potential Marker for the Early Detection of Head and Neck Cancer

Franzmann, E. J., Reategui, E. P., Pedroso, F. E., Pernas, F. G., Karakullukçu, B., Carraway, K. L., Hamilton, K., Singal, R., & Goodwin, W. J. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0011 · Cited by 150

Simultaneous measurement of cortisol and cortisone in human saliva using liquid chromatography-tandem mass spectrometry: application in basal and stimulated conditions

Perogamvros, I., Owen, L. J., Newell-Price, J., Ray, D. W., Trainer, P. J., & Keevil, B. G. (2009) · Journal of Chromatography B · doi:10.1016/j.jchromb.2009.09.014 · Cited by 140

Direct Radioimmunoassay (RIA) of salivary testosterone: correlation with free and total serum testosterone

Vittek, J., l'Hommedieu, D., Gordon, G. G., Rappaport, S. C., & Southren, A. L. (1985) · Life Sciences · doi:10.1016/0024-3205(85)90540-5 · Cited by 134

Noninvasively measuring blood glucose using saliva

Yamaguchi, M., Mitsumori, M., & Kano, Y. (1998) · IEEE Engineering in Medicine and Biology Magazine · doi:10.1109/51.677170 · Cited by 129

Identification of Leptin in Human Saliva

Gröschl, M., Rauh, M., Wagner, R., Neuhuber, W., Metzler, M., Tamgüney, G., Zenk, J., Schoof, E., Dörr, H. G., Blum, W. F., et al. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.11.7998 · Cited by 127

Measuring tobacco smoke exposure: quantifying nicotine/cotinine concentration in biological samples by colorimetry, chromatography and immunoassay methods

Dhar, P. (2004) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2004.01.009 · Cited by 126

Comparative study of the concentration of salivary and blood glucose in type 2 diabetic patients

Vasconcelos, A. C. U., Soares, M. S. M., de Almeida, P. C., & Soares, T. C. (2010) · Journal of Oral Science · doi:10.2334/josnusd.52.293 · Cited by 123

Salivary testosterone: a reliable approach to the diagnosis of male hypogonadism

Arregger, A. L., Contreras, L. N., Tumilasci, O. R., Aquilano, D. R., & Cardoso, E. M. L. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.02937.x · Cited by 118

Label-free, chemiresistor immunosensor for stress biomarker cortisol in saliva

Tlili, C., Myung, N. V., Shetty, V., & Mulchandani, A. (2011) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2011.04.045 · Cited by 117

Detection of Human Immunodeficiency Virus Antibodies in Oral Fluids

Hodinka, R. L., Nagashunmugam, T., & Malamud, D. (1998) · Clinical and Diagnostic Laboratory Immunology · doi:10.1128/cdli.5.4.419-426.1998 · Cited by 117

New enzyme immunoassay for salivary cortisol

Raff, H., Homar, P. J., & Skoner, D. P. (2003) · Clinical Chemistry · doi:10.1373/49.1.203 · Cited by 116

Dithiobis(succinimidyl propionate) modified gold microarray electrode based electrochemical immunosensor for ultrasensitive detection of cortisol

Arya, S. K., Chornokur, G., Venugopal, M., & Bhansali, S. (2010) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2010.03.016 · Cited by 115

Patterns of Salivary Estradiol and Progesterone across the Menstrual Cycle

Gandara, B., LeResche, L., & Mancl, L. (2007) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1384.022 · Cited by 114

Evaluation of a new, rapid test for detecting HCV infection, suitable for use with blood or oral fluid

Lee, S. R., Kardos, K. W., Schiff, E. R., Berne, C. A., Mounzer, K., Banks, A. T., Tatum, H. A., Friel, T. J., DeMicco, M. P., Lee, W. M., et al. (2010) · Journal of Virological Methods · doi:10.1016/j.jviromet.2010.12.009 · Cited by 111

Identification of a biomarker for sleep drive in flies and humans

Seugnet, L., Boero, J., Gottschalk, L., Duntley, S. P., & Shaw, P. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609463104 · Cited by 110

Bioelectrochemical Switches for the Quantitative Detection of Antibodies Directly in Whole Blood

Vallée‐Bélisle, A., Ricci, F., Uzawa, T., Xia, F., & Plaxco, K. W. (2012) · Journal of the American Chemical Society · doi:10.1021/ja305720w · Cited by 109

Cotton fabric-based electrochemical device for lactate measurement in saliva

Malon, R. S. P., Chua, K. Y., Wicaksono, D. H. B., & Córcoles, E. P. (2014) · The Analyst · doi:10.1039/c4an00201f · Cited by 105

Non-invasive biosensors in clinical analysis

Guilbault, G. G., Palleschi, G., & Lubrano, G. J. (1995) · Biosensors and Bioelectronics · doi:10.1016/0956-5663(95)96856-t · Cited by 102

Late-night salivary cortisol measurement in the diagnosis of Cushing’s syndrome

Carroll, T., Raff, H., & Findling, J. W. (2008) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0837 · Cited by 97

Immunosensor with fluid control mechanism for salivary cortisol analysis

Yamaguchi, M., Matsuda, Y., Sasaki, S., SASAKI, M., Kadoma, Y., Imai, Y., Niwa, D., & Shetty, V. (2012) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2012.08.016 · Cited by 96

Optical protein sensor for detecting cancer markers in saliva

Tan, W., Sabet, L., Li, Y., Yu, T., Klokkevold, P. R., Wong, D. T., & Ho, C. (2008) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2008.03.037 · Cited by 95

Developmental validation of a point-of-care, salivary α-amylase biosensor

Shetty, V., Zigler, C. M., Robles, T. F., Elashoff, D. A., & Yamaguchi, M. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.07.008 · Cited by 93

Salivary and plasma bound and “free” testosterone in men and women

Khan‐Dawood, F. S., Choe, J. K., & Dawood, M. Y. (1984) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(84)90723-3 · Cited by 93

Salivary cortisol measurement—a reliable method for the diagnosis of Cushing's syndrome.

Trilck, M., Flitsch, J., Lüdecke, D., Jung, R., & Petersenn, S. (2005) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2005-837667 · Cited by 93 · cited 1×

Disposable electrochemiluminescent biosensor for lactate determination in saliva

Ballesta Claver, J., Valencia Mirón, M. C., & Capitán-Vallvey, L. F. (2009) · The Analyst · doi:10.1039/b821922b · Cited by 93

Towards a simple, saliva-based test for the detection of oral cancer.

Wong, D. T. (2006) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.6.3.267 · Cited by 92

Salivary glucose levels and oral candidal carriage in type II diabetics

Sashikumar, R., & Ranganathan, K. (2010) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/j.tripleo.2009.12.042 · Cited by 90

Novel Impedimetric Immunosensor for Detection of Pathogenic Bacteria Streptococcus pyogenes in Human Saliva

Ahmed, A., Rushworth, J. V., Wright, J. D., & Millner, P. A. (2013) · Analytical Chemistry · doi:10.1021/ac403253j · Cited by 89

The Clinical Efficacy of Reflexology in Nursing Home Residents with Dementia

Hodgson, N., & Andersen, S. (2008) · Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2007.0577 · Cited by 87

The potential use of saliva to detect recurrence of disease in women with breast carcinoma

Bigler, L. R., Streckfus, C. F., Copeland, L., Burns, R., Dai, X., Kuhn, M., Martin, P., & Bigler, S. A. (2002) · Journal of Oral Pathology and Medicine · doi:10.1034/j.1600-0714.2002.00123.x · Cited by 85

Correlation Between Salivary α-Amylase Activity and Pain Scale in Patients With Chronic Pain

Shirasaki, S., FUJII, H., TAKAHASHI, M., Sato, T., Ebina, M., Noto, Y., & Hirota, K. (2007) · Regional Anesthesia & Pain Medicine · doi:10.1016/j.rapm.2006.11.008 · Cited by 85

Salivary protein factors are elevated in breast cancer patients

Brooks, M. N., Wang, J., Li, Y., Zhang, R., Elashoff, D. A., & Wong, D. T. (2008) · Molecular Medicine Reports · doi:10.3892/mmr.1.3.375 · Cited by 84

Catecholamines in human saliva

Kennedy, B. P., Dillon, E., Mills, P. J., & Ziegler, M. G. (2001) · Life Sciences · doi:10.1016/s0024-3205(01)01111-0 · Cited by 84

Ultrasensitive detection of testosterone using conjugate linker technology in a nanoparticle-enhanced surface plasmon resonance biosensor

Mitchell, J. S., & Lowe, T. E. (2008) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2008.11.018 · Cited by 84

Salivary cortisol as a tool for physiological studies and diagnostic strategies

Castro, M., Elias, P. C. L., Martinelli Jr., C. E., Antonini, S. R. R., Santiago, L., & Moreira, A. C. (2000) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2000001000006 · Cited by 83

Rapid ultrasensitive measurement of salivary cortisol using nano-linker chemistry coupled with surface plasmon resonance detection

Mitchell, J. S., Lowe, T. E., & Ingram, J. R. (2008) · The Analyst · doi:10.1039/b817083p · Cited by 79

Testosterone deficiency: a common, unrecognized syndrome

Tostain, J., & Blanc, F. (2008) · Nature Clinical Practice Urology · doi:10.1038/ncpuro1167 · Cited by 78

Determination of salivary glucose in healthy adults

Soares, M. S. M., Batista-Filho, M., Pimentel, M.-J., Passos, I. A., & Küstner, E. C. (2009) · Medicina oral, patología oral y cirugía bucal · doi:10.4317/medoral.14.e510 · Cited by 75

Biosensors for medical applications

Higson, S. P. J. (2012) · Woodhead Publishing Limited eBooks · doi:10.1533/9780857097187 · Cited by 73

Association of Infection Due to Helicobacter pylori with Specific Upper Gastrointestinal Pathology

Blaser, M. J., Perez-Perez, G. I., Lindenbaum, J., Schneidman, D., Deventer, G. V., Marin-Sorensen, M., & Weinstein, W. M. (1991) · Clinical Infectious Diseases · doi:10.1093/clinids/13.supplement_8.s704 · Cited by 72

Salivary Phosphate-Binding Chewing Gum Reduces Hyperphosphatemia in Dialysis Patients

Savica, V., Accent, L. A. C. G., Monardo, P., Davis, P. A., Granata, A. R. M., Santoro, D., Savica, R., Musolino, R. F., Comelli, M. C., & Bellinghieri, G. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008020130 · Cited by 69

In‐dental‐office screening for diabetes mellitus using gingival crevicular blood

Beikler, T., Kuczek, A., Petersilka, G., & Flemmig, T. F. (2002) · Journal Of Clinical Periodontology · doi:10.1034/j.1600-051x.2002.290306.x · Cited by 68

An immunoelectrochemical sensor for salivary cortisol measurement

Sun, K., Ramgir, N. S., & Bhansali, S. (2008) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2008.03.018 · Cited by 68

Development of an Au/ZnO thin film surface plasmon resonance-based biosensor immunoassay for the detection of carbohydrate antigen 15‐3 in human saliva

Liang, Y.-H., Chang, C., Chen, C., Chu-Su, Y., & Lin, C. (2012) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2012.09.001 · Cited by 65

Salivary zinc finger protein 510 peptide as a novel biomarker for detection of oral squamous cell carcinoma in early stages

Jou, Y.-J., Lin, C.-D., Lai, C., Tang, C., Huang, S., Tsai, M.-H., Chen, S., Kao, J., & Lin, C. (2011) · Clinica Chimica Acta · doi:10.1016/j.cca.2011.04.004 · Cited by 64

An automated integrated platform for rapid and sensitive multiplexed protein profiling using human saliva samples

Nie, S., Henley, W. H., Miller, S. E., Zhang, H., Mayer, K. M., Dennis, P. J., Oblath, E. A., Alarie, J. P., Wu, Y., Oppenheim, F. G., et al. (2014) · Lab on a Chip · doi:10.1039/c3lc51303c · Cited by 62

Micromachined sensor for lactate monitoring in saliva

Schabmueller, C. G. J., Loppow, D., Piechotta, G., Schütze, B., Albers, J., & Hintsche, R. (2005) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2005.09.015 · Cited by 59

Development of conductometric biosensor array for simultaneous determination of maltose, lactose, sucrose and glucose

Soldatkin, O. O., Peshkova, V. M., Saiapina, O., Kucherenko, I. S., Dudchenko, O. Y., Melnyk, V. G., Vasylenko, Семеничева, Л. М., Soldatkin, A. P., & Dzyadevych, S. V. (2013) · Talanta · doi:10.1016/j.talanta.2013.04.065 · Cited by 58

Effect of a proprietary Magnolia and Phellodendronextract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial

Kalman, D., Feldman, S., Feldman, R., Schwartz, H. I., Krieger, D., & Garrison, R. (2008) · Nutrition Journal · doi:10.1186/1475-2891-7-11 · Cited by 58

A biosensor for the determination of amylase activity

Zajoncová, L., Jı́lek, M., Beranová, V., & Peč, P. (2004) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2004.01.006 · Cited by 56

Flow-injection-type biosensor system for salivary amylase activity

Yamaguchi, M., Kanemaru, M., Kanemori, T., & Mizuno, Y. (2003) · Biosensors and Bioelectronics · doi:10.1016/s0956-5663(03)00007-1 · Cited by 53

Increased Cyfra 21-1 concentration in saliva from primary oral squamous cell carcinoma patients

Zhong, L., Zhang, C., Zheng, J., Jiang, L., Chen, W., & Zhang, Z. (2007) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2007.05.005 · Cited by 53

Effects of a 30-km race upon salivary lactate correlation with blood lactate

Santos, R. V. T., Almeida, A. L. R., Caperuto, E. C., Martins, E., & Costa Rosa, L. F. B. P. (2006) · Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2006.07.001 · Cited by 51

The Potential Use of Gingival Crevicular Blood for Measuring Glucose to Screen for Diabetes: An Examination Based on Characteristics of the Blood Collection Site

Strauss, S. M., Wheeler, A. J., Russell, S. L., Brodsky, A., Davidson, R. M., Gluzman, R., Lin, L., Malo, R. G., Salis, B., Schoor, R., et al. (2009) · Journal of Periodontology · doi:10.1902/jop.2009.080542 · Cited by 51

Amperometric biosensor for determining human salivary phosphate

Kwan, R. C. H., Leung, H. F., Hon, P. Y. T., Cheung, H. C. F., Hirota, K., & Renneberg, R. (2005) · Analytical Biochemistry · doi:10.1016/j.ab.2005.05.021 · Cited by 50

Essential Oil Inhalation on Blood Pressure and Salivary Cortisol Levels in Prehypertensive and Hypertensive Subjects

Kim, I., Kim, C., Seong, K., Hur, M., Lim, H. M., & Lee, M. S. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/984203 · Cited by 50

Free epinephrine, norepinephrine and dopamine in saliva and plasma of healthy adults.

Schwab, K., Heubel, G., & Bartels, H. (1992) · PubMed · Cited by 48

Salivary-specific immunoglobulin G in the diagnosis of Helicobacter pylori infection in dyspeptic patients.

Luzza, F., Maletta, M., Imeneo, M., Marcheggiano, A., Iannoni, C., Biancone, L., & Pallone, F. (1995) · PubMed · Cited by 48

Anaerobic Threshold Determination With Analysis of Salivary Amylase

Calvo, F. Á., Chicharro, J. L., Bandrés, F., Lucı́a, A., Pérez, M., Álvarez, J., Mojares, L. L., Vaquero, A. F., & Legido, J. C. (1997) · Canadian Journal of Applied Physiology · doi:10.1139/h97-035 · Cited by 48

Novel micromachined silicon sensor for continuous glucose monitoring

Piechotta, G., Albers, J., & Hintsche, R. (2005) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2005.02.008 · Cited by 48

Salivary Phosphate Secretion in Chronic Kidney Disease

Savica, V., Calò, L. A., Santoro, D., Monardo, P., Granata, A. R. M., & Bellinghieri, G. (2007) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2007.10.018 · Cited by 47

A disposable biosensor for the determination of alpha-amylase in human saliva

Mahosenaho, M., Caprio, F., Micheli, L., Sesay, A. M., Palleschi, G., & Virtanen, V. (2010) · Microchimica Acta · doi:10.1007/s00604-010-0360-y · Cited by 45

Use of thiolated oligonucleotides as anti-fouling diluents in electrochemical peptide-based sensors

McQuistan, A., Zaitouna, A. J., Echeverría, E., & Lai, R. Y. (2014) · Chemical Communications · doi:10.1039/c4cc01290a · Cited by 45

Salivary and blood lactate after supramaximal exercise in sprinters and long‐distance runners

Ohkuwa, T., Itoh, H., Yamazaki, Y., & Sato, Y. (1995) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.1995.tb00046.x · Cited by 42

The feasibility of ambulatory biosensor measurement of salivary alpha amylase: Relationships with self-reported and naturalistic psychological stress

Robles, T. F., Shetty, V., Zigler, C. M., Glover, D. A., Elashoff, D. A., Murphy, D. A., & Yamaguchi, M. (2010) · Biological Psychology · doi:10.1016/j.biopsycho.2010.10.006 · Cited by 42

Salivary immunoglobulin G assay to diagnose Helicobacter pylori infection in children

Luzza, F., Oderda, G., Maletta, M., Imeneo, M., Mesuraca, L., Chioboli, E., Lerro, P., Guandalini, S., & Pallone, F. (1997) · Journal of Clinical Microbiology · doi:10.1128/jcm.35.12.3358-3360.1997 · Cited by 41

Detection of HCV antibodies in oral fluid

Cock, L. D., Hutse, V., Verhaegen, E., Quoilin, S., Vandenberghe, H., & Vranckx, R. (2004) · Journal of Virological Methods · doi:10.1016/j.jviromet.2004.09.001 · Cited by 40

Design and characterization of an electrochemical peptide-based sensor fabricated via“click” chemistry

Gerasimov, J. Y., & Lai, R. Y. (2011) · Chemical Communications · doi:10.1039/c1cc12783g · Cited by 39

Detection of Helicobacter pylori infection by saliva IgG testing.

Fallone, C. A., Elizov, M., Cleland, P., Thompson, J. A., Wild, G., Lough, J., Faria, J., & Barkun, A. N. (1996) · PubMed · Cited by 38

Determination of lactate in human saliva with an electrochemical enzyme probe

Palleschi, G., Faridnia, M. H., Lubrano, G. J., & Guilbault, G. G. (1991) · Analytica Chimica Acta · doi:10.1016/s0003-2670(00)80215-9 · Cited by 37

Diagnosis of Intestinal Amebiasis Using Salivary IgA Antibody Detection

del Muro, R., Acosta, E., Merino, E., Glender, W., & Ortíz-Ortíz, L. (1990) · The Journal of Infectious Diseases · doi:10.1093/infdis/162.6.1360 · Cited by 37

Non-invasive monitoring of gingival crevicular fluid for estimation of blood glucose level

Yamaguchi, M., Kawabata, Y., Kambe, S., W⇘rdell, K., Nystrom, F. H., Naitoh, K., & Yoshida, H. (2004) · Medical & Biological Engineering & Computing · doi:10.1007/bf02344706 · Cited by 36

Detection of hepatitis C virus antibodies in oral fluid specimens for prevalence studies

González, V., Martró, E., Folch, C., Esteve, A., Matas, L., Montoliu, A., Grifols, J. R., Bolao, F., Tural, C., Muga, R., et al. (2007) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-007-0408-z · Cited by 35

Simultaneous transdermal extraction of glucose and lactate from human subjects by reverse iontophoresis

Connolly (2008) · International Journal of Nanomedicine · doi:10.2147/ijn.s1728 · Cited by 35

Bioelectrode for detection of human salivary amylase

Santos, T. V. D. S., Teixeira, R. R., Franco, D. L., Madurro, J. M., Brito‐Madurro, A. G., & Espíndola, F. S. (2011) · Materials Science and Engineering C · doi:10.1016/j.msec.2011.12.005 · Cited by 33

Endogenous testosterone and competition: the effect of “fasting”

Booth, A., Mazur, A., & Dabbs, J. M. (1993) · Steroids · doi:10.1016/0039-128x(93)90036-m · Cited by 33

Screening for type 2 diabetes mellitus using gingival crevicular blood

Khader, Y. S., Al‐Zu'bi, B., Judeh, A., & Rayyan, M. R. (2006) · International Journal of Dental Hygiene · doi:10.1111/j.1601-5037.2006.00206.x · Cited by 31

Antibody modified gold micro array electrode based electrochemical immunosensor for ultrasensitive detection of cortisol in saliva and ISF

Arya, S. K., Chornokur, G., Venugopal, M., & Bhansali, S. (2010) · Procedia Engineering · doi:10.1016/j.proeng.2010.09.230 · Cited by 30

Development of an oral biosensor for salivary amylase using a monodispersed silver for signal amplification

Aluoch, A. O., Sadik, O. A., & Bedi, G. S. (2005) · Analytical Biochemistry · doi:10.1016/j.ab.2005.02.003 · Cited by 30

Diagnostic significance of salivary testosterone measurement revisited: using liquid chromatography/mass spectrometry and enzyme-linked immunosorbent assay

Yasuda, M., Honma, S., Furuya, K., Yoshii, T., Kamiyama, Y., Ide, H., Muto, S., & Horie, S. (2008) · Journal of Men s Health · doi:10.1016/j.jomh.2007.12.004 · Cited by 30

Flat-Chip Microanalytical Enzyme Sensor for Salivary Amylase Activity

Yamaguchi, M., Deguchi, M., & Wakasugi, J. (2005) · Biomedical Microdevices · doi:10.1007/s10544-005-6071-1 · Cited by 28

Salivary Biosensors for Screening Trauma-Related Psychopathology

Shetty, V., & Yamaguchi, M. (2010) · Oral and Maxillofacial Surgery Clinics of North America · doi:10.1016/j.coms.2010.01.004 · Cited by 27

Simultaneous quantitative analysis of salivary cortisol and cortisone in Korean adults using LC-MS/MS

Lee, S.-H., Kwon, S.-H., Shin, H.-J., Lim, H. S., Singh, R., Lee, K.-R., & Kim, Y. J. (2010) · BMB Reports · doi:10.5483/bmbrep.2010.43.7.506 · Cited by 26

Label-free fluorescent biosensor based on the target recycling and Thioflavin T-induced quadruplex formation for short DNA species of c-erbB-2 detection

Chen, J., Lin, J. L., Zhang, X., Cai, S., Wu, D., Li, C., Yang, S., & Zhang, J. (2014) · Analytica Chimica Acta · doi:10.1016/j.aca.2014.01.053 · Cited by 26

Using conventional HIV tests on oral fluid

Fransen, K., Vermoesen, T., Beelaert, G., Menten, J., Hutse, V., Wouters, K., Platteau, T., & Florence, É. (2013) · Journal of Virological Methods · doi:10.1016/j.jviromet.2013.08.004 · Cited by 25

Gingival crevicular blood: As a non-invasive screening tool for diabetes mellitus in dental clinics

Shetty, N., Shankarapillai, R., Mathur, L. K., Manohar, B., Mathur, A., & Jain, M. (2013) · Journal of Indian Society of Periodontology · doi:10.4103/0972-124x.118319 · Cited by 25

AN EVALUATION OF SALIVA AS AN ALTERNATIVE TO PLASMA FOR THE DETECTION OF HEPATITIS C VIRUS ANTIBODIES

Moorthy, M., Daniel, H., Kurian, G., & Abraham, P. (2008) · Indian Journal of Medical Microbiology · doi:10.4103/0255-0857.42116 · Cited by 25

PERFORMANCE OF A WESTERN IMMUNOBLOT ASSAY TO DETECT SPECIFIC ANTI-TOXOPLASMA GONDII IGG ANTIBODIES IN HUMAN SALIVA

Ströhle, A., Schmid, K., Heinzer, I., Naguleswaran, A., & Hemphill, A. F. (2005) · Journal of Parasitology · doi:10.1645/ge-423r · Cited by 25

Association of Serum Phosphate and Related Factors in ESRD-Related Vascular Calcification

Zheng, C., Lu, K., Wu, C., Hsu, Y., & Lin, Y. (2011) · International Journal of Nephrology · doi:10.4061/2011/939613 · Cited by 23

Evaluation of Time-Course Changes of Gingival Crevicular Fluid Glucose Levels in Diabetics

Yamaguchi, M., Takada, R., Kambe, S., Hatakeyama, T., Naitoh, K., Yamazaki, K., & Kobayashi, M. (2005) · Biomedical Microdevices · doi:10.1007/s10544-005-6172-x · Cited by 22

Salivary phosphate as an indicator of ovulation

Ben‐Aryeh, H., Filmar, S., Gutman, D., Szargfl, R., & Paldi, E. (1976) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(76)90868-1 · Cited by 21

Assessment of Blood Glucose Using Gingival Crevicular Blood in Diabetic and Non-Diabetic Patients: A Chair Side Method

Sharma, A. (2013) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2013/7705.3854 · Cited by 21

Potential for diagnosis of intestinal nematode infections through antibody detection in saliva

Needham, C., Lillywhite, J. E., Beasley, N. M. R., Didier, J. M., Kihamia, C. M., & Bundy, D. A. P. (1996) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(96)90306-5 · Cited by 20

Immunodiagnosis of human leptospirosis using saliva

da Silva, M. V., Camargo, E. D., Vaz, A. J., & Batista, L. I. V. (1992) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(92)90113-q · Cited by 19

Point-of-use measurement of salivary cortisol levels

Yamaguchi, M., Yoshikawa, S., Tahara, Y., Niwa, D., Imai, Y., & Shetty, V. (2009) · Proceedings of IEEE Sensors/Proceedings of IEEE Sensors ... · doi:10.1109/icsens.2009.5398143 · Cited by 18

Application of carbon nanotubes layered on silicon wafer for the detection of breast cancer marker carbohydrate antigen 15-3 by immuno-polymerase chain reaction

Sadhasivam, S., Chen, J.-C., Savitha, S., Chang, C.-W., & Lin, F. (2013) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-013-5060-9 · Cited by 17

Preparation of Disposable Saliva α-Amylase Biosensor

Chao-Shi, Z. O. U., Mi, Z. H. O. U., Xie, G., Peng, L. U. O., Xiong, X., Xu, H., & Zheng, J. (2008) · Chinese Journal of Analytical Chemistry · doi:10.1016/s1872-2040(08)60068-7 · Cited by 17

Monitor of antibodies in human saliva using a piezoelectric quartz crystal biosensor

Tajima, I., Asami, O., & Sugiura, E. (1998) · Analytica Chimica Acta · doi:10.1016/s0003-2670(97)00596-5 · Cited by 17

Immunoglobulin A1 and A2 subclass of salivary antibodies to Candida albicans in patients with oral candidosis.

Jeganathan, S., Ufomata, D., Hobkirk, J. A., & Ivanyi, L. (1987) · PubMed Central · Cited by 15

A new approach to noninvasive measurement of blood glucose using saliva analyzing system

Mitsumori, M., Yamaguchi, M., & Kano, Y. (2002) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/iembs.1998.746929 · Cited by 15

Screening for diabetes mellitus using gingival crevicular blood with the help of a self-monitoring device

Gaikwad, S., Jadhav, V., Gurav, A. N., Shete, A., & Dearda, H. M. (2013) · Journal of Periodontal & Implant Science · doi:10.5051/jpis.2013.43.1.37 · Cited by 15

Measuring salivary androgens as a useful tool in the diagnosis of polycystic ovary syndrome.

Szydlarska, D., Grzesiuk, W., Kondracka, A., Bartoszewicz, Z., & Bar‐Andziak, E. (2012) · PubMed · Cited by 15

Recognition of Multiple Classes of Hepatitis C Antibodies Increases Detection Sensitivity in Oral Fluid

Zmuda, J. F., Wagoneer, B., Liotta, L. A., & Whiteley, G. (2001) · Clinical and Diagnostic Laboratory Immunology · doi:10.1128/cdli.8.6.1267-1270.2001 · Cited by 14

The Correlation of Blood Glucose with Salivary Glucose Level in Diabetic Patients

Azizi, A., & Modaberi, A. (2014) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 13

Gingival Crevicular Blood for Assessment of Blood Glucose Levels

Sarlati, F., Pakmehr, E., Khoshru, K., & Akhondi, N. (2010) · Tabriz University of Medical Sciences · doi:10.5681/jpid.2010.003 · Cited by 12

Routine practice HCV infection screening with saliva samples: multicentric study in an intravenous drug user population

Lucidarme, D., Decoster, A., Fremaux, D., Harbonnier, J., Jacob, C., Vosgien, V., Josse, P., Villéger, P., Henrio, C., Prouvost-Keller, B., et al. (2007) · Gastroentérologie Clinique et Biologique · doi:10.1016/s0399-8320(07)89415-2 · Cited by 12

Zinc oxide nanostructures for electrochemical cortisol biosensing

Vabbina, P. K., Kaushik, A. K., Tracy, K., Bhansali, S., & Pala, N. (2014) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.2051156 · Cited by 11

Antibodies to the metacestode of taenia solium in the saliva from patients with neurocysticercosis

Acosta, E. (1990) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.1860040204 · Cited by 10

Salivary kinetics of prednisolone in man

Lowe, J. R., & Dixon, J. S. (1983) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1983.tb02965.x · Cited by 10

Utility of salivary melatonin measurements in the assessment of the pineal physiology in newborn infants

Bağcı, S., Mueller, A., REINSBERG, J., Heep, A., Bartmann, P., & Franz, A. R. (2010) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2010.04.059 · Cited by 10

Evaluation of Salivary Electrolytes during Normal Menstrual Cycle with Special Reference to Ovulation

Alagendran (2010) · American Journal of Applied Sciences · doi:10.3844/ajassp.2010.1066.1072 · Cited by 9

Development of a low cost self-sensing Piezoresistive Microcantilever biosensor and read-out circuitry for measuring salivary-amylase activity

Madzhi, N. K., Khuan, L. Y., Abdullah, M. F., & Ahmad, A. (2010) · International Conference on Electronics Computer Technology · doi:10.1109/icectech.2010.5480002 · Cited by 8

Gingival crevicular blood glucose assessment as a chairside test for diabetic patients with chronic periodontitis: A clinical study

Suneetha, K., & Rambabu, T. (2012) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.98044 · Cited by 6

Salivary Testosterone in Prostatic Carcinoma

Navarro, M. A., Aguiló, F., Villabona, C., Torrecilla, C., & Bonnin, R. (1989) · British Journal of Urology · doi:10.1111/j.1464-410x.1989.tb05194.x · Cited by 6

Detection of IgA anti-Entamoeba histolytica in the patients' saliva.

Em, E. H., & Arafa, W. A. S. (2004) · PubMed · Cited by 3

Diyabetli Hastalarda Tükrük Glukoz Seviyelerinin Serum Glukoz Seviyesi ve Glisemik Durum ile İlişkisi

Shanbhag, V. K. L. (2014) · Cukurova Medical Journal (Çukurova Üniversitesi Tıp Fakültesi Dergisi) · doi:10.17826/cutf.96265 · Cited by 1

Development of noninvasive procedure for monitoring blood glucose level using gingival crevicular bleeding

Gupta, A. B., Gupta, N., Jain, N., Garg, R., Atreja, G., & Walia, S. S. (2013) · Stomatoloski glasnik Srbije · doi:10.2298/sgs1303124g · Cited by 1

Wearable biosensors for healthcare monitoring

Kim, J., Campbell, A. S., de Ávila, B. E.-F., & Wang, J. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0045-y · Cited by 3,373

Wearable and flexible electronics for continuous molecular monitoring

Yang, Y., & Gao, W. (2019) · Chemical Society Reviews · doi:10.1039/c7cs00730b · Cited by 1,315

Wearable sensors for monitoring the physiological and biochemical profile of the athlete

Seshadri, D. R., Li, R. T., Voos, J. E., Rowbottom, J. R., Alfes, C. M., Zorman, C. A., & Drummond, C. K. (2019) · npj Digital Medicine · doi:10.1038/s41746-019-0150-9 · Cited by 537

Non-Invasive Blood Glucose Monitoring Technology: A Review

Tang, L., Chang, S. J., Chen, C.-J., & Liu, J.-T. (2020) · Sensors · doi:10.3390/s20236925 · Cited by 481

Wearable Biosensors: An Alternative and Practical Approach in Healthcare and Disease Monitoring

Sharma, A., Badea, M., Tiwari, S., & Marty, J. (2021) · Molecules · doi:10.3390/molecules26030748 · Cited by 387

Review Article Saliva-Based Biosensors: Noninvasive Monitoring Tool for Clinical Diagnostics

Malon, R. S. P., Sadir, S., Malarvili, M. B., & Córcoles, E. P. (2016)

Salivary Biomarkers for Clinical Applications

Zhang, L., Xiao, H., & Wong, D. T. (2009) · Molecular Diagnosis & Therapy · doi:10.1007/bf03256330 · Cited by 114

A Brief Review on Recent Lab-on-Chip and Nanotechnology driven advances in Salivary Biomarkers Biosensing for oral disease diagnosisPreprint

Sharma, R., & Patel, A. (2023) · ChemRxiv · doi:10.26434/chemrxiv-2023-lwrsl

Saliva: A Versatile Diagnostic Tool for Health Assessment

Patel, M. F., & Deore, S. (2025) · Indo-American Journal of Pharma and Bio Sciences

Biosensors for saliva biomarkers

Aydın, E. B., Aydın, M., & Sezgintürk, M. K. (2022) · Advances in clinical chemistry · doi:10.1016/bs.acc.2022.11.001 · Cited by 11