Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms

The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function

Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481

Macrophage activation and polarization: nomenclature and experimental guidelines

Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337

Macrophage plasticity and polarization: in vivo veritas

Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528

The M1 and M2 paradigm of macrophage activation: Time for reassessment

Martinez, F. O., & Gordon, S. (2014) · F1000Prime Reports · doi:10.12703/p6-13 · Cited by 4,689

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578

What we talk about when we talk about fat

Rosen, E. D., & Spiegelman, B. M. (2014) · Cell · doi:10.1016/j.cell.2013.12.012 · Cited by 2,373

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

Gomez Perdiguero, E., Klapproth, K., Schulz, C., Busch, K., Azzoni, E., Crozet, L., Garner, H., Trouillet, C., de Bruijn, M. F., Geissmann, F., et al. (2015) · Nature · doi:10.1038/nature13989 · Cited by 2,339 · cited 1×

The cellular and signaling networks linking the immune system and metabolism in disease

Osborn, O., & Olefsky, J. M. (2012) · Nature Medicine · doi:10.1038/nm.2627 · Cited by 1,551

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

Epelman, S., Lavine, K. J., Beaudin, A. E., Sojka, D. K., Carrero, J. A., Calderon, B., Brija, T., Gautier, E. L., Ivanov, S., Satpathy, A. T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.11.019 · Cited by 1,494

Pazopanib for treatment of typical solitary fibrous tumours: a multicentre, single-arm, phase 2 trial

Martín‐Broto, J., Cruz, J., Penel, N., Cesne, A. L., Hindi, N., Luna, P., Moura, D. S., Bernabéu, D., de Álava, E., López‐Guerrero, J. A., et al. (2020) · The Lancet Oncology · doi:10.1016/s1470-2045(19)30826-5 · Cited by 94

Macrophages—common culprit in obesity and asthma

Sharma, N., Akkoyunlu, M., & Rabin, R. L. (2017) · Allergy · doi:10.1111/all.13369 · Cited by 93

Unsaturated polyurethane films grafted with enantiomeric polylysine promotes macrophage polarization to a M2 phenotype through PI3K/Akt1/mTOR axis

Duan, Y., Zheng, H., Li, Z., Yao, Y., Ding, J., Wang, X., Nakkala, J. R., Zhang, D., Wang, Z., Zuo, X., et al. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120012 · Cited by 93

Roles of Matrix Metalloproteinases and Their Natural Inhibitors in Metabolism: Insights into Health and Disease

Molière, S., Jaulin, A., Tomasetto, C., & Dali‐Youcef, N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310649 · Cited by 98

Tumor‐infiltrating M2 macrophage in pretreatment biopsy sample predicts response to chemotherapy and survival in esophageal cancer

Yamamoto, K., Makino, T., Sato, E., Noma, T., Urakawa, S., Takeoka, T., Yamashita, K., Saito, T., Tanaka, K., Takahashi, T., et al. (2020) · Cancer Science · doi:10.1111/cas.14328 · Cited by 85

Macrophage Phenotypes in Normal and Diabetic Wound Healing and Therapeutic Interventions

Sadoun, H. A. (2022) · Cells · doi:10.3390/cells11152430 · Cited by 96

Macrophages under pressure: the role of macrophage polarization in hypertension

Harwani, S. C. (2017) · Translational research · doi:10.1016/j.trsl.2017.10.011 · Cited by 95

Adipocytes and Macrophages Interplay in the Orchestration of Tumor Microenvironment: New Implications in Cancer Progression

Corrêa, L. H., Corrêa, R., Farinasso, C. M., Dourado, L. P. D. S., & Magalhães, K. G. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01129 · Cited by 92

Tumor-Associated Macrophages in Gliomas—Basic Insights and Treatment Opportunities

Andersen, J. K., Miletić, H., & Hossain, J. A. (2022) · Cancers · doi:10.3390/cancers14051319 · Cited by 94

ZnO‐CuS/F127 Hydrogels with Multienzyme Properties for Implant‐Related Infection Therapy by Inhibiting Bacterial Arginine Biosynthesis and Promoting Tissue Repair

Sun, Y., Zhang, W., Luo, Z., Zhu, C., Zhang, Y., Zheng, S. S., Shen, C., Yao, X., Wang, Y., & Wang, X. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202415778 · Cited by 91

Alterations in Blood Monocyte Functions in Parkinson's Disease

Nissen, S. K., Shrivastava, K., Schulte, C., Otzen, D. E., Goldeck, D., Berg, D., Møller, H. J., Maetzler, W., & Romero‐Ramos, M. (2019) · Movement Disorders · doi:10.1002/mds.27815 · Cited by 89

Lung Macrophage Functional Properties in Chronic Obstructive Pulmonary Disease

Akata, K., & van Eeden, S. F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030853 · Cited by 95

Macrophage Repolarization as a Therapeutic Strategy for Osteosarcoma

Anand, N., Peh, K. H., & Kolesar, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032858 · Cited by 94

Macrophages in Organ Transplantation

Ordikhani, F., Pothula, V., Sánchez-Tarjuelo, R., Jordan, S., & Ochando, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.582939 · Cited by 91

Significance and in vivo detection of iron-laden microglia in white matter multiple sclerosis lesions

Gillen, K. M., Mubarak, M., Nguyen, T. D., & Pitt, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00255 · Cited by 88

Macrophages and Intervertebral Disc Degeneration

Koroth, J., Buko, E. O., Abbott, R., Johnson, C. P., Ogle, B. M., Stone, L. S., Ellingson, A. M., & Bradley, E. W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021367 · Cited by 92

Cell-Based Delivery of Interleukin-13 Directs Alternative Activation of Macrophages Resulting in Improved Functional Outcome after Spinal Cord Injury

Dooley, D., Lemmens, E., Vangansewinkel, T., Blon, D. L., Hoornaert, C., Ponsaerts, P., & Hendrix, S. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.11.005 · Cited by 89

Modulating tumor-associated macrophages to enhance the efficacy of immune checkpoint inhibitors: A TAM-pting approach

Chamseddine, A. N., Assi, T., Mir, O., & Chouaïb, S. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107986 · Cited by 89

Bladder cancer, inflammageing and microbiomes

Martin, A., Woolbright, B. L., Umar, S., Ingersoll, M. A., & Taylor, J. A. (2022) · Nature Reviews Urology · doi:10.1038/s41585-022-00611-3 · Cited by 89

Immune System and Hepatocellular Carcinoma (HCC): New Insights into HCC Progression

Kotsari, M., Dimopoulou, V., Koskinas, J. S., & Armakolas, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411471 · Cited by 93

Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages

Waqas, S. F. H., Hoang, A. C., Lin, Y., Ampem, G., Azegrouz, H., Balogh, L., Thuróczy, J., Chen, J., Gerling, I., Nam, S., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90152 · Cited by 89

Hyperbaric oxygen reduces inflammation, oxygenates injured muscle, and regenerates skeletal muscle via macrophage and satellite cell activation

Oyaizu, T., Enomoto, M., Yamamoto, N., Tsuji, K., Horie, M., Muneta, T., Sekiya, I., Okawa, A., & Yagishita, K. (2018) · Scientific Reports · doi:10.1038/s41598-018-19670-x · Cited by 84

Local Immunomodulation with Anti-inflammatory Cytokine-Encoding Lentivirus Enhances Functional Recovery after Spinal Cord Injury

Park, J., Decker, J. T., Margul, D. J., Smith, D. R., Cummings, B. J., Anderson, A. J., & Shea, L. D. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.04.022 · Cited by 88

Photobiomodulation and different macrophages phenotypes during muscle tissue repair

Souza, N. H. C., Mesquita‐Ferrari, R. A., Rodrigues, M. F. S. D., da Silva, D. D. F. T., Ribeiro, B. G., Alves, A. N., Garcia, M. P., Nunes, F. D., da Silva, E. M., França, C. M., et al. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13757 · Cited by 84

IgG4 drives M2a macrophages to a regulatory M2b‐like phenotype: potential implication in immune tolerance

Bianchini, R., Roth‐Walter, F., Ohradanova‐Repic, A., Flicker, S., Hufnagl, K., Fischer, M. B., Stockinger, H. S. J., & Jensen‐Jarolim, E. (2018) · Allergy · doi:10.1111/all.13635 · Cited by 83

High dose-rate brachytherapy of localized prostate cancer converts tumors from cold to hot

Keam, S. P., Halse, H. M., Nguyen, T. Q., Wang, M., Losio, N. V. K., Mitchell, C., Caramia, F., Byrne, D. J., Haupt, S., Ryland, G. L., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-000792 · Cited by 85

Tetrahedral Framework Nucleic Acid Promotes the Treatment of Bisphosphonate-Related Osteonecrosis of the Jaws by Promoting Angiogenesis and M2 Polarization

Zhao, D., Cui, W., Liu, M., Li, J., Sun, Y., Shi, S., Lin, S., & Lin, Y. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c13839 · Cited by 82

New Insights and Novel Therapeutic Potentials for Macrophages in Myocardial Infarction

Zhang, Z., Tang, J., Cui, X., Qin, B., Zhang, J., Zhang, H., Zhang, H., Liu, G., Wang, W., & Zhang, J. (2021) · Inflammation · doi:10.1007/s10753-021-01467-2 · Cited by 86

Macrophages in tumor: An inflammatory perspective

Goswami, K. K., Bose, A., & Baral, R. (2021) · Clinical Immunology · doi:10.1016/j.clim.2021.108875 · Cited by 88

Relationship between podoplanin-expressing cancer-associated fibroblasts and the immune microenvironment of early lung squamous cell carcinoma

Suzuki, J., Aokage, K., Neri, S., Sakai, T., Hashimoto, H., Su, Y., Yamazaki, S., Nakamura, H., Tane, K., Miyoshi, T., et al. (2020) · Lung Cancer · doi:10.1016/j.lungcan.2020.12.020 · Cited by 83

Sulforaphane Inhibits Lipopolysaccharide-Induced Inflammation, Cytotoxicity, Oxidative Stress, and miR-155 Expression and Switches to Mox Phenotype through Activating Extracellular Signal-Regulated Kinase 1/2–Nuclear Factor Erythroid 2-Related Factor 2/Antioxidant Response Element Pathway in Murine Microglial Cells

Eren, E., Tüfekçi, K. U., Isci, K. B., Tastan, B., Genç, K., & Genç, Ş. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00036 · Cited by 84

Expanded Regulatory T Cells Induce Alternatively Activated Monocytes With a Reduced Capacity to Expand T Helper-17 Cells

Romano, M., Fanelli, G., Tan, N., Nova‐Lamperti, E., McGregor, R., Lechler, R. I., Lombardi, G., & Scottà, C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01625 · Cited by 84

Chemical Modulation of in Vivo Macrophage Function with Subpopulation-Specific Fluorescent Prodrug Conjugates

Fernández, A., Vermeren, M., Humphries, D. C., Subirós‐Funosas, R., Barth, N. D., Campana, L., MacKinnon, A. C., Feng, Y., & Vendrell, M. (2017) · ACS Central Science · doi:10.1021/acscentsci.7b00262 · Cited by 81

Serum and Ectopic Endometrium from Women with Endometriosis Modulate Macrophage M1/M2 Polarization via the Smad2/Smad3 Pathway

Nie, M., Xie, Q., Wu, Y., He, H., Zou, L., She, X., & Wu, X. (2018) · Journal of Immunology Research · doi:10.1155/2018/6285813 · Cited by 81

Altered chemokine profile in Refractory Mycoplasma pneumoniae pneumonia infected children

Lee, Y., Chang, C., Lee, W., Liu, T., Tsai, C., Tsai, T.-A., Tsai, C.-K., Kuo, K.-C., Chen, C., Niu, C.-K., et al. (2020) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2020.03.030 · Cited by 81

Antioxidant and Anti-Inflammatory Compounds from Edible Plants with Anti-Cancer Activity and Their Potential Use as Drugs

Cuevas-Cianca, S. I., Romero-Castillo, C., Gálvez-Romero, J. L., Juárez, Z. N., & Hernández, L. R. (2023) · Molecules · doi:10.3390/molecules28031488 · Cited by 88

Macrophage Polarization: An Important Candidate Regulator for Lung Diseases

Deng, L., Jian, Z., Xu, T., Li, F., Deng, H., Zhou, Y., Lai, S., Xu, Z., & Zhu, L. (2023) · Molecules · doi:10.3390/molecules28052379 · Cited by 85

Transcriptional control of apoptotic cell clearance by macrophage nuclear receptors

Rőszer, T. (2016) · APOPTOSIS · doi:10.1007/s10495-016-1310-x · Cited by 80

Adipose tissue macrophages develop from bone marrow–independent progenitors in Xenopus laevis and mouse

Waqas, S. F. H., Noble, A. M., Hoang, A. C., Ampem, G., Popp, M., Strauß, S., Guille, M., & Rőszer, T. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.1a0317-082rr · Cited by 81

The macrophage marker translocator protein (TSPO) is down-regulated on pro-inflammatory ‘M1’ human macrophages

Narayan, N., Mandhair, H., Smyth, E., Dakin, S. G., Kiriakidis, S., Wells, L., Owen, D., Sabokbar, A., & Taylor, P. (2017) · PLOS ONE · doi:10.1371/journal.pone.0185767 · Cited by 79

Zoledronic acid exacerbates inflammation through M1 macrophage polarization

Kaneko, J., Okinaga, T., Hikiji, H., Ariyoshi, W., Yoshiga, D., Habu, M., Tominaga, K., & Nishihara, T. (2018) · Inflammation and Regeneration · doi:10.1186/s41232-018-0074-9 · Cited by 83

Immunohistochemical Identification of Human Skeletal Muscle Macrophages.

Kosmac, K., Peck, B. D., Walton, R. G., Mula, J., Kern, P., Bamman, M., Dennis, R., Jacobs, C., Lattermann, C., Johnson, D. L., et al. (2018) · Bio-protocol · doi:10.21769/bioprotoc.2883 · Cited by 63

Host Response to Biomaterials for Cartilage Tissue Engineering: Key to Remodeling

Fu, W. E., Liu, S., Chen, M., Tian, G., Zha, K., Yang, Z., Jiang, S., Li, M., Sui, X., Chen, Z., et al. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.664592 · Cited by 78

Microbial resistance to nanotechnologies: An important but understudied consideration using antimicrobial nanotechnologies in orthopaedic implants

Wu, Z., Chan, B., Low, J., Chu, J. J. H., Hey, H. W. D., & Tay, A. K. P. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.02.014 · Cited by 79

Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics for knee osteoarthritis

Figueroa‐Valdés, A. I., Luz‐Crawford, P., Herrera-Luna, Y., Georges, N., García, C., Tobar, H. E., Araya, M. J., Matas, J., Meneses, D. D., de la Fuente, C., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-03088-x · Cited by 84

Activation of myeloid and endothelial cells by CD40L gene therapy supports T-cell expansion and migration into the tumor microenvironment

Eriksson, E., Moreno, R., Milenova, I. E., Liljenfeldt, L., Dieterich, L. C., Christiansson, L. H., Karlsson, H., Ullenhag, G. J., Mangsbo, S. M., Dimberg, A., et al. (2016) · Gene Therapy · doi:10.1038/gt.2016.80 · Cited by 79

Melittin suppresses tumor progression by regulating tumor-associated macrophages in a Lewis lung carcinoma mouse model

Lee, C., Bae, S.-J. S., Joo, H., & Bae, H. (2017) · Oncotarget · doi:10.18632/oncotarget.18627 · Cited by 79

The biology of serous cavity macrophages

Bain, C. C., & Jenkins, S. J. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.01.003 · Cited by 78

Characterization of M1 and M2 polarization phenotypes in peritoneal macrophages after treatment with graphene oxide nanosheets

Rojo, J. M., Diez‐Orejas, R., Cicuéndez, M., Casarrubios, L., Rojo, J. M., & Portolés, M. T. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.12.063 · Cited by 84

Macrophage Immunometabolism and Inflammaging: Roles of Mitochondrial Dysfunction, Cellular Senescence, CD38, and NAD

Yarbro, J. R., Emmons, R. S., & Pence, B. D. (2020) · Immunometabolism · doi:10.20900/immunometab20200026 · Cited by 83

Macrophage efferocytosis in health and disease

Razi, S., Khojini, J. Y., Kargarijam, F., Panahi, S., Tahershamsi, Z., Tajbakhsh, A., & Hayat, S. M. G. (2023) · Cell Biochemistry and Function · doi:10.1002/cbf.3780 · Cited by 84

Macrophage polarization: an effective approach to targeted therapy of inflammatory bowel disease

Du, Y., Rong, L., Cong, Y., Shen, L., Zhang, N., & Wang, B. (2021) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.1901079 · Cited by 81

Mesenchymal stem cells enhance NOX2-dependent reactive oxygen species production and bacterial killing in macrophages during sepsis

Rabani, R., Volchuk, A., Jerkić, M., Ormesher, L., Garcés‐Ramírez, L., Canton, J., Masterson, C. H., Gagnon, S., Tatham, K. C., Marshall, J. C., et al. (2018) · European Respiratory Journal · doi:10.1183/13993003.02021-2017 · Cited by 77

Pharmacological targets of metabolism in disease: Opportunities from macrophages

Castegna, A., Gissi, R., Menga, A., Montopoli, M., Favia, M., Viola, A., & Canton, M. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107521 · Cited by 75

The Role of Tissue-Resident Macrophages in the Development and Treatment of Inflammatory Bowel Disease

Ma, S., Zhang, J., Liu, H., Li, S., & Wang, Q. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.896591 · Cited by 81

Materials Strategies to Overcome the Foreign Body Response

Zhou, X., Wang, Y., Ji, J., & Zhang, P. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202304478 · Cited by 80

The deleterious interplay between tumor epithelia and stroma in cholangiocarcinoma

Cadamuro, M., Stecca, T., Brivio, S., Mariotti, V., Fiorotto, R., Spirlı̀, C., Strazzabosco, M., & Fabris, L. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.07.028 · Cited by 76

Anti-inflammatory effect for atherosclerosis progression by sodium-glucose cotransporter 2 (SGLT-2) inhibitor in a normoglycemic rabbit model

Lee, S.-G., Lee, S.-J., Lee, J.-J., Kim, J.-S., Lee, O.-H., Kim, C.-K., Kim, D., Lee, Y.-H., Oh, J., Park, S., et al. (2020) · Korean Circulation Journal · doi:10.4070/kcj.2019.0296 · Cited by 75

Macrophage polarization and activation at the interface of multi-walled carbon nanotube-induced pulmonary inflammation and fibrosis

Dong, J., & Ma, Q. (2018) · Nanotoxicology · doi:10.1080/17435390.2018.1425501 · Cited by 75

Galectin-9 modulates immunity by promoting Th2/M2 differentiation and impacts survival in patients with metastatic melanoma

Enninga, E. A. L., Nevala, W. K., Holtan, S. G., Leontovich, A. A., & Markovic, S. N. (2016) · Melanoma Research · doi:10.1097/cmr.0000000000000281 · Cited by 77

Evidence for M2 macrophages in granulomas from pulmonary sarcoidosis: A new aspect of macrophage heterogeneity

Shamaei, M., Mortaz, E., Pourabdollah, M., Garssen, J., Tabarsi, P., Velayati, A. A., & Adcock, I. M. (2017) · Human Immunology · doi:10.1016/j.humimm.2017.10.009 · Cited by 75

Antibody Therapy Targeting CD47 and CD271 Effectively Suppresses Melanoma Metastasis in Patient-Derived Xenografts

Ngo, M., Han, A., Lakatos, A., Sahoo, D., Hachey, S. J., Weiskopf, K., Beck, A. H., Weissman, I. L., & Boiko, A. D. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.07.004 · Cited by 75

Dioscin elicits anti‐tumour immunity by inhibiting macrophage M2 polarization via JNK and STAT3 pathways in lung cancer

Cui, L., Yang, G., Ye, J., Yao, Y., Lu, G., Chen, J., Fang, L., Lu, S., & Zhou, J. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15563 · Cited by 74

Reactive oxygen species / photothermal therapy dual-triggered biomimetic gold nanocages nanoplatform for combination cancer therapy via ferroptosis and tumor-associated macrophage repolarization mechanism

Wei, Y., Wang, Z., Yang, J., Xu, R. F., Deng, H., Ma, S., Fang, T., Zhang, J., & Shen, Q. (2021) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2021.09.160 · Cited by 77

Inflammation: a matter of immune cell life and death

Bender, E. C., Tareq, H. S., & Suggs, L. J. (2025) · npj Biomedical Innovations. · doi:10.1038/s44385-025-00010-4 · Cited by 80

Extracellular Matrix Protein Tenascin C Increases Phagocytosis Mediated by CD47 Loss of Function in Glioblastoma

Ma, D., Liu, S., Lal, B., Wei, S., Wang, S., Zhan, D., Zhang, H., Lee, R. S., Gao, P., López-Bertoni, H., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3125 · Cited by 73

The inflammatory role of phagocyte apoptotic pathways in rheumatic diseases

Cuda, C. M., Pope, R. M., & Perlman, H. (2016) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.132 · Cited by 78

Multiplex immunoassay characterization and species comparison of inflammation in acute and non-acute ischemic infarcts in human and mouse brain tissue

Nguyen, T. V., Frye, J. B., Zbesko, J. C., Stepanović, K., Hayes, M. I., Urzua, A., Serrano, G. E., Beach, T. G., & Doyle, K. P. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0371-y · Cited by 73

Immunomodulation and Mobilization of Progenitor Cells by Extracellular Matrix Bioscaffolds for Volumetric Muscle Loss Treatment

Dziki, J. L., Sicari, B. M., Wolf, M. T., Cramer, M. C., & Badylak, S. F. (2016) · Tissue Engineering Part A · doi:10.1089/ten.tea.2016.0340 · Cited by 72

ASGR1 and its enigmatic relative, CLEC10A

Hoober, J. K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144818 · Cited by 74

Obesity/Type II diabetes alters macrophage polarization resulting in a fibrotic tendon healing response

Ackerman, J. E., Geary, M. B., Orner, C. A., Bawany, F., & Loiselle, A. E. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181127 · Cited by 72

Regulation of Macrophage and Dendritic Cell Function by Chondroitin Sulfate in Innate to Antigen-Specific Adaptive Immunity

Hatano, S., & Watanabe, H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00232 · Cited by 72

Human Intestinal Mononuclear Phagocytes in Health and Inflammatory Bowel Disease

Caër, C., & Wick, M. J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00410 · Cited by 76

Dendrimer size effects on the selective brain tumor targeting in orthotopic tumor models upon systemic administration

Liaw, K., Zhang, F., Mangraviti, A., Kannan, S., Tyler, B., & Kannan, R. M. (2020) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10160 · Cited by 69

Tumor-Associated Macrophages as Major Immunosuppressive Cells in the Tumor Microenvironment

Ghebremedhin, A., Athavale, D., Zhang, Y.-T. Y., Yao, X., Balch, C., & Song, S. (2024) · Cancers · doi:10.3390/cancers16193410 · Cited by 79

Cancer‐associated fibroblasts in nonsmall cell lung cancer: From molecular mechanisms to clinical implications

Wong, K. Y., Cheung, A. H. K., Chen, B., Chan, W. N., Yu, J. Q., Lo, K. W., Kang, W., & To, K. F. (2022) · International Journal of Cancer · doi:10.1002/ijc.34127 · Cited by 78

Evolutionary Aspects of Macrophages Polarization

Edholm, E., Rhoo, K. H., & Robert, J. (2017) · Results and problems in cell differentiation · doi:10.1007/978-3-319-54090-0_1 · Cited by 70

Reducing inflammation through delivery of lentivirus encoding for anti-inflammatory cytokines attenuates neuropathic pain after spinal cord injury

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Gao, Y., Wang, Z., Öğülür, İ., Li, S., Yazıcı, D., Li, X., Pat, Y., Zheng, Y., Babayev, H., Zeyneloglu, C., et al. (2025) · Allergy · doi:10.1111/all.16620 · Cited by 76

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