Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms

The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function

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Macrophage plasticity and polarization: in vivo veritas

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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

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A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

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What we talk about when we talk about fat

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Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

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The cellular and signaling networks linking the immune system and metabolism in disease

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Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

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Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer

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Biological Effects of Nanoparticles on Macrophage Polarization in the Tumor Microenvironment

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Metabolic influence on macrophage polarization and pathogenesis

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Understanding the Role of the Gut Microbiome in Brain Development and Its Association With Neurodevelopmental Psychiatric Disorders

Dash, S., Syed, Y. A., & Khan, M. R. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.880544 · Cited by 193

Reduced oxidative capacity in macrophages results in systemic insulin resistance

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Human mesenchymal stromal cell-secreted lactate induces M2-macrophage differentiation by metabolic reprogramming

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Cystic Fibrosis Lung Immunity: The Role of the Macrophage

Bruscia, E. M., & Bonfield, T. L. (2016) · Journal of Innate Immunity · doi:10.1159/000446825 · Cited by 168

Macrophages in pancreatitis: Mechanisms and therapeutic potential

Hu, F., Lou, N., Jiao, J., Guo, F., Xiang, H., & Shang, D. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110693 · Cited by 163

Role of metabolic reprogramming in pro-inflammatory cytokine secretion from LPS or silica-activated macrophages

Marrocco, A., & Ortiz, L. A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.936167 · Cited by 173

Aged marrow macrophages expand platelet-biased hematopoietic stem cells via interleukin-1B

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Macrophages and Bone Remodeling

Weivoda, M. M., & Bradley, E. W. (2023) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4773 · Cited by 166

Airway macrophages as the guardians of tissue repair in the lung

Puttur, F. K., Gregory, L. G., & Lloyd, C. M. (2019) · Immunology and Cell Biology · doi:10.1111/imcb.12235 · Cited by 167

Intracranial Aneurysms: Pathology, Genetics, and Molecular Mechanisms

Xu, Z., Rui, Y., Hagan, J. P., & Kim, D. (2019) · NeuroMolecular Medicine · doi:10.1007/s12017-019-08537-7 · Cited by 155

The Role of Metabolic Remodeling in Macrophage Polarization and Its Effect on Skeletal Muscle Regeneration

Santa, F. D., Vitiello, L., Torcinaro, A., & Ferraro, E. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7420 · Cited by 157

Activation of immunosuppressive network in the aging process

Salminen, A. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100998 · Cited by 155

Targeting macrophage immunometabolism: Dawn in the darkness of sepsis

Kumar, V. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.03.005 · Cited by 150

Microglial priming of antigen presentation and adaptive stimulation in Alzheimer’s disease

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Activated Mesenchymal Stem Cells Interact with Antibiotics and Host Innate Immune Responses to Control Chronic Bacterial Infections

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Extracellular Vesicles from Amnion-Derived Mesenchymal Stem Cells Ameliorate Hepatic Inflammation and Fibrosis in Rats

Ohara, M., Ohnishi, S., Hosono, H., Yamamoto, K., Yuyama, K., Nakamura, H., Fu, Q., Maehara, O., Suda, G., & Sakamoto, N. (2018) · Stem Cells International · doi:10.1155/2018/3212643 · Cited by 150

Inflammation and biomaterials: role of the immune response in bone regeneration by inorganic scaffolds

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Preparation and Use of Decellularized Extracellular Matrix for Tissue Engineering

McInnes, A. D., Moser, M., & Chen, D. (2022) · Journal of Functional Biomaterials · doi:10.3390/jfb13040240 · Cited by 146

Gelatin-based Hydrogel Degradation and Tissue Interaction in vivo : Insights from Multimodal Preclinical Imaging in Immunocompetent Nude Mice

Tondera, C., Hauser, S., Krüger‐Genge, A., Jung, F., Neffe, A. T., Lendlein, A., Klopfleisch, R., Steinbach, J., Neuber, C., & Pietzsch, J. (2016) · Theranostics · doi:10.7150/thno.16614 · Cited by 142

Macrophages with regulatory functions, a possible new therapeutic perspective in autoimmune diseases

Benedetto, P. D., Ruscitti, P., Vadasz, Z., Toubi, E., & Giacomelli, R. (2019) · Autoimmunity Reviews · doi:10.1016/j.autrev.2019.102369 · Cited by 140

Macrophage membrane coated nanoparticles: a biomimetic approach for enhanced and targeted delivery

Khatoon, N., Zhang, Z., Zhou, C., & Chu, M. (2022) · Biomaterials Science · doi:10.1039/d1bm01664d · Cited by 144

A neuropeptide, Substance-P, directly induces tissue-repairing M2 like macrophages by activating the PI3K/Akt/mTOR pathway even in the presence of IFNγ

Lim, J. E., Chung, E., & Son, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-09639-7 · Cited by 136

Cell Surface CD36 Protein in Monocyte/Macrophage Contributes to Phagocytosis during the Resolution Phase of Ischemic Stroke in Mice

Woo, M., Yang, J., Beltran, C., & Cho, S. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.750018 · Cited by 136

Mesenchymal Stem and Stromal Cells Harness Macrophage-Derived Amphiregulin to Maintain Tissue Homeostasis

Ko, J. H., Kim, H. J., Jeong, H. J., Lee, H. J., & Oh, J. Y. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.02.062 · Cited by 132

Adipose tissue macrophage in obesity-associated metabolic diseases

Yao, J., Wu, D., & Qiu, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.977485 · Cited by 151

Adoptive transfer of M2 macrophages reduces neuropathic pain via opioid peptides

Pannell, M., Łabuz, D., Celik, M. Ö., Keye, J., Batra, A., Siegmund, B., & Machelska, H. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0735-z · Cited by 137

Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype

Pinto, S., Cunha, C., Barbosa, M., Vaz, A. R., & Brites, D. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00273 · Cited by 135

CD5L Promotes M2 Macrophage Polarization through Autophagy-Mediated Upregulation of ID3

Sanjurjo, L., Aran, G., Téllez, É., Amézaga, N., Armengol, C., López, D., Prats, C., & Sarrias, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00480 · Cited by 134

Prognostic Significance of Tumor-Associated Macrophage Content in Head and Neck Squamous Cell Carcinoma: A Meta-Analysis

Kumar, A., Knops, A. M., Swendseid, B. P., Martinez-Outschoom, U., Harshyne, L. A., Philp, N. J., Rodeck, U., Luginbuhl, A., Cognetti, D. M., Johnson, J. M., et al. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00656 · Cited by 140

Peripheral Administration of IL-13 Induces Anti-inflammatory Microglial/Macrophage Responses and Provides Neuroprotection in Ischemic Stroke

Kołosowska, N., Keuters, M. H., Wojciechowski, S., Keksa-Goldsteine, V., Laine, M. T., Malm, T., Goldsteins, G., Koıstınaho, J., & Dhungana, H. (2019) · Neurotherapeutics · doi:10.1007/s13311-019-00761-0 · Cited by 133

Bromodomain inhibitors, JQ1 and I-BET 762, as potential therapies for pancreatic cancer

Leal, A. S., Williams, C. R., Royce, D. B., Pioli, P. A., Sporn, M. B., & Liby, K. T. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.02.021 · Cited by 135

Metabolic programming of macrophage functions and pathogens control

Koo, S.-J., & Garg, N. J. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101198 · Cited by 135

Pancreatic cancer is marked by complement-high blood monocytes and tumor-associated macrophages

Kemp, S. B., Steele, N. G., Carpenter, E. S., Donahue, K. L., Bushnell, G. G., Morris, A. H., The, S., Orbach, S. M., Sirihorachai, V. R., Nwosu, Z. C., et al. (2021) · Life Science Alliance · doi:10.26508/lsa.202000935 · Cited by 129

Strontium Functionalized in Biomaterials for Bone Tissue Engineering: A Prominent Role in Osteoimmunomodulation

You, J., Zhang, Y., & Zhou, Y. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.928799 · Cited by 137

Biomimetic Tissue Engineering: Tuning the Immune and Inflammatory Response to Implantable Biomaterials

Taraballi, F., Sushnitha, M., Tsao, C., Bauza, G., Liverani, C., Shi, A., & Tasciotti, E. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800490 · Cited by 128

The Role of Immune Cells in Post-Stroke Angiogenesis and Neuronal Remodeling: The Known and the Unknown

Ma, Y., Yang, S., He, Q., Zhang, D., & Chang, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.784098 · Cited by 131

Gefitinib inhibits M2-like polarization of tumor-associated macrophages in Lewis lung cancer by targeting the STAT6 signaling pathway

Tariq, M., Zhang, J., Liang, G., He, Q., Ding, L., & Yang, B. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.124 · Cited by 127

Current and future biomarkers in allergic asthma

Zissler, U. M., Bieren, J. E., Jakwerth, C. A., Chaker, A. M., & Schmidt‐Weber, C. B. (2015) · Allergy · doi:10.1111/all.12828 · Cited by 126

Communications Between Bone Marrow Macrophages and Bone Cells in Bone Remodeling

Chen, K., Jiao, Y., Liu, L., Huang, M., He, C., He, W., Hou, J., Yang, M., Luo, X., & Li, C. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.598263 · Cited by 125

TLR2 stimulation impairs anti-inflammatory activity of M2-like macrophages, generating a chimeric M1/M2 phenotype

Quero, L., Hanser, E., Manigold, T., Tiaden, A. N., & Kyburz, D. (2017) · Arthritis Research & Therapy · doi:10.1186/s13075-017-1447-1 · Cited by 123

Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages

Yu, H., Dilbaz, S., Coßmann, J., Hoang, A. C., Diedrich, V., Herwig, A., Harauma, A., Hoshi, Y., Moriguchi, T., Landgraf, K., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci125646 · Cited by 128

Advanced Strategies for Modulation of the Material–Macrophage Interface

Huyer, L. D., Pascual‐Gil, S., Wang, Y., Mandla, S., Yee, B., & Radisic, M. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201909331 · Cited by 123

Macrophage-targeted nanomedicine for chronic diseases immunotherapy

Song, Y., Huang, Y., Zhou, F., Ding, J., & Zhou, W. (2021) · Chinese Chemical Letters · doi:10.1016/j.cclet.2021.08.090 · Cited by 128

The role of macrophages during acute kidney injury: destruction and repair

Han, H. I., Skvarca, L. B., Espiritu, E. B., Davidson, A. J., & Hukriede, N. A. (2018) · Pediatric Nephrology · doi:10.1007/s00467-017-3883-1 · Cited by 124

Autocrine VEGF signalling on M2 macrophages regulates PD ‐L1 expression for immunomodulation of T cells

Lai, Y., Wahyuningtyas, R., Aui, S., & Chang, K. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14027 · Cited by 131

Human Placental Hofbauer Cells Maintain an Anti-inflammatory M2 Phenotype despite the Presence of Gestational Diabetes Mellitus

Schliefsteiner, C., Peinhaupt, M., Kopp, S., Loegl, J., Lang, I., Hiden, U., Heinemann, Á., Desoyé, G., & Wadsack, C. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00888 · Cited by 120

M1 and M2 polarization of macrophages: a mini-review

Lee, K. Y. (2019) · Medical Biological Science and Engineering · doi:10.30579/mbse.2019.2.1.1 · Cited by 130

Key Aging-Associated Alterations in Primary Microglia Response to Beta-Amyloid Stimulation

Caldeira, C., Cunha, C., Vaz, A. R., Falcão, A. S., Barateiro, A., Seixas, E., Fernandes, A., & Brites, D. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00277 · Cited by 117

Transplantation of mesenchymal stem cells genetically engineered to overexpress interleukin-10 promotes alternative inflammatory response in rat model of traumatic brain injury

Peruzzaro, S., Andrews, M., Gharaibeh, A., Pupiec, O., Resk, M., Story, D. T., Maiti, P., Rossignol, J., & Dunbar, G. L. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1383-2 · Cited by 119

Matrix stiffness and tumor-associated macrophages modulate epithelial to mesenchymal transition of human adenocarcinoma cells

Alonso‐Nocelo, M., Raimondo, T. M., Vining, K. H., López‐López, R., de la Fuente, M., & Mooney, D. J. (2018) · Biofabrication · doi:10.1088/1758-5090/aaafbc · Cited by 120

Cx3CR1 Expression Identifies Distinct Macrophage Populations That Contribute Differentially to Inflammation and Repair

Burgess, M. O., Wicks, K., Gardasevic, M., & Mace, K. A. (2019) · ImmunoHorizons · doi:10.4049/immunohorizons.1900038 · Cited by 119

Targeting tumor‑associated macrophages in the tumor microenvironment (Review)

Zhou, K., Cheng, T., Zhan, J., Peng, X., Zhang, Y., Wen, J., Chen, X., & Ying, M. (2020) · Oncology Letters · doi:10.3892/ol.2020.12097 · Cited by 122

Interleukin-34-NF-κB Signaling Aggravates Myocardial Ischemic/Reperfusion Injury by Facilitating Macrophage Recruitment and Polarization

Zhuang, L., Zong, X., Yang, Q., Fan, Q., & Tao, R. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2023.104744 · Cited by 114

Influenza virus replication in macrophages: balancing protection and pathogenesis

Cline, T. D., Beck, D., & Bianchini, E. A. (2017) · Journal of General Virology · doi:10.1099/jgv.0.000922 · Cited by 115

Direct electrical stimulation enhances osteogenesis by inducing Bmp2 and Spp1 expressions from macrophages and preosteoblasts

Srirussamee, K., Mobini, S., Cassidy, N. J., & Cartmell, S. H. (2019) · Biotechnology and Bioengineering · doi:10.1002/bit.27142 · Cited by 112

An Emerging Target in the Battle against Osteoarthritis: Macrophage Polarization

Sun, Y., Zuo, Z., & Kuang, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228513 · Cited by 109

Effect of Platelet-Rich Plasma on M1/M2 Macrophage Polarization

Uchiyama, R., Toyoda, E., Maehara, M., Wasai, S., Omura, H., Watanabe, M., & Sato, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052336 · Cited by 115

The Role of Innate and Adaptive Immune Cells in Skeletal Muscle Regeneration

Ziemkiewicz, N., Hilliard, G. M., Pullen, N., & Garg, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063265 · Cited by 124

FGFR4 regulates tumor subtype differentiation in luminal breast cancer and metastatic disease

García‐Recio, S., Thennavan, A., East, M. P., Parker, J. S., Cejalvo, J. M., Garay, J. P., Hollern, D. P., He, X., Mott, K. R., Galván, P., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci130323 · Cited by 109

Macrophage-specific nanotechnology driven CD163 overexpression in human macrophages results in an M2 phenotype under inflammatory conditions

Alvarado-Vázquez, P. A., Bernal, L., Paige, C., Grosick, R., Vilrriales, C. M., Ferreira, D. W., Ulecia-Morón, C., & Romero-Sandoval, E. (2017) · Immunobiology · doi:10.1016/j.imbio.2017.05.011 · Cited by 92

Periosteum tissue engineering in an orthotopic in vivo platform

Baldwin, J., Wagner, F., Martine, L. C., Holzapfel, B. M., Theodoropoulos, C., Bas, O., Savi, F. M., Werner, C., De‐Juan‐Pardo, E. M., & Hutmacher, D. W. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.11.016 · Cited by 105

Understanding the Biology of Self-Renewing Macrophages

Rőszer, T. (2018) · Cells · doi:10.3390/cells7080103 · Cited by 115

Early Growth Response Gene-2 Is Essential for M1 and M2 Macrophage Activation and Plasticity by Modulation of the Transcription Factor CEBPβ

Veremeyko, T., Yung, A. W. Y., Anthony, D. C., Strekalova, T. V., & Ponomarev, E. D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02515 · Cited by 107

Macrophage Polarization and Plasticity in Systemic Lupus Erythematosus

Ahamada, M. M., Jia, Y., & Wu, X. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.734008 · Cited by 108

USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy

Wang, Y.-C., Wu, Y.-S., Hung, C.-Y., Wang, S., Young, M.-J., Hsu, T., & Hung, J. (2018) · Nature Communications · doi:10.1038/s41467-018-06178-1 · Cited by 107

Transcriptional profiling identifies novel regulators of macrophage polarization

Gerrick, K. Y., Gerrick, E. R., Gupta, A. K., Wheelan, S. J., Yegnasubramanian, S., & Jaffee, E. M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0208602 · Cited by 105

microRNA-328 in exosomes derived from M2 macrophages exerts a promotive effect on the progression of pulmonary fibrosis via FAM13A in a rat model

Yao, M., Zhang, W., Ma, W., Liu, Q., Xing, L., & Zhao, G.-F. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0255-x · Cited by 107

Inflammatory resolution and vascular barrier restoration after retinal ischemia reperfusion injury

Abcouwer, S. F., Shanmugam, S., Muthusamy, A., Lin, C., Kong, D., Hager, H. M., Liu, X., & Antonetti, D. A. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02237-5 · Cited by 108

Macrophage regulation of angiogenesis in health and disease

Martin, P. B., & Gurevich, D. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.06.010 · Cited by 114

Senescent cells and macrophages: key players for regeneration?

Elder, S. S., & Emmerson, E. (2020) · Open Biology · doi:10.1098/rsob.200309 · Cited by 114

Resolvin E1 attenuates atherosclerosis in absence of cholesterol-lowering effects and on top of atorvastatin

Salic, K., Morrison, M. C., Verschuren, L., Wielinga, P. Y., Wu, L., Kleemann, R., Gjorstrup, P., & Kooistra, T. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.05.001 · Cited by 105

Hypoxia modifies the polarization of macrophages and their inflammatory microenvironment, and inhibits malignant behavior in cancer cells

Ke, X., Chen, C., Song, Y., Cai, Q., Li, J., Tang, Y., Han, X., Qu, W., Chen, A., Wang, H., et al. (2019) · Oncology Letters · doi:10.3892/ol.2019.10956 · Cited by 105

Limitations and opportunities for immune checkpoint inhibitors in pediatric malignancies

Park, J. A., & Cheung, N. V. (2017) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2017.05.006 · Cited by 105

Effect of stimulation time on the expression of human macrophage polarization markers

Purcu, D. U., Korkmaz, A., Günalp, S., Helvaci, D. G., Erdal, Y., Doğan, Y., Süner, A., Wingender, G., & Sağ, D. (2022) · PLoS ONE · doi:10.1371/journal.pone.0265196 · Cited by 119

Dual Tumor Microenvironment Remodeling by Glucose‐Contained Radical Copolymer for MRI‐Guided Photoimmunotherapy

Cheng, H., Fan, X., Ye, E., Chen, H., Yang, J., Ke, L., You, M., Liu, M., Zhang, Y., Wu, Y., et al. (2021) · Advanced Materials · doi:10.1002/adma.202107674 · Cited by 102

Advances in the Regulation of Macrophage Polarization by Mesenchymal Stem Cells and Implications for ALI/ARDS Treatment

Liu, C., Xiao, K., & Xie, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.928134 · Cited by 111

Mechano-Immunomodulation: Mechanoresponsive Changes in Macrophage Activity and Polarization

Adams, S., Wuescher, L. M., Worth, R., & Yildirim-Ayan, E. (2019) · Annals of Biomedical Engineering · doi:10.1007/s10439-019-02302-4 · Cited by 96

The role of PD-1/PD-L1 axis and macrophage in the progression and treatment of cancer

Cai, J., Qi, Q., Qian, X., Han, J. G., Zhu, X., Zhang, Q., & Xia, R. (2019) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-019-02879-2 · Cited by 103

Hofbauer cells of M2a, M2b and M2c polarization may regulate feto-placental angiogenesis

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Pro-inflammatory Aorta-Associated Macrophages Are Involved in Embryonic Development of Hematopoietic Stem Cells

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