Cited by 1,762Immune cells in cancerPhagocytosis and Immune RegulationCardiac Fibrosis and Remodeling

The DOI matches its Crossref record; 209 of the 209 references it cites were found in a registry or an index.

Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms

Open access

Rőszer, Tamás·2015·Mediators of Inflammation

DOI 10.1155/2015/816460PMC PMC4452191

Open this paper in CoChat — free account Open PDF

Abstract

The alternatively activated or M2 macrophages are immune cells with high phenotypic heterogeneity and are governing functions at the interface of immunity, tissue homeostasis, metabolism, and endocrine signaling. Today the M2 macrophages are identified based on the expression pattern of a set of M2 markers. These markers are transmembrane glycoproteins, scavenger receptors, enzymes, growth factors, hormones, cytokines, and cytokine receptors with diverse and often yet unexplored functions. This review discusses whether these M2 markers can be reliably used to identify M2 macrophages and define their functional subdivisions. Also, it provides an update on the novel signals of the tissue environment and the neuroendocrine system which shape the M2 activation. The possible evolutionary roots of the M2 macrophage functions are also discussed.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1155/2015/816460

Cites

209 of 209 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function
Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481
Macrophage activation and polarization: nomenclature and experimental guidelines
Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337
Macrophage plasticity and polarization: in vivo veritas
Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335
Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528
The M1 and M2 paradigm of macrophage activation: Time for reassessment
Martinez, F. O., & Gordon, S. (2014) · F1000Prime Reports · doi:10.12703/p6-13 · Cited by 4,689
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578
What we talk about when we talk about fat
Rosen, E. D., & Spiegelman, B. M. (2014) · Cell · doi:10.1016/j.cell.2013.12.012 · Cited by 2,373
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
Gomez Perdiguero, E., Klapproth, K., Schulz, C., Busch, K., Azzoni, E., Crozet, L., Garner, H., Trouillet, C., de Bruijn, M. F., Geissmann, F., et al. (2015) · Nature · doi:10.1038/nature13989 · Cited by 2,339 · cited 1×
“However, it is shown that the resident tissue macrophages have heterogeneous progeny [187, 188].”
Background
The cellular and signaling networks linking the immune system and metabolism in disease
Osborn, O., & Olefsky, J. M. (2012) · Nature Medicine · doi:10.1038/nm.2627 · Cited by 1,551
Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation
Epelman, S., Lavine, K. J., Beaudin, A. E., Sojka, D. K., Carrero, J. A., Calderon, B., Brija, T., Gautier, E. L., Ivanov, S., Satpathy, A. T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.11.019 · Cited by 1,494

Flagged first, then by citations

Show all 209 references

Research works printed but not linked: 1

10.1189/jlb.4AB0813-434R · DOI

Sorted by citations

Items 301–400 of 1,002

Tendon Immune Regeneration: Insights on the Synergetic Role of Stem and Immune Cells during Tendon Regeneration
Russo, V., Khatib, M. E., Prencipe, G., Citeroni, M. R., Faydaver, M., Mauro, A., Berardinelli, P., Cerveró-Varona, A., Haidar-Montes, A. A., Turriani, M., et al. (2022) · Cells · doi:10.3390/cells11030434 · Cited by 73
Engineered polysaccharides for controlling innate and adaptive immune responses
Nam, J., Kim, A., Kim, K. H., Moon, J. H., Baig, J., Phoo, M. T., Moon, J. J., & Son, S. (2024) · Nature Reviews Bioengineering · doi:10.1038/s44222-024-00193-2 · Cited by 76
Effect of Cocoa Polyphenolic Extract on Macrophage Polarization from Proinflammatory M1 to Anti‐Inflammatory M2 State
Dugo, L., Belluomo, M. G., Fanali, C., Russo, M., Cacciola, F., Maccarrone, M., & Sardanelli, A. M. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/6293740 · Cited by 67
TGF-β1 Suppresses the Type I IFN Response and Induces Mitochondrial Dysfunction in Alveolar Macrophages
Grunwell, J. R., Yeligar, S. M., Stephenson, S. T., Ping, X. D., Gauthier, T. W., Fitzpatrick, A. M., & Brown, L. A. S. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701325 · Cited by 66
Single-Cell Profiling Reveals Divergent, Globally Patterned Immune Responses in Murine Skin Inflammation
Liu, Y., Cook, C. P., Sedgewick, A. J., Zhang, S., Fassett, M. S., Ricardo-González, R. R., Harirchian, P., Kashem, S. W., Hanakawa, S., Leistico, J. R., et al. (2020) · iScience · doi:10.1016/j.isci.2020.101582 · Cited by 61
Inflammation-Related Changes in Mood Disorders and the Immunomodulatory Role of Lithium
Sakrajda, K., & Szczepankiewicz, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041532 · Cited by 65
Functionalized Nanoparticles Targeting Tumor-Associated Macrophages as Cancer Therapy
He, Y., Júnior, R. F. D. A., Cruz, L. J., & Eich, C. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13101670 · Cited by 65
Staphylococcus aureus biofilm elicits the expansion, activation and polarization of myeloid-derived suppressor cells in vivo and in vitro
Peng, K., Hsieh, C., Huang, T., Chen, P., Shih, H., Lee, M. S.-S., & Chang, P. (2017) · PLoS ONE · doi:10.1371/journal.pone.0183271 · Cited by 65
NETosis: an emerging therapeutic target in renal diseases
Juha, M., Molnár, A., Jakus, Z., & Ledó, N. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1253667 · Cited by 67
Mesenchymal Stromal Cell-Derived Microvesicles Regulate an Internal Pro-Inflammatory Program in Activated Macrophages
Agudelo, J. S. H., Braga, T. T., Amano, M. T., Cenedeze, M. A., Cavinato, R. A., dos Santos, A. R. P., Muscará, M. N., Teixeira, S. A., Cruz, M. C., Castoldi, Â., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00881 · Cited by 63
Focus on Early Events: Pathogenesis of Pulmonary Arterial Hypertension Development
Rafikova, O., Ghouleh, I. A., & Rafikov, R. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7673 · Cited by 66
RAGE acts as an oncogenic role and promotes the metastasis of human lung cancer
Chen, M., Chen, K., Chang, G., Lin, H., Wu, C., Kao, W.-H., Teng, C. J., Hsu, S., & Yang, T. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2432-1 · Cited by 66
Macrophage Cytokines Enhance Cell Proliferation of Normal Prostate Epithelial Cells through Activation of ERK and Akt
Dang, T., & Liou, G. (2018) · Scientific Reports · doi:10.1038/s41598-018-26143-8 · Cited by 63
The spectrum of macrophage activation by immunometabolism
Kang, S., & Kumanogoh, A. (2020) · International Immunology · doi:10.1093/intimm/dxaa017 · Cited by 64
Fibrotic Scar in CNS Injuries: From the Cellular Origins of Fibroblasts to the Molecular Processes of Fibrotic Scar Formation
Ayazi, M., Zivkovic, S., Hammel, G., Stefanovic, B., & Ren, Y. (2022) · Cells · doi:10.3390/cells11152371 · Cited by 67
Inflammatory Macrophage Interleukin-1β Mediates High-Fat Diet-Induced Heart Failure With Preserved Ejection Fraction
Liu, H., Huang, Y., Zhao, Y., Kang, G.-J., Feng, F., Wang, X., Liu, M., Shi, G., Revelo, X. S., Bernlohr, D., et al. (2022) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2022.08.003 · Cited by 62
The markers to delineate different phenotypes of macrophages related to metabolic disorders
Wei, Q., Deng, Y., Yang, Q., Zhan, A., & Wang, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1084636 · Cited by 66
Stromal fibroblasts present in breast carcinomas promote tumor growth and angiogenesis through adrenomedullin secretion
Benyahia, Z., Dussault, N., Cayol, M., Sigaud, R., Berenguer‐Daizé, C., Delfino, C., Tounsi, A., Garcia, S., Martin, P., Mabrouk, K., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.14999 · Cited by 68
Macrophage-Derived Protein S Facilitates Apoptotic Polymorphonuclear Cell Clearance by Resolution Phase Macrophages and Supports Their Reprogramming
Lumbroso, D., Soboh, S., Maimon, A., Schif‐Zuck, S., Ariel, A., & Burstyn‐Cohen, T. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00358 · Cited by 65
CTHRC1 promotes wound repair by increasing M2 macrophages via regulating the TGF-β and notch pathways
Qin, S., Zheng, J., Xia, Z., Qian, J., Deng, C.-L., & Yang, S. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.01.055 · Cited by 59
Erythropoietin promotes M2 macrophage phagocytosis of Schwann cells in peripheral nerve injury
Govindappa, P. K., & Elfar, J. C. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04671-6 · Cited by 62
Effect of glial cells on remyelination after spinal cord injury
Liu, B., Wang, Y.-Y., Wang, H., Liu, X.-K., Li, R., Zhang, P., Chu, Z., Wang, C., Liu, H.-R., Qi, J., et al. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.217354 · Cited by 63
Tumor-associated macrophages and crown-like structures in adipose tissue in breast cancer
Cha, Y. J., Kim, E.-S., & Koo, J. S. (2018) · Breast Cancer Research and Treatment · doi:10.1007/s10549-018-4722-1 · Cited by 63
The role of immune cells in brain development and neurodevelopmental diseases
Tanabe, S., & Yamashita, T. (2018) · International Immunology · doi:10.1093/intimm/dxy041 · Cited by 66
Hemp (Cannabis sativa L.) Protein Hydrolysates Promote Anti-Inflammatory Response in Primary Human Monocytes
Rodriguez-Martin, N. M., Montserrat-de la Paz, S., Toscano, R., Grao-Cruces, E., Villanueva, A., Pedroche, J., Millan, F., & Millan-Linares, M. C. (2020) · Biomolecules · doi:10.3390/biom10050803 · Cited by 61
IGF1 Treatment Improves Cardiac Remodeling after Infarction by Targeting Myeloid Cells
Heinen, A., Nederlof, R., Panjwani, P., Spychala, A., Tschaidse, T., Reffelt, H., Boy, J., Raupach, A., Gödecke, S., Petzsch, P., et al. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.10.020 · Cited by 65
Inflammatory M1-like macrophages polarized by NK-4 undergo enhanced phenotypic switching to an anti-inflammatory M2-like phenotype upon co-culture with apoptotic cells
Kohno, K., Koya-Miyata, S., Harashima, A., Tsukuda, T., Katakami, M., Ariyasu, T., Ushio, S., & Iwaki, K. (2021) · Journal of Inflammation · doi:10.1186/s12950-020-00267-z · Cited by 61
CD44 variant isoform 9 emerges in response to injury and contributes to the regeneration of the gastric epithelium
Bertaux‐Skeirik, N., Wunderlich, M., Teal, E. L., Chakrabarti, J. L., Biesiada, J., Mahé, M. M., Sundaram, N., Gabre, J. T., Hawkins, J., Jian, G., et al. (2017) · The Journal of Pathology · doi:10.1002/path.4918 · Cited by 61
Interactions between macrophages and helminths
Coakley, G., & Harris, N. L. (2020) · Parasite Immunology · doi:10.1111/pim.12717 · Cited by 59
Retracted:Leishmania infection activates host mTOR for its survival by M2 macrophage polarization
Kumar, A., Das, S., Mandal, A., Verma, S., Abhishek, K., Kumar, A., Kumar, V., Ghosh, A. K., & Das, P. K. (2018) · Parasite Immunology · doi:10.1111/pim.12586 · Cited by 60
Retracted
Macrophages as Promising Carriers for Nanoparticle Delivery in Anticancer Therapy
Wróblewska, A., Szczygieł, A., Szermer-Olearnik, B., & Pajtasz‐Piasecka, E. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s421173 · Cited by 65
The Importance of M1-and M2-Polarized Macrophages in Glioma and as Potential Treatment Targets
Ren, J., Xu, B., Ren, J., Liu, Z., Cai, L., Zhang, X., Wang, W., Li, S., Jin, L., & Ding, L. (2023) · Brain Sciences · doi:10.3390/brainsci13091269 · Cited by 63
Advances in Engineered Macrophages: A New Frontier in Cancer Immunotherapy
Yang, S., Wang, Y., Jia, J., Fang, Y., Yang, Y., Yuan, W., & Hu, J. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06616-7 · Cited by 66
Differential Macrophage Polarization from Pneumocystis in Immunocompetent and Immunosuppressed Hosts: Potential Adjunctive Therapy during Pneumonia
Nandakumar, V., Hebrink, D. M., Jenson, P. E., Kottom, T. J., & LIMPER, A. H. (2016) · Infection and Immunity · doi:10.1128/iai.00939-16 · Cited by 61
Placental Hofbauer Cell Polarization Resists Inflammatory Cues In Vitro
Schliefsteiner, C., Ibesich, S., & Wadsack, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030736 · Cited by 59
S-1-Propenylcysteine Promotes IL-10-Induced M2c Macrophage Polarization through Prolonged Activation of IL-10R/STAT3 Signaling
Miki, S., Suzuki, J.-I., Takashima, M., Ishida, M., Kokubo, H., & Yoshizumi, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-01866-3 · Cited by 58
Extracellular HSP90α Induces MyD88-IRAK Complex-Associated IKKα/β−NF-κB/IRF3 and JAK2/TYK2−STAT-3 Signaling in Macrophages for Tumor-Promoting M2-Polarization
Fan, C.-S., Chen, C.-C., Chen, L.-L., Chua, K. V., Hung, H.-C., Hsu, J. T.-A., & Huang, T.-S. (2022) · Cells · doi:10.3390/cells11020229 · Cited by 60
Lipoxin A4 selectively programs the profile of M2 tumor‐associated macrophages which favour control of tumor progression
Simões, R. L., de Brito, N. M., Cunha‐Costa, H., Morandi, V., Fierro, I. M., Roitt, I. M., & Barja‐Fidalgo, C. (2016) · International Journal of Cancer · doi:10.1002/ijc.30424 · Cited by 58
Changes in Nerve Growth Factor Expression and Macrophage Phenotype Following Intervertebral Disc Injury in Mice
Nakawaki, M., Uchida, K., Miyagi, M., Inoue, G., Kawakubo, A., Satoh, M., & Takaso, M. (2019) · Journal of Orthopaedic Research® · doi:10.1002/jor.24308 · Cited by 57
Immunomodulatory Effects of Genetic Alterations Affecting the Kynurenine Pathway
Boros, F. A., & Vécsei, L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02570 · Cited by 58
The varying roles of macrophages in kidney injury and repair
Wen, Y., & Crowley, S. D. (2020) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000595 · Cited by 59
Diverse homeostatic and immunomodulatory roles of immune cells in the developing mouse lung at single cell resolution
Domingo-Gonzalez, R., Zanini, F., Che, X., Liu, M., Jones, R. C., Swift, M. A., Quake, S. R., Cornfield, D. N., & Alvira, C. M. (2020) · eLife · doi:10.7554/elife.56890 · Cited by 59
Neuropathophysiological Mechanisms and Treatment Strategies for Post-traumatic Epilepsy
Sharma, S., Tiarks, G., Haight, J. A., & Bassuk, A. G. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.612073 · Cited by 58
Leishmaniasis: Immune Cells Crosstalk in Macrophage Polarization
Almeida, F. S., Vanderley, S. E. R., Comberlang, F. C., de Andrade, A. G., Silva, L. H. A. C., Silva, E. D. S., Palmeira, P. H. D. S., do Amaral, I. P. G., & Keesen, T. S. L. (2023) · Tropical Medicine and Infectious Disease · doi:10.3390/tropicalmed8050276 · Cited by 66
Chondroprotective effect of high-molecular-weight hyaluronic acid on osteoarthritic chondrocytes in a co-cultivation inflammation model with M1 macrophages
Bauer, C., Niculescu-Morzsa, E., Jeyakumar, V., Kern, D., Späth, S., & Nehrer, S. (2016) · Journal of Inflammation · doi:10.1186/s12950-016-0139-y · Cited by 55
Glucan and Mannan—Two Peas in a Pod
Короленко, Т. А., Bgatova, N. P., & Větvička, V. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133189 · Cited by 57
Intrahepatic cholangiocarcinoma: Morpho-molecular pathology, tumor reactive microenvironment, and malignant progression
Sirica, A. E., Strazzabosco, M., & Cadamuro, M. (2020) · Advances in cancer research · doi:10.1016/bs.acr.2020.10.005 · Cited by 59
M1 and M2 Macrophages Polarization via mTORC1 Influences Innate Immunity and Outcome of Ehrlichia Infection
Ahmed, I., & Ismail, N. (2020) · Journal of Cellular Immunology · doi:10.33696/immunology.2.029 · Cited by 64
The Role of NF-κB in Uterine Spiral Arteries Remodeling, Insight into the Cornerstone of Preeclampsia
Socha, M. W., Malinowski, B., Puk, O., Wartęga, M., Stankiewicz, M., Kazdepka-Ziemińska, A., & Wiciński, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020704 · Cited by 56
Does the Interaction between Local and Systemic Inflammation Provide a Link from Psychology and Lifestyle to Tissue Health in Musculoskeletal Conditions?
Klyne, D. M., Barbe, M. F., James, G., & Hodges, P. W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147299 · Cited by 57
The Importance of Metabolism for Immune Homeostasis in Allergic Diseases
Rodríguez‐Coira, J., Villaseñor, A., Izquierdo, E., Huang, M., Barker‐Tejeda, T. C., Radzikowska, U., Sokołowska, M., & Barber, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.692004 · Cited by 58
Dual-function hydrogels with sequential release of GSK3β inhibitor and VEGF inhibit inflammation and promote angiogenesis after stroke
Liu, Y., Zhang, F., Long, L., Li, J., Liu, Z., Hu, C., Chen, X., Zan, X., Xu, J., & Wang, Y. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.133671 · Cited by 56
Peptide-Based Bioconjugates and Therapeutics for Targeted Anticancer Therapy
Yang, S.-B., Banik, N., Han, B., Lee, D.-N., & Park, J. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14071378 · Cited by 60
Macrophage inflammatory and regenerative response periodicity is programmed by cell cycle and chromatin state
Dániel, B., Belk, J. A., Meier, S. L., Chen, A. Y., Sándor, K., Czimmerer, Z., Varga, Z., Bene, K., Buquicchio, F. A., Qi, Y., et al. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.11.017 · Cited by 57
Interaction of endothelial cells with macrophages—linking molecular and metabolic signaling
Kalucka, J. M., Bierhansl, L., Wielockx, B., Carmeliet, P., & Eelen, G. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1946-6 · Cited by 57
M2 macrophages and their role in rheumatic diseases
Bhattacharya, S., & Aggarwal, A. (2018) · Rheumatology International · doi:10.1007/s00296-018-4120-3 · Cited by 56
Exosome and Macrophage Crosstalk in Sleep-Disordered Breathing-Induced Metabolic Dysfunction
Khalyfa, A., Gozal, D., & Gozal, D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113383 · Cited by 57
The bacterial siderophore enterobactin confers survival advantage to Salmonella in macrophages
Saha, P., Xiao, X., Yeoh, B. S., Chen, Q., Katkere, B., Kirimanjeswara, G. S., & Vijay–Kumar, M. (2018) · Gut Microbes · doi:10.1080/19490976.2018.1546519 · Cited by 56
RNA editing enzyme APOBEC3A promotes pro-inflammatory M1 macrophage polarization
Alqassim, E., Sharma, S., Khan, A., Emmons, T. R., Gomez, E. C., Alahmari, A. A., Singel, K. L., Mark, J., Davidson, B. A., McGray, A. R., et al. (2021) · Communications Biology · doi:10.1038/s42003-020-01620-x · Cited by 54
Dural Immune Cells, CGRP, and Migraine
Balcziak, L. K., & Russo, A. F. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.874193 · Cited by 58
Melanoma exosome induction of endothelial cell GM-CSF in pre-metastatic lymph nodes may result in different M1 and M2 macrophage mediated angiogenic processes
Hood, J. L. (2016) · Medical Hypotheses · doi:10.1016/j.mehy.2016.07.009 · Cited by 55
Transplantation of human amnion prevents recurring adhesions and ameliorates fibrosis in a rat model of sciatic nerve scarring
Lemke, A., Ferguson, J., Gross, K., Penzenstadler, C., Bradl, M., Mayer, R. L., Gerner, C., Redl, H. R., & Wolbank, S. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.11.042 · Cited by 55
Amniotic mesenchymal stem cells mitigate osteoarthritis progression in a synovial macrophage‐mediated in vitro explant coculture model
Topoluk, N., Steckbeck, K., Siatkowski, S., Burnikel, B. G., Tokish, J., & Mercuri, J. J. (2017) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2610 · Cited by 55
Inflammatory response under zinc deficiency is exacerbated by dysfunction of the T helper type 2 lymphocyte–M2 macrophage pathway
Kido, T., Ishiwata, K., Suka, M., & Yanagisawa, H. (2019) · Immunology · doi:10.1111/imm.13033 · Cited by 46
RELMα-expressing macrophages protect against fatal lung damage and reduce parasite burden during helminth infection
Krljanac, B., Schubart, C., Naumann, R., Wirtz, S. J., Culemann, S., Krönke, G., & Voehringer, D. (2019) · Science Immunology · doi:10.1126/sciimmunol.aau3814 · Cited by 55
Applications of Biomaterials for Immunosuppression in Tissue Repair and Regeneration
Shen, P. F., Chen, Y., Luo, S., Fan, Z., Wang, J., Chang, J., & Deng, J. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.03.019 · Cited by 56
Fibroblast growth factor signaling in macrophage polarization: impact on health and diseases
Shen, L., Li, Y., & Zhao, H. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1390453 · Cited by 55
Mesenchymal Stem Cells Recruit CCR2+ Monocytes To Suppress Allergic Airway Inflammation
Takeda, K., Webb, T. L., Ning, F., Shiraishi, Y., Regan, D. P., Chow, L., Smith, M. J., Ashino, S., Guth, A., Hopkins, S., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1700562 · Cited by 56
Inflammation: major denominator of obesity, Type 2 diabetes and Alzheimer’s disease-like pathology?
Kacířová, M., Zmeškalová, A., Kořínková, L., Železná, B., Kuneš, J., & Maletı́nská, L. (2020) · Clinical Science · doi:10.1042/cs20191313 · Cited by 56
Endometriosis and Cancer: Exploring the Role of Macrophages
Artemova, D. A., Vishnyakova, P., Khashchenko, K. E. P., Elchaninov, A. V., Sukhikh, G. T., & Fatkhudinov, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105196 · Cited by 53
Single-cell sequencing reveals the evolution of immune molecules across multiple vertebrate species
Jiao, A., Zhang, C., Wang, X., Sun, L., Liu, H., Su, Y., Lei, L., Li, W., Ding, R., Ding, C., et al. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.02.017 · Cited by 53
Macrophages and platelets in liver fibrosis and hepatocellular carcinoma
Casari, M., Siegl, D., Deppermann, C., & Schuppan, D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1277808 · Cited by 55
Sestrin2 Suppresses Classically Activated Macrophages-Mediated Inflammatory Response in Myocardial Infarction through Inhibition of mTORC1 Signaling
Yang, K., Xu, C., Zhang, Y., He, S., & Li, D. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00728 · Cited by 53
Importance of GPCR-Mediated Microglial Activation in Alzheimer’s Disease
Haque, M. E., Kim, I., Jakaria, M., Akther, M., & Choi, D. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00258 · Cited by 55
Tumor-associated macrophages derived CCL18 promotes metastasis in squamous cell carcinoma of the head and neck
She, L., Qin, Y., Wang, J., Liu, C., Zhu, G., Guo, L., Wei, M., Chen, C., Liu, G., Zhang, D., et al. (2018) · Cancer Cell International · doi:10.1186/s12935-018-0620-1 · Cited by 53
Vitamin B Complex Treatment Attenuates Local Inflammation after Peripheral Nerve Injury
Ehmedah, A., Nedeljković, P., Đačić, S., Repac, J., Pavlovic, B. D., Vučević, D., Peković, S., & Nedeljković, B. B. (2019) · Molecules · doi:10.3390/molecules24244615 · Cited by 53
Prognostic Value of Tumor-Associated Macrophages in Clear Cell Renal Cell Carcinoma: A Systematic Review and Meta-Analysis
Shen, H., Liu, J., Chen, S., Ma, X., Ying, Y., Li, J., Wang, W., Wang, X., & Xie, L. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.657318 · Cited by 53
Macrophage subtype and cytokine expression characterization during the acute inflammatory phase of mouse bone fracture repair
McCauley, J., Bitsaktsis, C., & Cottrell, J. (2020) · Journal of Orthopaedic Research · doi:10.1002/jor.24603 · Cited by 52
MicroRNA‐99 family in cancer and immunity
Eniafe, J., & Jiang, S. (2020) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1635 · Cited by 51
Macrophage Implication in IPF: Updates on Immune, Epigenetic, and Metabolic Pathways
Pokhreal, D., Crestani, B., & Helou, D. G. (2023) · Cells · doi:10.3390/cells12172193 · Cited by 54
Regulation of alveolar macrophage death in pulmonary fibrosis: a review
Yang, G., Yang, Y., Liu, Y., & Liu, X. (2023) · APOPTOSIS · doi:10.1007/s10495-023-01888-4 · Cited by 57
Visualizing Macrophage Phenotypes and Polarization in Diseases: From Biomarkers to Molecular Probes
Ni, D., Zhou, H., Wang, P., Xu, F., & Li, C. (2023) · Phenomics · doi:10.1007/s43657-023-00129-7 · Cited by 56
Analysis of IL-4/STAT6 Signaling in Macrophages
Waqas, S. F., Ampem, G., & Rőszer, T. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9195-2_17 · Cited by 52
Self-citation
Differential expression of inflammatory and anti-inflammatory mediators by M1 and M2 macrophages after photobiomodulation with red or infrared lasers
Sousa, K. D. B., Rodrigues, M. F. S. D., Santos, D. D. S., Mesquita‐Ferrari, R. A., Nunes, F. D., da Silva, D. D. F. T., Bussadori, S. K., & Fernandes, K. P. S. (2019) · Lasers in Medical Science · doi:10.1007/s10103-019-02817-1 · Cited by 56
Schwann cells promote lung cancer proliferation by promoting the M2 polarization of macrophages
Zhou, Y., Li, J., Han, B., Zhong, R., & Zhong, H. (2020) · Cellular Immunology · doi:10.1016/j.cellimm.2020.104211 · Cited by 54
Macrophage Polarization, Metabolic Reprogramming, and Inflammatory Effects in Ischemic Heart Disease
Sun, X., Li, Y., Deng, Q., Hu, Y., Dong, J., Wang, W., Wang, Y., & Li, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.934040 · Cited by 54
Age-related changes in human bone marrow mesenchymal stromal cells: morphology, gene expression profile, immunomodulatory activity and miRNA expression
Massaro, F., Corrillon, F., Stamatopoulos, B., Dubois, N., Ruer, A., Meuleman, N., Bron, D., & Lagneaux, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1267550 · Cited by 55
Withaferin A Associated Differential Regulation of Inflammatory Cytokines
Dubey, S., Yoon, H., Cohen, M. S., Nagarkatti, P. S., Nagarkatti, M., & Karan, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00195 · Cited by 51
Rg6, a rare ginsenoside, inhibits systemic inflammation through the induction of interleukin-10 and microRNA-146a
Paik, S., Choe, J. H., Choi, G.-E., Kim, J.-E., Kim, J., Song, G., & Jo, E. (2019) · Scientific Reports · doi:10.1038/s41598-019-40690-8 · Cited by 51
Cell stemness, epithelial-to-mesenchymal transition, and immunoevasion: Intertwined aspects in cancer metastasis
Romano, S., Tufano, M., D’Arrigo, P., Vigorito, V., Russo, S., & Romano, M. F. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.08.015 · Cited by 51
M2 macrophage polarization modulates epithelial-mesenchymal transition in cisplatin-induced tubulointerstitial fibrosis
Yu, C.-C., Chien, C., & Chang, T.-C. (2016) · Biomedicine · doi:10.7603/s40681-016-0005-5 · Cited by 50
Intrahepatic macrophage populations in the pathophysiology of primary sclerosing cholangitis
Chen, Y., Arndtz, K., Webb, G. J., Corrigan, M., Akiror, S., Liaskou, E., Woodward, P., Adams, D., Weston, C. J., & Hirschfield, G. M. (2019) · JHEP Reports · doi:10.1016/j.jhepr.2019.10.003 · Cited by 49
Impaired wound healing in type 1 diabetes is dependent on 5-lipoxygenase products
Ramalho, T. R. D. O., Filgueiras, L. R., Silva, I., Pessoa, A. F. M., & Jancar, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-32589-7 · Cited by 52
Galanin is a potent modulator of cytokine and chemokine expression in human macrophages
Koller, A., Brunner, S. M., Bianchini, R., Ramspacher, A., Emberger, M., Sternberg, F., Schlager, S., & Kofler, B. (2019) · Scientific Reports · doi:10.1038/s41598-019-43704-7 · Cited by 50
Allogeneic adipose-derived stem cells promote ischemic muscle repair by inducing M2 macrophage polarization via the HIF-1α/IL-10 pathway
Liu, J., Qiu, P., Qin, J., Wu, X., Wang, X., Yang, X., Li, B., Zhang, W., Ye, K., Peng, Z., et al. (2020) · Stem Cells · doi:10.1002/stem.3250 · Cited by 51
Tenascin-C Function in Glioma: Immunomodulation and Beyond
Yalçın, F., Dzaye, O. D. A., & Xia, S. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-48457-6_9 · Cited by 48
Skeletal muscle healing by M1-like macrophages produced by transient expression of exogenous GM-CSF
Martins, L. D. O., Gallo, C. C., Honda, T. S. B., Alves, P. T., Stilhano, R. S., Rosa, D. S., Koh, T. J., & Han, S. W. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01992-1 · Cited by 52
Generation and Functional Characterization of Monocytes and Macrophages Derived from Human Induced Pluripotent Stem Cells
Cao, X., van den Hil, F. E., Mummery, C. L., & Orlova, V. V. (2020) · Current Protocols in Stem Cell Biology · doi:10.1002/cpsc.108 · Cited by 52
The Interplay between Salmonella and Intestinal Innate Immune Cells in Chickens
Ijaz, A., Veldhuizen, E. J. A., Broere, F., Rutten, V. P. M. G., & Jansen, C. A. (2021) · Pathogens · doi:10.3390/pathogens10111512 · Cited by 49
CTLA4-Ig treatment induces M1–M2 shift in cultured monocyte-derived macrophages from healthy subjects and rheumatoid arthritis patients
Cutolo, M., Soldano, S., Gotelli, E., Montagna, P., Campitiello, R., Paolino, S., Pizzorni, C., Sulli, A., Smith, V. M., & Tardito, S. (2021) · Arthritis Research & Therapy · doi:10.1186/s13075-021-02691-9 · Cited by 49

Authors: Rőszer, T.
Affiliations: Universität Ulm (DE)
Corresponding author: Rőszer, Tamás
ORCID: Rőszer, Tamás
Venue: Mediators of Inflammation
Publisher: Wiley
Published: 2015-01
Volume: 2015
Issue: 1
Pages: 816460-816460
ISSN: 0962-9351 (ISSN-L)
1466-1861
DOI: 10.1155/2015/816460
PMC: PMC4452191
OpenAlex: W1518095394
Cited by: 1,762
References: 209
Citations by year: 2026: 105 · 2025: 169 · 2024: 198 · 2023: 189 · 2022: 214 · 2021: 215 · 2020: 203 · 2019: 150 · 2018: 143 · 2017: 109 · 2016: 58 · 2015: 9
FWCI: 10.01
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (vor, 137 d)
Locations: Mediators of Inflammation (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Universität Ulm
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords: M2 macrophages, scavenger receptors, tissue microenvironment, tissue homeostasis, hormone signaling
MeSH terms: Humans, Macrophage Activation, Macrophages, Neurosecretory Systems

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks