Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms

The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function

Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481

Macrophage activation and polarization: nomenclature and experimental guidelines

Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337

Macrophage plasticity and polarization: in vivo veritas

Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528

The M1 and M2 paradigm of macrophage activation: Time for reassessment

Martinez, F. O., & Gordon, S. (2014) · F1000Prime Reports · doi:10.12703/p6-13 · Cited by 4,689

A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells

Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578

What we talk about when we talk about fat

Rosen, E. D., & Spiegelman, B. M. (2014) · Cell · doi:10.1016/j.cell.2013.12.012 · Cited by 2,373

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

Gomez Perdiguero, E., Klapproth, K., Schulz, C., Busch, K., Azzoni, E., Crozet, L., Garner, H., Trouillet, C., de Bruijn, M. F., Geissmann, F., et al. (2015) · Nature · doi:10.1038/nature13989 · Cited by 2,339 · cited 1×

The cellular and signaling networks linking the immune system and metabolism in disease

Osborn, O., & Olefsky, J. M. (2012) · Nature Medicine · doi:10.1038/nm.2627 · Cited by 1,551

Embryonic and Adult-Derived Resident Cardiac Macrophages Are Maintained through Distinct Mechanisms at Steady State and during Inflammation

Epelman, S., Lavine, K. J., Beaudin, A. E., Sojka, D. K., Carrero, J. A., Calderon, B., Brija, T., Gautier, E. L., Ivanov, S., Satpathy, A. T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.11.019 · Cited by 1,494

The Tumor Microenvironment Innately Modulates Cancer Progression

Hinshaw, D. C., & Shevde, L. A. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-3962 · Cited by 3,270

Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS–) vs. Alternatively Activated Macrophages

Orecchioni, M., Ghosheh, Y., Pramod, A. B., & Ley, K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01084 · Cited by 2,063

The metabolic signature of macrophage responses

Viola, A., Munari, F., Sánchez-Rodríguez, R., Scolaro, T., & Castegna, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01462 · Cited by 2,021

Macrophage Polarization States in the Tumor Microenvironment

Boutilier, A. J., & Elsawa, S. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136995 · Cited by 1,631

The Role of Macrophages in Acute and Chronic Wound Healing and Interventions to Promote Pro-wound Healing Phenotypes

Krzyszczyk, P., Schloss, R. S., Palmer, A. F., & Francois Berthiaume, B. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00419 · Cited by 1,598

Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas

Moncada, R., Barkley, D., Wagner, F., Chiodin, M., Devlin, J. C., Baron, M., Hajdu, C. H., Simeone, D. M., & Yanai, I. (2020) · Nature Biotechnology · doi:10.1038/s41587-019-0392-8 · Cited by 1,045

Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020

(2020) · doi:10.3390/ijms21207794 · Cited by 1,039

Implications of macrophage polarization in autoimmunity

Funes, S. C., Rios, M., Escobar‐Vera, J., & Kalergis, A. M. (2018) · Immunology · doi:10.1111/imm.12910 · Cited by 1,005

Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD

Na, Y. R., Stakenborg, M., Seok, S. H., & Matteoli, G. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0172-4 · Cited by 900

MSC exosomes mediate cartilage repair by enhancing proliferation, attenuating apoptosis and modulating immune reactivity

Zhang, S., Chuah, S. J., Lai, R. C., Hui, J. H. P., Lim, S. K., & Toh, W. S. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2017.11.028 · Cited by 919

M2b macrophage polarization and its roles in diseases

Wang, L., Zhang, S.-X., Wu, H., Rong, X., & Guo, J. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ru1018-378rr · Cited by 919

Macrophage Phenotypes Regulate Scar Formation and Chronic Wound Healing

Hesketh, M., Sahin, K. B., West, Z. E., & Murray, R. Z. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071545 · Cited by 852

A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling

Qian, J., Olbrecht, S., Boeckx, B., Vos, H., Laoui, D., Etlioglu, E., Wauters, E., Pomella, V., Verbandt, S., Busschaert, P., et al. (2020) · Cell Research · doi:10.1038/s41422-020-0355-0 · Cited by 845

The liver cancer immune microenvironment: Therapeutic implications for hepatocellular carcinoma

Donné, R., & Lujambio, A. (2022) · Hepatology · doi:10.1002/hep.32740 · Cited by 659

Evaluating the Polarization of Tumor-Associated Macrophages Into M1 and M2 Phenotypes in Human Cancer Tissue: Technicalities and Challenges in Routine Clinical Practice

Jayasingam, S. D., Citartan, M., Tang, T., Zin, A. A. M., Ang, K., & Ch’ng, E. S. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2019.01512 · Cited by 652

M1/M2 macrophages and their overlaps – myth or reality?

Strizova, Z. O., Benešová, I., Bartolini, R., Novysedlák, R., Cecrdlova, E., Foley, L. K., & Stříž, I. (2023) · Clinical Science · doi:10.1042/cs20220531 · Cited by 709

Myc Cooperates with Ras by Programming Inflammation and Immune Suppression

Kortlever, R. M., Sodir, N. M., Wilson, C. H., Burkhart, D. L., Pellegrinet, L., Brown Swigart, L., Littlewood, T. D., & Evan, G. I. (2017) · Cell · doi:10.1016/j.cell.2017.11.013 · Cited by 553

Exosome‐Guided Phenotypic Switch of M1 to M2 Macrophages for Cutaneous Wound Healing

Kim, H., Wang, S. Y., Kwak, G., Yang, Y., Kwon, I. C., & Kim, S. H. (2019) · Advanced Science · doi:10.1002/advs.201900513 · Cited by 542

Myeloid immunosuppression and immune checkpoints in the tumor microenvironment

Nakamura, K., & Smyth, M. J. (2019) · Cellular and Molecular Immunology · doi:10.1038/s41423-019-0306-1 · Cited by 530

Metabolism, metabolites, and macrophages in cancer

Li, M., Yang, Y., Xiong, L., Jiang, P., Wang, J., & Li, C. (2023) · Journal of Hematology & Oncology · doi:10.1186/s13045-023-01478-6 · Cited by 564

Macrophages and the maintenance of homeostasis

Mosser, D. M., Hamidzadeh, K., & Gonçalves, R. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00541-3 · Cited by 526

Macrophage polarization: an important role in inflammatory diseases

Luo, M., Zhao, F., Cheng, H., Su, M., & Wang, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1352946 · Cited by 531

Tumor‐associated macrophages in liver cancer: From mechanisms to therapy

Cheng, K., Cai, N., Zhu, J., Yang, X., Liang, H., & Zhang, W. (2022) · 癌症：英文版 · doi:10.1002/cac2.12345 · Cited by 478

Material stiffness influences the polarization state, function and migration mode of macrophages

Sridharan, R., Cavanagh, B., Cameron, A. R., Kelly, D. J., & O'Brien, F. J. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.02.048 · Cited by 450

Macrophages: The Good, the Bad, and the Gluttony

Ross, E. A., Devitt, A., & Johnson, J. R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.708186 · Cited by 450

p16(Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli

Hall, B. M., Balan, V., Gleiberman, A. S., Strom, E., Krasnov, P., Virtuoso, L. P., Rydkina, E., Vujcic, S., Balan, K., Gitlin, I. I., et al. (2017) · Aging · doi:10.18632/aging.101268 · Cited by 407

Immune Cells in the BBB Disruption After Acute Ischemic Stroke: Targets for Immune Therapy?

Qiu, Y., Zhang, C., Chen, A., Wang, H.-L., Zhou, Y., Li, Y., & Hu, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.678744 · Cited by 414

Macrophage Polarization and Osteoporosis: A Review

Muñoz, J., Akhavan, N. S., Mullins, A. P., & Arjmandi, B. H. (2020) · Nutrients · doi:10.3390/nu12102999 · Cited by 391

Tumor-associated macrophages: potential therapeutic strategies and future prospects in cancer

Li, C., Xu, X., Wei, S., Jiang, P., Xue, L., & Wang, J. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001341 · Cited by 360

Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets

Guan, F., Wang, R., Yi, Z., Luo, P., Liu, W., Xie, Y., Liu, Z., Xia, Z., Zhang, H., & Cheng, Q. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02124-y · Cited by 371

Macrophage biology in the peripheral nervous system after injury

Zigmond, R. E., & Echevarría, F. D. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.12.001 · Cited by 383

Regulating IRFs in IFN Driven Disease

Jefferies, C. A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00325 · Cited by 364

Macrophages: An Inflammatory Link Between Angiogenesis and Lymphangiogenesis

Corliss, B. A., Azimi, M. S., Munson, J. M., Peirce, S. M., & Murfee, W. L. (2016) · Microcirculation · doi:10.1111/micc.12259 · Cited by 356

Dual roles and therapeutic targeting of tumor-associated macrophages in tumor microenvironments

Xu, J., Ding, L., Mei, J., Hu, Y., Kong, X., Dai, S., Bu, T., Xiao, Q., & Ding, K. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02325-5 · Cited by 389

Crosstalk between cancer and immune cells: Role of tumor‐associated macrophages in the tumor microenvironment

Wang, J., Li, D., Cang, H., & Guo, B. (2019) · Cancer Medicine · doi:10.1002/cam4.2327 · Cited by 363

The choice of phorbol 12-myristate 13-acetate differentiation protocol influences the response of THP-1 macrophages to a pro-inflammatory stimulus

Lund, M. E., To, J., O’Brien, B. A., & Donnelly, S. (2016) · Journal of Immunological Methods · doi:10.1016/j.jim.2016.01.012 · Cited by 345

Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging

Ma, S., Sun, S., Geng, L., Song, M., Wang, W., Ye, Y., Ji, Q., Zou, Z., Wang, S., He, X., et al. (2020) · Cell · doi:10.1016/j.cell.2020.02.008 · Cited by 349

Major pathways involved in macrophage polarization in cancer

Kerneur, C., Cano, C. E., & Olive, D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1026954 · Cited by 359

Tumor-associated macrophages: an effective player of the tumor microenvironment

Basak, U., Sarkar, T., Mukherjee, S., Chakraborty, S., Dutta, A., Dutta, S., Nayak, D., Kaushik, S., Das, T., & Sa, G. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1295257 · Cited by 356

Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages

Runtsch, M. C., Angiari, S., Hooftman, A., Wadhwa, R., Zhang, Y., Zheng, Y., Spina, J. S., Ruzek, M. C., Argiriadi, M. A., McGettrick, A. F., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.02.002 · Cited by 343

Tumors induce de novo steroid biosynthesis in T cells to evade immunity

Mahata, B., Pramanik, J., van der Weyden, L., Polański, K., Kar, G., Riedel, A., Chen, X. X., Fonseca, N. A., Kundu, K., Campos, L. S., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17339-6 · Cited by 333

Role of exosomal non-coding RNAs from tumor cells and tumor-associated macrophages in the tumor microenvironment

Xu, Z., Chen, Y., Ma, L., Chen, Y., Liu, J., Guo, Y., Yu, T., Zhang, L., Zhu, L., & Shu, Y. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.01.046 · Cited by 337

Hypoxia-induced tumor exosomes promote M2-like macrophage polarization of infiltrating myeloid cells and microRNA-mediated metabolic shift

Park, J. E., Dutta, B., Tse, S. W., Gupta, N., Tan, C. F., Low, J. K., Yeoh, K. W., Kon, O. L., Tam, J. P., & Sze, S. K. (2019) · Oncogene · doi:10.1038/s41388-019-0782-x · Cited by 320

Resolution of inflammation in bone regeneration: From understandings to therapeutic applications

Newman, H., Shih, Y.-R. V., & Varghese, S. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121114 · Cited by 318

Atherosclerosis and Inflammation: Insights from the Theory of General Pathological Processes

Gusev, E., & Sarapultsev, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097910 · Cited by 357

Mapping macrophage polarization over the myocardial infarction time continuum

Mouton, A. J., DeLeon‐Pennell, K. Y., Gonzalez, O. J. R., Flynn, E. R., Freeman, T. C., Saucerman, J. J., Garrett, M. R., Ma, Y., Harmancey, R., & Lindsey, M. L. (2018) · Basic Research in Cardiology · doi:10.1007/s00395-018-0686-x · Cited by 317

Galectin-3 Activation and Inhibition in Heart Failure and Cardiovascular Disease: An Update

Suthahar, N., Meijers, W. C., Silljé, H. H. W., Ho, J. E., Liu, F., & de Boer, R. A. (2017) · Theranostics · doi:10.7150/thno.22196 · Cited by 309

Macrophage spatial heterogeneity in gastric cancer defined by multiplex immunohistochemistry

Huang, Y., Wang, M., Yu, S. Y., Costanzo, N. D., Mitchell, C., Achuthan, A. A., Hamilton, J. A., Busuttil, R. A., & Boussioutas, A. (2019) · Nature Communications · doi:10.1038/s41467-019-11788-4 · Cited by 301

Macrophage reaction against biomaterials in the mouse model–phenotypes, functions and markers

Klopfleisch, R. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.07.003 · Cited by 298

When Immune Cells Turn Bad—Tumor-Associated Microglia/Macrophages in Glioma

Roesch, S., Rapp, C., Dettling, S., & Herold‐Mende, C. C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020436 · Cited by 305

Diverse macrophages polarization in tumor microenvironment

Rhee, I. (2016) · Archives of Pharmacal Research · doi:10.1007/s12272-016-0820-y · Cited by 295

Macrophage Related Chronic Inflammation in Non-Healing Wounds

Li, M., Hou, Q., Zhong, L., Zhao, Y., & Fu, X. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.681710 · Cited by 307

Alternatively activated macrophages; a double-edged sword in allergic asthma

Abdelaziz, M. H., Abdelwahab, S. F., Wan, J., Cai, W., Wang, H., Cheng, J., Kesavan, D. K., Vasudevan, A., Sadek, A., Su, Z., et al. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02251-w · Cited by 289

Advances in the role of STAT3 in macrophage polarization

Xia, T., Zhang, M., Lei, W., Yang, R., Fu, S.-P., Fan, Z., Yang, Y., & Zhang, T. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1160719 · Cited by 306

Macrophages, Inflammation, and Lung Cancer

Conway, E. M., Pikor, L. A., Kung, S. H. Y., Hamilton, M. J., Lam, S. C., Lam, W. L., & Bennewith, K. L. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201508-1545ci · Cited by 295

Single tumor-initiating cells evade immune clearance by recruiting type II macrophagesPreprint

Guo, X., Zhao, Y., Yan, H., Yang, Y., Shen, S., Dai, X., Ji, X., Ji, F., Gong, X., Li, L., et al. (2017) · Genes & Development · doi:10.1101/gad.294348.116 · Cited by 290

Dissecting the immune suppressive human prostate tumor microenvironment via integrated single-cell and spatial transcriptomic analyses

Hirz, T., Mei, S., Sarkar, H., Kfoury, Y. S., Wu, S., Verhoeven, B. M., Subtelny, A. O., Zlatev, D. V., Wszolek, M. W., Salari, K., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36325-2 · Cited by 303

Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression

Gurevich, D., Severn, C. E., Twomey, C., Greenhough, A., Cash, J. L., Toye, A., Mellor, H., & Martin, P. (2018) · EMBO Journal · doi:10.15252/embj.201797786 · Cited by 252

Regulation of TNF-Induced Osteoclast Differentiation

Yao, Z., Getting, S. J., & Locke, I. C. (2021) · Cells · doi:10.3390/cells11010132 · Cited by 280

Meta-Inflammation and Metabolic Reprogramming of Macrophages in Diabetes and Obesity: The Importance of Metabolites

Russo, S. L. M. L., Kwiatkowski, M., Govorukhina, N. I., Bischoff, R., & Melgert, B. N. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.746151 · Cited by 286

Role of Macrophages in Acute Lung Injury and Chronic Fibrosis Induced by Pulmonary Toxicants

Laskin, D. L., Malaviya, R., & Laskin, J. D. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy309 · Cited by 272

Targeting of CD163+ Macrophages in Inflammatory and Malignant Diseases

Skytthe, M. K., Graversen, J. H., & Moestrup, S. K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155497 · Cited by 275

Acute Inflammation in Tissue Healing

Soliman, A. M., & Barreda, D. R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010641 · Cited by 301

Dual Roles of Graphene Oxide To Attenuate Inflammation and Elicit Timely Polarization of Macrophage Phenotypes for Cardiac Repair

Han, J., Kim, Y. S., Lim, M.-Y., Kim, H. Y., Kong, S., Kang, M., Choo, Y. W., Jun, J. H., Ryu, S., Jeong, H.-Y., et al. (2018) · ACS Nano · doi:10.1021/acsnano.7b09107 · Cited by 261

Cancer-associated fibroblasts promote an immunosuppressive microenvironment through the induction and accumulation of protumoral macrophages

Takahashi, H., Sakakura, K., Kudo, T., Toyoda, M., Kaira, K., Oyama, T., & Chikamatsu, K. (2016) · Oncotarget · doi:10.18632/oncotarget.14374 · Cited by 272

The impact of the lung environment on macrophage development, activation and function: diversity in the face of adversity

Bain, C. C., & MacDonald, A. S. (2022) · Mucosal Immunology · doi:10.1038/s41385-021-00480-w · Cited by 266

The many facets of macrophages in rheumatoid arthritis

Siouti, E., & Andreakos, E. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.03.029 · Cited by 255

The Role of Mitophagy in Innate Immunity

Gkikas, I., Palikaras, K., & Tavernarakis, N. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01283 · Cited by 248

Mechanobiology of Macrophages: How Physical Factors Coregulate Macrophage Plasticity and Phagocytosis

Jain, N., Moeller, J., & Vogel, V. (2019) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-062117-121224 · Cited by 237

Melanoma exosomes promote mixed M1 and M2 macrophage polarization

Bardi, G. T., Smith, M. A. L., & Hood, J. L. (2018) · Cytokine · doi:10.1016/j.cyto.2018.02.002 · Cited by 235

Deciphering the performance of macrophages in tumour microenvironment: a call for precision immunotherapy

Toledo, B., Chen, L. Z., Paniagua-Sancho, M., Marchal, J. A., Perán, M., & Giovannetti, E. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01559-0 · Cited by 255

Therapeutic Targeting of Hepatic Macrophages for the Treatment of Liver Diseases

van der Heide, D., Weiskirchen, R., & Bansal, R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02852 · Cited by 239

Lactobacillus plantarum ‐derived extracellular vesicles induce anti‐inflammatory M2 macrophage polarization in vitro

Kim, W., Lee, E. J., Bae, I., Myoung, K., Kim, S. T., Park, P. J., Lee, K., Pham, A. V. Q., Ko, J., Oh, S. H., et al. (2020) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2020.1793514 · Cited by 232

Selective inhibition of TGFβ1 activation overcomes primary resistance to checkpoint blockade therapy by altering tumor immune landscape

Martin, C. J., Datta, A., Littlefield, C., Kalra, A., Chapron, C., Wawersik, S., Dagbay, K. B., Brueckner, C. T., Nikiforov, A., Danehy, F. T., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay8456 · Cited by 224

Regulatory Effects and Interactions of the Wnt and OPG-RANKL-RANK Signaling at the Bone-Cartilage Interface in Osteoarthritis

Kovács, B., Vajda, E., & Nagy, E. E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184653 · Cited by 224

Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage

Kim, K.-H., Kim, Y. H., Son, J. E., Lee, J. H., Kim, S., Choe, M. S., Moon, J. H., Zhong, J., Fu, K., Lenglin, F., et al. (2017) · Cell Research · doi:10.1038/cr.2017.126 · Cited by 224

Progesterone-Related Immune Modulation of Pregnancy and Labor

Shah, N. M., Lai, P. F., Imami, N., & Johnson, M. R. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00198 · Cited by 225

The Current State of Nanoparticle-Induced Macrophage Polarization and Reprogramming Research

Miao, X., Leng, X., & Zhang, Q. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020336 · Cited by 218

Targeting of M2-like tumor-associated macrophages with a melittin-based pro-apoptotic peptide

Lee, C., Jeong, H., Bae, Y., Shin, K., Kang, S., Kim, H., Oh, J., & Bae, H. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0610-4 · Cited by 211

Blame the signaling: Role of cAMP for the resolution of inflammation

Tavares, L. P., Negreiros-Lima, G. L., Lima, K. M., Silva, P., Pinho, V., Teixeira, M. M., & Sousa, L. P. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105030 · Cited by 214

TNF signaling and macrophages govern fin regeneration in zebrafish larvae

Nguyen-Chi, M., Laplace-Builhé, B., Travnickova, J., Luz-Crawford, P., Tejedor, G., Lutfalla, G., Kissa, K., Jorgensen, C., & Djouad, F. (2017) · Cell Death & Disease · doi:10.1038/cddis.2017.374 · Cited by 190

Macrophage p38α promotes nutritional steatohepatitis through M1 polarization

Zhang, X., Fan, L., Wu, J., Xu, H., Leung, W. Y., Fu, K., Wu, J., Liu, K., Man, K., Yang, X., et al. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.03.014 · Cited by 205

An M1-like Macrophage Polarization in Decidual Tissue during Spontaneous Preterm Labor That Is Attenuated by Rosiglitazone Treatment

Xu, Y., Romero, R. J., Miller, D., Kadam, L., Mial, T. N., Plazyo, O., Garcia‐Flores, V., Hassan, S. S., Xu, Z., Tarca, A. L., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502055 · Cited by 202

Hofbauer Cells: Their Role in Healthy and Complicated Pregnancy

Reyes, L., & Golos, T. G. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02628 · Cited by 200

Characterization of the immune microenvironment of diffuse intrinsic pontine glioma: implications for development of immunotherapy

Lieberman, N. A. P., DeGolier, K., Kovar, H. M., Davis, A. D., Hoglund, V. J., Stevens, J., Winter, C., Deutsch, G. H., Furlan, S. N., Vitanza, N. A., et al. (2018) · Neuro-Oncology · doi:10.1093/neuonc/noy145 · Cited by 194

Neutrophils in Post-myocardial Infarction Inflammation: Damage vs. Resolution?

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Control of innate immune response by biomaterial surface topography, energy, and stiffness

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Emerging Function and Clinical Values of Exosomal MicroRNAs in Cancer

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A scaffold laden with mesenchymal stem cell-derived exosomes for promoting endometrium regeneration and fertility restoration through macrophage immunomodulation

Xin, L., Lin, X., Zhou, F., Li, C., Wang, X., Yu, H., Pan, Y., Fei, H., Ma, L., & Zhang, S. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.06.029 · Cited by 202

Overcoming the Immunosuppressive Tumor Microenvironment of Hodgkin Lymphoma Using Chimeric Antigen Receptor T Cells

Ruella, M., Klichinsky, M., Kenderian, S. S., Shestova, O. E., Ziober, A. F., Kraft, D. O., Feldman, M. D., Wasik, M. A., June, C. H., & Gill, S. I. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0850 · Cited by 197

Regulatory cells and the effect of cancer immunotherapy

Iglesias-Escudero, M., Arias-González, N., & Martínez-Cáceres, E. M. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01714-0 · Cited by 204

Molecular Mechanisms Modulating the Phenotype of Macrophages and Microglia

Amici, S. A., Dong, J., & Guerau‐de‐Arellano, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01520 · Cited by 200

CSF1R‐ and SHP2‐Inhibitor‐Loaded Nanoparticles Enhance Cytotoxic Activity and Phagocytosis in Tumor‐Associated Macrophages

Ramesh, A., Kumar, S., Nandi, D., & Kulkarni, A. A. (2019) · Advanced Materials · doi:10.1002/adma.201904364 · Cited by 191

Similarities and differences between mesenchymal stem/progenitor cells derived from various human tissues

Kozłowska, U., Krawczenko, A., Futoma, K., Jurek, T., Rorat, M., Patrzałek, D., & Klimczak, A. (2019) · World Journal of Stem Cells · doi:10.4252/wjsc.v11.i6.347 · Cited by 188

Generation of monocyte-derived tumor-associated macrophages using tumor-conditioned media provides a novel method to study tumor-associated macrophages in vitro

Benner, B. N., Scarberry, L., Suarez‐Kelly, L. P., Duggan, M. C., Campbell, A. R., Smith, E., Lapurga, G., Jiang, K., Butchar, J. P., Tridandapani, S., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0622-0 · Cited by 188

Macrophage Polarization in Cardiac Tissue Repair Following Myocardial Infarction

Kim, Y., Nurakhayev, S., Nurkesh, A., Zharkinbekov, Z., & Saparov, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052715 · Cited by 189

Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment

Wang, Z., Kim, S. Y., Tu, W., Kim, J., Xu, A. M., Yang, Y. M., Matsuda, M., Reolizo, L., Tsuchiya, T., Billet, S., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.04.013 · Cited by 185

Abnormal M1/M2 macrophage phenotype profiles in the small airway wall and lumen in smokers and chronic obstructive pulmonary disease (COPD)

Eapen, M. S., Hansbro, P. M., McAlinden, K. D., Kim, R., Ward, C., Hackett, T., Walters, E. H., & Sohal, S. S. (2017) · Scientific Reports · doi:10.1038/s41598-017-13888-x · Cited by 180

CD163-positive tumor-associated macrophages and CD8-positive cytotoxic lymphocytes are powerful diagnostic markers for the therapeutic stratification of osteosarcoma patients: An immunohistochemical analysis of the biopsies fromthe French OS2006 phase 3 trial

Gomez‐Brouchet, A., Illac, C., Gilhodes, J., Bouvier, C., Aubert, S., Guinebretière, J., Marie, B., Larousserie, F., Entz‐Werlé, N., Pinieux, G. D. B. D., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1331193 · Cited by 180

Tumor immune microenvironment in head and neck cancers

Chen, S. M. Y., Krinsky, A. L., Woolaver, R. A., Wang, X., Chen, Z., & Wang, J. H. (2020) · Molecular Carcinogenesis · doi:10.1002/mc.23162 · Cited by 184

Attributes of alternatively activated (M2) macrophages

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The M1 and M2 paradigm of macrophage activation: Time for reassessment

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Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways

Zhou, D., Huang, C., Lin, Z., Zhan, S., Kong, L., Fang, C., & Li, J. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2013.11.004 · Cited by 778

Macrophage Activation: Glancing into Diversity

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