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Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms
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The alternatively activated or M2 macrophages are immune cells with high phenotypic heterogeneity and are governing functions at the interface of immunity, tissue homeostasis, metabolism, and endocrine signaling. Today the M2 macrophages are identified based on the expression pattern of a set of M2 markers. These markers are transmembrane glycoproteins, scavenger receptors, enzymes, growth factors, hormones, cytokines, and cytokine receptors with diverse and often yet unexplored functions. This review discusses whether these M2 markers can be reliably used to identify M2 macrophages and define their functional subdivisions. Also, it provides an update on the novel signals of the tissue environment and the neuroendocrine system which shape the M2 activation. The possible evolutionary roots of the M2 macrophage functions are also discussed.
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“In turn, the appearance of anti-inflammatory cytokines, such as IL-10, IL-4 or IL-13, promotes the M2 phenotype, which is coordinated by the STAT-6 transcription factor [192,193,194].”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [193]
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Cites
The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function
Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481
Macrophage activation and polarization: nomenclature and experimental guidelines
Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337
Macrophage plasticity and polarization: in vivo veritas
Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335
MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528
The M1 and M2 paradigm of macrophage activation: Time for reassessment
Martinez, F. O., & Gordon, S. (2014) · F1000Prime Reports · doi:10.12703/p6-13 · Cited by 4,689
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578
What we talk about when we talk about fat
Rosen, E. D., & Spiegelman, B. M. (2014) · Cell · doi:10.1016/j.cell.2013.12.012 · Cited by 2,373
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
Gomez Perdiguero, E., Klapproth, K., Schulz, C., Busch, K., Azzoni, E., Crozet, L., Garner, H., Trouillet, C., de Bruijn, M. F., Geissmann, F., et al. (2015) · Nature · doi:10.1038/nature13989 · Cited by 2,339 · cited 1×
“However, it is shown that the resident tissue macrophages have heterogeneous progeny [187, 188].”
BackgroundThe cellular and signaling networks linking the immune system and metabolism in disease
Osborn, O., & Olefsky, J. M. (2012) · Nature Medicine · doi:10.1038/nm.2627 · Cited by 1,551
Epelman, S., Lavine, K. J., Beaudin, A. E., Sojka, D. K., Carrero, J. A., Calderon, B., Brija, T., Gautier, E. L., Ivanov, S., Satpathy, A. T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.11.019 · Cited by 1,494
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Items 501–600 of 1,002
Liu, Y., Xue, M., Han, Y., Li, Y., Xiao, B., Wang, W., Yu, J., & Ye, X. (2023) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10500 · Cited by 38
Immunoregulatory role of platelet derivatives in the macrophage-mediated immune response
Anitua, E., Troya, M., & Alkhraisat, M. H. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1399130 · Cited by 40
Brain incoming call from glia during neuroinflammation: Roles of extracellular vesicles
D’Egidio, F., Castelli, V., d’Angelo, M., Ammannito, F., Quintiliani, M., & Cimini, A. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106663 · Cited by 41
Choi, H., Bae, S., Choi, G., Lee, H., Son, T., Kim, J. S., An, S., Lee, H. S., Seo, J. H., Kwon, H., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201902753r · Cited by 38
Kim, Y., Oreffo, R. O. C., & Dawson, J. I. (2022) · Bone · doi:10.1016/j.bone.2022.116389 · Cited by 38
Venugopal, D., Vishwakarma, S., Kaur, I., & Samavedi, S. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.06.004 · Cited by 38
Essential Minerals and Metabolic Adaptation of Immune Cells
Alghamdi, M. A., Gutierrez, J., & Komarnytsky, S. (2022) · Nutrients · doi:10.3390/nu15010123 · Cited by 44
Li, C., Liu, C., Zhang, J., Lu, Y., Jiang, B., Xiong, H., & Li, C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1296687 · Cited by 42
Advances in the regulation of macrophage polarization by the tumor microenvironment
Peng, M., Zhu, Y., Hu, Y., Wen, J., & Huang, W. (2025) · Discover Oncology · doi:10.1007/s12672-025-03258-9 · Cited by 44
Redox-Sensitive Innate Immune Pathways During Macrophage Activation in Type 1 Diabetes
Burg, A. R., & Tse, H. M. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7243 · Cited by 40
Mohammadi, S., Jazi, M. S., Sedighi, S., & Memarian, A. (2017) · Clinical Rheumatology · doi:10.1007/s10067-017-3922-0 · Cited by 38
The phosphatase PPM1A controls monocyte-to-macrophage differentiation
Smith, S. R., Schaaf, K., Rajabalee, N., Wagner, F., Duverger, A. E., Kutsch, O., & Sun, J. (2018) · Scientific Reports · doi:10.1038/s41598-017-18832-7 · Cited by 37
Roles of Macrophage Subtypes in Bowel Anastomotic Healing and Anastomotic Leakage
Shi, J., Wu, Z., Li, Z., & Ji, J. (2018) · Journal of Immunology Research · doi:10.1155/2018/6827237 · Cited by 39
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2844-6 · Cited by 39
Lee, Y., & Lee, J. (2019) · Nutrients · doi:10.3390/nu11050975 · Cited by 38
MicroRNAs: As Critical Regulators of Tumor- Associated Macrophages
Chatterjee, B., Saha, P., Bose, S., Shukla, D., Chatterjee, N., Kumar, S., Tripathi, P. P., & Srivastava, A. K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197117 · Cited by 37
Zarrilli, G., Businello, G., Dieci, M. V., Paccagnella, S., Carraro, V., Cappellesso, R., Miglietta, F., Griguolo, G., Guarneri, V., Mele, M. L., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218102 · Cited by 38
Acharya, S., & Kim, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094299 · Cited by 40
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Lee, Y., Gupta, D. P., Park, S. H., Yang, H., & Song, G. J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.612981 · Cited by 37
Bianconi, A., Aruta, G., Rizzo, F., Salvati, L. F., Zeppa, P., Garbossa, D., & Cofano, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084166 · Cited by 38
Moncada, R., Wagner, F., Chiodin, M., Devlin, J. C., Baron, M., Hajdu, C. H., Simeone, D. M., & Yanai, I. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/254375 · Cited by 38
Yi, C., Wu, S., Duan, Q., Liu, L., Li, L., Luo, Y., & Wang, A. (2023) · PeerJ · doi:10.7717/peerj.15060 · Cited by 38
Ferroptosis: Biology and Role in Gastrointestinal Disease
Escuder‐Rodríguez, J.-J., Liang, D., Jiang, X., & Sinicrope, F. A. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.01.051 · Cited by 41
Targeting Macrophages: Therapeutic Approaches in Diabetic Kidney Disease
Lin, D.-W., Yang, T., Ho, C., Shih, Y., Lin, C., & Hsu, Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084350 · Cited by 40
WNT11 Promotes immune evasion and resistance to Anti-PD-1 therapy in liver metastasis
Jiang, W., Guan, B., Sun, H., Mi, Y., Cai, S., Wan, R., Li, X., Lian, P., Li, D., & Zhao, S. (2025) · Nature Communications · doi:10.1038/s41467-025-56714-z · Cited by 39
Therapeutic benefits of phosphodiesterase 4B inhibition after traumatic brain injury
Wilson, N. M., Gurney, M. E., Dietrich, W. D., & Atkins, C. M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178013 · Cited by 38
Ahmed, F. N., Ibrahim, A. M., Cooper, C., Kumar, A., & Crawley, A. M. (2019) · Cells · doi:10.3390/cells8040374 · Cited by 36
Monocyte Based Correlates of Immune Activation and Viremia in HIV-Infected Long-Term Non-Progressors
Prabhu, V. M., Singh, A. K., Padwal, V., Nagar, V. S., Patil, P., & Patel, V. V. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02849 · Cited by 37
Targeting macrophages: a novel avenue for cancer drug discovery
Kumar, S., Ramesh, A., & Kulkarni, A. A. (2020) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2020.1733525 · Cited by 37
Ehmedah, A., Nedeljković, P., Đačić, S., Repac, J., Drašković-Pavlović, B., Vučević, D., Peković, S., & Nedeljković, B. B. (2020) · Molecules · doi:10.3390/molecules25225426 · Cited by 37
Nanoparticles to Target and Treat Macrophages: The Ockham’s Concept?
Medrano-Bosch, M., Moreno-Lanceta, A., & Melgar‐Lesmes, P. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13091340 · Cited by 40
Adipose Tissue Immunometabolism and Apoptotic Cell Clearance
Rőszer, T. (2021) · Cells · doi:10.3390/cells10092288 · Cited by 41
Self-citationPalombo, R., Passacantilli, I., Terracciano, F., Capone, A., Matteocci, A., Tournier, S., Alberdi, A., Chiurchiù, V., Volpe, E., & Paronetto, M. P. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.216042 · Cited by 40
Zhang, H., Shan, W., Yang, Z., Zhang, Y., Wang, M., Gao, L., Zeng, L., Zhao, Q., & Liu, J. (2023) · Epigenetics · doi:10.1080/15592294.2023.2188667 · Cited by 37
Roles of differently polarized macrophages in the initiation and progressionof pancreatic cancer
Störz, P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1237711 · Cited by 36
Günalp, S., Helvaci, D. G., Oner, A., Bursalı, A., Conforte, A. J., Güner, H., Karakülah, G., Szegezdi, É., & Sağ, D. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1209249 · Cited by 38
Exploring the polarization of M1 and M2 macrophages in the context of skin diseases
Apeku, E., Tantuoyir, M. M., Zheng, R., & Tanye, N. (2024) · Molecular Biology Reports · doi:10.1007/s11033-023-09014-y · Cited by 36
Kouidhi, S., Noman, M. Z., Kiéda, C., Elgaaïed, A. B., & Chouaïb, S. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00114 · Cited by 39
Dubayee, M. S. A., Alayed, H., Almansour, R., Alqaoud, N., Alnamlah, R., Obeid, D., Alshahrani, A. S., Zhra, M., Nasr, A., Al-Bawab, A., et al. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00537 · Cited by 36
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Brady, R. V., & Thamm, D. H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1176807 · Cited by 35
Barbe, M. F., Harris, M. Y., Cruz, G. E., Amin, M., Billett, N. M., Dorotan, J. T., Day, E. P., Kim, S. Y., & Bove, G. M. (2021) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-021-04270-0 · Cited by 35
Miyamoto, T., Murphy, B., & Zhang, N. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1104694 · Cited by 35
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Whytock, K. L., Divoux, A., Sun, Y., Pino, M. F., Yu, G., Jin, C. A., Robino, J. J., Plekhanov, A., Varlamov, O., Smith, S. R., et al. (2024) · Aging Cell · doi:10.1111/acel.14287 · Cited by 39
Kang, M., Jia, H., Mei, F., Ren, H.-L., Gao, J., Liu, Y., Zhang, L., & Zhou, M.-S. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1467089 · Cited by 41
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Wang, H., Yiqiang, Z., Cai, J., & Guo, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1716041 · Cited by 38
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Kang, J.-H., Kim, J., Gim, J., & Lee, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262412056 · Cited by 39
Varela, P., Sartori, S., Viebahn, R., Salber, J., & Ciardelli, G. (2019) · Journal of Applied Biomaterials & Functional Materials · doi:10.1177/2280800019830355 · Cited by 35
Induction of Macrophage M2b/c Polarization by Adipose Tissue-Derived Mesenchymal Stem Cells
Sun, M., Sun, L., Huang, C., Chen, B., & Zhou, Z. (2019) · Journal of Immunology Research · doi:10.1155/2019/7059680 · Cited by 33
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Wang, Y., Zhao, C., Wang, R.-Y., Du, Q.-X., Liu, J., & Pan, J. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03199-y · Cited by 35
de Leve, S., Wirsdörfer, F., Cappuccini, F., Schütze, A., Meyer, A. V., Roeck, K., Thompson, L. F., Fischer, J. W., Stuschke, M., & Jendrossek, V. (2017) · The FASEB Journal · doi:10.1096/fj.201601228r · Cited by 38
Iacobini, C., Fantauzzi, C. B., Bedini, R., Pecci, R., Bartolazzi, A., Amadio, B., Pesce, C. M., Pugliese, G., & Menini, S. (2018) · Metabolism · doi:10.1016/j.metabol.2018.02.001 · Cited by 34
Li, L., Ni, L., Heary, R. F., & Elkabes, S. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01748-x · Cited by 34
Mitchell, M. I., Ma, J., Carter, C. L., & Loudig, O. D. (2022) · Cancers · doi:10.3390/cancers14143350 · Cited by 34
Xu, Z., Li, S., Wan, L., Hu, J., Lü, H., & Zhang, T. (2022) · Journal of Orthopaedic Research® · doi:10.1002/jor.25454 · Cited by 35
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Zaid, A. K. M. A., & Ariel, A. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115204 · Cited by 35
Chan, M. W. Y., & Viswanathan, S. (2019) · Cytotherapy · doi:10.1016/j.jcyt.2019.02.002 · Cited by 34
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Syed, S. N., Frank, A.-C., Raue, R., & Brüne, B. (2019) · Cells · doi:10.3390/cells8121482 · Cited by 37
Wang, B., Li, Q., Wang, J., Zhao, S., Nashun, B., Li, Q., & Chen, X. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00570-5 · Cited by 38
Al-Omar, M. S., Jabir, M. S., Karsh, E. H., Kadhim, R. J., Sulaiman, G. M., Taqi, Z. J., Khashan, K. S., Mohammed, H. A., Khan, R. A., & Mohammed, S. A. A. (2021) · Nanomaterials · doi:10.3390/nano11061382 · Cited by 34
Chang, B., Koo, B.-S., & Kim, S.-Y. (2021) · Foods · doi:10.3390/foods10081966 · Cited by 34
Chia, Z., Yang, L., Cheng, T.-Y., Chen, Y., Cheng, H.-L., Hsu, F., Wang, Y., Chen, Y., Huang, T., Fang, Y.-S., et al. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c13647 · Cited by 33
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Ou, L., Tan, X., Qiao, S., Wu, J., Su, Y., Xie, W., Jin, N., He, J., Luo, R., Lai, X., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c03857 · Cited by 36
Chen, H., Sévin, D. C., Griffith, G. R., Vappiani, J., Booty, L. M., van Roomen, C. P. A. A., Kuiper, J., den Dunnen, J., de Jonge, W. J., Prinjha, R. K., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114741 · Cited by 35
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Chaudhari, A. A., Kim, W. H., & Lillehoj, H. S. (2018) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2018.10.011 · Cited by 33
Yang, D. C. H., & Chen, C. (2018) · PubMed · Cited by 33
Epigenetic Regulation of Macrophage Marker Expression Profiles in Kawasaki Disease
Guo, M. M., Chang, L., Huang, Y., Wang, F., & Kuo, H. (2020) · Frontiers in Pediatrics · doi:10.3389/fped.2020.00129 · Cited by 33
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Su, B., Han, H., Gong, Y., Li, X., Ji, C., Yao, J., Yang, J., Hu, W., Zhao, W., Li, J., et al. (2020) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-020-02791-6 · Cited by 33
Badeaux, M. D., Rolig, A. S., Agnello, G., Enzler, D., Kasiewicz, M. J., Priddy, L., Wiggins, J. F., Muir, A., Sullivan, M. R., Cleef, J. V., et al. (2021) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-20-0317 · Cited by 35
Ko, W.-C. C., Li, L., Young, T., McLean-Mandell, R., DENG, A. C., Vanguri, V. K., Dresser, K., & Harris, J. E. (2021) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2021.04.030 · Cited by 33
Thomann, S., Weiler, S. M. E., Wei, T., Sticht, C., Torre, C. D. L., Tóth, M., Rose, F., Tang, Y., Ritz, T., Ball, C. R., et al. (2021) · Liver International · doi:10.1111/liv.15048 · Cited by 35
Bahiraii, S., Brenner, M., Yan, F., Weckwerth, W., & Heiß, E. H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.935692 · Cited by 33
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Rao, D., Huang, D., Si, M.-Y., Lu, H., Tang, Z., & Zhang, Z. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1142539 · Cited by 33
Bucher, C. H., Berkmann, J. C., Burkhardt, L.-M., Paschke, C., Schlundt, C., Lang, A., Wolter, A., Damerau, A., Geißler, S., Volk, H., et al. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00834-9 · Cited by 36
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Álvarez, B., Revilla, C., Poderoso, T., Ezquerra, Á., & Domínguez, J. (2023) · Cells · doi:10.3390/cells12162103 · Cited by 35
Hussain, Z., Bertran, T., Finetti, P., Lohmann, E., Mamessier, É., Bidaut, G., Bertucci, F., Rêgo, M. J. B. D. M., & Tomasini, R. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01388-7 · Cited by 32
Zhang, J., Sun, D., Liao, Y., Cao, B., Gao, R., Zeng, Z., Zheng, C., Wei, Y., & Guo, X. (2024) · Biomaterials Research · doi:10.34133/bmr.0029 · Cited by 32
Xu, W., Huang, W., Cai, X., Dang, Z., Hao, L., & Wang, L. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c06661 · Cited by 32
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Kovaleva, O. V., Rashidova, M. A., Sinyov, V. V., Malashenko, O. S., & Gratchev, A. N. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1638102 · Cited by 33
Liu, R., Shen, Y., Wei, Y. J., Zhu, C., Yao, X., Gu, X., Qi, L., & Sun, H. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118025 · Cited by 37
Merz, C., Sykora, J., Marschall, V., Richards, D. M., Heinonen, K., Müller, M. R., Thiemann, M., Schnyder, T., Fricke, H., Hill, O., et al. (2018) · Journal of Immunotherapy · doi:10.1097/cji.0000000000000246 · Cited by 32
Eosinophil Activation by Toll-Like Receptor 4 Ligands Regulates Macrophage Polarization
Yoon, J.-Y., Um, H.-N., Jang, J., Bae, Y., Park, W., Kim, H. J., Yoon, M., Chung, I. Y., & Jung, Y. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00329 · Cited by 32
Messex, J. K., Byrd, C. J., Thomas, M. U., & Liou, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084247 · Cited by 36
Macrophage polarization and acceleration of atherosclerotic plaques in a swine model
Lee, S.-G., Oh, J., Bong, S.-K., Kim, J., Park, S., Kim, S. H., Park, S., Lee, S., & Jang, Y. (2018) · PLoS ONE · doi:10.1371/journal.pone.0193005 · Cited by 33
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Metadata
- Authors
- Rőszer, T.
- Affiliations
- Universität Ulm (DE)
- Corresponding author
- Rőszer, Tamás
- ORCID
- Rőszer, Tamás
- Venue
- Mediators of Inflammation
- Publisher
- Wiley
- Published
- 2015-01
- Volume
- 2015
- Issue
- 1
- Pages
- 816460-816460
- ISSN
- 0962-9351 (ISSN-L)
- 1466-1861
- PMC
- PMC4452191
- OpenAlex
- W1518095394
- Cited by
- 1,762
- References
- 209
- Citations by year
- 2026: 105 · 2025: 169 · 2024: 198 · 2023: 189 · 2022: 214 · 2021: 215 · 2020: 203 · 2019: 150 · 2018: 143 · 2017: 109 · 2016: 58 · 2015: 9
- FWCI
- 10.01
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Mediators of Inflammation (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Universität Ulm
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- M2 macrophages, scavenger receptors, tissue microenvironment, tissue homeostasis, hormone signaling
- MeSH terms
- Humans, Macrophage Activation, Macrophages, Neurosecretory Systems
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