The Human Gut Microbiome and Body Metabolism: Implications for Obesity and Diabetes
Open accessAbstract
BACKGROUND: Obesity, metabolic syndrome, and type 2 diabetes are major public health challenges. Recently, interest has surged regarding the possible role of the intestinal microbiota as potential novel contributors to the increased prevalence of these 3 disorders. CONTENT: Recent advances in microbial DNA sequencing technologies have resulted in the widespread application of whole-genome sequencing technologies for metagenomic DNA analysis of complex ecosystems such as the human gut. Current evidence suggests that the gut microbiota affect nutrient acquisition, energy harvest, and a myriad of host metabolic pathways. CONCLUSION: Advances in the Human Microbiome Project and human metagenomics research will lead the way toward a greater understanding of the importance and role of the gut microbiome in metabolic disorders such as obesity, metabolic syndrome, and diabetes.
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Commensal gut microbiota play an important role in regulating metabolic and inflammatory conditions.
“Commensal gut microbiota play an important role in regulating metabolic and inflammatory conditions.”
From Using Corticosteroids to Reshape the Gut Microbiome: Implications for Inflammatory Bowel Diseases (2015) · cites this paper as [2]
Gut microbiota can cause or contribute to a variety of metabolic, inflammatory, and immunologic diseases.
“On the other hand, gut microbiota can also cause or contribute to a variety of metabolic, inflammatory, and immunologic diseases.2–4”
From Using Corticosteroids to Reshape the Gut Microbiome: Implications for Inflammatory Bowel Diseases (2015) · cites this paper as [2]
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Wu, T., Yang, L., Jiang, J., Ni, Y., Zhu, J., Zheng, X., Wang, Q., Lu, X., & Fu, Z. (2018) · Life Sciences · doi:10.1016/j.lfs.2017.11.049 · Cited by 126 · see citing works
Lee, J., Yang, W., Hostetler, A., Schultz, N., Suckow, M. A., Stewart, K. L., Kim, D. D., & Kim, H. S. (2016) · BMC Microbiology · doi:10.1186/s12866-016-0686-7 · Cited by 107 · see citing works
Protective Effects of Ghrelin on Fasting-Induced Muscle Atrophy in Aging Mice
Wu, C.-S., Wei, Q., Wang, H., Kim, D. M., Balderas, M., Wu, G., Lawler, J., Safe, S., Guo, S., Devaraj, S., et al. (2020) · The Journals of Gerontology: Series A · doi:10.1093/gerona/gly256 · Cited by 81 · see citing works
Self-citationPhytochemistry, Ethnomedicine, and Pharmacology of Acacia
(2018) · Studies in Natural Products Chemistry · doi:10.1016/b978-0-444-64057-4.00009-0 · Cited by 52 · see citing works
Mindikoglu, A. L., Opekun, A. R., Gagan, S. K., & Devaraj, S. (2017) · Gastroenterology Research and Practice · doi:10.1155/2017/3932491 · Cited by 49 · see citing works
Self-citation
- Authors
- Devaraj, S., Hemarajata, P., & Versalovic, J.
- Affiliations
- Baylor College of Medicine (US)
- Corresponding author
- Versalovic, James
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-04-01
- Volume
- 59
- Issue
- 4
- Pages
- 617-628
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- PMC
- PMC3974587
- OpenAlex
- W2102453940
- Cited by
- 321
- References
- 79
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 19 · 2023: 24 · 2022: 28 · 2021: 28 · 2020: 20 · 2019: 36 · 2018: 36 · 2017: 38 · 2016: 16 · 2015: 28 · 2014: 16 · 2013: 13
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Clinical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK56338-06A2, R01DK065075, UH3DK083990, P30DK056338)
- National Center for Complementary and Integrative Health (R01AT004326)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- gut microbiota, obesity, type 2 diabetes, metabolic syndrome, host metabolism, energy harvesting, nutrient acquisition, metagenomics, Human Microbiome Project
- MeSH terms
- Amino Acids, Animals, Diabetes Mellitus, Humans, Intestinal Mucosa, Intestines, Obesity, Carbohydrate Metabolism, Metagenome
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