Cited by 48Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyStress Responses and Cortisol

Distribution of Corticotropin-Releasing Factor and Urocortin 1 in the Vole Brain

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Lim, Miranda M., Tsivkovskaia, Natalia O., Bai, Yaohui, Young, Larry J., Ryabinin, Andrey E.·2006·Brain, Behavior and Evolution

Abstract

Brain receptor patterns for the corticotropin-releasing factor (CRF) receptors, CRF1 and CRF2, are dramatically different between monogamous and promiscuous vole species, and CRF physiologically regulates pair bonding behavior in the monogamous prairie vole. However, it is uncertain whether species differences also exist in the neuroanatomical distribution of the endogenous ligands for the CRF1 and CRF2 receptors, such as CRF and urocortin-1 (Ucn1). We compared the expression of CRF and Ucn1 in four vole species, monogamous prairie and pine voles, and promiscuous meadow and montane voles, using in situ hybridization of CRF and Ucn1 mRNA. Our results reveal that CRF mRNA expression patterns in all four vole species appear highly conserved throughout the brain, including the olfactory bulb, nucleus accumbens, bed nucleus of the stria terminalis, medial preoptic area, central amygdala, hippocampus, posterior thalamus, and cerebellum. Similarly, Ucn1 mRNA primarily localized to the Edinger-Westphal nucleus in all four vole species. Immunocytochemistry in prairie and meadow voles confirmed localization of CRF and Ucn1 protein to these previously identified brain regions. These data demonstrate a striking dichotomy between the extraordinary species diversity of brain receptor patterns when compared to the highly conserved brain distributions of their respective ligands. Our findings generate novel hypotheses regarding the evolutionary mechanisms underlying the neural circuitry of species-typical social behaviors.

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  • Monogamous and non-monogamous vole species differ greatly in brain distribution of CRF-R1 and CRF-R2, while CRF peptide distribution is highly conserved.

    “Monogamous and non-monogamous species of voles differ greatly in the distribution of CRF-R1 and CRF-R2 in the brain, even while the distribution of CRF peptide is highly conserved (Lim et al 2005; Lim et al 2006).”

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Research works printed but not linked: 3

  1. Bittencourt JC, Vaughan J, Arias C, Rissman RA, Vale WW, Sawchenko PE. Urocortin expression in rat brain: evidence against a pervasive relationship of urocortin-containing projections with targets bearing type 2 CRF receptors. J Comp Neurol. 1999;415:285–312. [PubMed] [Google Scholar]
  2. Hammock EAD, Lim MM, Nair HP, Young LJ (2005) Vasopressin V1a receptor levels are associated with a regulatory microsatellite and behavior. Genes Brain Behav (in press). [DOI] [PubMed]
  3. Vertes RP, Fortin WJ, Crane AM. Projections of the median raphe nucleus in the rat. J Comp Neurol. 1999;407:555–582. [PubMed] [Google Scholar]

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Authors
Lim, M. M., Tsivkovskaia, N. O., Bai, Y., Young, L. J., & Ryabinin, A. E.
Affiliations
  • Emory University (US)
  • Oregon Health & Science University (US)
Venue
Brain, Behavior and Evolution
Publisher
S. Karger AG
Published
2006
Volume
68
Issue
4
Pages
229-240
ISSN
  • 0006-8977 (ISSN-L)
  • 1421-9743
OpenAlex
W2061262656
Cited by
48
References
49
Citations by year
2026: 1 · 2025: 1 · 2023: 3 · 2022: 1 · 2021: 6 · 2020: 3 · 2019: 2 · 2017: 4 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 2
FWCI
3.45
Type
journal article
Language
en
Open access
Locations
  • Brain Behavior and Evolution (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Science Foundation
  • North Carolina State University
  • National Institute on Alcohol Abuse and Alcoholism (R01AA013738, AA013738)
  • National Institute of Mental Health (F30MH065050, MH65050)
  • National Center for Research Resources (RR-00 165, P51RR000165)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
corticotropin-releasing factor, urocortin 1, CRF1 receptor, CRF2 receptor, voles, Microtus ochrogaster, Microtus pennsylvanicus, montane vole, pine vole, monogamy, pair bonding, evolution of social behavior, brain receptor distribution, Edinger-Westphal nucleus
MeSH terms
Animals, Autoradiography, Binding Sites, Brain, Corticotropin-Releasing Hormone, Arvicolinae, Female, Immunohistochemistry, Male, Nucleus Accumbens, Raphe Nuclei, In Situ Hybridization, Urocortins

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