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Cited by 336Neuroendocrine regulation and behaviorStress Responses and CortisolNeuropeptides and Animal Physiology

Social isolation induces behavioral and neuroendocrine disturbances relevant to depression in female and male prairie voles

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Grippo, Angela J., Gerena, Davida, Huang, Jonathan, Kumar, Narmda, Shah, Maulin, Ughreja, Raj, Sue Carter, C.·2007·Psychoneuroendocrinology
DOI 10.1016/j.psyneuen.2007.07.004PMC PMC2174914
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Abstract

Supportive social interactions may be protective against stressors and certain mental and physical illness, while social isolation may be a powerful stressor. Prairie voles are socially monogamous rodents that model some of the behavioral and physiological traits displayed by humans, including sensitivity to social isolation. Neuroendocrine and behavioral parameters, selected for their relevance to stress and depression, were measured in adult female and male prairie voles following 4 weeks of social isolation versus paired housing. In Experiment 1, oxytocin-immunoreactive cell density was higher in the hypothalamic paraventricular nucleus (PVN) and plasma oxytocin was elevated in isolated females, but not in males. In Experiment 2, sucrose intake, used as an operational definition of hedonia, was reduced in both sexes following 4 weeks of isolation. Animals then received a resident-intruder test, and were sacrificed either 10 min later for the analysis of circulating hormones and peptides, or 2h later to examine neural activation, indexed by c-Fos expression in PVN cells immunoreactive for oxytocin or corticotropin-releasing factor (CRF). Compared to paired animals, plasma oxytocin, ACTH and corticosterone were elevated in isolated females and plasma oxytocin was elevated in isolated males, following the resident-intruder test. The proportion of cells double-labeled for c-Fos and oxytocin or c-Fos and CRF was elevated in isolated females, and the proportion of cells double-labeled for c-Fos and oxytocin was elevated in isolated males following this test. These findings suggest that social isolation induces behavioral and neuroendocrine responses relevant to depression in male and female prairie voles, although neuroendocrine responses in females may be especially sensitive to isolation.

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  • Social isolation through partner separation precipitates anxiety and depression-like behaviors in monogamous voles, which could be prevented by repeated subcutaneous injection of oxytocin.

    “For example, social isolation through partner separation precipitates anxiety and depression-like behaviors in monogamous voles (25), which could be prevented by repeated subcutaneous injection of OXT (26).”

    From Dissecting the Role of Oxytocin in the Formation and Loss of Social Relationships (2016) · cites this paper as [25]

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  1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. fourth. Washington, DC: American Psychiatric Association; 2000. text revision. [Google Scholar]
  2. Anisman H, Zacharko RM. Depression as a consequence of inadequate neurochemical adaptation in response to stressors. Br J Psychiatry. 1992;160 15:36–43. [PubMed] [Google Scholar]
  3. Asnis GM, Halbreich U, Ryan ND, Rabinowicz H, Puig-Antich J, Nelson B, Novacenko H, Friedman JH. The relationship of the dexamethasone suppression test (1 mg and 2 mg) to basal plasma cortisol levels in endogenous depression. Psychoneuroendocrinology. 1987;12:295–301. doi: 10.1016/0306-4530(87)90054-0. [DOI] [PubMed] [Google Scholar] · DOI
  4. Azpíroz A, Fano E, Garmendia L, Arregi A, Cacho R, Beitia G, Brain PF. Effects of chronic mild stress (CMS) and imipramine administration, on spleen mononuclear cell proliferation response, serum corticosterone level and brain norepinephrine content in male mice. Psychoneuroendocrinology. 1999;24:345–361. doi: 10.1016/s0306-4530(98)00084-5. [DOI] [PubMed] [Google Scholar] · DOI
  5. Banki CM, Karmacsi L, Bissette G, Nemeroff CB. CSF corticotropin-releasing hormone and somatostatin in major depression: response to antidepressant treatment and relapse. Eur Neuropsychopharmacol. 1992;2:107–113. doi: 10.1016/0924-977x(92)90019-5. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  6. Beck KD, Luine VN. Sex differences in behavioral and neurochemical profiles after chronic stress: role of housing conditions. Physiol Behav. 2002;75:661–673. doi: 10.1016/s0031-9384(02)00670-4. [DOI] [PubMed] [Google Scholar] · DOI
  7. Bosch OJ, Krömer SA, Brunton PJ, Neumann ID. Release of oxytocin in the hypothalamic paraventricular nucleus, but not central amygdala or lateral septum in lactating residents and virgin intruders during maternal defence. Neuroscience. 2004;124:439–448. doi: 10.1016/j.neuroscience.2003.11.028. [DOI] [PubMed] [Google Scholar] · DOI
  8. Carter CS, Altemus M. Oxytocin, vasopressin and depression. In: den Boer JA, George MS, Ter Horst GJ, editors. Current and future developments in psychopharmacology. Amsterdam: Benecke N.I.; 2005. pp. 201–216. [Google Scholar]
  9. Carter CS, Keverne EB. The neurobiology of social affiliation and pair bonding. Horm Brain Behav. 2002;1:299–337. [Google Scholar]
  10. Carter CS, Witt DM, Schneider J, Harris ZL, Volkening D. Male stimuli are necessary for female sexual behavior and uterine growth in prairie voles (Microtus ochrogaster) Horm Behav. 1987;21:74–82. doi: 10.1016/0018-506x(87)90032-8. [DOI] [PubMed] [Google Scholar] · DOI
  11. Cho MM, DeVries AC, Williams JR, Carter CS. The effects of oxytocin and vasopressin on partner preferences in male and female prairie voles (Microtus ochrogaster) Behav Neurosci. 1999;113:1071–1080. doi: 10.1037//0735-7044.113.5.1071. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  12. Cushing BS, Klein D, Hoffman GE, Carter CS, Le WW, De Vries GJ. Comparison of fixation techniques: immersion versus perfusion. Horm Behav. 2001;39:329. [Google Scholar]
  13. Dalla C, Antoniou K, Drossopoulou G, Xagoraris M, Kokras N, Sfikakis A, Papadopoulou-Daifoti Z. Chronic mild stress impact: are females more vulnerable? Neuroscience. 2005;135:703–714. doi: 10.1016/j.neuroscience.2005.06.068. [DOI] [PubMed] [Google Scholar] · DOI
  14. DeVries GJ, Simerly RB. Anatomy, development and functions of sexually dimorphic neural circuits in the mammalian brain. In: Arnold AP, Etgen AM, Fharbach SE, Rubin RT, Pfaff D, editors. Hormones, brain and behavior. IV. San Diego: Academic Press; 2002. pp. 137–192. [Google Scholar]
  15. Ehlers CL, Kaneko WM, Owens MJ, Nemeroff CB. Effects of gender and social isolation on electroencephalogram and neuroendocrine parameters in rats. Biol Psychiatry. 1993;33:358–366. doi: 10.1016/0006-3223(93)90325-8. [DOI] [PubMed] [Google Scholar] · DOI
  16. Fowler CD, Liu Y, Ouimet C, Wang Z. The effects of social environment on adult neurogenesis in the female prairie vole. J Neurobiol. 2002;51:115–128. doi: 10.1002/neu.10042. [DOI] [PubMed] [Google Scholar] · DOI
  17. Froger N, Palazzo E, Boni C, Hanoun N, Saurini F, Joubert C, Dutriez-Casteloot I, Enache M, Maccari S, Barden N, Cohen-Salmon C, Hamon M, Lanfumey L. Neurochemical and behavioral alterations in glucocorticoid receptor-impaired transgenic mice after chronic mild stress. J Neurosci. 2004;24:2787–2796. doi: 10.1523/JNEUROSCI.4132-03.2004. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  18. Galea LAM, McEwen BS, Tanapat P, Deak T, Spencer RL, Dhabhar FS. Sex differences in dendritic atrophy of CA3 pyramidal neurons in response to chronic restraint stress. Neuroscience. 1997;81:689–697. doi: 10.1016/s0306-4522(97)00233-9. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  19. Garlow SJ, Nemeroff CB. The neurochemistry of mood disorders: clinical studies. In: Charney DS, Nestler EJ, editors. Neurobiology of mental illness. 2nd. New York: Oxford University Press; 2004. pp. 440–460. [Google Scholar]
  20. Getz LL, Carter CS. Prairie-vole partnerships. Am Scientist. 1996;84:56–62. [Google Scholar]
  21. Glowa JR, Gold PW. Corticotropin releasing hormone produces profound anorexigenic effects in the rhesus monkey. Neuropeptides. 1991;18:55–61. doi: 10.1016/0143-4179(91)90164-e. [DOI] [PubMed] [Google Scholar] · DOI
  22. Grippo AJ, Beltz TG, Johnson AK. Behavioral and cardiovascular changes in the chronic mild stress model of depression. Physiol Behav. 2003;78:703–710. doi: 10.1016/s0031-9384(03)00050-7. [DOI] [PubMed] [Google Scholar] · DOI
  23. Grippo AJ, Beltz TG, Weiss RM, Johnson AK. The effects of chronic fluoxetine treatment on chronic mild stress-induced cardiovascular changes and anhedonia. Biol Psychiatry. 2006;59:309–316. doi: 10.1016/j.biopsych.2005.07.010. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  24. Grippo AJ, Cushing BS, Carter CS. Depression-like behavior and stressor-induced neuroendocrine activation in female prairie voles exposed to chronic social isolation. Psychosom Med. 2007;69:149–157. doi: 10.1097/PSY.0b013e31802f054b. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI · Paper page
  25. Grippo AJ, Francis J, Beltz TG, Felder RB, Johnson AK. Neuroendocrine and cytokine profile of chronic mild stress-induced anhedonia. Physiol Behav. 2005a;84:697–706. doi: 10.1016/j.physbeh.2005.02.011. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  26. Grippo AJ, Moffitt JA, Johnson AK. Cardiovascular alterations and autonomic imbalance in an experimental model of depression. Am J Physiol Regul Integr Comp Physiol. 2002;282:R1333–R1341. doi: 10.1152/ajpregu.00614.2001. [DOI] [PubMed] [Google Scholar] · DOI
  27. Grippo AJ, Sullivan NR, Damjanoska KJ, Crane JW, Carrasco GA, Shi J, Chen Z, Garcia F, Muma NA, van de Kar LD. Chronic mild stress induces behavioral and physiological changes and may alter serotonin 1A receptor function in male and cycling female rats. Psychopharmacology. 2005b;179:769–780. doi: 10.1007/s00213-004-2103-4. [DOI] [PubMed] [Google Scholar] · DOI
  28. Heinrichs M, Baumgartner T, Kirschbaum C, Ehlert U. Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biol Psychiatry. 2003;54:1389–1398. doi: 10.1016/s0006-3223(03)00465-7. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  29. Heinrichs SC, Menzaghi F, Pich EM, Britton KT, Koob GF. The role of CRF in behavioral aspects of stress. Ann NY Acad Sci. 1995;771:92–104. doi: 10.1111/j.1749-6632.1995.tb44673.x. [DOI] [PubMed] [Google Scholar] · DOI
  30. Insel TR, Young LJ. The neurobiology of attachment. Nat Rev Neurosci. 2001;2:129–136. doi: 10.1038/35053579. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  31. Keller MB, Klein DN, Hirschfeld RM, Kocsis JH, McCullough JP, Miller I, First MB, Holzer CP, Keitner GI, Marin DB, et al. Results of the DSM-IV mood disorder field trial. Am J Psychiatry. 1995;152:843–849. doi: 10.1176/ajp.152.6.843. [DOI] [PubMed] [Google Scholar] · DOI
  32. Kennett GA, Chaouloff F, Marcou M, Curzon G. Female rats are more vulnerable than males in an animal model of depression: the possible role of serotonin. Brain Res. 1986;382:416–421. doi: 10.1016/0006-8993(86)91355-7. [DOI] [PubMed] [Google Scholar] · DOI
  33. Kiecolt-Glaser JK, Newton TL. Marriage and health: his and hers. Psychol Bull. 2001;127:472–503. doi: 10.1037/0033-2909.127.4.472. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  34. Kim JW, Kirkpatrick B. Social isolation in animal models of relevance to neuropsychiatric disorders. Biol Psychiatry. 1996;40:918–922. doi: 10.1016/0006-3223(95)00546-3. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  35. Kramer KM, Cushing BS, Carter CS, Wu J, Ottinger MA. Sex and species differences in plasma oxytocin using an enzyme immunoassay. Can J Zool. 2004;82:1194–1200. [Google Scholar]
  36. Legros JJ, Chiodera P, Geenen V, von Frenckell R. Confirmation of the inhibitory influence of exogenous oxytocin in cortisol and ACTH in man: evidence of reproducibility. Acta Endocrinol. 1987;114:345–349. doi: 10.1530/acta.0.1140345. [DOI] [PubMed] [Google Scholar] · DOI
  37. Li Q, Brownfield MS, Battaglia G, Cabrera TM, Levy AD, Rittenhouse PA, van de Kar LD. Long-term treatment with the antidepressants fluoxetine and desipramine potentiates endocrine responses to the serotonin agonist 6-chloro-2-[1-piperazinyl]-pyrazine (MK-212) and (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HCL (DOI) J Pharmacol Exp Ther. 1993;266:836–844. [PubMed] [Google Scholar]
  38. Light KC, Grewen KM, Amico JA, Boccia M, Brownley KA, Johns JM. Deficits in plasma oxytocin responses and increased negative affect, stress, and blood pressure in mothers with cocaine exposure during pregnancy. Addict Behav. 2004;29:1541–1564. doi: 10.1016/j.addbeh.2004.02.062. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI
  39. Liu Y, Curtis JT, Fowler CD, Spencer C, Houpt T, Wang ZX. Differential expression of vasopressin, oxytocin and corticotrophin-releasing hormone messenger RNA in the paraventricular nucleus of the prairie vole brain following stress. J Neuroendocrinol. 2001;13:1059–1065. doi: 10.1046/j.1365-2826.2001.00729.x. [DOI] [PubMed] [Google Scholar] · DOI
  40. Maier SF, Watkins LR. Stressor controllability and learned helplessness: the roles of the dorsal raphe nucleus, serotonin, and corticotropin-releasing factor. Neurosci Biobehav Rev. 2005;29:829–841. doi: 10.1016/j.neubiorev.2005.03.021. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  41. Mantella RC, Vollmer RR, Rinaman L, Li X, Amico JA. Enhanced corticosterone concentrations and attenuated Fos expression in the medial amygdala of female oxytocin knockout mice exposed to psychogenic stress. Am J Physiol Regul Integr Comp Physiol. 2004;287:R1495–R1504. doi: 10.1152/ajpregu.00387.2004. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  42. McCarthy MM, Altemus M. Central nervous system actions of oxytocin and modulation of behavior in humans. Mol Med Today. 1997;3:269–275. doi: 10.1016/S1357-4310(97)01058-7. [DOI] [PubMed] [Google Scholar] · DOI
  43. McCormick CM, Robarts D, Kopeikina K, Kelsey JE. Long-lasting, sex- and age-specific effects of social stressors on corticosterone responses to restraint and on locomotor responses to psychostimulants in rats. Horm Behav. 2005;48:64–74. doi: 10.1016/j.yhbeh.2005.01.008. [DOI] [PubMed] [Google Scholar] · DOI
  44. Michelini LC, Marcelo MC, Amico J, Morris M. Oxytocinergic regulation of cardiovascular function: studies in oxytocin-deficient mice. Am J Physiol Heart Circ Physiol. 2003;284:H2269–H2276. doi: 10.1152/ajpheart.00774.2002. [DOI] [PubMed] [Google Scholar] · DOI
  45. Mitchell PJ, Fairhall SJ, Fletcher A, Redfern PH. Effects of single and repeated electroconvulsive shock on the social and agonistic behaviour of resident rats. Neuropharmacology. 2003;44:911–925. doi: 10.1016/s0028-3908(03)00075-3. [DOI] [PubMed] [Google Scholar] · DOI
  46. Neumann ID. Involvement of the brain oxytocin system in stress coping: interactions with the hypothamo-pituitary-adrenal axis. Prog Brain Res. 2002;139:147–162. doi: 10.1016/s0079-6123(02)39014-9. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  47. Neumann ID, Krömer SA, Toschi N, Ebner K. Brain oxytocin inhibits the (re)activity of the hypothalamo-pituitary-adrenal axis in male rats: involvement of hypothalamic and limbic brain regions. Regul Pept. 2000;96:31–38. doi: 10.1016/s0167-0115(00)00197-x. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  48. Nishioka T, Anselmo-Franci JA, Li P, Callahan MF, Morris M. Stress increases oxytocin release within the hypothalamic paraventricular nucleus. Brain Res. 1998;781:57–61. doi: 10.1016/s0006-8993(97)01159-1. [DOI] [PubMed] [Google Scholar] · DOI
  49. Nomura M, Saito J, Ueta Y, Muglia LJ, Pfaff DW, Ogawa S. Enhanced up-regulation of corticotropin-releasing hormone gene expression in response to restraint stress in the hypothalamic paraventricular nucleus of oxytocin gene-deficient male mice. J Neuroendocrinol. 2003;15:1054–1061. doi: 10.1046/j.1365-2826.2003.01095.x. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  50. Palanza P. Animal models of anxiety and depression; how are females different? Neurosci Biobehav Rev. 2001;25:219–233. doi: 10.1016/s0149-7634(01)00010-0. [DOI] [PubMed] [Google Scholar] · DOI
  51. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. 5th. New York: Elsevier; 2005. [DOI] [PubMed] [Google Scholar]
  52. Ploog DW. The place of the Triune Brain in psychiatry. Physiol Behav. 2003;79:487–493. doi: 10.1016/s0031-9384(03)00154-9. [DOI] [PubMed] [Google Scholar] · DOI
  53. Plotsky PM, Thrivikraman KV, Nemeroff CB, Caldji C, Sharma S, Meaney MJ. Long-term consequences of neonatal rearing on central corticotropin-releasing factor systems in adult male rat offspring. Neuropsychopharmacology. 2005;30:2192–2204. doi: 10.1038/sj.npp.1300769. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  54. Post RM. Transduction of psychosocial stress into the neurobiology of recurrent affective disorder. Am J Psychiatry. 1992;149:999–1010. doi: 10.1176/ajp.149.8.999. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  55. Raadsheer FC, van Heerikhuize JJ, Lucassen PJ, Hoogendijk WJG, Tilders FJH, Swaab DF. Corticotropin-releasing hormone mRNA levels in the paraventricular nucleus of patients with Alzheimer's disease and depression. Am J Psychiatry. 1995;152:1372–1376. doi: 10.1176/ajp.152.9.1372. [DOI] [PubMed] [Google Scholar] · DOI
  56. Sánchez MM, Aguado F, Sánchez-Toscano F, Saphier D. Neuroendocrine and immunocytochemical demonstrations of decreased hypothalamo-pituitary-adrenal axis responsiveness to restraint stress after long-term social isolation. Endocrinology. 1998;139:579–587. doi: 10.1210/endo.139.2.5720. [DOI] [PubMed] [Google Scholar] · DOI
  57. Sullivan Hanley NR, Van de Kar LD. Serotonin and the neuroendocrine regulation of the hypothalamic-pituitary-adrenal axis in health and disease. Vitam Horm. 2003;66:189–255. doi: 10.1016/s0083-6729(03)01006-9. [DOI] [PubMed] [Google Scholar] · DOI
  58. Tafet GE, Bernardini R. Psychoneuroendocrinological links between chronic stress and depression Prog Neuropsychopharmacol. Biol Psychiatry. 2003;27:893–903. doi: 10.1016/S0278-5846(03)00162-3. [DOI] [PubMed] [Google Scholar] · DOI
  59. Takayanagi Y, Yoshida M, Bielsky IF, Ross HE, Kawamata M, Onaka T, Yanagisawa T, Kimura T, Matzuk MM, Young LJ, Nishimori K. Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice. Proc Natl Acad Sci. 2005;102:16096–16101. doi: 10.1073/pnas.0505312102. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI · Paper page
  60. Taylor SE, Gonzaga GC, Klein LC, Hu P, Greendale GA, Seeman TE. Relation of oxytocin to psychological stress responses and hypothalamic-pituitary-adrenocortical axis activity in older women. Psychosom Med. 2006;68:238–245. doi: 10.1097/01.psy.0000203242.95990.74. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  61. Wang ZX, Zhuo L, Hulihan TJ, Insel TR. Imunoreactivity of central vasopressin and oxytocin pathways in microtine rodents: a quantitative comparative study. J Comp Neurol. 1996;366:726–737. doi: 10.1002/(SICI)1096-9861(19960318)366:4<726::AID-CNE11>3.0.CO;2-D. [DOI] [PubMed] [Google Scholar] · DOI
  62. Williams JR, Insel TR, Harbaugh CR, Carter CS. Oxytocin administered centrally facilitates formation of a partner preference in female prairie voles. J Neuroendocrinol. 1994;6:247–250. doi: 10.1111/j.1365-2826.1994.tb00579.x. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  63. Willner P, Towell A, Sampson D, Sophokleous S, Muscat R. Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacology. 1987;93:358–364. doi: 10.1007/BF00187257. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  64. Windle RJ, Kershaw YM, Shanks N, Wood SA, Lightman SL, Ingram CD. Oxytocin attenuates stress-induced c-fos mRNA expression in specific forebrain regions associated with modulation of hypothalamo-pituitary-adrenal activity. J Neurosci. 2004;24:2974–2982. doi: 10.1523/JNEUROSCI.3432-03.2004. [DOI] [PMC free article] [PubMed] [Google Scholar] · DOI · Paper page
  65. Windle RJ, Shanks N, Lightman SL, Ingram CD. Central oxytocin administration reduces stress-induced corticosterone release and anxiety behavior in rats. Endocrinology. 1997;138:2829–2834. doi: 10.1210/endo.138.7.5255. [DOI] [PubMed] [Google Scholar] · DOI · Paper page
  66. Wotjak CT, Naruo T, Muraoka S, Simchen R, Landgraf R, Engelmann M. Forced swimming stimulates the expression of vasopressin and oxytocin in magnocellular neurons of the rat hypothalamic paraventricular nucleus. Eur J Neurosci. 2001;13:2273–2281. doi: 10.1046/j.0953-816x.2001.01613.x. [DOI] [PubMed] [Google Scholar] · DOI
  67. Young EA, Abelson JL, Cameron OG. Effect of comorbid anxiety disorders on the hypothalamic-pituitary-adrenal axis response to a social stressor in major depression. Biol Psychiatry. 2004;56:113–120. doi: 10.1016/j.biopsych.2004.03.017. [DOI] [PubMed] [Google Scholar] · DOI

Cited by

Sorted by citations

Authors
Grippo, A. J., Gerena, D., Huang, J., Kumar, N., Shah, M., Ughreja, R., & Sue Carter, C.
Affiliations
University of Illinois Chicago (US)
Corresponding author
Grippo, Angela J.
ORCID
Venue
Psychoneuroendocrinology
Publisher
Elsevier BV
Published
2007-09
Volume
32
Issue
8-10
Pages
966-980
ISSN
0306-4530 (ISSN-L)
DOI
10.1016/j.psyneuen.2007.07.004
PMC
PMC2174914
OpenAlex
W1991777443
Cited by
336
References
18
Citations by year
2026: 11 · 2025: 15 · 2024: 18 · 2023: 14 · 2022: 21 · 2021: 20 · 2020: 16 · 2019: 17 · 2018: 22 · 2017: 21 · 2016: 16 · 2015: 27 · 2014: 17 · 2013: 22 · 2012: 25
FWCI
16.67
Type
journal article
Language
en
Open access
Licence
Locations
  • Psychoneuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (MH 67446, MH 73233, F32MH073233, MH72935, R21MH067446, R01MH072935)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 48390, P01HD038490)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
social isolation, depression, Microtus ochrogaster, oxytocin, paraventricular nucleus, c-fos, corticotropin-releasing factor, ACTH, corticosterone, sucrose intake, hedonia, resident-intruder test, sex differences, neuroendocrine stress response, social monogamy
MeSH terms
Adrenocorticotropic Hormone, Aggression, Animals, Behavior, Animal, Body Weight, Corticosterone, Arvicolinae, Depression, Eating, Female, Male, Neurosecretory Systems, Oxytocin, Social Isolation, Stress, Psychological

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