Corticotropin-releasing factor induces social preferences in male prairie voles
Abstract
Exposure to stressors facilitates the formation of social preferences in monogamous male prairie voles (Microtus ochrogaster). In the present study, the hypothesis was tested that treatment with corticotropin-releasing factor (CRF), a neuropeptide released during stress, is capable of inducing social preferences in male prairie voles. The effects of five doses of CRF (0.01, 0.1, 1.0, 10 and 100 ng; i.c.v.) on social preference were assessed. Exogenous CRF did not alter the amount of social contact that occurred between the experimental animal and partner during the initial cohabitation period. However, when tested after 3 h of cohabitation, animals that had been treated with 0.1 or 1.0 ng CRF spent significantly more time in physical contact with the partner than a stranger. In contrast, 3 h of cohabitation was not sufficient to induce social preferences in animals pre-treated with an artificial CSF vehicle or other doses of CRF. Furthermore, co-administration of a CRF receptor antagonist prevented the formation of CRF-induced social preferences. These data provide support for a role of the hypothalamic-pituitary-adrenal axis in social bonding in prairie voles.
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Pair bonding in male prairie voles is enhanced by activation of CRF receptors in the brain, an effect localized to the NAC shell.
“Pair bonding in males is also enhanced by activation of CRF receptors in the brain, an effect which can be localized to the NAC shell (DeVries et al 2002; Lim et al 2007).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as DeVries et al 2002
Central activation of the CRF system facilitates pair bond formation, even in the absence of mating, in male prairie voles.
“central activation of the CRF system facilitates pair bond formation, even in the absence of mating”
From Oxytocin and Social Relationships: From Attachment to Bond Disruption (2017) · cites this paper as DeVries et al. 2002
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- Authors
- DeVries, A.
- Affiliations
- The Ohio State University (US)
- Corresponding author
- DeVries, A
- ORCID
- DeVries, A
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2002-08
- Volume
- 27
- Issue
- 6
- Pages
- 705-714
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2113772526
- Cited by
- 97
- References
- 35
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 4 · 2022: 5 · 2021: 1 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 7 · 2013: 4 · 2012: 7
- FWCI
- 5.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute for Health and Care Research
- National Institutes of Health (5k05mh001050-03, 5r01mh045836-03)
- National Institute of Mental Health (MH01050, MH 45836)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD038490, HD38490)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- corticotropin-releasing factor, social preferences, Microtus ochrogaster, monogamy, social bonding, hypothalamic-pituitary-adrenal axis, CRF receptor antagonists, stress, intracerebroventricular administration
- MeSH terms
- Animals, Behavior, Animal, Corticotropin-Releasing Hormone, Arvicolinae, Male, Social Behavior
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