CRF receptors in the nucleus accumbens modulate partner preference in prairie voles
Open accessAbstract
Recent evidence suggests a role for corticotropin-releasing factor (CRF) in the regulation of pair bonding in prairie voles. We have previously shown that monogamous and non-monogamous vole species have dramatically different distributions of CRF receptor type 1 (CRF(1)) and CRF receptor type 2 (CRF(2)) in the brain and that CRF(1) and CRF(2) receptor densities in the nucleus accumbens (NAcc) are correlated with social organization. Monogamous prairie and pine voles have significantly lower levels of CRF receptor type 1 (CRF(1)), and significantly higher levels of type 2 (CRF(2)) binding, in NAcc than non-monogamous meadow and montane voles. Here, we report that microinjections of CRF directly into the NAcc accelerate partner preference formation in male prairie voles. Control injections of CSF into NAcc, and CRF into caudate-putamen, did not facilitate partner preference. Likewise, CRF injections into NAcc of non-monogamous meadow voles also did not facilitate partner preference. In prairie voles, this CRF facilitation effect was blocked by co-injection of either CRF(1) or CRF(2) receptor antagonists into NAcc. Immunocytochemical staining for CRF and Urocortin-1 (Ucn-1), two endogenous ligands for CRF(1) and CRF(2) receptors in the brain, revealed that CRF, but not Ucn-1, immunoreactive fibers were present in NAcc. This supports the hypothesis that local CRF release into NAcc could activate CRF(1) or CRF(2) receptors in the region. Taken together, our results reveal a novel role for accumbal CRF systems in social behavior.
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Activation of CRF receptors by microinjections of CRF directly into the NAc accelerates partner preference formation in male prairie voles.
“activation of cortisol-releasing factor (CRF) receptors by microinjections of CRF directly into the NAc accelerates partner preference formation in male prairie voles [545].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [545]
Pair bonding in male prairie voles is enhanced by activation of CRF receptors in the brain, an effect localized to the NAC shell.
“Pair bonding in males is also enhanced by activation of CRF receptors in the brain, an effect which can be localized to the NAC shell (DeVries et al 2002; Lim et al 2007).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Lim et al 2007
Local infusion of CRF into the NAc accelerates partner preference formation in male prairie voles.
“local infusion of CRF into the NAc accelerates partner preference formation in male prairie voles”
From Oxytocin and Social Relationships: From Attachment to Bond Disruption (2017) · cites this paper as Lim et al. 2007
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- Authors
- Lim, M. M., Liu, Y., Ryabinin, A. E., Bai, Y., Wang, Z., & Young, L. J.
- Affiliations
- Emory University (US)
- Florida State University (US)
- Oregon Health & Science University (US)
- Corresponding author
- Young, Larry J.
- Venue
- Hormones and Behavior
- Publisher
- Elsevier BV
- Published
- 2007-04
- Volume
- 51
- Issue
- 4
- Pages
- 508-515
- ISSN
- 0018-506X (ISSN-L)
- PMC
- PMC2128037
- OpenAlex
- W2066857239
- Cited by
- 99
- References
- 40
- Citations by year
- 2025: 3 · 2024: 5 · 2023: 5 · 2022: 1 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 8 · 2017: 4 · 2016: 4 · 2015: 9 · 2014: 6 · 2013: 7 · 2012: 9
- FWCI
- 9.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hormones and Behavior (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R01AA013738)
- National Institute of Mental Health (K02MH064692, F30MH065050, R01MH058616)
- National Center for Research Resources (P51RR000165)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- corticotropin-releasing factor, CRF1 receptor, nucleus accumbens, mate preferences, pair bonding, Microtus ochrogaster, monogamy, social organization, urocortin 1, CRF receptor antagonists, social behavior, Microtus pennsylvanicus, montane vole
- MeSH terms
- Analysis of Variance, Animals, Corticotropin-Releasing Hormone, Arvicolinae, Female, Male, Microinjections, Nucleus Accumbens, Pair Bond, Receptors, Corticotropin-Releasing Hormone, Mating Preference, Animal
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