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Sarcopenia, Cachexia and Aging: Diagnosis, Mechanisms and Therapeutic Options - A Mini-Review
Open accessAbstract
By the year 2050, individuals over the age of 65 years will comprise 20% of the US population. Loss of muscle mass and strength is common in this age group and it is associated with increased dependence, frailty and mortality. Sarcopenia, defined as the loss of muscle mass and function associated with aging, and cachexia, defined as weight loss due to an underlying illness, are muscle wasting disorders of particular relevance in the aging population, but they go largely unrecognized. In this review we highlight the common pathophysiological mechanisms underlying muscle loss in sarcopenia and cachexia, the factors unique to each condition and means of diagnosing and differentiating them clinically. Therapeutic options including exercise, nutritional therapy, androgens and growth hormone as well as their practical limitations are discussed. We also shed light on newer agents being developed as potential therapeutic options for wasting diseases.
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“Protein synthesis is reduced under Os conditions [107, 108]”
From The critical role of oxidative stress in sarcopenic obesity (2021) · cites this paper as [107]
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“In sarcopenia, the loss of muscle mass and strength leads to reductions in physical activity and mobility, inducing Os, exacerbating sarcopenia, and generating an endless circle [107, 108, 110].”
From The critical role of oxidative stress in sarcopenic obesity (2021) · cites this paper as [107]
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“Moreover, in physiological conditions, PI-3K/Akt inhibits the forkhead box transcription factor O (Fox-O) (a potent inductor of the ubiquitin-proteasome system (UPS)), while mTOR decreases caspase activity. PI-3K/Akt/mTOR activity declines during aging, promoting the catabolic pathway.”
From The critical role of oxidative stress in sarcopenic obesity (2021) · cites this paper as [107]
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“Also, physical inactivity (a characteristic of obesity and sarcopenia in aging) indirectly inhibits the mTOR pathway through Fox-O stimulation [107, 108].”
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Sarcopenia: European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Martin, F. C., Michel, J.-P., Rolland, Y., Schneider, S. M., et al. (2010) · Age and Ageing · doi:10.1093/ageing/afq034 · Cited by 11,601
Fielding, R. A., Vellas, B., Evans, W. J., Bhasin, S., Morley, J. E., Newman, A. B., Abellan van Kan, G., Andrieu, S., Bauer, J., Breuille, D., et al. (2011) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2011.01.003 · Cited by 3,256
Janssen, I., Heymsfield, S. B., & Ross, R. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50216.x · Cited by 3,139
Bodine, S. C., Stitt, T. N., Gonzalez, M., Kline, W. O., Stover, G. L., Bauerlein, R., Zlotchenko, E., Scrimgeour, A., Lawrence, J. C., Glass, D. J., et al. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-1014 · Cited by 2,752
Evans, W., Morley, J., Argilés, J., Bales, C., Baracos, V., Guttridge, D., Jatoi, A., Kalantar-zadeh, K., Lochs, H., Mantovani, G., et al. (2008) · Clinical Nutrition · doi:10.1016/j.clnu.2008.06.013 · Cited by 2,341
Bhasin, S., Cunningham, G. R., Hayes, F. J., Matsumoto, A. M., Snyder, P. J., Swerdloff, R. S., & Montori, V. M. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2354 · Cited by 1,954
Muscaritoli, M., Anker, S. D., Argilés, J., Aversa, Z., Bauer, J. M., Biolo, G., Boirie, Y., Bosaeus, I., Cederholm, T., Costelli, P., et al. (2010) · Clinical Nutrition · doi:10.1016/j.clnu.2009.12.004 · Cited by 1,732
High-Intensity Strength Training in Nonagenarians: Effects on Skeletal Muscle
Fiatarone, M. A. (1990) · JAMA · doi:10.1001/jama.1990.03440220053029 · Cited by 1,593
The healthcare costs of sarcopenia in the United States
Janssen, I., Shepard, D. S., Katzmarzyk, P. T., & Roubenoff, R. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52014.x · Cited by 1,546
Adverse Events Associated with Testosterone Administration
Basaria, S., Coviello, A. D., Travison, T. G., Storer, T. W., Farwell, W. R., Jette, A. M., Eder, R., Tennstedt, S., Ulloor, J., Zhang, A., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1000485 · Cited by 1,494
Aging of skeletal muscle: a 12-yr longitudinal study
Frontera, W. R., Hughes, V. A., Fielding, R. A., Fiatarone, M. A., Evans, W. J., & Roubenoff, R. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.4.1321 · Cited by 1,443
Human aging, muscle mass, and fiber type composition.
Evans, W. J., & Lexell, J. (1995) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/50a.special_issue.11 · Cited by 1,308
Bischoff-Ferrari, H. A., Dawson-Hughes, B. F., Staehelin, H. B., Orav, E. J., Stuck, A. E., Theiler, R., Wong, J. B., Egli, A., Kiel, D. P., & Henschkowski, J. (2009) · BMJ · doi:10.1136/bmj.b3692 · Cited by 1,303
Progressive resistance strength training for improving physical function in older adults
Liu, C.-J., & Latham, N. K. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002759.pub2 · Cited by 1,258
Signaling in Muscle Atrophy and Hypertrophy
Sandri, M. (2008) · Physiology · doi:10.1152/physiol.00041.2007 · Cited by 866
Morley, J. E., Kaiser, F. E., Perry, H. M., Patrick, P., Morley, P. M. K., Stauber, P. M., Vellas, B., Baumgartner, R. N., & Garry, P. J. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90057-3 · Cited by 830
Cachexia: pathophysiology and clinical relevance1,2
Morley, J. E., Thomas, D. R., & Wilson, M.-M. G. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.4.735 · Cited by 786
Nutritional recommendations for the management of sarcopenia
Morley, J. E., Argiles, J. M., Evans, W. J., Bhasin, S., Cella, D., Deutz, N. E. P., Doehner, W., Fearon, K. C. H., Ferrucci, L., Hellerstein, M. K., et al. (2010) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2010.04.014 · Cited by 664
Srinivas-Shankar, U., Roberts, S. A., Connolly, M. J., O'Connell, M. D. L., Adams, J. E., Oldham, J. A., & Wu, F. C. W. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1251 · Cited by 629
Emmelot-Vonk, M. H., Verhaar, H. J. J., Nakhai Pour, H. R., Aleman, A., Lock, T. M. T. W., Bosch, J. L. H. R., Grobbee, D. E., & van der Schouw, Y. T. (2008) · JAMA · doi:10.1001/jama.2007.51 · Cited by 518
Satellite cell content is specifically reduced in type II skeletal muscle fibers in the elderly
Verdijk, L. B., Koopman, R., Schaart, G., Meijer, K., Savelberg, H. H. C. M., & van Loon, L. J. C. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00278.2006 · Cited by 489
The Association of Plasma IL-6 Levels With Functional Disability in Community-Dwelling Elderly
Cohen, H. J., Pieper, C. F., Harris, T., Rao, K. M. K., & Currie, M. S. (1997) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/52a.4.m201 · Cited by 476
Jatoi, A. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.20.2.567 · Cited by 411
Dalton, J. T., Barnette, K. G., Bohl, C. E., Hancock, M. L., Rodriguez, D., Dodson, S. T., Morton, R. A., & Steiner, M. S. (2011) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1007/s13539-011-0034-6 · Cited by 403
Baldwin, C., Spiro, A., A’Hern, R., & Emery, P. W. (2012) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djr556 · Cited by 401
Dobs, A. S., Boccia, R. V., Croot, C. C., Gabrail, N. Y., Dalton, J. T., Hancock, M. L., Johnston, M. A., & Steiner, M. S. (2013) · The Lancet Oncology · doi:10.1016/s1470-2045(13)70055-x · Cited by 391
Onder, G., Penninx, B. W., Balkrishnan, R., Fried, L. P., Chaves, P. H., Williamson, J., Carter, C., Bari, M. D., Guralnik, J. M., & Pahor, M. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08024-8 · Cited by 339
International working group on Sarcopenia
Chumlea, W. M. C., Cesari, M., Evans, W. J., Ferrucci, L., Fielding, R. A., Pahor, M., Studenski, S. A., & Vellas, B. J. (2011) · The journal of nutrition health & aging · doi:10.1007/s12603-011-0092-7 · Cited by 338
Megestrol acetate for treatment of anorexia-cachexia syndrome
García, V. R., Briz, E. L., Sanchís, R. C., Perales, J. L. G., & Bort-Martí, S. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004310.pub3 · Cited by 296
Brown, W. F. (1972) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.35.6.845 · Cited by 283
Autophagic Degradation Contributes to Muscle Wasting in Cancer Cachexia
Penna, F., Costamagna, D., Pin, F., Camperi, A., Fanzani, A., Chiarpotto, E., Cavallini, G., Bonelli, G., Baccino, F. M., & Costelli, P. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.12.023 · Cited by 279
Cachexia: prevalence and impact in medicine
Tan, B. H. L., & Fearon, K. C. H. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328300ecc1 · Cited by 266
Nass, R., Pezzoli, S. S., Oliveri, M. C., Patrie, J. T., Harrell, F. E., Clasey, J. L., Heymsfield, S. B., Bach, M. A., Vance, M. L., & Thorner, M. O. (2008) · Annals of Internal Medicine · doi:10.7326/0003-4819-149-9-200811040-00003 · Cited by 255
A humanized anti-IL-6 antibody (ALD518) in non-small cell lung cancer
Bayliss, T. J., Smith, J., Schuster, M. K., Dragnev, K. H., & Rigas, J. R. (2011) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2011.627850 · Cited by 250
Sumukadas, D., Witham, M. D., Struthers, A. D., & McMurdo, M. E. T. (2007) · Canadian Medical Association Journal · doi:10.1503/cmaj.061339 · Cited by 246
Reed, S. A., Sandesara, P. B., Judge, S. M., & Judge, A. R. (2011) · The FASEB Journal · doi:10.1096/fj.11-189977 · Cited by 231
Yarasheski, K. E., Pak-Loduca, J., Hasten, D. L., Obert, K. A., Brown, M. B., & Sinacore, D. R. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.1.e118 · Cited by 226
Bhasin, S., Taylor, W. E., Singh, R., Artaza, J., Sinha-Hikim, I., Jasuja, R., Choi, H., & Gonzalez-Cadavid, N. F. (2003) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/58.12.m1103 · Cited by 215
Kang, C., Chung, E., Diffee, G., & Ji, L. L. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.08.004 · Cited by 174
The Anabolic Androgenic Steroid Oxandrolone in the Treatment of Wasting and Catabolic Disorders
Orr, R., & Singh, M. F. (2004) · Drugs · doi:10.2165/00003495-200464070-00004 · Cited by 174
Effects of an Oral Growth Hormone Secretagogue in Older Adults
White, H. K., Petrie, C. D., Landschulz, W. H., MacLean, D. B., Taylor, A., Lyles, K. W., Wei, J. Y., Hoffman, A. R., Salvatori, R., Ettinger, M. P., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0632 · Cited by 173
Garcia, J. M., Friend, J., & Allen, S. (2012) · Supportive Care in Cancer · doi:10.1007/s00520-012-1500-1 · Cited by 170
Self-citationCURRENT NUTRITIONAL RECOMMENDATIONS AND NOVEL DIETARY STRATEGIES TO MANAGE SARCOPENIA
Calvani, R., Miccheli, A., Landi, F., Bossola, M., Cesari, M., Leeuwenburgh, C., Sieber, C. C., Bernabei, R., & Marzetti, E. (2013) · The Journal of Frailty & Aging · doi:10.14283/jfa.2013.7 · Cited by 164
Bari, M. D., van de Poll-Franse, L. V., Onder, G., Kritchevsky, S. B., Newman, A. B., Harris, T. B., Williamson, J. D., Marchionni, N., & Pahor, M. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52265.x · Cited by 140
Hormone Replacement Therapy and Physical Function in Healthy Older Men. Time to Talk Hormones?
Giannoulis, M. G., Martin, F. C., Nair, K. S., Umpleby, A. M., & Sonksen, P. (2012) · Endocrine Reviews · doi:10.1210/er.2012-1002 · Cited by 132
Marzetti, E., Carter, C. S., Wohlgemuth, S. E., Lees, H. A., Giovannini, S., Anderson, B., Quinn, L. S., & Leeuwenburgh, C. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.12.008 · Cited by 113
Thalidomide for managing cancer cachexia
Reid, J., Mills, M. E., Cantwell, M. M., Cardwell, C. R., Murray, L., & Donnelly, M. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008664.pub2 · Cited by 109
Resistance exercise and nutrition to counteract muscle wasting
Little, J. P., & Phillips, S. M. (2009) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h09-093 · Cited by 102
Drummond, M. J., Miyazaki, M., Dreyer, H. C., Pennings, B., Dhanani, S., Volpi, E., Esser, K. A., & Rasmussen, B. B. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90842.2008 · Cited by 100
Current and Future Pharmacologic Treatment of Sarcopenia
Rolland, Y., Onder, G., Morley, J. E., Guyonnet, S., van Kan, G. A., & Vellas, B. J. (2011) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2011.03.008 · Cited by 95
Targeting myostatin for therapies against muscle-wasting disorders.
Tsuchida, K. (2008) · PubMed · Cited by 84
Apoptosis is present in skeletal muscle of cachectic gastro-intestinal cancer patients
Busquets, S., Deans, C., Figueras, M., Moore‐Carrasco, R., López-Soriano, F. J., Fearon, K. C. H., & Argilés, J. M. A. (2007) · Clinical Nutrition · doi:10.1016/j.clnu.2007.06.005 · Cited by 74
Bladder cancer-induced skeletal muscle wasting: disclosing the role of mitochondria plasticity.
Padrão, A., Oliveira, P., Vitorino, R., Colaço, B., Pires, M., Márquez, M., Castellanos, E., Neuparth, M., Teixeira, C., Costa, C., et al. (2013) · International Journal of Biochemistry and Cell Biology · doi:10.1016/j.biocel.2013.04.014 · Cited by 61
Update on melanocortin interventions for cachexia: Progress toward clinical application
DeBoer, M. D. (2009) · Nutrition · doi:10.1016/j.nut.2009.07.003 · Cited by 35
Muscle atrophy in cachexia: can dietary protein tip the balance?
den Kamp, C. M. O., LANGEN, R. C. J., Haegens, A., & Schols, A. M. W. J. (2009) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3283319399 · Cited by 34
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Tuttle, C. S. L., Thang, L. A. N., & Maier, A. B. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101185 · Cited by 664
Sarcopenia and Cardiovascular Diseases
Damluji, A. A., Alfaraidhy, M., AlHajri, N., Rohant, N. N., Kumar, M., Al Malouf, C., Bahrainy, S., Ji Kwak, M., Batchelor, W. B., Forman, D. E., et al. (2023) · Circulation · doi:10.1161/circulationaha.123.064071 · Cited by 645
Treatment of Diabetes in Older Adults: An Endocrine Society* Clinical Practice Guideline
LeRoith, D., Biessels, G. J., Braithwaite, S. S., Casanueva, F. F., Draznin, B., Halter, J. B., Hirsch, I. B., McDonnell, M. E., Molitch, M. E., Murad, M. H., et al. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00198 · Cited by 616
Sarcopenia: assessment of disease burden and strategies to improve outcomes
Liguori, I., Russo, G., Aran, L., Bulli, G., Curcio, F., Della‐Morte, D., Gargiulo, G., Testa, G., Cacciatore, F., Bonaduce, D., et al. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s149232 · Cited by 319
A review of sarcopenia: Enhancing awareness of an increasingly prevalent disease
Marty, E., Liu, Y., Samuel, A. M., Or, O., & Lane, J. (2017) · Bone · doi:10.1016/j.bone.2017.09.008 · Cited by 310
Metadata
- Authors
- Ali, S., & Garcia, J. M.
- Affiliations
- Michael E. DeBakey VA Medical Center (US)
- Venue
- Gerontology
- Publisher
- S. Karger AG
- Published
- 2014
- Volume
- 60
- Issue
- 4
- Pages
- 294-305
- ISSN
- 0304-324X (ISSN-L)
- 1423-0003
- PMC
- PMC4112511
- OpenAlex
- W2124477946
- Cited by
- 462
- References
- 56
- Citations by year
- 2026: 22 · 2025: 40 · 2024: 39 · 2023: 51 · 2022: 48 · 2021: 60 · 2020: 51 · 2019: 38 · 2018: 46 · 2017: 30 · 2016: 17 · 2015: 18 · 2014: 2
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Gerontology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01 CX000174, I01 BX002807, I01-BX000507)
- National Institute on Aging (R03AG040583, AG040583, T32AG000183)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- sarcopenia, cachexia, aging, muscle atrophy, muscle mass loss, frailty, pathophysiological mechanisms, diagnosis, exercise therapy, nutritional therapy, androgens, growth hormone
- MeSH terms
- Aged, Aging, Androgens, Cachexia, Dietary Proteins, Exercise Therapy, Humans, Muscle Proteins, Receptors, Androgen, Muscle, Skeletal, Appetite Stimulants, Human Growth Hormone, Ghrelin, Sarcopenia
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