Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises: Part I: Aging Arteries: A “Set Up” for Vascular Disease

Hemodynamic Patterns of Age-Related Changes in Blood Pressure: The Framingham Heart Study

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Is Pulse Pressure Useful in Predicting Risk for Coronary Heart Disease?

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Aortic Stiffness Is an Independent Predictor of Primary Coronary Events in Hypertensive Patients

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Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients

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Does the Relation of Blood Pressure to Coronary Heart Disease Risk Change With Aging?: The Framingham Heart Study

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Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women

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Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises

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Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises

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Effects of age and aerobic capacity on arterial stiffness in healthy adults.

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Aging‐Induced Adaptations of Microvascular Reactivity

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Exercise, Vascular Stiffness, and Tissue Transglutaminase

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INDICES OF VASCULAR STIFFNESS AND WAVE REFLECTION IN RELATION TO BODY MASS INDEX OR BODY FAT IN HEALTHY SUBJECTS

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Fenofibrate Improves Vascular Endothelial Function by Reducing Oxidative Stress While Increasing Endothelial Nitric Oxide Synthase in Healthy Normolipidemic Older Adults

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Growth Factors, Nutrient Signaling, and Cardiovascular Aging

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Knowledge Gaps in Cardiovascular Care of Older Adults: A Scientific Statement from the American Heart Association, American College of Cardiology, and American Geriatrics Society: Executive Summary

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Small vessel disease to subcortical dementia: a dynamic model, which interfaces aging, cholinergic dysregulation and the neurovascular unit

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Aging affects vascular structure and function in a limb-specific manner

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Exercise training improves neurovascular control and functional capacity in heart failure patients regardless of age

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Angiogenesis, Cancer, and Vascular Aging

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Melatonin as an Anti-Aging Therapy for Age-Related Cardiovascular and Neurodegenerative Diseases

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Dietary Sodium Restriction and Association with Urinary Marinobufagenin, Blood Pressure, and Aortic Stiffness

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Assessment of dynamic cerebral autoregulation and cerebrovascular CO 2 reactivity in ageing by measurements of cerebral blood flow and cortical oxygenation

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Role of NFκB in age-related vascular endothelial dysfunction in humans

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Associations between Skeletal Muscle and Myocardium in Aging: A Syndrome of “Cardio‐Sarcopenia”?

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Alteration of Cardiac Performance and Serum B-Type Natriuretic Peptide Level in Healthy Aging

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Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging

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Collagenase-resistant collagen promotes mouse aging and vascular cell senescence

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Influence of age on the association between lifestyle factors and risk of hypertension

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ACCF 2012 Health Policy Statement on Patient-Centered Care in Cardiovascular Medicine

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Circulating anti-geronic factors from heterochonic parabionts promote vascular rejuvenation in aged mice: transcriptional footprint of mitochondrial protection, attenuation of oxidative stress, and rescue of endothelial function by young blood

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The aging venous system: from varicosities to vascular cognitive impairment

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Non-invasive cardiac imaging techniques and vascular tools for the assessment of cardiovascular disease in type 2 diabetes mellitus

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Comorbidity of cardiovascular diseases with mood and anxiety disorder: A population based 4‐year study

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SIRT1 in cardiovascular aging

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Biochemical Markers of Aging for Longitudinal Studies in Humans

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The effect of an advanced glycation end-product crosslink breaker and exercise training on vascular function in older individuals: A randomized factorial design trial

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Ascorbic acid increases cardiovagal baroreflex sensitivity in healthy older men

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High eccentric strength training reduces heart rate variability in healthy older men

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The Singapore Heart Failure Outcomes and Phenotypes (SHOP) Study and Prospective Evaluation of Outcome in Patients With Heart Failure With Preserved Left Ventricular Ejection Fraction (PEOPLE) Study: Rationale and Design

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The role of senescence, telomere dysfunction and shelterin in vascular aging

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Vascular endothelial function and oxidative stress are related to dietary niacin intake among healthy middle-aged and older adults

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Characterizing the Heterogeneity of Aging: A Vision for a Staging System for Aging

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Tumor necrosis factor-α inhibition improves endothelial function and decreases arterial stiffness in estrogen-deficient postmenopausal women

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Mechanisms of Physical Activity Limitation in Chronic Lung Diseases

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Noncoding RNAs regulate NF-κB signaling to modulate blood vessel inflammation

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Diabetes Impairs Angiogenesis and Induces Endothelial Cell Senescence by Up-Regulating Thrombospondin-CD47-Dependent Signaling

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Secreted protein acidic and rich in cysteine facilitates age-related cardiac inflammation and macrophage M1 polarization

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Confounding effects of heart rate on pulse wave velocity in paced patients with a low degree of atherosclerosis.

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Late-age Onset Systemic Sclerosis

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Aging Negatively Affects Estrogens-Mediated Effects on Nitric Oxide Bioavailability by Shifting ERα/ERβ Balance in Female Mice

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Salicylate Treatment Improves Age-Associated Vascular Endothelial Dysfunction: Potential Role of Nuclear Factor B and Forkhead Box O Phosphorylation

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Habitual aerobic exercise does not protect against micro- or macrovascular endothelial dysfunction in healthy estrogen-deficient postmenopausal women

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Interaction between mTOR pathway inhibition and autophagy induction attenuates adriamycin-induced vascular smooth muscle cell senescence through decreased expressions of p53/p21/p16

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Upregulation of Aortic Adhesion Molecules During Aging

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Inorganic nitrite supplementation for healthy arterial aging

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Extracellular Matrix in Aging Aorta

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Enfermedad cardiovascular en el anciano

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Association between brachial–ankle pulse wave velocity and 3-year mortality in community-dwelling older adults

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Effects of relaxin on systemic arterial hemodynamics and mechanical properties in conscious rats: sex dependency and dose response

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Impact of Aging on Endurance and Neuromuscular Physical Performance: The Role of Vascular Senescence

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Lifelong voluntary aerobic exercise prevents age‐ and Western diet‐ induced vascular dysfunction, mitochondrial oxidative stress and inflammation in mice

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Growth, telomere dynamics and successful and unsuccessful human aging

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Chronic aerobic exercise training attenuates aortic stiffening and endothelial dysfunction through preserving aortic mitochondrial function in aged rats

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Passive leg movement and nitric oxide-mediated vascular function: the impact of age

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Aging is associated with changes to the biomechanical properties of the posterior cerebral artery and parenchymal arterioles

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α7 Nicotinic Acetylcholine Receptor Relieves Angiotensin II–Induced Senescence in Vascular Smooth Muscle Cells by Raising Nicotinamide Adenine Dinucleotide–Dependent SIRT1 Activity

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Aortic Root Remodeling and Risk of Heart Failure in the Framingham Heart Study

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Acute effects of ingestion of a novel whey-derived extract on vascular endothelial function in overweight, middle-aged men and women

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Pulse-Waveform Analysis of Normal Population using Laser Speckle Flowgraphy

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Cardiovascular Effects of 1 Year of Alagebrium and Endurance Exercise Training in Healthy Older Individuals

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Report of the National Heart, Lung, and Blood Institute Working Group on the Role of Microbiota in Blood Pressure Regulation

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Vascular smooth muscle cell‐specific progerin expression in a mouse model of Hutchinson–Gilford progeria syndrome promotes arterial stiffness: Therapeutic effect of dietary nitrite

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Running on Empty: Cardiovascular Reserve Capacity and Late Effects of Therapy in Cancer Survivorship

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Effect of age on carotid arterial intima-media thickness in childhood

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Aortic Stiffness: Epidemiology, Risk Factors, and Relevant Biomarkers

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Methionine restriction - Association with redox homeostasis and implications on aging and diseases

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Potential Effects of Akkermansia Muciniphila in Aging and Aging-Related Diseases: Current Evidence and Perspectives

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Age-Associated Increase in Arterial Stiffness Measured According to the Cardio-Ankle Vascular Index without Blood Pressure Changes in Healthy Adults

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Age-Related Differences in the Prevalence of Potential Drug-Drug Interactions in Ambulatory Dyslipidaemic Patients Treated with Statins

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Long-term atorvastatin improves age-related endothelial dysfunction by ameliorating oxidative stress and normalizing eNOS/iNOS imbalance in rat aorta

Gong, X., Ma, Y., Ruan, Y., Guo-hua, F., & Wu, S. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.01.015 · Cited by 66

Wnt Signaling and Aging-Related Heart Disorders

Naito, A. T., Shiojima, I., & Komuro, I. (2010) · Circulation Research · doi:10.1161/circresaha.110.223776 · Cited by 64

Aging exacerbates negative remodeling and impairs endothelial regeneration after balloon injury

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Does senescence give rise to disease?

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Brachial-ankle pulse wave velocity and prognosis in patients with atherosclerotic cardiovascular disease: a systematic review and meta-analysis

Sang, T., Lv, N., Dang, A., Cheng, N., & Zhang, W. (2021) · Hypertension Research · doi:10.1038/s41440-021-00678-2 · Cited by 63

Large elastic artery stiffness with aging: novel translational mechanisms and interventions.

Fleenor, B. S. (2013) · Europe PMC (PubMed Central) · Cited by 63

Matrix Metalloproteinase-28 Deletion Amplifies Inflammatory and Extracellular Matrix Responses to Cardiac Aging

Ma, Y., Chiao, Y. A., Zhang, J., Manicone, A. M., Jin, Y.-F., & Lindsey, M. L. (2011) · Microscopy and Microanalysis · doi:10.1017/s1431927611012220 · Cited by 63

Vascular burden and APOE ε4 are associated with white matter microstructural decline in cognitively normal older adults

Williams, O. A., An, Y., Beason‐Held, L. L., Huo, Y., Ferrucci, L., Landman, B. A., & Resnick, S. M. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.12.009 · Cited by 66

Impact of Multiple Cardiovascular Risk Factors on Brachial Artery Distensibility in Young AdultsThe Bogalusa Heart Study

Urbina, E., KIELTKYA, L., TSAI, J., SRINIVASAN, S., & Berenson, G. S. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2004.12.017 · Cited by 63

Crosslink breakers: a new approach to cardiovascular therapy

Sušić, D., Varagić, J., Ahn, J., & Frohlich, E. D. (2004) · Current Opinion in Cardiology · doi:10.1097/01.hco.0000127135.73849.4f · Cited by 63

Vascular Dysfunction, Oxidative Stress, and Inflammation in Autosomal Dominant Polycystic Kidney Disease

Nowak, K. L., Wang, W., Farmer‐Bailey, H., Gitomer, B. Y., Malaczewski, M., Klawitter, J., Jovanovich, A. J., & Chonchol, M. (2018) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.05850518 · Cited by 62

The ageing endothelium, cardiovascular risk and disease in man

Versari, D., Daghini, E., Virdis, A., Ghiadoni, L., & Taddei, S. (2008) · Experimental Physiology · doi:10.1113/expphysiol.2008.043356 · Cited by 62

Comparison between automated and manual measurements of carotid intima-media thickness in clinical practice

Silva, A. C. S. E., Freire, Ribeiro, Barbosa, Nogueira, Almeida, A., Barbosa, Lana, & Antonio (2009) · Vascular Health and Risk Management · doi:10.2147/vhrm.s5745 · Cited by 61

G lyoxalase I reduces glycative and oxidative stress and prevents age‐related endothelial dysfunction through modulation of endothelial nitric oxide synthase phosphorylation

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Increased proinflammatory and oxidant gene expression in circulating mononuclear cells in older adults: amelioration by habitual exercise

Gano, L. B., Donato, A. J., Pierce, G. L., Pasha, H. M., Magerko, K. A., Roeca, C. M., & Seals, D. R. (2011) · Physiological Genomics · doi:10.1152/physiolgenomics.00204.2010 · Cited by 64

Regulation of Vascular Tone and Pulse Wave Velocity in Human Muscular Conduit Arteries

Fok, H., Jiang, B., Clapp, B. R., & Chowienczyk, P. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.198788 · Cited by 62

GDF11 Decreases Pressure Overload–Induced Hypertrophy, but Can Cause Severe Cachexia and Premature Death

Harper, S. C., Johnson, J. P., Borghetti, G., Zhao, H., Wang, T., Wallner, M., Kubo, H., Feldsott, E. A., Yang, Y., Joo, Y., et al. (2018) · Circulation Research · doi:10.1161/circresaha.118.312955 · Cited by 63

Perivascular adipose tissue‐derived stromal cells contribute to vascular remodeling during aging

Pan, X., Ruan, C., Liu, X., Kong, L., Ma, Y., Wu, Q., Li, H., Sun, Y., Chen, A., Zhao, Q., et al. (2019) · Aging Cell · doi:10.1111/acel.12969 · Cited by 63

Exendin-4 alleviates angiotensin II-induced senescence in vascular smooth muscle cells by inhibiting Rac1 activation via a cAMP/PKA-dependent pathway

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Benefit of glyceryl trinitrate on arterial stiffness is directly due to effects on peripheral arteries

Pauca, A. L., Kon, N. D., & O’Rourke, M. F. (2005) · Heart · doi:10.1136/hrt.2004.057356 · Cited by 61

Cardiac and vascular changes in elderly atherosclerotic mice: the influence of gender

Pereira, T. D. M. C., Nogueira, B. V., Freitas‐Lima, L. C., Porto, M. L., Arruda, J. A., Vasquez, E. C., & Meyrelles, S. S. (2010) · Lipids in Health and Disease · doi:10.1186/1476-511x-9-87 · Cited by 61

Long non-coding RNAs in the failing heart and vasculature

Hermans-Beijnsberger, S., van Bilsen, M., & Schroen, B. L. M. (2018) · Non-coding RNA Research · doi:10.1016/j.ncrna.2018.04.002 · Cited by 63

Molecular Mechanisms Underlying the Cardiovascular Benefits of SGLT2i and GLP-1RA

Khat, D. Z., & Husain, M. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1011-7 · Cited by 65

The Age-Related Increase in Arterial Stiffness Is Augmented in Phases According to the Severity of Hypertension

Tomiyama, H., Arai, T., Koji, Y., Yambe, M., Motobe, K., ZAYDUN, G., Yamamoto, Y., Hori, S., & Yamashina, A. (2004) · Hypertension Research · doi:10.1291/hypres.27.465 · Cited by 60

A Vascular Theory of Aging

Couteur, D. G. L., & Lakatta, E. G. (2010) · The Journals of Gerontology Series A · doi:10.1093/gerona/glq135 · Cited by 59

Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises. Part III: cellular and molecular clues to heart and arterial aging. Circulation

Lakatta, E. G., Levy, D. A., & Levy, D. A. (2015)

Aging and Cardiovascular Disease

Wissler, R. W., & Robert, L. (1996) · Circulation · doi:10.1161/01.cir.93.9.1608 · Cited by 19

Aging of the Heart and Arteries: A Set-up for Cardiovascular Disease Leading to Heart Failure

Lakatta, E. G. (2006) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2006.08.040

Aging’s Accomplice in Harming the Cardiovascular System

Wei, Y. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315217

Aging Issues in Cardiology

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