Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises: Part I: Aging Arteries: A “Set Up” for Vascular Disease

Hemodynamic Patterns of Age-Related Changes in Blood Pressure: The Framingham Heart Study

Franklin, S. S., Gustin, W., Wong, N. D., Larson, M. G., Weber, M. A., Kannel, W. B., & Levy, D. (1997) · Circulation · doi:10.1161/01.cir.96.1.308 · Cited by 2,321

Impact of Aortic Stiffness on Survival in End-Stage Renal Disease

Blacher, J., Guerin, A. P., Pannier, B., Marchais, S. J., Safar, M. E., & London, G. M. (1999) · Circulation · doi:10.1161/01.cir.99.18.2434 · Cited by 2,138

Is Pulse Pressure Useful in Predicting Risk for Coronary Heart Disease?

Franklin, S. S., Khan, S. A., Wong, N. D., Larson, M. G., & Levy, D. A. (1999) · Circulation · doi:10.1161/01.cir.100.4.354 · Cited by 1,756

Aortic Stiffness Is an Independent Predictor of Primary Coronary Events in Hypertensive Patients

Boutouyrie, P., Tropeano, A., Asmar, R. G., Gautier, I., Bénétos, A., Lacolley, P. J., & Laurent, S. (2002) · Hypertension · doi:10.1161/hy0102.099031 · Cited by 1,745

Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients

Blacher, J., Asmar, R., Djane, S., London, G. M., & Safar, M. E. (1999) · Hypertension · doi:10.1161/01.hyp.33.5.1111 · Cited by 1,493

Does the Relation of Blood Pressure to Coronary Heart Disease Risk Change With Aging?: The Framingham Heart Study

Franklin, S. S., Larson, M. G., Khan, S. A., Wong, N. D., Leip, E. P., Kannel, W. B., & Levy, D. (2001) · Circulation · doi:10.1161/01.cir.103.9.1245 · Cited by 1,390

Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women

Celermajer, D. S., Sørensen, K. E., Spiegelhalter, D. J., Georgakopoulos, D., Robinson, J. T. C., & Deanfield, J. E. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90305-0 · Cited by 1,354

Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises

Lakatta, E. G., & Levy, D. A. (2003) · Circulation · doi:10.1161/01.cir.0000048893.62841.f7 · Cited by 1,257

Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises

Lakatta, E. G. (2003) · Circulation · doi:10.1161/01.cir.0000048894.99865.02 · Cited by 1,105

Effects of age and aerobic capacity on arterial stiffness in healthy adults.

Vaitkevicius, P. V., Fleg, J. L., Engel, J.-H., O’Connor, F. C., Wright, J. G., Lakatta, L. E., Yin, F. C. P., & Lakatta, E. G. (1993) · Circulation · doi:10.1161/01.cir.88.4.1456 · Cited by 1,085

Mitochondrial Oxidative Stress, Mitochondrial DNA Damage and Their Role in Age-Related Vascular Dysfunction

Mikhed, Y., Daiber, A., & Steven, S. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160715918 · Cited by 257

Translational evidence that impaired autophagy contributes to arterial ageing

LaRocca, T. J., Henson, G. D., Thorburn, A. M., Sindler, A. L., Pierce, G. L., & Seals, D. R. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.229690 · Cited by 258

Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: Role of circulating factors and SIRT1

Csiszár, A., Labinskyy, N., Jiménez, R., Pinto, J. T., Ballabh, P., Losonczy, G., Pearson, K. J., de Cabo, R., & Ungvari, Z. I. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.06.004 · Cited by 248

Relative contribution of cardiovascular risk factors and rheumatoid arthritis clinical manifestations to atherosclerosis

del Rincón, I., Freeman, G. L., Haas, R. W., O’Leary, D. H., & Escalante, A. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21397 · Cited by 244

The Role of Autophagy in Vascular Biology

Nussenzweig, S. C., Verma, S., & Finkel, T. (2015) · Circulation Research · doi:10.1161/circresaha.116.303805 · Cited by 245

Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down‐regulation of NADPH oxidase

Durrant, J., Seals, D. R., Connell, M. L., Russell, M. J., Lawson, B. R., Folian, B. J., Donato, A. J., & Lesniewski, L. A. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.169771 · Cited by 250

Autophagy in Cardiovascular Aging

Abdellatif, M., Sedej, S., Carmona-Gutierrez, D., Madeo, F., & Kroemer, G. (2018) · Circulation Research · doi:10.1161/circresaha.118.312208 · Cited by 239

Antithrombotic therapy in the elderly: expert position paper of the European Society of Cardiology Working Group on Thrombosis

Andreotti, F., Rocca, B., Husted, S., Ajjan, R., ten Berg, J. M., Cattaneo, M., Collet, J., Caterina, R. D., Fox, K. A. A., Halvorsen, S., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv304 · Cited by 239

Vital Signs in Older Patients: Age-Related Changes

Chester, J. G., & Rudolph, J. L. (2010) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2010.04.009 · Cited by 250

Mechanisms Underlying Caloric Restriction and Lifespan Regulation

Ungvari, Z. I., Parrado‐Fernández, C., Csiszár, A., & de Cabo, R. (2008) · Circulation Research · doi:10.1161/circresaha.107.168369 · Cited by 243

Aging is associated with greater nuclear NFκB, reduced IκBα, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans

Donato, A. J., Black, A. D., Jablonski, K. L., Gano, L. B., & Seals, D. R. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00438.x · Cited by 237

Dietary Sodium Restriction Rapidly Improves Large Elastic Artery Compliance in Older Adults With Systolic Hypertension

Gates, P. E., Tanaka, H., Hiatt, W. R., & Seals, D. R. (2004) · Hypertension · doi:10.1161/01.hyp.0000132767.74476.64 · Cited by 236

Role of Inflammation in the Pathogenesis of Arterial Stiffness

Park, S., & Lakatta, E. G. (2012) · Yonsei Medical Journal · doi:10.3349/ymj.2012.53.2.258 · Cited by 238

Effects of short-term dietary nitrate supplementation on blood pressure, O2uptake kinetics, and muscle and cognitive function in older adults

Kelly, J., Fulford, J., Vanhatalo, A., Blackwell, J. R., French, O., Bailey, S. J., Gilchrist, M., Winyard, P. G., & Jones, A. M. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00406.2012 · Cited by 232

Aerobic exercise training and vascular function with ageing in healthy men and women

Seals, D. R., Nagy, E., & Moreau, K. L. (2019) · The Journal of Physiology · doi:10.1113/jp277764 · Cited by 231

The Cardiovascular Continuum extended: Aging effects on the aorta and microvasculature

O’Rourke, M. F., Safar, M. E., & Dzau, V. J. (2010) · Vascular Medicine · doi:10.1177/1358863x10382946 · Cited by 228

Heart failure with preserved ejection fraction

Gladden, J. D., Linke, W. A., & Redfield, M. M. (2014) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-014-1480-8 · Cited by 235

The Relationship of Age With Regional Aortic Stiffness and Diameter

Hickson, S. S., Butlin, M., Graves, M. J., Taviani, V., Avolio, A. P., McEniery, C. M., & Wilkinson, I. B. (2010) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2010.09.016 · Cited by 226

Endothelial dysfunction in aged humans is related with oxidative stress and vascular inflammation

Rodríguez‐Mañas, L., El‐Assar, M., Vallejo, S., Bonnardeaux, P. L.-D., Solı́s, J., Torregrossa, R. P., Montes, M., Nevado, J. B., Castro, M., Gómez‐Guerrero, C., et al. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00466.x · Cited by 225

Cardiac Care for Older Adults

Forman, D. E., Rich, M. W., Alexander, K. P., Zieman, S., Maurer, M. S., Najjar, S. S., Cleveland, J. C., Krumholz, H. M., & Wenger, N. K. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.02.014 · Cited by 228

Nicotinamide Riboside—The Current State of Research and Therapeutic Uses

Mehmel, M., Jovanović, N. D., & Spitz, U. P. (2020) · Nutrients · doi:10.3390/nu12061616 · Cited by 231

So! What's aging? Is cardiovascular aging a disease?

Lakatta, E. G. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.04.005 · Cited by 221

Knowledge Gaps in Cardiovascular Care of the Older Adult Population

Rich, M. W., Chyun, D. A., Skolnick, A. H., Alexander, K. P., Forman, D. E., Kitzman, D. W., Maurer, M. S., McClurken, J. B., Resnick, B. M., Shen, W. K., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000380 · Cited by 225

Arterial structure and function in vascular ageing: are you as old as your arteries?

Thijssen, D. H. J., Carter, S. E., & GREEN, D. J. (2015) · The Journal of Physiology · doi:10.1113/jp270597 · Cited by 218

The Role of Oxidative Stress and Inflammation in Cardiovascular Aging

Wu, J., Xia, S., Kalionis, B., Wan, W., & Sun, T. (2014) · BioMed Research International · doi:10.1155/2014/615312 · Cited by 233

Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging: Sodium nitrite and vascular dysfunction with aging

Sindler, A. L., Fleenor, B. S., Calvert, J. W., Marshall, K. D., Zigler, M. L., Lefer, D. J., & Seals, D. R. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00679.x · Cited by 218

Effects of Hypoperfusion in Alzheimer's Disease

Austin, B. P., Nair, V. A., Meier, T. B., Xu, G., Rowley, H. A., Carlsson, C. M., Johnson, S. C., & Prabhakaran, V. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-0010 · Cited by 226

Elevated Circulating Trimethylamine N-Oxide Levels Contribute to Endothelial Dysfunction in Aged Rats through Vascular Inflammation and Oxidative Stress

Li, T., Chen, Y., Gua, C., & Li, X. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00350 · Cited by 216

Vasculoprotective Effects of Anti-Tumor Necrosis Factor-α Treatment in Aging

Csiszár, A., Labinskyy, N., Smith, K. E., Rivera, A., Orosz, Z. Z., & Ungvari, Z. I. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.060708 · Cited by 214

Curcumin supplementation improves vascular endothelial function in healthy middle-aged and older adults by increasing nitric oxide bioavailability and reducing oxidative stress

Santos‐Parker, J. R., Strahler, T. R., Bassett, C. J., Bispham, N. Z., Chonchol, M. B., & Seals, D. R. (2017) · Aging · doi:10.18632/aging.101149 · Cited by 214

Bad Marriage, Broken Heart? Age and Gender Differences in the Link between Marital Quality and Cardiovascular Risks among Older Adults

Liu, H., & Waite, L. J. (2014) · Journal of Health and Social Behavior · doi:10.1177/0022146514556893 · Cited by 218

Oxidative stress in atherogenesis and arterial thrombosis: the disconnect between cellular studies and clinical outcomes

Madamanchi, N. R., Hakim, Z. S., & Runge, M. S. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2004.01085.x · Cited by 216

Arterial stiffening with ageing is associated with transforming growth factor-β1-related changes in adventitial collagen: reversal by aerobic exercise

Fleenor, B. S., Marshall, K. D., Durrant, J., Lesniewski, L. A., & Seals, D. R. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.194753 · Cited by 212

APOE ε4 Genotype and Longitudinal Changes in Cerebral Blood Flow in Normal Aging

Thambisetty, M., Beason‐Held, L. L., An, Y., Kraut, M. A., & Resnick, S. M. (2010) · Archives of Neurology · doi:10.1001/archneurol.2009.913 · Cited by 208

Advanced glycation endproduct crosslink breaker (alagebrium) improves endothelial function in patients with isolated systolic hypertension

Zieman, S. J., Melenovský, V., Clattenburg, L., Corretti, M. C., Capriotti, A. R., Gerstenblith, G., & Kass, D. A. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e328013e7dd · Cited by 210

Hemodynamic Responses to Rapid Saline Loading

Fujimoto, N., Borlaug, B. A., Lewis, G. D., Hastings, J. L., Shafer, K. M., Bhella, P. S., Carrick‐Ranson, G., & Levine, B. D. (2012) · Circulation · doi:10.1161/circulationaha.112.111302 · Cited by 208

An Update on the Role of Cardiorespiratory Fitness, Structured Exercise and Lifestyle Physical Activity in Preventing Cardiovascular Disease and Health Risk

Ozemek, C., Laddu, D., Lavie, C. J., Claeys, H., Kaminsky, L. A., Ross, R., Wisløff, U., Arena, R. A., & Blair, S. N. (2018) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2018.11.005 · Cited by 224

The autophagy enhancer spermidine reverses arterial aging

LaRocca, T. J., Gioscia‐Ryan, R. A., Hearon, C. M., & Seals, D. R. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.04.004 · Cited by 216

Age Decreases Endothelial Progenitor Cell Recruitment Through Decreases in Hypoxia-Inducible Factor 1α Stabilization During Ischemia

Chang, E. I., Loh, S. A., Ceradini, D. J., Chang, E. I., Lin, S.-E., Bastidas, N., Aarabi, S., Chan, D. A., Freedman, M. L., Giaccia, A. J., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.715847 · Cited by 206

Polyamines: Functions, Metabolism, and Role in Human Disease Management

Sagar, N. A., Tarafdar, S., Agarwal, S., Tarafdar, A., & Sharma, S. (2021) · Medical Sciences · doi:10.3390/medsci9020044 · Cited by 210

Multisystem physiological perspective of human frailty and its modulation by physical activity

Taylor, J. A., Greenhaff, P. L., Bartlett, D. B., Jackson, T., Duggal, N. A., & Lord, J. M. (2022) · Physiological Reviews · doi:10.1152/physrev.00037.2021 · Cited by 218

The Aging Heart: Figure 1.Preprint

Chiao, Y. A., & Rabinovitch, P. S. (2015) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a025148 · Cited by 204

Vascular senescence in cardiovascular and metabolic diseases

Katsuumi, G., Shimizu, I., Yoshida, Y., & Minamino, T. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00018 · Cited by 196

Caloric restriction: powerful protection for the aging heart and vasculature

Weiss, E. P., & Fontana, L. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00685.2011 · Cited by 198

Arterial Aging and Subclinical Arterial Disease are Fundamentally Intertwined at Macroscopic and Molecular Levels

Lakatta, E. G., Wang, M., & Najjar, S. S. (2009) · Medical Clinics of North America · doi:10.1016/j.mcna.2009.02.008 · Cited by 201

Proximal Aortic Distensibility Is an Independent Predictor of All-Cause Mortality and Incident CV Events

Redheuil, A. B., Wu, C. O., Kachenoura, N., Ohyama, Y., Yan, R. T., Bertoni, A. G., Hundley, G. W., Duprez, D. A., Jacobs, D. R., Daniels, L. B., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.09.060 · Cited by 197

Vascular Endothelial Estrogen Receptor α Is Modulated by Estrogen Status and Related to Endothelial Function and Endothelial Nitric Oxide Synthase in Healthy Women

Gavin, K. M., Seals, D. R., Silver, A., & Moreau, K. L. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0278 · Cited by 202

Validation of the transfer function technique for generating central from peripheral upper limb pressure waveform

Gallagher, D., Adji, A. I., & O’Rourke, M. F. (2004) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2004.05.027 · Cited by 194

RAGE signaling in inflammation and arterial aging

Li, L. (2009) · Frontiers in bioscience · doi:10.2741/3315 · Cited by 195

Older Adults in the Cardiac Intensive Care Unit: Factoring Geriatric Syndromes in the Management, Prognosis, and Process of Care: A Scientific Statement From the American Heart Association

Damluji, A. A., Forman, D. E., van Diepen, S., Alexander, K. P., Page, R. L., II, Hummel, S. L., Menon, V., Katz, J. N., Albert, N. M., Afilalo, J., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000741 · Cited by 204

Nucleotide Excision DNA Repair Is Associated With Age-Related Vascular Dysfunction

Durik, M., Kavousi, M., van der Pluijm, I., Isaacs, A. J., Cheng, C., Verdonk, K., Loot, A. E., Oeseburg, H., Bhaggoe, U. M., Leijten, F. P. J., et al. (2012) · Circulation · doi:10.1161/circulationaha.112.104380 · Cited by 190

Flavonoids in modulation of cell survival signalling pathways

Mansuri, M. L., Parihar, P., Solanki, I., & Parihar, M. S. (2014) · Genes & Nutrition · doi:10.1007/s12263-014-0400-z · Cited by 189

The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice

Gano, L. B., Donato, A. J., Pasha, H. M., Hearon, C. M., Sindler, A. L., & Seals, D. R. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00377.2014 · Cited by 190

Aortic Root Remodeling Over the Adult Life Course

Lam, C. S. P., Xanthakis, V., SULLIVAN, L. M., Lieb, W., Aragam, J. R., Redfield, M. M., Mitchell, G. F., Benjamin, E. J., & Vasan, R. S. (2010) · Circulation · doi:10.1161/circulationaha.110.937839 · Cited by 185

Frailty and sarcopenia as the basis for the phenotypic manifestation of chronic diseases in older adults

Angulo, J., Assar, M. E., & Rodríguez‐Mañas, L. (2016) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2016.06.001 · Cited by 195

Suppression of the gut microbiome ameliorates age‐related arterial dysfunction and oxidative stress in mice

Brunt, V. E., Gioscia‐Ryan, R. A., Richey, J. J., Zigler, M. C., Cuevas, L. M., Gonzalez, A., Vázquez‐Baeza, Y., Battson, M. L., Smithson, A. T., Gilley, A. D., et al. (2019) · The Journal of Physiology · doi:10.1113/jp277336 · Cited by 182

Old Age and the Hepatic Sinusoid

Couteur, D. G. L., Warren, A., Cogger, V. C., Smedsrød, B. H., Sørensen, K. K., de Cabo, R., Fraser, R., & McCuskey, R. S. (2008) · The Anatomical Record · doi:10.1002/ar.20661 · Cited by 177

Angiotensin II Activates Matrix Metalloproteinase Type II and Mimics Age-Associated Carotid Arterial Remodeling in Young Rats

Wang, M., Zhang, J., Spinetti, G., Jiang, L., Monticone, R. E., Zhao, D., Cheng, L., Krawczyk, M., Talan, M. I., Pintus, G., et al. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61229-1 · Cited by 178

Rat Aortic MCP-1 and Its Receptor CCR2 Increase With Age and Alter Vascular Smooth Muscle Cell Function

Spinetti, G., Wang, M., Monticone, R. E., Zhang, J., Zhao, D., & Lakatta, E. G. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000134529.65173.08 · Cited by 178

Arterial stiffness and dementia pathology

Hughes, T. M., Wagenknecht, L. E., Craft, S., Mintz, A., HEISS, G. M., Palta, P., Wong, D. F., Zhou, Y., Knopman, D. S., Mosley, T. H., et al. (2018) · Neurology · doi:10.1212/wnl.0000000000005259 · Cited by 184

Estrogen-related mechanisms in sex differences of hypertension and target organ damage

Sabbatini, A. R., & Kararigas, G. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00306-7 · Cited by 191

Age-dependent changes in myocardial matrix metalloproteinase/tissue inhibitor of metalloproteinase profiles and fibroblast function

Lindsey, M. L., Goshorn, D. K., Squires, C. E., ESCOBAR, G., HENDRICK, J., Mingoia, J. T., Sweterlitsch, S. E., & Spinale, F. G. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.11.029 · Cited by 176

Tetrahydrobiopterin augments endothelium‐dependent dilatation in sedentary but not in habitually exercising older adults

Eskurza, I., Myerburgh, L. A., Kahn, Z. D., & Seals, D. R. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.092734 · Cited by 175

MicroRNAs Expression Profiles in Cardiovascular Diseases

Bronze-da-Rocha, E. (2014) · BioMed Research International · doi:10.1155/2014/985408 · Cited by 177

Life-long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice

Donato, A. J., Walker, A. E., Magerko, K. A., Bramwell, R. C., Black, A. D., Henson, G. D., Lawson, B. R., Lesniewski, L. A., & Seals, D. R. (2013) · Aging Cell · doi:10.1111/acel.12103 · Cited by 170

Dietary Sodium Restriction Reverses Vascular Endothelial Dysfunction in Middle-Aged/Older Adults With Moderately Elevated Systolic Blood Pressure

Jablonski, K., Racine, M. L., Geolfos, C. J., Gates, P. E., Chonchol, M., McQueen, M. B., & Seals, D. R. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.09.010 · Cited by 173

Physical activity and cardiovascular aging: Physiological and molecular insights

Jakovljević, D. G. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.05.016 · Cited by 186

The AGE-RAGE Axis: Implications for Age-Associated Arterial Diseases

Senatus, L. M., & Schmidt, A. M. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00187 · Cited by 167

Low Cardiac Index Is Associated With Incident Dementia and Alzheimer Disease: The Framingham Heart Study

Jefferson, A. L., Beiser, A. S., Himali, J. J., Seshadri, S., O’Donnell, C. J., Manning, W. J., Wolf, P. A., Au, R., & Benjamin, E. J. (2015) · Circulation · doi:10.1161/circulationaha.114.012438 · Cited by 169

Unique Aspects of the Elderly Surgical Population

Yang, R., Wolfson, M., & Lewis, M. C. (2011) · Geriatric Orthopaedic Surgery & Rehabilitation · doi:10.1177/2151458510394606 · Cited by 169

Arginase and vascular aging

Santhanam, L., Christianson, D. W., Nyhan, D. P., & Berkowitz, D. E. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90627.2008 · Cited by 166

Rationale, design, methods and baseline characteristics of the Asklepios Study

Rietzschel, E., Buyzere, M. D., Bekaert, S., Segers, P., Bacquer, D. D., Cooman, L., Damme, P. V., Cassiman, P., Langlois, M. R., Oostveldt, P. V., et al. (2007) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/hjr.0b013e328012c380 · Cited by 167

Is Sex Good for Your Health? A National Study on Partnered Sexuality and Cardiovascular Risk among Older Men and Women

Liu, H., Waite, L. J., Shen, S., & Wang, D. H. (2016) · Journal of Health and Social Behavior · doi:10.1177/0022146516661597 · Cited by 166

Multifaceted Mechanisms of Vascular Calcification in Aging

Pescatore, L. A., Gamarra, L. F., & Liberman, M. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.311576 · Cited by 167

The Role of Oxidative Stress in Cardiovascular Aging and Cardiovascular Diseases

Izzo, C., Vitillo, P., Pietro, P. D., Visco, V., Strianese, A., Virtuoso, N., Ciccarelli, M., Galasso, G., Carrizzo, A., & Vecchione, C. (2021) · Life · doi:10.3390/life11010060 · Cited by 177

Diabetes and vessel wall remodelling: from mechanistic insights to regenerative therapies

Spinetti, G., Kränkel, N., Emanueli, C., & Madeddu, P. R. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn039 · Cited by 165

Histone deacetylase activity governs diastolic dysfunction through a nongenomic mechanism

Jeong, M. Y., Lin, Y. H., Wennersten, S. A., Demos-Davies, K. M., Cavasin, M. A., Mahaffey, J. H., Monzani, V., Saripalli, C., Mascagni, P., Reece, T. B., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aao0144 · Cited by 163

Short‐term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress

Rippe, C., Lesniewski, L. A., Connell, M. L., LaRocca, T. J., Donato, A. J., & Seals, D. R. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00557.x · Cited by 160

Vascular smooth muscle-specific progerin expression accelerates atherosclerosis and death in a mouse model of Hutchinson-Gilford progeria syndrome

Hamczyk, M. R., Villa-Bellosta, R., Gonzalo, P., Andrés-Manzano, M. J., Nogales, P., Bentzon, J. F., López-Otín, C., & Andrés, V. (2018) · Circulation · doi:10.1161/circulationaha.117.030856 · Cited by 153

Aortic Stiffness Increases Upon Receipt of Anthracycline Chemotherapy

Chaosuwannakit, N., D'Agostino, R., Hamilton, C. A., Lane, K. S., Ntim, W. O., Lawrence, J. A., Melin, S. A., Ellis, L. R., Torti, F. M., Little, W. C., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.23.8527 · Cited by 157

Aging women and their endothelium: probing the relative role of estrogen on vasodilator function

Somani, Y. B., Pawelczyk, J. A., Souza, M. J. D., Kris‐Etherton, P. M., & Proctor, D. N. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00430.2018 · Cited by 164

Biomechanical characterization of ventricular–arterial coupling during aging: A multi-scale model study

Liang, F., Takagi, S., Himeno, R., & Liu, H. (2009) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2009.01.010 · Cited by 154

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Nowak, K. L., Rossman, M. J., Chonchol, M., & Seals, D. R. (2018) · Hypertension · doi:10.1161/hypertensionaha.117.10439 · Cited by 155

Hemodynamics

Secomb, T. W. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150038 · Cited by 152

Low-Dose Mineralocorticoid Receptor Blockade Prevents Western Diet–Induced Arterial Stiffening in Female Mice

DeMarco, V. G., Habibi, J., Jia, G., Aroor, A. R., Ramirez‐Perez, F. I., Martinez‐Lemus, L. A., Bender, S. B., Garro, M., Hayden, M. R., Sun, Z., et al. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05674 · Cited by 151

Involvement of NADPH oxidase in age-associated cardiac remodeling

Wang, M., Zhang, J., Walker, S. J., Dworakowski, R., Lakatta, E. G., & Shah, A. M. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.01.006 · Cited by 151

Polyamines: their significance for maintaining health and contributing to diseases

Xuan, M., Gu, X., Li, J., Huang, D., Chen, X., & He, Y. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01373-0 · Cited by 169

Age and flow-mediated dilation: a comparison of dilatory responsiveness in the brachial and popliteal arteries

Parker, B. A., Ridout, S. J., & Proctor, D. N. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00190.2006 · Cited by 150

Age‐related changes in the hepatic sinusoidal endothelium impede lipoprotein transfer in the rat†

Hilmer, S. N., Cogger, V. C., Fraser, R., McLean, A. J., SULLIVAN, D. R., & Couteur, D. G. L. (2005) · Hepatology · doi:10.1002/hep.20937 · Cited by 149

Defective autophagy in atherosclerosis: to die or to senesce?

Grootaert, M. O. J., Roth, L., Schrijvers, D. M., De Meyer, G. R. Y., & Martinet, W. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/7687083 · Cited by 147

The aging heart

Obas, V., & Vasan, R. S. (2018) · Clinical Science · doi:10.1042/cs20171156 · Cited by 148

Telomeres and Mitochondria in the Aging Heart

Moslehi, J. J., DePinho, R. A., & Sahin, E. (2012) · Circulation Research · doi:10.1161/circresaha.111.246868 · Cited by 154

Long non-coding RNA H19 regulates endothelial cell aging via inhibition of STAT3 signalling

Hofmann, P., Sommer, J., Theodorou, K., Kirchhof, L., Fischer, A., Li, Y., Matic, L. P., Hedin, U., Mäegdefessel, L., Dimmeler, S., et al. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy206 · Cited by 149

The role of inflammatory and fibrogenic pathways in heart failure associated with aging

Chen, W., & Frangogiannis, N. G. (2010) · Heart Failure Reviews · doi:10.1007/s10741-010-9161-y · Cited by 147

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Fleenor, B. S., Sindler, A. L., Marvi, N. K., Howell, K. L., Zigler, M. L., Yoshizawa, M., & Seals, D. R. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.10.008 · Cited by 148

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Lesniewski, L. A., Durrant, J., Connell, M. L., Henson, G. D., Black, A. D., Donato, A. J., & Seals, D. R. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01276.2010 · Cited by 142

Physiological Features of Aging Persons

Aalami, O. (2003) · Archives of Surgery · doi:10.1001/archsurg.138.10.1068 · Cited by 145

Age‐Associated Changes in the Vascular Renin‐Angiotensin System in Mice

Yoon, H. E., Kim, E. N., Kim, M. Y., Lim, J. H., Jang, I. E., Ban, T. H., Shin, S. J., Park, C. W., Chang, Y. S., & Choi, B. S. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/6731093 · Cited by 152

The protective effect of resveratrol on vascular aging by modulation of the renin–angiotensin system

Kim, E. N., Kim, M. Y., Lim, J. H., Kim, Y., Shin, S. J., Park, C. W., Kim, Y., Chang, Y. S., Yoon, H. E., & Choi, B. S. (2018) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2018.01.043 · Cited by 142

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Kirkman, D. L., Robinson, A. T., Rossman, M. J., Seals, D. R., & Edwards, D. G. (2021) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00917.2020 · Cited by 150

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Lakatta, E. G., Levy, D. A., & Levy, D. A. (2015)

Aging and Cardiovascular Disease

Wissler, R. W., & Robert, L. (1996) · Circulation · doi:10.1161/01.cir.93.9.1608 · Cited by 19

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Lakatta, E. G. (2006) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2006.08.040

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Wei, Y. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315217

Aging Issues in Cardiology

(2004) · Developments in cardiovascular medicine · doi:10.1007/978-1-4419-8865-2 · Cited by 6