Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises: Part I: Aging Arteries: A “Set Up” for Vascular Disease

Hemodynamic Patterns of Age-Related Changes in Blood Pressure: The Framingham Heart Study

Franklin, S. S., Gustin, W., Wong, N. D., Larson, M. G., Weber, M. A., Kannel, W. B., & Levy, D. (1997) · Circulation · doi:10.1161/01.cir.96.1.308 · Cited by 2,321

Impact of Aortic Stiffness on Survival in End-Stage Renal Disease

Blacher, J., Guerin, A. P., Pannier, B., Marchais, S. J., Safar, M. E., & London, G. M. (1999) · Circulation · doi:10.1161/01.cir.99.18.2434 · Cited by 2,138

Is Pulse Pressure Useful in Predicting Risk for Coronary Heart Disease?

Franklin, S. S., Khan, S. A., Wong, N. D., Larson, M. G., & Levy, D. A. (1999) · Circulation · doi:10.1161/01.cir.100.4.354 · Cited by 1,756

Aortic Stiffness Is an Independent Predictor of Primary Coronary Events in Hypertensive Patients

Boutouyrie, P., Tropeano, A., Asmar, R. G., Gautier, I., Bénétos, A., Lacolley, P. J., & Laurent, S. (2002) · Hypertension · doi:10.1161/hy0102.099031 · Cited by 1,745

Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients

Blacher, J., Asmar, R., Djane, S., London, G. M., & Safar, M. E. (1999) · Hypertension · doi:10.1161/01.hyp.33.5.1111 · Cited by 1,493

Does the Relation of Blood Pressure to Coronary Heart Disease Risk Change With Aging?: The Framingham Heart Study

Franklin, S. S., Larson, M. G., Khan, S. A., Wong, N. D., Leip, E. P., Kannel, W. B., & Levy, D. (2001) · Circulation · doi:10.1161/01.cir.103.9.1245 · Cited by 1,390

Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women

Celermajer, D. S., Sørensen, K. E., Spiegelhalter, D. J., Georgakopoulos, D., Robinson, J. T. C., & Deanfield, J. E. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90305-0 · Cited by 1,354

Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises

Lakatta, E. G., & Levy, D. A. (2003) · Circulation · doi:10.1161/01.cir.0000048893.62841.f7 · Cited by 1,257

Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises

Lakatta, E. G. (2003) · Circulation · doi:10.1161/01.cir.0000048894.99865.02 · Cited by 1,105

Effects of age and aerobic capacity on arterial stiffness in healthy adults.

Vaitkevicius, P. V., Fleg, J. L., Engel, J.-H., O’Connor, F. C., Wright, J. G., Lakatta, L. E., Yin, F. C. P., & Lakatta, E. G. (1993) · Circulation · doi:10.1161/01.cir.88.4.1456 · Cited by 1,085

Associations of cardiovascular biomarkers and plasma albumin with exceptional survival to the highest ages

Hirata, T., Arai, Y., Yuasa, S., Abe, Y., Takayama, M., Sasaki, T., Kunitomi, A., Inagaki, H., Endo, M., Morinaga, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17636-0 · Cited by 138

Role of Gender in Heart Failure with Normal Left Ventricular Ejection Fraction

Regitz‐Zagrosek, V., Brokat, S., & Tschöpe, C. (2006) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2006.08.011 · Cited by 142

Advanced Glycation Endproduct Crosslinking in the Cardiovascular System

Zieman, S. J., & Kass, D. A. (2004) · Drugs · doi:10.2165/00003495-200464050-00001 · Cited by 142

Aerobic exercise and other healthy lifestyle factors that influence vascular aging

Santos‐Parker, J. R., LaRocca, T. J., & Seals, D. R. (2014) · AJP Advances in Physiology Education · doi:10.1152/advan.00088.2014 · Cited by 153

Left ventricular structure and diastolic function with human ageing Relation to habitual exercise and arterial stiffness

Gates, P. E. (2003) · European Heart Journal · doi:10.1016/j.ehj.2003.09.026 · Cited by 144

Habitual exercise and vascular ageing

Seals, D. R., Walker, A. E., Pierce, G. L., & Lesniewski, L. A. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.178822 · Cited by 173

Defining vascular aging and cardiovascular risk

Laurent, S. (2012) · Journal of Hypertension · doi:10.1097/hjh.0b013e328353e501 · Cited by 139

Vascular Dysfunction in Aging: Potential Effects of Resveratrol, an Anti- Inflammatory Phytoestrogen

Labinskyy, N., Csiszár, A., Veress, G., Stef, G., Pacher, P., Oroszi, G., WU, J. M., & Ungvari, Z. I. (2006) · Current Medicinal Chemistry · doi:10.2174/092986706776360987 · Cited by 140

Vascular Aging across the Menopause Transition in Healthy Women

Moreau, K. L., & Hildreth, K. L. (2014) · Advances in Vascular Medicine · doi:10.1155/2014/204390 · Cited by 138

Diabetes and ageing‐induced vascular inflammation

Assar, M. E., Angulo, J., & Rodríguez‐Mañas, L. (2015) · The Journal of Physiology · doi:10.1113/jp270841 · Cited by 143

The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species

Carmona‐Gutiérrez, D., Zimmermann, A., Kainz, K., Pietrocola, F., Chen, G., Maglioni, S., Schiavi, A., Nah, J., Mertel, S., Beuschel, C. B., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08555-w · Cited by 138

Late-life restoration of mitochondrial function reverses cardiac dysfunction in old mice

Chiao, Y. A., Zhang, H., Sweetwyne, M. T., Whitson, J. D., Ting, Y. S., Basisty, N., Pino, L. K., Quarles, E. K., Nguyen, N.-H. T., Campbell, M. D., et al. (2020) · eLife · doi:10.7554/elife.55513 · Cited by 136

Decline in endothelial function across the menopause transition in healthy women is related to decreased estradiol and increased oxidative stress

Moreau, K. L., Hildreth, K. L., Klawitter, J., Blatchford, P. J., & Kohrt, W. M. (2020) · GeroScience · doi:10.1007/s11357-020-00236-7 · Cited by 136

Vascular Hyperpermeability and Aging

Oakley, R. P. (2014) · Aging and Disease · doi:10.14336/ad.2014.0500114 · Cited by 138

Epidemiology of atrial fibrillation

Rich, M. W. (2009) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-008-9337-8 · Cited by 135

Vascular Aging in Women: is Estrogen the Fountain of Youth?

Novella, S., Dantas, A. P., Segarra, G., Medina, P., & Hermenegildo, C. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00165 · Cited by 148

MicroRNA-34a Induces Vascular Smooth Muscle Cells Senescence by SIRT1 Downregulation and Promotes the Expression of Age-Associated Pro-inflammatory Secretory Factors

Badi, I., Burba, I., Ruggeri, C., Zeni, F., Bertolotti, M., Scopece, A., Pompilio, G., & Raucci, A. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu180 · Cited by 136

CD36 Expression Contributes to Age-Induced Cardiomyopathy in Mice

Koonen, D. P. Y., Febbraio, M., Bonnet, S., Nagendran, J., Young, M. E., Michelakis, E. D., & Dyck, J. R. B. (2007) · Circulation · doi:10.1161/circulationaha.107.712901 · Cited by 137

Superoxide‐lowering therapy with TEMPOL reverses arterial dysfunction with aging in mice

Fleenor, B. S., Seals, D. R., Zigler, M. L., & Sindler, A. L. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00783.x · Cited by 133

Age-Related Changes in the Elastic Tissue of the Human Aorta

Fritze, O., Romero, B., Schleicher, M., Jacob, M. P., Oh, D., STARCHER, B. C., Schenke‐Layland, K., Buján, J., & Stock, U. A. (2011) · Journal of Vascular Research · doi:10.1159/000331278 · Cited by 132

A Randomized Double-Blind Trial of Enalapril in Older Patients With Heart Failure and Preserved Ejection Fraction

Kitzman, D. W., Hundley, W. G., Brubaker, P. H., Morgan, T. M., Moore, J. B., Stewart, K. P., & Little, W. C. (2010) · Circulation Heart Failure · doi:10.1161/circheartfailure.109.898916 · Cited by 131

Changing the Timing of Antihypertensive Therapy to Reduce Nocturnal Blood Pressure in CKD: An 8-Week Uncontrolled Trial

Minutolo, R., Gabbai, F. B., Borrelli, S., Scigliano, R., Trucillo, P., Baldanza, D., Laurino, S., Mascia, S., Conte, G., & Nicola, L. D. (2007) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2007.07.020 · Cited by 132

Early vascular aging and the role of central blood pressure

Kotsis, V., Stabouli, S., Karafillis, I., & Nilsson, P. M. (2011) · Journal of Hypertension · doi:10.1097/hjh.0b013e32834a4d9f · Cited by 130

Heart Failure With Preserved Ejection Fraction Expert Panel Report

Parikh, K. S., Sharma, K., Fiuzat, M., Surks, H. K., George, J. T., Honarpour, N., Depré, C., Desvigne-Nickens, P. M., Nkulikiyinka, R., Lewis, G. D., et al. (2018) · JACC Heart Failure · doi:10.1016/j.jchf.2018.06.008 · Cited by 129

Calpain-1 Regulation of Matrix Metalloproteinase 2 Activity in Vascular Smooth Muscle Cells Facilitates Age-Associated Aortic Wall Calcification and Fibrosis

Jiang, L., Zhang, J., Monticone, R. E., Telljohann, R. S., Wu, J. T., Wang, M., & Lakatta, E. G. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.196840 · Cited by 130

Vascular endothelial cells senescence is associated with NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation via reactive oxygen species (ROS)/thioredoxin-interacting protein (TXNIP) pathway

Yin, Y., Zhou, Z., Liu, W., Chang, Q., Sun, G., & Dai, Y. (2017) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2017.01.001 · Cited by 131

Arterial Stiffness

Avolio, A. P. (2013) · Pulse · doi:10.1159/000348620 · Cited by 130

Copper deficiency may be a leading cause of ischaemic heart disease

DiNicolantonio, J. J., Mangan, D. F., & O’Keefe, J. H. (2018) · Open Heart · doi:10.1136/openhrt-2018-000784 · Cited by 129

Successful Aging: The Role of Physical Activity

Chodzko-Zajko, W. J., Schwingel, A., & Park, C. H. (2008) · American Journal of Lifestyle Medicine · doi:10.1177/1559827608325456 · Cited by 142

Aging in the Cardiovascular System: Lessons from Hutchinson-Gilford Progeria Syndrome

Hamczyk, M. R., del Campo, L., & Andrés, V. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021317-121454 · Cited by 134

Effect of Age on Complexity and Causality of the Cardiovascular Control: Comparison between Model-Based and Model-Free Approaches

Porta, A., Faes, L., Bari, V., Marchi, A., Bassani, T., Nollo, G., Perseguini, N. M., Milan, J. C., Minatel, V., Borghi‐Silva, A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089463 · Cited by 127

Regional and Global Right Ventricular Function in Healthy Individuals Aged 20–90 Years: A Pulsed Doppler Tissue Imaging Study Umeå General Population Heart Study

Lindqvist, P., Waldenström, A. P., Henein, M. Y., Mörner, S., & Kazzam, E. E. (2005) · Echocardiography · doi:10.1111/j.1540-8175.2005.04023.x · Cited by 127

Mouse models of ageing and their relevance to disease

Kõks, S., Dogan, S., Tuna, B. G., González-Navarro, H., Potter, P., & Vandenbroucke, R. E. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.10.001 · Cited by 125

The Impact of Aging on Cardio and Cerebrovascular Diseases

Izzo, C., Carrizzo, A., Alfano, A., Virtuoso, N., Capunzo, M., Calabrese, M., Simone, E. D., Sciarretta, S., Frati, G., Oliveti, M., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020481 · Cited by 134

The effect of lifelong exercise frequency on arterial stiffness

Shibata, S., Fujimoto, N., Hastings, J. L., Carrick‐Ranson, G., Bhella, P. S., Hearon, C. M., & Levine, B. D. (2018) · The Journal of Physiology · doi:10.1113/jp275301 · Cited by 124

The scientific basis of caloric restriction leading to longer life

Fontana, L. (2009) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32831ef1ba · Cited by 124

No difference in the skeletal muscle angiogenic response to aerobic exercise training between young and aged men

Gavin, T. P., Ruster, R. S., Carrithers, J. A., Zwetsloot, K. A., Kraus, R. M., Evans, C. A., Knapp, D. J., Drew, J. L., McCartney, J. S., Garry, J. P., et al. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.143198 · Cited by 126

The Impact of Cardiovascular Risk Factors on Aortic Stiffness and Wave Reflections Depends on Age

McEniery, C. M., Yasmin, Y., Maki-Petaja, K. M., McDonnell, B. J., Munnery, M. M., Hickson, S. S., Franklin, S. S., Cockcroft, J. R., & Wilkinson, I. B. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.156950 · Cited by 124

Mitochondria-targeted antioxidant therapy with MitoQ ameliorates aortic stiffening in old mice

Gioscia‐Ryan, R. A., Battson, M. L., Cuevas, L. M., Eng, J. S., Murphy, M. P., & Seals, D. R. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00670.2017 · Cited by 127

The Conundrum of Arterial Stiffness, Elevated Blood Pressure, and Aging

AlGhatrif, M., & Lakatta, E. G. (2015) · Current Hypertension Reports · doi:10.1007/s11906-014-0523-z · Cited by 123

Habitually exercising older men do not demonstrate age‐associated vascular endothelial oxidative stress

Pierce, G. L., Donato, A. J., LaRocca, T. J., Eskurza, I., Silver, A., & Seals, D. R. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2011.00748.x · Cited by 122

Nitrite Reduction and Cardiovascular Protection

Omar, S. A., & Webb, A. J. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.01.012 · Cited by 121

Shift Work Is a Risk Factor for Increased Blood Pressure in Japanese Men

Suwazono, Y., Dochi, M., Sakata, K., Okubo, Y., Oishi, M., ­Tanaka, K., Kobayashi, E., & Nogawa, K. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.114553 · Cited by 121

Inflammation, Oxidative Stress, Vascular Aging and Atherosclerotic Ischemic Stroke

Koutsaliaris, I. K., Moschonas, I. C., Pechlivani, L., Tsouka, A. N., & Tselepis, A. D. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666210921161711 · Cited by 123

Differential Modulation of Nitric Oxide Synthases in Aging: Therapeutic Opportunities

Cáu, S. B. D. A., Carneiro, F. S., & Tostes, R. C. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00218 · Cited by 131

Atherothrombosis and Oxidative Stress: Mechanisms and Management in Elderly

Violi, F., Loffredo, L., Carnevale, R., Pignatelli, P., & Pastori, D. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6963 · Cited by 125

Time‐Efficient Inspiratory Muscle Strength Training Lowers Blood Pressure and Improves Endothelial Function, NO Bioavailability, and Oxidative Stress in Midlife/Older Adults With Above‐Normal Blood Pressure

Craighead, D. H., Heinbockel, T. C., Freeberg, K. A., Rossman, M. J., Jackman, R. A., Jankowski, L. R., Hamilton, M. N., Ziemba, B. P., Reisz, J. A., D’Alessandro, A., et al. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.020980 · Cited by 128

Nanoparticles in the diagnosis and treatment of vascular aging and related diseases

Xu, H., Li, S., & Liu, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01082-z · Cited by 130

Edward F. Adolph Distinguished Lecture: The remarkable anti-aging effects of aerobic exercise on systemic arteries

Seals, D. R. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00362.2014 · Cited by 118

Noncoding RNA in age-related cardiovascular diseases

Greco, S., Gorospe, M., & Martelli, F. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.01.011 · Cited by 119

Age‐related changes in endothelial nitric oxide synthase phosphorylation and nitric oxide dependent vasodilation: evidence for a novel mechanism involving sphingomyelinase and ceramide‐activated phosphatase 2A

SMITH, A. R. W., Visioli, F., Frei, B. B., & Hagen, T. M. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00232.x · Cited by 118

Dose-response relationship of endurance training for autonomic circulatory control in healthy seniors

Okazaki, K., Iwasaki, K., Prasad, A., Palmer, M. D., Martini, E. R., Fu, Q., Arbab‐Zadeh, A., Zhang, R., & Levine, B. D. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00085.2005 · Cited by 122

Effect of age on O2 uptake kinetics and the adaptation of muscle deoxygenation at the onset of moderate-intensity cycling exercise

DeLorey, D. S., Kowalchuk, J. M., & Paterson, D. H. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01179.2003 · Cited by 120

Preoperative assessment of the older surgical patient: honing in on geriatric syndromes

Groban, L., Kim, S., & Brooks, A. K. (2014) · Clinical Interventions in Aging · doi:10.2147/cia.s75285 · Cited by 117

Hypertension and Its Role in Cognitive Function: Current Evidence and Challenges for the Future

Hughes, T. M., & Sink, K. M. (2015) · American Journal of Hypertension · doi:10.1093/ajh/hpv180 · Cited by 117

The renin–angiotensin system and its involvement in vascular disease

van Thiel, B. S., van der Pluijm, I., Riet, L. T., Essers, J., & Danser, A. H. J. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.090 · Cited by 120

Heat therapy: mechanistic underpinnings and applications to cardiovascular health

Brunt, V. E., & Minson, C. T. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00141.2020 · Cited by 121

Elevated Mineralocorticoid Receptor Activity in Aged Rat Vascular Smooth Muscle Cells Promotes a Proinflammatory Phenotype via Extracellular Signal-Regulated Kinase 1/2 Mitogen-Activated Protein Kinase and Epidermal Growth Factor Receptor-Dependent Pathways

Krug, A. W., Allenhöfer, L., Monticone, R. E., Spinetti, G., Gekle, M., Wang, M., & Lakatta, E. G. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.148783 · Cited by 115

High serum pentosidine concentrations are associated with increased arterial stiffness and thickness in patients with type 2 diabetes

Yoshida, N., Okumura, K.-I., & Aso, Y. (2005) · Metabolism · doi:10.1016/j.metabol.2004.09.014 · Cited by 138

Rejuvenation of Human Cardiac Progenitor Cells With Pim-1 Kinase

Mohsin, S., Khan, M., Nguyen, J., Alkatib, M., Siddiqi, S., Hariharan, N., Wallach, K., Monsanto, M. M., Gude, N. A., Dembitsky, W. P., et al. (2013) · Circulation Research · doi:10.1161/circresaha.113.302302 · Cited by 114

The Epidemiology of Atrial Fibrillation in Elderly Persons: The Tip of the Iceberg

Go, A. S. (2005) · The American Journal of Geriatric Cardiology · doi:10.1111/j.1076-7460.2005.02278.x · Cited by 114

Neurodegeneration and Inflammation

DeLegge, M. H., & Smoke, A. (2008) · Nutrition in Clinical Practice · doi:10.1177/011542650802300135 · Cited by 114

The Future of Aging Therapies

Hadley, E. C., Lakatta, E. G., Morrison‐Bogorad, M., Warner, H. R., & Hodes, R. J. (2005) · Cell · doi:10.1016/j.cell.2005.01.030 · Cited by 111

Lower capillarization, VEGF protein, and VEGF mRNA response to acute exercise in the vastus lateralis muscle of aged vs. young women

Croley, A. N., Zwetsloot, K. A., Westerkamp, L. M., Ryan, N. A., Pendergast, A. M., Hickner, R. C., Pofahl, W. E., & Gavin, T. P. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00498.2005 · Cited by 113

Aging affects the cardiovascular responses to cold stress in humans

Hess, K. L., Wilson, T. E., Sauder, C. L., Gao, Z., Ray, C. A., & Monahan, K. D. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00605.2009 · Cited by 118

The Implications of Aging on Vascular Health

Ahmed, B., Rahman, A. A., Lee, S., & Malhotra, R. K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252011188 · Cited by 134

Multi-Ethnic Study of Atherosclerosis (MESA)

Blaha, M. J., & DeFilippis, A. P. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.05.006 · Cited by 124

MFG‐E8 activates proliferation of vascular smooth muscle cells via integrin signaling

Wang, M., Fu, Z., Wu, J. T., Zhang, J., Jiang, L., Khazan, B., Telljohann, R. S., Zhao, M., Krug, A. W., Pikilidou, M. I., et al. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00813.x · Cited by 112

Empowering Adult Stem Cells for Myocardial Regeneration

Mohsin, S., Siddiqi, S., Collins, B. L., & Sussman, M. A. (2011) · Circulation Research · doi:10.1161/circresaha.111.243071 · Cited by 111

Epidemiology, Pathophysiology, and Prognosis of Heart Failure in the Elderly

Thomas, S., & Rich, M. W. (2007) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2006.08.001 · Cited by 111

Magnesium and Hypertension in Old Age

Dominguez, L. J., Veronese, N., & Barbagallo, M. (2020) · Nutrients · doi:10.3390/nu13010139 · Cited by 119

Effects of different exercise interventions on heart rate variability and cardiovascular health factors in older adults: a systematic review

Grässler, B., Thielmann, B., Böckelmann, I., & Hökelmann, A. (2021) · European Review of Aging and Physical Activity · doi:10.1186/s11556-021-00278-6 · Cited by 111

Selective MicroRNA Suppression in Human Thoracic Aneurysms

Jones, J. A., Stroud, R. E., O’Quinn, E. C., Black, L. E., Barth, J. L., Elefteriades, J. A., Bavaria, J. E., Gorman, J. H., Gorman, R. C., Spinale, F. G., et al. (2011) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.111.960419 · Cited by 113

Thrombospondin-1 signaling through CD47 inhibits cell cycle progression and induces senescence in endothelial cells

Gao, Q., Chen, K., Gao, L., Zheng, Y., & Yang, Y.-G. (2016) · Cell Death & Disease · doi:10.1038/cddis.2016.155 · Cited by 110

Pathology of mouse models of accelerated aging

Harkema, L., Youssef, S. A., & de Bruin, A. (2016) · Veterinary Pathology · doi:10.1177/0300985815625169 · Cited by 105

Aging-induced biological changes and cardiovascular diseases.

Fajemiroye, J. O., Cunha, L. C. D., Saavedra-Rodríguez, R., Rodrigues, K. L., Naves, L. M., Mourão, A. A., Silva, E. F. D., Williams, N. E. E., Martins, J. L. R., Sousa, R. B., et al. (2018) · BioMed Research International · doi:10.1155/2018/7156435 · Cited by 109

Bradykinin Protects Against Oxidative Stress–Induced Endothelial Cell Senescence

Oeseburg, H., Iusuf, D., van der Harst, P., van Gilst, W. H., Henning, R. H., & Roks, A. J. M. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.123729 · Cited by 108

Hazard identification of particulate matter on vasomotor dysfunction and progression of atherosclerosis

Möller, P., Mikkelsen, L., Vesterdal, L. K., Folkmann, J. K., Forchhammer, L., Roursgaard, M., Danielsen, P. H., & Loft, S. H. (2011) · Critical Reviews in Toxicology · doi:10.3109/10408444.2010.533152 · Cited by 108

Relationship between carotid intima-media thickness and arterial stiffness in children after Kawasaki disease

Cheung, Y.-F., Wong, S. J., & Ho, M. (2006) · Archives of Disease in Childhood · doi:10.1136/adc.2006.096628 · Cited by 108

Impaired flow-mediated dilation with age is not explained by l -arginine bioavailability or endothelial asymmetric dimethylarginine protein expression

Gates, P. E., Boucher, M. L., Silver, A., Monahan, K. D., & Seals, D. R. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00660.2006 · Cited by 107

Microcirculation and Macrocirculation in Hypertension: A Dangerous Cross-Link?

Laurent, S., Rosei, C. A., Bruno, R. M., & Rizzoni, D. (2022) · Hypertension · doi:10.1161/hypertensionaha.121.17962 · Cited by 111

Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence

Mahoney, S. A., Venkatasubramanian, R., Darrah, M. A., Ludwig, K. R., VanDongen, N. S., Greenberg, N., Longtine, A. G., Hutton, D. A., Brunt, V. E., Campisi, J., et al. (2023) · Aging Cell · doi:10.1111/acel.14060 · Cited by 111

Components of Hemodynamic Load and Cardiovascular Events

Cooper, L. L., Rong, J., Benjamin, E. J., Larson, M. G., Levy, D. A., Vita, J. A., Hamburg, N. M., Vasan, R. S., & Mitchell, G. F. (2014) · Circulation · doi:10.1161/circulationaha.114.011357 · Cited by 107

Milk Fat Globule Protein Epidermal Growth Factor-8

Fu, Z., Wang, M., Guček, M., Zhang, J., Wu, J. T., Jiang, L., Monticone, R. E., Khazan, B., Telljohann, R. S., Mattison, J. A., et al. (2009) · Circulation Research · doi:10.1161/circresaha.108.187088 · Cited by 105

Arterial Stiffness Is Related to Insulin Resistance in Nondiabetic Hypertensive Older Adults

Sengstock, D. M., Vaitkevicius, P. V., & Supiano, M. A. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1686 · Cited by 106

Mechanisms of aging-induced impairment of endothelium-dependent relaxation: role of tetrahydrobiopterin

Blackwell, K. A., Sorenson, J. P., Richardson, D. M., Smith, L. A., Suda, O., Nath, K. A., & Katušić, Z. S. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00248.2004 · Cited by 109

Arterial Stiffness, Physical Function, and Functional Limitation

Brunner, E. J., Shipley, M. J., Witte, D. R., Singh‐Manoux, A., Britton, A. R., Tabák, Á. G., McEniery, C. M., Wilkinson, I. B., & Mika Kivimaki, B. (2011) · Hypertension · doi:10.1161/hypertensionaha.110.168864 · Cited by 106

Aortic elongation part I: the normal aortic ageing process

Adriaans, B. P., Heuts, S., Gerretsen, S. C., Cheriex, E. C., Vos, R., Natour, E., Maessen, J. G., Nia, P. S., Crijns, H. J. G. M., Wildberger, J. E., et al. (2018) · Heart · doi:10.1136/heartjnl-2017-312866 · Cited by 104

Myocardial Regeneration and Stem Cell Repair

Leri, A., Kajstura, J., Anversa, P., & Frishman, W. H. (2008) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2007.11.002 · Cited by 103

Increased Aortic Calpain-1 Activity Mediates Age-Associated Angiotensin II Signaling of Vascular Smooth Muscle Cells

Jiang, L., Wang, M., Zhang, J., Monticone, R. E., Telljohann, R. S., Spinetti, G., Pintus, G., & Lakatta, E. G. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002231 · Cited by 103

Cardiac Disorders as Risk Factors for Alzheimer's Disease

Alves, T. C. T. F., Ferreira, L. K., Wajngarten, M., & Busatto, G. F. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091561 · Cited by 107

Vascular aging: insights from studies on cellular senescence, stem cell aging, and progeroid syndromes

Minamino, T., & Komuro, I. (2008) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio1324 · Cited by 104

Significance of atypical symptoms for the diagnosis and management of myocardial infarction in elderly patients admitted to emergency departments

Grosmaître, P., Vavasseur, O. L., Yachouh, E., Courtial, Y., Jacob, X., Meyran, S., & Lantelme, P. (2013) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2013.04.010 · Cited by 101

Carotid Arterial Stiffness and Its Relationship to Exercise Intolerance in Older Patients With Heart Failure and Preserved Ejection Fraction

Kitzman, D. W., Herrington, D. M., Brubaker, P. H., Moore, J. B., Eggebeen, J., & Haykowsky, M. J. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.00163 · Cited by 100

Vascular ageing: Underlying mechanisms and clinical implications

Laina, A., Stellos, K., & Stamatelopoulos, K. S. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.06.007 · Cited by 106

Heart Failure with Preserved Ejection Fraction: Persistent Diagnosis, Therapeutic Enigma

Bhuiyan, T., & Maurer, M. S. (2011) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-011-0184-2 · Cited by 102

Review of ‘the Potential Role of Arterial Stiffness in the Pathogenesis of Alzheimer’s Disease’

Hughes, T. M., Craft, S., & López, O. L. (2015) · Neurodegenerative Disease Management · doi:10.2217/nmt.14.53 · Cited by 105

Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain

Benameur, T., Soleti, R., Panaro, M. A., Torre, M. E. L., Monda, V., Messina, G., & Porro, C. (2021) · Molecules · doi:10.3390/molecules26164794 · Cited by 105

Oxidative stress in vascular senescence: lessons from successfully aging species

Ungvari, Z. I. (2008) · Frontiers in bioscience · doi:10.2741/3064 · Cited by 103

Age- and gender-related changes in plaque composition in patients with acute coronary syndrome: the PROSPECT study

Ruiz-García, J., Lerman, A., Weisz, G., Maehara, A., Mintz, G. S., Fahy, M. P., Xu, K., Lansky, A. J., Cristea, E., Farah, T. G., et al. (2012) · EuroIntervention · doi:10.4244/eijv8i8a142 · Cited by 101

Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises. Part III: cellular and molecular clues to heart and arterial aging. Circulation

Lakatta, E. G., Levy, D. A., & Levy, D. A. (2015)

Aging and Cardiovascular Disease

Wissler, R. W., & Robert, L. (1996) · Circulation · doi:10.1161/01.cir.93.9.1608 · Cited by 19

Aging of the Heart and Arteries: A Set-up for Cardiovascular Disease Leading to Heart Failure

Lakatta, E. G. (2006) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2006.08.040

Aging’s Accomplice in Harming the Cardiovascular System

Wei, Y. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315217

Aging Issues in Cardiology

(2004) · Developments in cardiovascular medicine · doi:10.1007/978-1-4419-8865-2 · Cited by 6