Clinical Features of 8295 Patients With Resistant Hypertension Classified on the Basis of Ambulatory Blood Pressure Monitoring
Abstract
We aimed to estimate the prevalence of resistant hypertension through both office and ambulatory blood pressure monitoring in a large cohort of treated hypertensive patients from the Spanish Ambulatory Blood Pressure Monitoring Registry. In addition, we also compared clinical features of patients with true or white-coat–resistant hypertension. In December 2009, we identified 68 045 treated patients with complete information for this analysis. Among them, 8295 (12.2% of the database) had resistant hypertension (office blood pressure ≥140 and/or 90 mm Hg while being treated with ≥3 antihypertensive drugs, 1 of them being a diuretic). After ambulatory blood pressure monitoring, 62.5% of patients were classified as true resistant hypertensives, the remaining 37.5% having white-coat resistance. The former group was younger, more frequently men, with a longer duration of hypertension and a worse cardiovascular risk profile. The group included larger proportions of smokers, diabetics, target organ damage (including left ventricular hypertrophy, impaired renal function, and microalbuminuria), and documented cardiovascular disease. Moreover, true resistant hypertensives exhibited in a greater proportion a riser pattern (22% versus 18%; P <0.001). In conclusion, this study first reports the prevalence of resistant hypertension in a large cohort of patients in usual daily practice. Resistant hypertension is present in 12% of the treated hypertensive population, but among them more than one third have normal ambulatory blood pressure. A worse risk profile is associated with true resistant hypertension, but this association is weak, thus making it necessary to assess ambulatory blood pressure monitoring for a correct diagnosis and management.
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Among treated adults with hypertension, prevalent apparent treatment-resistant hypertension occurs in 15% to 18% of clinic-based samples.
“Among treated adults with hypertension, prevalent aTRH occurs in ≈12% to 15% of population-based13–16 and 15% to 18% of clinic-based reports.17–20”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [18]
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Cites
2007 Guidelines for the Management of Arterial Hypertension
Mancia, G., Backer, G. D., Dominiczak, A. F., Cífková, R., Fagard, R. H., Germanò, G., Grassi, G. M., Heagerty, A. M., Kjeldsen, S. E., Laurent, S., et al. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e3281fc975a · Cited by 5,818 · see citing works
Self-citationPickering, T. G., Hall, J. E., Appel, L. J., Falkner, B. E., Graves, J., Hill, M. N., Jones, D. W., Kurtz, T., Sheps, S. G., & Roccella, E. J. (2005) · Circulation · doi:10.1161/01.cir.0000154900.76284.f6 · Cited by 3,985 · see citing works
Resistant Hypertension: Diagnosis, Evaluation, and Treatment
Calhoun, D. A., Jones, D. W., Textor, S. C., Goff, D. C., Murphy, T. P., Toto, R. D., White, A. J., Cushman, W. C., White, W. B., Sica, D. A., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.189141 · Cited by 2,232 · see citing works
Pickering, T. G., Hall, J. E., Appel, L. J., Falkner, B. E., Graves, J., Hill, M. N., Jones, D. W., Kurtz, T., Sheps, S. G., & Roccella, E. J. (2005) · Hypertension · doi:10.1161/01.hyp.0000150859.47929.8e · Cited by 2,051 · see citing works
Ambulatory blood pressure. An independent predictor of prognosis in essential hypertension.
Verdecchia, P., Porcellati, C., Schillaci, G., Borgioni, C., Ciucci, A., Battistelli, M., Guerrieri, M., Gatteschi, C., Zampi, I., Santucci, A., et al. (1994) · Hypertension · doi:10.1161/01.hyp.24.6.793 · Cited by 1,671 · see citing works
O'Brien, E., Asmar, R., Beilin, L., Imai, Y., Mallion, J.-M., Mancia, G., Mengden, T., Myers, M., Padfield, P., Palatini, P., et al. (2003) · Journal of Hypertension · doi:10.1097/00004872-200305000-00001 · Cited by 1,655 · see citing works
Staessen, J. A. (1999) · JAMA · doi:10.1001/jama.282.6.539 · Cited by 1,592 · see citing works
Resistant Hypertension: Diagnosis, Evaluation, and Treatment
Calhoun, D. A., Jones, D. W., Textor, S. C., Goff, D. C., Murphy, T. P., Toto, R. D., White, A. J., Cushman, W. C., White, W. B., Sica, D. A., et al. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.189141 · Cited by 1,404 · see citing works
Dolan, E., Stanton, A., Thijs, L., Hinedi, K., Atkins, N., McClory, S., Hond, E. D., McCormack, P., Staessen, J. A., & O’Brien, E. (2005) · Hypertension · doi:10.1161/01.hyp.0000170138.56903.7a · Cited by 1,227 · see citing works
Ohkubo, T., Hozawa, A., Yamaguchi, J., Kikuya, M., Ohmori, K., Michimata, M., Matsubara, M., Hashimoto, J., Hoshi, H., Araki, T., et al. (2002) · Journal of Hypertension · doi:10.1097/00004872-200211000-00017 · Cited by 1,053 · see citing works
Cushman, W. C., Ford, C. E., Cutler, J. A., Margolis, K. L., Davis, B. R., Grimm, R. H., Black, H. R., Hamilton, B. P., Holland, J., Nwachuku, C., et al. (2002) · The Journal of Clinical Hypertension · doi:10.1111/j.1524-6175.2002.02045.x · Cited by 979 · see citing works
Hermida, R. C., Ayala, D. E., Mojón, A., & Fernández, J. R. (2010) · Chronobiology International · doi:10.3109/07420528.2010.510230 · Cited by 608 · see citing works
Prognostic Value of Ambulatory Blood Pressure Monitoring in Refractory Hypertension
Redón, J., Campos, C., Narciso, M. L., Rodicio, J. L., Pascual, J. M., & Ruilope, L. M. (1998) · Hypertension · doi:10.1161/01.hyp.31.2.712 · Cited by 418 · see citing works
Self-citationPIERDOMENICO, S., LAPENNA, D., BUCCI, A., DITOMMASO, R., DIMASCIO, R., MANENTE, B., CALDARELLA, M., NERI, M., CUCCURULLO, F., & MEZZETTI, A. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2005.05.014 · Cited by 409 · see citing works
Prevalence and Factors Associated With Circadian Blood Pressure Patterns in Hypertensive Patients
de la Sierra, A., Redon, J., Banegas, J. R., Segura, J., Parati, G., Gorostidi, M., de la Cruz, J. J., Sobrino, J., Llisterri, J. L., Alonso, J., et al. (2009) · Hypertension · doi:10.1161/hypertensionaha.108.124008 · Cited by 379 · see citing works
Self-citationPrognostic Influence of Office and Ambulatory Blood Pressures in Resistant Hypertension
Salles, G. F., Cardoso, C. R. L., & Muxfeldt, E. S. (2008) · Archives of Internal Medicine · doi:10.1001/archinte.168.21.2340 · Cited by 293 · see citing works
Is resistant hypertension really resistant?
Brown, M. (2001) · American Journal of Hypertension · doi:10.1016/s0895-7061(01)02193-8 · Cited by 193 · see citing works
Effectiveness of Blood Pressure Control Outside the Medical Setting
Banegas, J. R., Segura, J., Sobrino, J., Rodríguez‐Artalejo, F., de la Sierra, A., de la Cruz, J. J., Gorostidi, M., Sarría‐Santamera, A., & Ruilope, L. M. (2006) · Hypertension · doi:10.1161/01.hyp.0000250557.63490.55 · Cited by 182 · see citing works
Self-citationPrognostic Value of Nocturnal Blood Pressure Reduction in Resistant Hypertension
Muxfeldt, E. S., Cardoso, C. R. L., & Salles, G. F. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.68 · Cited by 155 · see citing works
Twenty-four hour ambulatory blood pressure monitoring pattern of resistant hypertension
Muxfeldt, E. S., Bloch, K. V., Nogueira, A. R., & Salles, G. F. (2003) · Blood Pressure Monitoring · doi:10.1097/00126097-200310000-00001 · Cited by 135 · see citing works
Hermida, R. C., Ayala, D. E., Calvo, C., López, J. E., Mojón, A., Fontao, M. J., Soler, R., & Fernández, J. R. (2005) · Hypertension · doi:10.1161/01.hyp.0000172757.96281.bf · Cited by 125 · see citing works
Gorostidi, M., Sobrino, J., Segura, J., Sierra, C., de la Sierra, Á., del Rey, R. H., Vinyoles, E., Galcerán, J., LÓPEZ-EADY, M. D., Marín, R., et al. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e32809874a2 · Cited by 123 · see citing works
Self-citationTrue Resistant Hypertension: Is it Possible to Be Recognized in the Office?
Muxfeldt, E. S., Bloch, K. V., DAROCHANOGUEIRA, A., & Salles, G. F. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2005.06.013 · Cited by 105 · see citing works
Evaluación y tratamiento de la hipertensión arterial en España. Documento de consenso
de la Sierra, A., Gorostidi, M., Marín, R., Redón, J., Banegas, J. R., Armario, P., Puig, J. G., Zarco, J., Llisterri, J. L., Sanchís, C., et al. (2008) · Medicina Clínica · doi:10.1157/13124015 · Cited by 98 · see citing works
Self-citationAmbulatory Blood Pressure Measurement
O'Brien, E. T. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.100008 · Cited by 85 · see citing works
Urinary albumin excretion is associated with true resistant hypertension
Oliveras, A., Armario, P., HERNANDEZDELREY, R., Arroyo, J. A., Poch, E., Larrousse, M., Roca-Cusachs, A., & de la Sierra, A. (2009) · Journal of Human Hypertension · doi:10.1038/jhh.2009.35 · Cited by 62 · see citing works
Self-citationClinical characteristics of isolated clinic hypertension
Vinyoles, E., Felip, À., Ribera, E. P., de la Sierra, A., Durá, R., del Rey, R. H., Sobrino, J., Gorostidi, M., de la Figuera, M., Segura, J., et al. (2008) · Journal of Hypertension · doi:10.1097/hjh.0b013e3282f3150b · Cited by 53 · see citing works
Self-citationSierra, C., de la Sierra, A., Sobrino, J., Segura, J., Banegas, J. R. B., Gorostidi, M., & Ruilope, L. M. (2007) · Medicina Clínica · doi:10.1157/13106673 · Cited by 41 · see citing works
Self-citationVeglio, F., Veglino, F., Rabbia, F., Riva, P., Martini, G., Genova, G. C., Milan, A., Paglieri, C., Carra, R., & Chiandussi, L. (2001) · Clinical and Experimental Hypertension · doi:10.1081/ceh-100102660 · Cited by 41 · see citing works
Muxfeldt, E. S., Nogueira, A. D. R., Salles, G. F., & Bloch, K. V. (2004) · Sao Paulo Medical Journal · doi:10.1590/s1516-31802004000300003 · Cited by 39 · see citing works
del Rey, R. H., Armario, P., Martín‐Baranera, M., & Castellanosa, P. (2006) · Medicina Clínica · doi:10.1157/13091263 · Cited by 19 · see citing works
Self-citationStergiou, G. S., & Nasothimiou, E. G. (2008) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e328305b983 · Cited by 16 · see citing works
Flagged first, then by citations
Research works printed but not linked: 4
- Herna ´ndez del Rey R, Armario P, Martín-Baranera M, Castellanos P. Clustering of cardiovascular risk factors and prevalence of metabolic syndrome in subjects with resistant hypertension [in Spanish]. Med Clín (Barc). 2006;127:241-245.
- Sierra C, De la Sierra A, Sobrino J, Segura J, Banegas JR, Gorostidi M, Ruilope LM. Ambulatory blood pressure monitoring (CABPM): clinical characteristics of 31,530 patients [in Spanish]. Med Clin (Barc). 2007; 129:1-5.
- O'Brien E, Asmar R, Beilin L, Imai Y, Mallion JM, Mancia G, Mengden T, Myers M, Padfield P, Palatini P, Parati G, Pickering T, Redon J, Staessen J, Stergiou G, Verdecchia P. European Society of Hypertension Working Group on Blood Pressure Monitoring. J Hypertens. 2003;21: 821-848.
- De la Sierra A, Gorostidi M, Marin R, Redon J, Banegas JR, Armario P, Garcia-Puig J, Zarco J, Llisterri JL, Sanchos C, Abarca B, Palomo V, Gomis R, Otero A, Villar F, Honorato J, Tamargo J, Lobos JM, Macías-Nu ´n ˜ez J, Sarria A, Aranda P, Ruilope LM. Evaluation and man- agement of hypertension in Spain: a consensus guide [in Spanish]. Med Clin (Barc). 2008;131:104 -116.
Cited by
Sorted by citations
2013 ESH/ESC Guidelines for the management of arterial hypertension
Authors Task Force Members, Mancia, G., Fagard, R., Narkiewicz, K., Redon, J., Zanchetti, A., Böhm, M., Christiaens, T., Cífková, R., Backer, G. D., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht151 · Cited by 13,638 · see citing works
Self-citationMancia, G., Fagard, R., Narkiewicz, K., Redón, J., Zanchetti, A., Böhm, M., Christiaens, T., Cifkova, R., De Backer, G., Dominiczak, A., et al. (2013) · Journal of Hypertension · doi:10.1097/01.hjh.0000431740.32696.cc · Cited by 5,655 · see citing works
Self-citationMancia, G., Kreutz, R., Brunström, M., Burnier, M., Grassi, G., Januszewicz, A., Muiesan, M. L., Tsioufis, K., Agabiti-Rosei, E., Algharably, E. A. E., et al. (2023) · Journal of Hypertension · doi:10.1097/hjh.0000000000003480 · Cited by 3,473 · see citing works
The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019)
Umemura, S., Arima, H., Arima, S., Asayama, K., Dohi, Y., Hirooka, Y., Horio, T., Hoshide, S., Ikeda, S., Ishimitsu, T., et al. (2019) · Hypertension Research · doi:10.1038/s41440-019-0284-9 · Cited by 1,880 · see citing works
Measurement of Blood Pressure in Humans: A Scientific Statement From the American Heart Association
Muntner, P., Shimbo, D., Carey, R. M., Charleston, J. B., Gaillard, T., Misra, S., Myers, M. G., Ogedegbe, G., Schwartz, J. E., Townsend, R. R., et al. (2019) · Hypertension · doi:10.1161/hyp.0000000000000087 · Cited by 1,512 · see citing works
European Society of hypertension position paper on ambulatory blood pressure monitoring
O’Brien, E., Parati, G., Stergiou, G., Asmar, R., Beilin, L., Bilo, G., Clement, D., de la Sierra, A., de Leeuw, P., Dolan, E., et al. (2013) · Journal of Hypertension · doi:10.1097/hjh.0b013e328363e964 · Cited by 1,419 · see citing works
Self-citationCarey, R. M., Calhoun, D. A., Bakris, G. L., Brook, R. D., Daugherty, S. L., Dennison-Himmelfarb, C. R., Egan, B. M., Flack, J. M., Gidding, S. S., Judd, E., et al. (2018) · Hypertension · doi:10.1161/hyp.0000000000000084 · Cited by 1,153 · see citing works
Incidence and Prognosis of Resistant Hypertension in Hypertensive Patients
Daugherty, S. L., Powers, J. D., Magid, D. J., Tavel, H. M., Masoudi, F. A., Margolis, K. L., O'Connor, P. J., Selby, J. V., & Ho, P. M. (2012) · Circulation · doi:10.1161/circulationaha.111.068064 · Cited by 930 · see citing works
2013 ESH/ESC Practice Guidelines for the Management of Arterial Hypertension
Mancia, G., Fagard, R. H., Narkiewicz, K., Redón, J., Zanchetti, A., Böhm, M., Christiaens, T. C., Cífková, R., Backer, G. D., Dominiczak, A. F., et al. (2013) · Blood Pressure · doi:10.3109/08037051.2014.868629 · Cited by 732 · see citing works
Self-citationMartínez-García, M.-A., Capote, F., Campos-Rodríguez, F., Lloberes, P., Díaz de Atauri, M. J., Somoza, M., Masa, J. F., González, M., Sacristán, L., Barbé, F., et al. (2013) · JAMA · doi:10.1001/jama.2013.281250 · Cited by 685 · see citing works
The Sympathetic Nervous System Alterations in Human Hypertension
Grassi, G., Mark, A., & Esler, M. (2015) · Circulation Research · doi:10.1161/circresaha.116.303604 · Cited by 616 · see citing works
Uncontrolled and Apparent Treatment Resistant Hypertension in the United States, 1988 to 2008
Egan, B. M., Zhao, Y., Axon, R. N., Brzezinski, W. A., & Ferdinand, K. C. (2011) · Circulation · doi:10.1161/circulationaha.111.030189 · Cited by 599 · see citing works
Nerenberg, K. A., Zarnke, K. B., Leung, A. A., Dasgupta, K., Butalia, S., McBrien, K., Harris, K. C., Nakhla, M., Cloutier, L., Gelfer, M., et al. (2018) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2018.02.022 · Cited by 573 · see citing works
Resistant hypertension? Assessment of adherence by toxicological urine analysis
Jung, O., Gechter, J. L., Wunder, C., Paulke, A., Bartel, C., Geiger, H., & Toennes, S. W. (2013) · Journal of Hypertension · doi:10.1097/hjh.0b013e32835e2286 · Cited by 474 · see citing works
Leung, A. A. C., Daskalopoulou, S. S., Dasgupta, K., McBrien, K., Butalia, S., Zarnke, K. B., Nerenberg, K. A., Harris, K. C., Nakhla, M. M., Cloutier, L., et al. (2017) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2017.03.005 · Cited by 318 · see citing works
Apparent and true resistant hypertension: definition, prevalence and outcomes
Judd, E. K., & Calhoun, D. A. (2014) · Journal of Human Hypertension · doi:10.1038/jhh.2013.140 · Cited by 275 · see citing works
Franklin, S. S., Thijs, L., Hansen, T. W., O'Brien, E. T., & Staessen, J. A. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01275 · Cited by 278 · see citing works
Esler, M., Böhm, M., Sievert, H., Rump, C., Schmieder, R. E., Krum, H., Mahfoud, F., & Schlaich, M. P. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu209 · Cited by 260 · see citing works
Mahfoud, F., Ukena, C., Schmieder, R. E., Cremers, B., Rump, L. C., Vonend, O., Weil, J., Schmidt, M. U., Hoppe, U. C., Zeller, T., et al. (2013) · Circulation · doi:10.1161/circulationaha.112.000949 · Cited by 249 · see citing works
Hypertension in Chronic Kidney Disease
Hamrahian, S. M., & Falkner, B. E. (2016) · Advances in experimental medicine and biology · doi:10.1007/5584_2016_84 · Cited by 260 · see citing works
Schmieder, R. E., Redón, J., Grassi, G. M., Kjeldsen, S. E., Mancia, G., Narkiewicz, K., Parati, G., Ruilope, L. M., van de Borne, P., & Tsioufis, C. P. (2012) · Journal of Hypertension · doi:10.1097/hjh.0b013e328352ce78 · Cited by 239 · see citing works
Self-citationSim, J. J., Bhandari, S. K., Shi, J., Reynolds, K., Calhoun, D. A., Kalantar-Zadeh, K., & Jacobsen, S. J. (2015) · Kidney International · doi:10.1038/ki.2015.142 · Cited by 238 · see citing works
Mahfoud, F., Lüscher, T. F., Andersson, B., Baumgärtner, I., Cífková, R., Mario, C. D., Doevendans, P. A., Fagard, R. H., Fajadet, J. C., Michel Komajda, N., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht154 · Cited by 234 · see citing works
Measuring, Analyzing, and Managing Drug Adherence in Resistant Hypertension
Burnier, M., Wuerzner, G., Struijker-Boudier, H., & Urquhart, J. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.00687 · Cited by 229 · see citing works
Prevalence of Apparent Treatment-Resistant Hypertension in the United States
Carey, R. M., Sakhuja, S., Calhoun, D. A., Whelton, P. K., & Muntner, P. (2019) · Hypertension · doi:10.1161/hypertensionaha.118.12191 · Cited by 222 · see citing works
Treatment of Resistant and Refractory Hypertension
Acelajado, M. C., Hughes, Z. H., Oparil, S., & Calhoun, D. A. (2019) · Circulation Research · doi:10.1161/circresaha.118.312156 · Cited by 219 · see citing works
Madhur, M. S., Elijovich, F., Alexander, M. R., Pitzer, A. L., Ishimwe, J., Beusecum, J. P. V., Patrick, D. M., Smart, C. D., Kleyman, T. R., Kingery, J. R., et al. (2021) · Circulation Research · doi:10.1161/circresaha.121.318052 · Cited by 215 · see citing works
Elmula, F. E. M. F., Hoffmann, P., Larstorp, A. C. K., Fossum, E., Brekke, M., Kjeldsen, S. E., Gjønnæss, E., Hjørnholm, U., Kjær, V. N., Rostrup, M., et al. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03246 · Cited by 209 · see citing works
Sim, J. J., Bhandari, S. K., Shi, J., Liu, I. L. A., Calhoun, D. A., McGlynn, E. A., Kalantar-Zadeh, K., & Jacobsen, S. J. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.06.017 · Cited by 206 · see citing works
Hermida, R. C., Smolensky, M. H., Ayala, D. E., Portaluppi, F., Crespo, J. J., Fabbian, F., Haus, E., Manfredini, R., Mojón, A., Moyá, A., et al. (2013) · Chronobiology International · doi:10.3109/07420528.2013.750490 · Cited by 203 · see citing works
Chiang, C., Wang, T., Ueng, K.-C., Lin, T., Yeh, H., Chen, C.-Y., Wu, Y.-J., Tsai, W., Chao, T., Chen, C.-H., et al. (2014) · Journal of the Chinese Medical Association · doi:10.1016/j.jcma.2014.11.005 · Cited by 201 · see citing works
Achelrod, D., Wenzel, U. O., & Frey, S. (2014) · American Journal of Hypertension · doi:10.1093/ajh/hpu151 · Cited by 198 · see citing works
Berra, E., Azizi, M., Capron, A., Høieggen, A., Rabbia, F., Kjeldsen, S. E., Staessen, J. A., Wallemacq, P., & Persu, A. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.07464 · Cited by 195 · see citing works
Resistant Hypertension: Incidence, Prevalence, and Prognosis
Pimenta, E., & Calhoun, D. A. (2012) · Circulation · doi:10.1161/circulationaha.112.097345 · Cited by 188 · see citing works
Ischemic heart disease in women: A focus on risk factors
Mehta, P. K., Wei, J., & WENGER, N. K. (2014) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2014.10.005 · Cited by 187 · see citing works
Kumbhani, D. J., Steg, P. G., Cannon, C. P., Eagle, K. A., Smith, S. C., Crowley, K., Goto, S., Ohman, E. M., Bakris, G. L., Perlstein, T. S., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs368 · Cited by 185 · see citing works
Calhoun, D. A., Booth, J. N., Oparil, S., Irvin, M. R., Shimbo, D., Lackland, D. T., Howard, G., Safford, M. M., & Muntner, P. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.02026 · Cited by 186 · see citing works
Resistant hypertension—its identification and epidemiology
Sarafidis, P., Georgianos, P., & Bakris, G. (2013) · Nature Reviews Nephrology · doi:10.1038/nrneph.2012.260 · Cited by 178 · see citing works
Testing for Primary Aldosteronism and Mineralocorticoid Receptor Antagonist Use Among U.S. Veterans
Cohen, J. B., Cohen, D. L., Herman, D. S., Leppert, J. T., Byrd, J. B., & Bhalla, V. (2020) · Annals of Internal Medicine · doi:10.7326/m20-4873 · Cited by 182 · see citing works
Prevalence and Prognostic Role of Resistant Hypertension in Chronic Kidney Disease Patients
Nicola, L. D., Gabbai, F. B., Agarwal, R., Chiodini, P., Borrelli, S., Bellizzi, V., Nappi, F., Conte, G., & Minutolo, R. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.12.061 · Cited by 172 · see citing works
Prevalence and Associated Factors of Obstructive Sleep Apnea in Patients with Resistant Hypertension
Muxfeldt, E. S., Margallo, V. S., Guimarães, G. M., & Salles, G. F. (2014) · American Journal of Hypertension · doi:10.1093/ajh/hpu023 · Cited by 169 · see citing works
Templin, C., Jaguszewski, M. J., Ghadri, J. R., Sudano, I., Gaehwiler, R., Hellermann, J. P., Schoenenberger-Berzins, R., Landmesser, U., Erné, P., Noll, G., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht141 · Cited by 168 · see citing works
Kim, H., Lee, E. M., Ahn, S. Y., Kim, K., Kim, H. C., Kim, J. H., Lee, H., Lee, J. H., Park, J., Cho, E. J., et al. (2023) · Clinical Hypertension · doi:10.1186/s40885-023-00234-9 · Cited by 167 · see citing works
Kario, K., Shin, J., Chen, C., Buranakitjaroen, P., Chia, Y., Divinagracia, R., Nailes, J., Hoshide, S., Siddique, S., Sison, J., et al. (2019) · The Journal of Clinical Hypertension · doi:10.1111/jch.13652 · Cited by 164 · see citing works
Screening Rates for Primary Aldosteronism in Resistant Hypertension
Jaffe, G., Gray, Z., Krishnan, G., Stedman, M. R., Zheng, Y., Han, J., Chertow, G. M., Leppert, J. T., & Bhalla, V. (2020) · Hypertension · doi:10.1161/hypertensionaha.119.14359 · Cited by 168 · see citing works
Štrauch, B., Petrák, O., Zelinka, T., Rosa, J., Krátká, Z., Indra, T., Chytil, L., Marešová, V., Kurcová, I., Holaj, R., et al. (2013) · Journal of Hypertension · doi:10.1097/hjh.0b013e3283652c61 · Cited by 163 · see citing works
Geisler, B. P., Egan, B. M., Cohen, J. T., Garner, A. M., Akehurst, R. L., Esler, M., & Pietzsch, J. B. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.07.029 · Cited by 160 · see citing works
Egan, B. M., Zhao, Y., Li, J., Brzezinski, W. A., Todoran, T. M., Brook, R. D., & Calhoun, D. A. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01448 · Cited by 158 · see citing works
de la Sierra, A., Banegas, J. R., Oliveras, A., Gorostidi, M., Segura, J., de la Cruz, J. J., Armario, P., & Ruilope, L. M. (2012) · Journal of Hypertension · doi:10.1097/hjh.0b013e328353634e · Cited by 147 · see citing works
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Vongpatanasin, W. (2014) · JAMA · doi:10.1001/jama.2014.5180 · Cited by 146 · see citing works
Irvin, M. R., Booth, J. N., Shimbo, D., Lackland, D. T., Oparil, S., Howard, G., Safford, M. M., Muntner, P., & Calhoun, D. A. (2014) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2014.03.003 · Cited by 146 · see citing works
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Gorostidi, M., Vinyoles, E., Banegas, J. R., & de la Sierra, A. (2015) · Hypertension Research · doi:10.1038/hr.2014.149 · Cited by 141 · see citing works
Self-citationMathiassen, O. N., Vase, H. Ø., Bech, J. N., Christensen, K. L., Buus, N. H., Schroeder, A. P., Lederballe, O., Rickers, H., Kampmann, U., Poulsen, P. L., et al. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000000977 · Cited by 138 · see citing works
Drapkina, O. M., Васильевна, К. А., Калинина, А. М., Avdeev, S. M., Викторович, А. М., Alexandrova, L. M., Анциферова, А. А., Dm, A., Ахмеджанов, Н. М., Balanova, Y. А., et al. (2022) · CARDIOVASCULAR THERAPY AND PREVENTION · doi:10.15829/1728-8800-2022-3235 · Cited by 172 · see citing works
Oxlund, C. S., Henriksen, J. E., Tarnow, L., Schousboe, K., Gram, J., & Jacobsen, I. A. (2013) · Journal of Hypertension · doi:10.1097/hjh.0b013e3283638b1a · Cited by 137 · see citing works
International Expert Consensus Statement
Schlaich, M. P., Schmieder, R. E., Bakris, G. L., Blankestijn, P. J., Böhm, M., Campese, V. M., Francis, D. P., Grassi, G. M., Hering, D., Katholi, R. E., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.08.1616 · Cited by 139 · see citing works
Self-citationde la Sierra, A., Gorostidi, M., Banegas, J. R., Segura, J., de la Cruz, J. J., & Ruilope, L. M. (2013) · American Journal of Hypertension · doi:10.1093/ajh/hpt175 · Cited by 135 · see citing works
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Chen, H., & Friedman, J. H. (2016) · Journal of the American Statistical Association · doi:10.1080/01621459.2016.1147356 · Cited by 129 · see citing works
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Burnier, M. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.08.015 · Cited by 132 · see citing works
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Malachias, M. V. B., Souza, W., Plavnik, F. L., Rodrigues, C., Brandão, A., Neves, M. F., Bortolotto, L. A., Franco, R., Figueiredo, C., Jardim, P., et al. (2016) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20160151 · Cited by 140 · see citing works
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Turner, J. R., Viera, A. J., & Shimbo, D. (2014) · The American Journal of Medicine · doi:10.1016/j.amjmed.2014.07.021 · Cited by 130 · see citing works
Effectiveness of Renal Denervation Therapy for Resistant Hypertension
Davis, M., Filion, K. B., Zhang, D., Eisenberg, M. J., Afilalo, J., Schiffrin, E. L., & Joyal, D. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.04.010 · Cited by 126 · see citing works
Esler, M. (2014) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2014.06.001 · Cited by 127 · see citing works
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Bruno, R. M., Palagini, L., Gemignani, A., Virdis, A., Giulio, A. D., Ghiadoni, L., Riemann, D. W., & Taddei, S. (2013) · Sleep Medicine · doi:10.1016/j.sleep.2013.04.020 · Cited by 125 · see citing works
Documento de información y consenso para la detección y manejo de la enfermedad renal crónica
Maset, R. G., Bover, J., Segura, J., Diezhandino, M. G., del Hoyo, J. C., Martín, J. E. S., Fácila, L., Gamarra, J., García‐Donaire, J. A., Matarin, L. G., et al. (2021) · Nefrología · doi:10.1016/j.nefro.2021.07.010 · Cited by 140 · see citing works
Self-citationClinical characteristics of patients with resistant hypertension: the RESIST-POL study
Florczak, E., Prejbisz, A., Szwench-Pietrasz, E., Śliwiński, P., Bieleń, P., Klisiewicz, A., Michałowska, I., Warchoł, E., Januszewicz, M., Kała, M., et al. (2013) · Journal of Human Hypertension · doi:10.1038/jhh.2013.32 · Cited by 120 · see citing works
Weitzman, D., Chodick, G., Shalev, V., Grossman, C., & Grossman, E. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03718 · Cited by 113 · see citing works
Resistant hypertension: patient characteristics, risk factors, co-morbidities and outcomes
Oliveras, A., & Sierra, À. (2013) · Journal of Human Hypertension · doi:10.1038/jhh.2013.77 · Cited by 113 · see citing works
Self-citationElmula, F. E. M. F., Hoffmann, P., Fossum, E., Brekke, M., Gjønnæss, E., Hjørnholm, U., Kjær, V. N., Rostrup, M., Kjeldsen, S. E., Os, I., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.01452 · Cited by 112 · see citing works
Hyperaldosteronism as a Common Cause of Resistant Hypertension
Calhoun, D. A. (2013) · Annual Review of Medicine · doi:10.1146/annurev-med-042711-135929 · Cited by 108 · see citing works
de la Sierra, A., Banegas, J. R., Segura, J., Gorostidi, M., & Ruilope, L. M. (2012) · Journal of Hypertension · doi:10.1097/hjh.0b013e328350bb40 · Cited by 108 · see citing works
Self-citationKario, K., Ogawa, H., Okumura, K., Okura, T., Saito, S., Ueno, T., Haskin, R., Negoita, M., Shimada, K., & on behalf of the SYMPLICITY HTN-Japan Investigators (2015) · Circulation Journal · doi:10.1253/circj.cj-15-0150 · Cited by 107 · see citing works
Diagnosis and treatment of arterial hypertension 2021
Ott, C., & Schmieder, R. E. (2021) · Kidney International · doi:10.1016/j.kint.2021.09.026 · Cited by 116 · see citing works
Fagard, R. H. (2011) · Heart · doi:10.1136/heartjnl-2011-300741 · Cited by 104 · see citing works
Borghi, C., Tubach, F., De Backer, G., Dallongeville, J., Guallar, E., Medina, J., Perk, J., Roy, C., Banegas, J. R., Rodriguez-Artalejo, F., et al. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.05.044 · Cited by 102 · see citing works
Self-citationRenal Denervation in Moderate Treatment-Resistant Hypertension
Ott, C., Mahfoud, F., Schmid, A., Ditting, T., Sobotka, P. A., Veelken, R. A., Spies, A., Ukena, C., Laufs, U., Uder, M., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.06.023 · Cited by 99 · see citing works
Guidance on ambulatory blood pressure monitoring: A statement from the HOPE Asia Network
Kario, K., Hoshide, S., Chia, Y. C., Buranakitjaroen, P., Siddique, S., Shin, J., Turana, Y., Park, S., Tsoi, K. K. F., Chen, C., et al. (2020) · Journal of Clinical Hypertension · doi:10.1111/jch.14128 · Cited by 99 · see citing works
Jordan, J., Kurschat, C. E., & Reuter, H. (2018) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2018.0557 · Cited by 107 · see citing works
A Short History of Automated Office Blood Pressure – 15 Years to SPRINT
Myers, M. G. (2016) · Journal of Clinical Hypertension · doi:10.1111/jch.12820 · Cited by 96 · see citing works
Tsioufis, C., Kasiakogias, A., Kordalis, A., Dimitriadis, K., Thomopoulos, C., Tsiachris, D., Vasileiou, P., Doumas, M., Makris, T., Papademetriou, V., et al. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000023 · Cited by 91 · see citing works
Obstructive sleep apnea syndrome as a cause of resistant hypertension
Parati, G., Ochoa, J. E., Bilo, G., Mattaliano, P., Salvi, P., Kario, K., & Lombardi, C. (2014) · Hypertension Research · doi:10.1038/hr.2014.80 · Cited by 88 · see citing works
Persu, A., Renkin, J. P., Thijs, L., & Staessen, J. A. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.195263 · Cited by 88 · see citing works
Resistant hypertension and target organ damage
Muiesan, M. L., Salvetti, M., Rizzoni, D., Paini, A., Agabiti-Rosei, C., Aggiusti, C., & Rosei, E. A. (2013) · Hypertension Research · doi:10.1038/hr.2013.30 · Cited by 86 · see citing works
How to Screen for Non-Adherence to Antihypertensive Therapy
Gupta, P., Patel, P., Horne, R., Buchanan, H., Williams, B., & Tomaszewski, M. (2016) · Current Hypertension Reports · doi:10.1007/s11906-016-0697-7 · Cited by 84 · see citing works
Hameed, M. A., Tebbit, L., Jacques, N., Thomas, M., & Dasgupta, I. (2015) · Journal of Human Hypertension · doi:10.1038/jhh.2015.38 · Cited by 82 · see citing works
Spironolactone versus sympathetic renal denervation to treat true resistant hypertension
Oliveras, A., Armario, P., Clarà, A. B. I., Atxer, L. S., González, S. V., Pascual, J., & de la Sierra, A. (2016) · Journal of Hypertension · doi:10.1097/hjh.0000000000001025 · Cited by 81 · see citing works
Self-citationRenal Denervation for the Treatment of Cardiovascular High Risk-Hypertension or Beyond?
Böhm, M., Linz, D., Ukena, C., Esler, M., & Mahfoud, F. (2014) · Circulation Research · doi:10.1161/circresaha.115.302522 · Cited by 77 · see citing works
Dudenbostel, T., Siddiqui, M., Oparil, S., & Calhoun, D. A. (2016) · Hypertension · doi:10.1161/hypertensionaha.116.06587 · Cited by 78 · see citing works
Prevalence of pseudoresistant hypertension due to inaccurate blood pressure measurement
Bhatt, H., Siddiqui, M., Judd, E., Oparil, S., & Calhoun, D. (2016) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2016.03.186 · Cited by 77 · see citing works
Resistant Hypertension in People With CKD: A Review
Fay, K., & Cohen, D. L. (2020) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2020.04.017 · Cited by 79 · see citing works
Renal sympathetic denervation: applications in hypertension and beyond
Böhm, M., Linz, D., Urban, D., Mahfoud, F., & Ukena, C. (2013) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2013.89 · Cited by 75 · see citing works
Ohya, Y., Arakawa, K., Arata, N., Arima, S., Arima, H., Asayama, K., Dohi, Y., Fukami, A., Furuhashi, M., Goto, K., et al. (2026) · Hypertension Research · doi:10.1038/s41440-025-02462-y · Cited by 81 · see citing works
What is the prevalence of resistant hypertension in the United States?
Roberie, D. R., & Elliott, W. J. (2012) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e328353ad6e · Cited by 74 · see citing works
Catheter-Based Renal Denervation for Resistant Hypertension
Papademetriou, V., Tsioufis, C. P., Sinhal, A. R., Chew, D. P., Meredith, I. T., Malaiapan, Y., Worthley, M. I., & Worthley, S. G. (2014) · Hypertension · doi:10.1161/hypertensionaha.114.03605 · Cited by 72 · see citing works
Gorostidi, M., Gijón‐Conde, T., Sierra, À., Rodilla, E., Rubio, E., Vinyoles, E., Oliveras, A., Santamaría, R., Segura, J., Molinero, A., et al. (2022) · Hipertensión y Riesgo Vascular · doi:10.1016/j.hipert.2022.09.002 · Cited by 81 · see citing works
Self-citationDoroszko, A., Januś, A., Szahidewicz-Krupska, E., Mazur, G. J., & Derkacz, A. (2015) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/58998 · Cited by 72 · see citing works
Stergiou, G. S., Brunström, M., MacDonald, T. M., Kyriakoulis, K. G., Bursztyn, M., Khan, N. A., Bakris, G. L., Κόλλιας, Α., Menti, A., Muntner, P., et al. (2022) · Journal of Hypertension · doi:10.1097/hjh.0000000000003240 · Cited by 71 · see citing works
Recognition and Management of Resistant Hypertension
Braam, B. G., Taler, S. J., Rahman, M., Fillaus, J. A., Greco, B., Forman, J. P., Reisin, E., Cohen, D. L., Saklayen, M. G., & Hedayati, S. S. (2016) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.06180616 · Cited by 71 · see citing works
Smith, S. M., Huo, T., Delia Johnson, B., Bittner, V., Kelsey, S. F., Vido Thompson, D., Noel Bairey Merz, C., Pepine, C. J., & Cooper‐DeHoff, R. M. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.113.000660 · Cited by 69 · see citing works
Brambilla, G., Bombelli, M., Seravalle, G., Cífková, R., Laurent, S., Narkiewicz, K., Facchetti, R., Redón, J., Mancia, G., & Grassi, G. M. (2013) · Journal of Hypertension · doi:10.1097/hjh.0b013e328363823f · Cited by 69 · see citing works
- Authors
- de la Sierra, A., Segura, J., Banegas, J. R., Gorostidi, M., de la Cruz, J. J., Armario, P., Oliveras, A., & Ruilope, L. M.
- Affiliations
- From the Department of Internal Medicine, Hospital Mutua Terrassa, University of Barcelona (A.d.l.S.), Hypertension Unit (J.S., L.M.R.), Hospital 12 de Octubre, Madrid, Spain; Department of Preventive Medicine and Public Health (J.R.B., J.J.d.l.C.), Autonomous University, Madrid, Spain; Department of Nephrology (M.G.), Hospital Universitario Central de Asturias, Oviedo, Spain; Department of Internal Medicine (P.A.), Hospital General de L'Hospitalet, Barcelona, Spain; Hypertension Unit (A.O.),...
- Universitat Autònoma de Barcelona (ES)
- Venue
- Hypertension
- Published
- 2011-05
- Volume
- 57
- Issue
- 5
- Pages
- 898-902
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2113750355
- Cited by
- 809
- References
- 32
- Citations by year
- 2026: 14 · 2025: 9 · 2024: 32 · 2023: 33 · 2022: 34 · 2021: 25 · 2020: 35 · 2019: 49 · 2018: 41 · 2017: 48 · 2016: 88 · 2015: 68 · 2014: 115 · 2013: 130 · 2012: 63
- FWCI
- 73.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Keywords
- resistant hypertension, white coat hypertension, ambulatory blood pressure monitoring, prevalence, cardiovascular risk profile, target organ damage, left ventricular hypertrophy, microalbuminuria, renal dysfunction, cardiovascular disease, duration of hypertension, smoking, diabetes mellitus, antihypertensive therapy
- MeSH terms
- Age Factors, Aged, Antihypertensive Agents, Blood Pressure, Female, Humans, Hypertension, Male, Middle Aged, Registries, Risk, Sex Factors, Smoking, Spain, Prevalence, Chi-Square Distribution, Blood Pressure Monitoring, Ambulatory, Statistics, Nonparametric
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