Determining the contribution of retinotopic discrimination to localization performance with a suprachoroidal retinal prosthesis
Open accessAbstract
Purpose: With a retinal prosthesis connected to a head-mounted camera, subjects can perform low vision tasks using a combination of electrode discrimination and head-directed localization. The objective of the present study was to investigate the contribution of retinotopic electrode discrimination (perception corresponding to the arrangement of the implanted electrodes with respect to their position beneath the retina) to visual performance for three recipients of a 24-channel suprachoroidal retinal implant. Proficiency in retinotopic discrimination may allow good performance with smaller head movements, and identification of this ability would be useful for targeted rehabilitation. Methods: Three participants with retinitis pigmentosa performed localization and grating acuity assessments using a suprachoroidal retinal prosthesis. We compared retinotopic and nonretinotopic electrode mapping and hypothesized that participants with measurable acuity in a normal retinotopic condition would be negatively impacted by the nonretinotopic condition. We also expected that participants without measurable acuity would preferentially use head movement over retinotopic information. Results: Only one participant was able to complete the grating acuity task. In the localization task, this participant exhibited significantly greater head movements and significantly lower localization scores when using the nonretinotopic electrode mapping. There was no significant difference in localization performance or head movement for the remaining two subjects when comparing retinotopic to nonretinotopic electrode mapping. Conclusions: Successful discrimination of retinotopic information is possible with a suprachoroidal retinal prosthesis. Head movement behavior during a localization task can be modified using a nonretinotopic mapping. Behavioral comparisons using retinotopic and nonretinotopic electrode mapping may be able to highlight deficiencies in retinotopic discrimination, with a view to address these deficiencies in a rehabilitation environment. (ClinicalTrials.gov number, NCT01603576).
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The presence of choroid, RPE, and debris of photoreceptors makes the selective stimulation of BCs extremely difficult, leading to poor spatial resolution.
“The presence of choroid, RPE, and debris of photoreceptors makes the selective stimulation of BCs extremely difficult, leading to poor spatial resolution [59,60].”
From Advances in visual prostheses: engineering and biological challenges (2022) · cites this paper as [59]
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- Authors
- Petoe, M. A., McCarthy, C. D., Shivdasani, M. N., Sinclair, N. C., Scott, A. F., Ayton, L. N., Barnes, N. M., Guymer, R. H., Allen, P. J., Blamey, P. J., & for the Bionic Vision Australia Consortium
- Affiliations
- Bionics Institute (AU)
- Data61 (AU)
- The University of Melbourne (AU)
- Australian National University (AU)
- Corresponding author
- Petoe, Matthew A.
- ORCID
- Venue
- Investigative Opthalmology & Visual Science
- Published
- 2017-06-28
- Volume
- 58
- Issue
- 7
- Pages
- 3231
- ISSN
- 0146-0404 (ISSN-L)
- 1552-5783
- OpenAlex
- W2729182987
- Cited by
- 23
- References
- 25
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 1 · 2021: 6 · 2020: 7 · 2019: 3 · 2018: 2 · 2017: 1
- FWCI
- 1.74
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Investigative Ophthalmology & Visual Science (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- ANU Open Research (Australian National University) (submittedVersion)
- Swinburne figshare (Swinburne University of Technology) (submittedVersion, cc-by)
- Swinburne figshare (Swinburne University of Technology) (cc-by)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (529923)
- State Government of Victoria
- Medical Research Council
- National Health and Medical Research Council (1082358, 529923)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- electrode mapping, retinitis pigmentosa, visual localization, head movement, grating acuity, low vision rehabilitation, head-mounted camera, visual prosthesis
- MeSH terms
- Blindness, Electrodes, Implanted, Evoked Potentials, Visual, Female, Humans, Male, Middle Aged, Retinitis Pigmentosa, Visual Acuity, Head Movements, Visual Prosthesis
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