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Cited by 202Neuroscience and Neural EngineeringRetinal Development and DisordersTactile and Sensory Interactions

Advances in retinal prosthesis systems

Open access
Bloch, Edward, Luo, Yvonne, da Cruz, Lyndon·2019·Therapeutic Advances in Ophthalmology
DOI 10.1177/2515841418817501PMC PMC6350159
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Abstract

Retinal prosthesis systems have undergone significant advances in the past quarter century, resulting in the development of several different novel surgical and engineering approaches. Encouraging results have demonstrated partial visual restoration, with improvement in both coarse objective function and performance of everyday tasks. To date, four systems have received marketing approval for use in Europe or the United States, with numerous others undergoing preclinical and clinical evaluation, reflecting the established safety profile of these devices for chronic implantation. This progress represents the first notion that the field of visual restorative medicine could offer blind patients a hope of real and measurable benefit. However, there are numerous complex engineering and biophysical obstacles still to be overcome, to reconcile the gap that remains between artificial and natural vision. Current developments in the form of enhanced image processing algorithms and data transfer approaches, combined with emerging nanofabrication and conductive polymerization techniques, herald an exciting and innovative future for retinal prosthetics. This review provides an update of retinal prosthetic systems currently undergoing development and clinical trials while also addressing future challenges in the field, such as the assessment of functional outcomes in ultra-low vision and strategies for tackling existing hardware and software constraints.

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  • Due to the considerable distance from BCs, high current amplitudes are required for retinal stimulation, possibly leading to damage due to overstimulation.

    “Due to the considerable distance from BCs, high current amplitudes are required for retinal stimulation, possibly leading to damage due to overstimulation [35,61].”

    From Advances in visual prostheses: engineering and biological challenges (2022) · cites this paper as [61]

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2 of the 106 references couldn’t be matched to a known paper.

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  1. [11]Foerster O. Beiträge zur Pathophysiologie der Sehbahn und der Sehsphäre. J Psychol Neurol 1929; 39: 463– 485.
  2. [29]Stanga PE Sahel J-A da Cruz L et al Patients blinded by outer retinal dystrophies area able to perceive simultaneous colors using the Argus® II retinal prosthesis system. Invest Ophthalmol Vis Sci 2012; 53: 6952.
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  5. [40]Walter P A fully intraocular approach for a bi-directional retinal prosthesis. In: Gabel VP (ed.) Artificial vision. Cham: Springer, 2016, pp. 151– 161.
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Authors
Bloch, E., Luo, Y., & da Cruz, L.
Affiliations
  • Moorfields Eye Hospital NHS Foundation Trust (GB)
  • Wellcome/EPSRC Centre for Interventional and Surgical Sciences, University College London, London, UK
Corresponding author
Bloch, Edward
ORCID
Venue
Therapeutic Advances in Ophthalmology
Publisher
SAGE Publications
Published
2019-01
Volume
11
Pages
2515841418817501-2515841418817501
ISSN
2515-8414 (ISSN-L)
DOI
10.1177/2515841418817501
PMC
PMC6350159
OpenAlex
W2909244976
Cited by
201
References
106
Citations by year
2026: 6 · 2025: 10 · 2024: 18 · 2023: 24 · 2022: 32 · 2021: 22 · 2020: 80 · 2019: 9
FWCI
4.76
Type
journal article
Language
en
Open access
Licence
Locations
  • Therapeutic Advances in Ophthalmology (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
Keywords
retinal prosthesis, vision restoration, blindness, image processing algorithms, data transmission, nanofabrication, conducting polymers, functional outcome assessment, clinical trials, artificial vision

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