The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Adipose-derived resistin and gut-derived resistin-like molecule–β selectively impair insulin action on glucose production
Open accessAbstract
The adipose-derived hormone resistin is postulated to link obesity to insulin resistance and diabetes. Here, the infusion of either resistin or the resistin-like molecule-beta (RELMbeta) rapidly induced severe hepatic but not peripheral insulin resistance. In the presence of physiologic hyperinsulinemia, the infusion of purified recombinant resistin, increasing circulating resistin levels by approximately twofold to 15-fold, inhibited glucose metabolism such that lower rates of glucose infusion were required to maintain the plasma glucose concentration at basal levels. The effects of resistin and RELMbeta on in vivo insulin action were completely accounted for by a marked increase in the rate of glucose production. These results support the notion that a novel family of fat- and gut-derived circulating proteins modulates hepatic insulin action.
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Metadata
- Authors
- Rajala, M. W., Obici, S., Scherer, P. E., & Rossetti, L.
- Venue
- Journal of Clinical Investigation
- Published
- 2003-01-15
- Volume
- 111
- Issue
- 2
- Pages
- 225-230
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2165708021
- Cited by
- 525
- References
- 5
- FWCI
- 41.48
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
