Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

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3. Senolytics and senomorphics: Natural and synthetic therapeutics in the treatment of aging and chronic diseases
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4. Osteoporosis: Pathophysiology and therapeutic options
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5. Senile Osteoporosis: The Involvement of Differentiation and Senescence of Bone Marrow Stromal Cells
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6. Human CD 8 + EMRA T cells display a senescence‐associated secretory phenotype regulated by p38 MAPK
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7. Discovery of piperlongumine as a potential novel lead for the development of senolytic agents
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8. Cellular senescence and the senescent secretory phenotype in age-related chronic diseases
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9. The impact of mitotic errors on cell proliferation and tumorigenesis
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10. Physiological Aging: Links Among Adipose Tissue Dysfunction, Diabetes, and Frailty
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11. Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue
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12. Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis
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13. Cellular senescence in bone
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14. Macrophages in age-related chronic inflammatory diseases
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15. DNA damage-induced type I interferon promotes senescence and inhibits stem cell function
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16. Immune aging, dysmetabolism, and inflammation in neurological diseases
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17. Telomere-driven diseases and telomere-targeting therapies
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18. Identification of senescence-associated circular RNAs (SAC-RNAs) reveals senescence suppressor CircPVT1
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19. Senescent tumor cells lead the collective invasion in thyroid cancer
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20. RETRACTED: Chronic Inflammation: Accelerator of Biological Aging
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21. Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence-associated secretory phenotype
    Lucia Terlecki‐Ζaniewicz, Ingo Lämmermann, Julie Latreille, Madhusudhan Reddy Bobbili, Vera Pils, Markus Schosserer, Regina Weinmüllner, Hanna Dellago, Susanna Skalicky, Dietmar Pum et al. · 2018 · Aging
22. A Narrative Review on Plasminogen Activator Inhibitor-1 and Its (Patho)Physiological Role: To Target or Not to Target?
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23. Keeping the senescence secretome under control: molecular reins on the senescence-associated secretory phenotype.
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24. Aging Hallmarks: The Benefits of Physical Exercise
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25. Aging Impairs Alveolar Macrophage Phagocytosis and Increases Influenza-Induced Mortality in Mice
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26. TP53 Mutations and Outcomes in Breast Cancer: Reading beyond the Headlines
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27. PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells
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28. Molecular mechanisms of renal aging
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29. The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence
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30. Senescent cells: SASPected drivers of age-related pathologies
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31. Age-Associated Mitochondrial Dysfunction Accelerates Atherogenesis
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32. Immunosenescence, aging and successful aging
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33. miR-21 and miR-146a: The microRNAs of inflammaging and age-related diseases
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34. The Emergence of Geroscience as an Interdisciplinary Approach to the Enhancement of Health Span and Life Span
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35. Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis
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36. Mechanisms of Aging and the Preventive Effects of Resveratrol on Age-Related Diseases
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37. Muscle-derived miR-34a increases with age in circulating extracellular vesicles and induces senescence of bone marrow stem cells
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38. Ionizing Radiation-Induced Endothelial Cell Senescence and Cardiovascular Diseases
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39. Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity
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40. NKG2D-CAR T cells eliminate senescent cells in aged mice and nonhuman primates
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41. Biology of premature ageing in survivors of cancer
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42. Cellular Aging Contributes to Failure of Cold-Induced Beige Adipocyte Formation in Old Mice and Humans
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43. Old Maids: Aging and Its Impact on Microglia Function
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44. Oxidative stress-induced premature senescence dysregulates VEGF and CFH expression in retinal pigment epithelial cells: Implications for Age-related Macular Degeneration
    Mariela Claudia Marazita, Andrea Vanesa Dugour, Melisa D. Marquioni‐Ramella, Juan Manuel Figueroa, Ángela M. Suburo · 2015 · Redox Biology
45. Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation
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46. The Role of Senescence in the Development of Nonalcoholic Fatty Liver Disease and Progression to Nonalcoholic Steatohepatitis
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47. Diabetes mellitus—advances and challenges in human β-cell proliferation
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48. A researcher’s guide to preclinical mouse NASH models
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49. The hypoxic microenvironment: A determinant of cancer stem cell evolution
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50. Oncogene-induced senescence: a double edged sword in cancer
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51. Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain
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52. Age-Associated Changes in the Immune System and Blood–Brain Barrier Functions
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53. The chromatin accessibility signature of human immune aging stems from CD8+ T cells
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54. Strategies targeting cellular senescence
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55. Cell cycle arrest and the evolution of chronic kidney disease from acute kidney injury
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56. The multifaceted benefits of walking for healthy aging: from Blue Zones to molecular mechanisms
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57. Vascular senescence in cardiovascular and metabolic diseases
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58. Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases
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59. Cell Senescence Abrogates the Therapeutic Potential of Human Mesenchymal Stem Cells in the Lethal Endotoxemia Model
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60. Inflammation and Oxidative Stress in Chronic Kidney Disease and Dialysis Patients
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61. Coming of age: molecular drivers of aging and therapeutic opportunities
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62. Therapeutic interventions for aging: the case of cellular senescence
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63. Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis
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64. Frailty in childhood cancer survivors
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65. Molecular and phenotypic biomarkers of aging
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66. Age-related macular degeneration: A two-level model hypothesis
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67. Cellular senescence and the tumour microenvironment
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68. Sex differences in inflammation, redox biology, mitochondria and autoimmunity
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69. The Signaling of Cellular Senescence in Diabetic Nephropathy
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70. Paracrine roles of cellular senescence in promoting tumourigenesis
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71. Age-related immune alterations and cerebrovascular inflammation
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72. Blocking elevated p38 MAPK restores efferocytosis and inflammatory resolution in the elderly
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73. Strategies to Prevent Sarcopenia in the Aging Process: Role of Protein Intake and Exercise
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74. Potential role of senescent macrophages in radiation-induced pulmonary fibrosis
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75. Reducing Senescent Cell Burden in Aging and Disease
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76. Advances in biological applications of self-assembled DNA tetrahedral nanostructures
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77. Parallels in Immunometabolic Adipose Tissue Dysfunction with Ageing and Obesity
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78. Obesity-associated mechanisms of hepatocarcinogenesis
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79. Senescence in Wound Repair: Emerging Strategies to Target Chronic Healing Wounds
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80. Impact of Yoga and Meditation on Cellular Aging in Apparently Healthy Individuals: A Prospective, Open‐Label Single‐Arm Exploratory Study
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81. Cellular senescence in cardiac diseases
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82. Emerging targets in osteoarthritis therapy
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83. Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology
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84. Inflammaging and human longevity in the omics era
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85. Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis
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86. Clinical strategies and animal models for developing senolytic agents
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87. Oxidative stress, cellular senescence and ageing
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88. Yoga- and meditation-based lifestyle intervention increases neuroplasticity and reduces severity of major depressive disorder: A randomized controlled trial
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89. Dynamic Modelling of Pathways to Cellular Senescence Reveals Strategies for Targeted Interventions
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90. Cell aging and cellular senescence in skin aging - Recent advances in fibroblast and keratinocyte biology
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91. Perturbation of Ribosome Biogenesis Drives Cells into Senescence through 5S RNP-Mediated p53 Activation
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92. From inflamm-aging to immune-paralysis: a slippery slope during aging for immune-adaptation
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93. TNFα-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion
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94. p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes
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95. Extrachromosomal telomere repeat DNA is linked to ALT development via cGAS-STING DNA sensing pathway
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96. DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging
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97. Apolipoprotein D takes center stage in the stress response of the aging and degenerative brain
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98. Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging
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99. The role of estrogen in cutaneous ageing and repair
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100. The role of cellular senescence in skin aging and age-related skin pathologies
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