White Matter Microstructure and Atypical Visual Orienting in 7-Month-Olds at Risk for Autism
Open accessAbstract
OBJECTIVE The authors sought to determine whether specific patterns of oculomotor functioning and visual orienting characterize 7-month-old infants who later meet criteria for an autism spectrum disorder (ASD) and to identify the neural correlates of these behaviors. METHOD Data were collected from 97 infants, of whom 16 were high-familial-risk infants later classified as having an ASD, 40 were high-familial-risk infants who did not later meet ASD criteria (high-risk negative), and 41 were low-risk infants. All infants underwent an eye-tracking task at a mean age of 7 months and a clinical assessment at a mean age of 25 months. Diffusion-weighted imaging data were acquired for 84 of the infants at 7 months. Primary outcome measures included average saccadic reaction time in a visually guided saccade procedure and radial diffusivity (an index of white matter organization) in fiber tracts that included corticospinal pathways and the splenium and genu of the corpus callosum. RESULTS Visual orienting latencies were longer in 7-month-old infants who expressed ASD symptoms at 25 months compared with both high-risk negative infants and low-risk infants. Visual orienting latencies were uniquely associated with the microstructural organization of the splenium of the corpus callosum in low-risk infants, but this association was not apparent in infants later classified as having an ASD. CONCLUSIONS Flexibly and efficiently orienting to salient information in the environment is critical for subsequent cognitive and social-cognitive development. Atypical visual orienting may represent an early prodromal feature of an ASD, and abnormal functional specialization of posterior cortical circuits directly informs a novel model of ASD pathogenesis.
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Our findings are consistent with reports of subtle motor differences at 6-7 months with respect to head control, lower activity level, and saccadic reaction times among infants who go on to develop ASD.
“Our findings are consistent with reports of subtle motor differences at 6–7 months with respect to head control [13], lower activity level [52], and saccadic reaction times [9] among infants who go on to develop ASD.”
From Behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life (2015) · cites this paper as [9]
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Self-citationAltered corpus callosum morphology associated with autism over the first 2 years of life
Wolff, J. J., Gerig, G., Lewis, J. D., Soda, T., Styner, M. A., Vachet, C., Botteron, K. N., Elison, J. T., Dager, S. R., Estes, A. M., et al. (2015) · Brain · doi:10.1093/brain/awv118 · Cited by 203 · see citing works
“the corpus callosum given its potential role in the early development of ASD (Elison et al., 2013).”
BackgroundResultInfluentialSelf-citationSinclair, D., Oranje, B., Razak, K. A., Siegel, S. J., & Schmid, S. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.029 · Cited by 198 · see citing works
“…to sensory stimuli are cardinal symptoms which have a debilitating impact on social interactions and daily functioning (Crane et al., 2009; Elison et al., 2013; Elsabbagh et al., 2013; Hirstein et al., 2001; Leekam et al., 2007; Minshew et al., 2002; Zwaigenbaum et al., 2005) ASD…”
Sasson, N. J., & Touchstone, E. W. (2013) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-013-1910-z · Cited by 189 · see citing works
Self-citationKlin, A., Shultz, S., & JONES, W. R. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.10.006 · Cited by 183 · see citing works
“Studies of early white matter development and visual orienting are underway (Elison et al., 2013; Wolff et al., 2012).”
BackgroundLongitudinal patterns of repetitive behavior in toddlers with autism
Wolff, J. J., Botteron, K. N., Dager, S. R., Elison, J. T., Estes, A. M., Gu, H., Hazlett, H. C., Pandey, J., Paterson, S. J., Schultz, R. T., et al. (2014) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12207 · Cited by 170 · see citing works
Self-citationJones, E. J. H., Venema, K., Earl, R., Lowy, R., Barnes, K., Estes, A., Dawson, G., & Webb, S. J. (2016) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-016-9139-8 · Cited by 164 · see citing works
“in work with high-risk infants [86, 99, 100].”
Self-citationToward a conceptual framework for early brain and behavior development in autism
Piven, J., Elison, J. T., & Zylka, M. J. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.131 · Cited by 163 · see citing works
“This functional coupling was not observed in the HR-ASD group, suggesting atypical cortical function in this area that is critical for subsequent cognitive development (25, 26).”
Self-citationThe development of autism spectrum disorders: variability and causal complexity
Wozniak, R. H., Leezenbaum, N. B., Northrup, J. B., West, K. L., & Iverson, J. M. (2016) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.1426 · Cited by 162 · see citing works
Sacrey, L.-A. R., Armstrong, V. L., Bryson, S. E., & Zwaigenbaum, L. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.10.011 · Cited by 160 · see citing works
Self-citationFrom early markers to neuro-developmental mechanisms of autism
Gliga, T., Jones, E. J. H., Bedford, R., Charman, T., & Johnson, M. H. (2014) · Developmental Review · doi:10.1016/j.dr.2014.05.003 · Cited by 150 · see citing works
Ameis, S. H., Lerch, J. P., Taylor, M. J., Lee, W., Viviano, J. D., Pipitone, J., Nazeri, A., Croarkin, P. E., Voineskos, A. N., Lai, M.-C., et al. (2016) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2016.15111435 · Cited by 155 · see citing works
Schmitt, L., Cook, E. H., Sweeney, J. A., & Mosconi, M. W. (2014) · Molecular Autism · doi:10.1186/2040-2392-5-47 · Cited by 155 · see citing works
“However, the majority of affected individuals also show sensorimotor abnormalities that may precede the emergence of social communication and cognitive deficits early in life [2-5].”
BackgroundKojovic, N., Hadid, L. B., Franchini, M., & Schaer, M. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8101508 · Cited by 162 · see citing works
“Slower attention disengagement has been shown to characterize the visual pattern in Sibs ASD who will develop ASD already at 6 months of life [57] and is known to persist throughout childhood [58].”
BackgroundJones, E. J. H., Dawson, G., Kelly, J. F., Estes, A. M., & Webb, S. J. (2017) · Autism Research · doi:10.1002/aur.1754 · Cited by 149 · see citing works
“…stimuli at 6 months [Chawarska, Macari, & Shic, 2013; Shic, Macari, & Chawarska, 2014], altered social/ nonsocial attention shifting at 7 months [Elison et al., 2013], declining attention to people in naturalistic contexts between 6 and 24 months [Ozonoff et al., 2010], and altered neural…”
Self-citationThe IBIS Network, Wolff, J. J., Swanson, M. R., Elison, J. T., Gerig, G., Pruett, J. R., Styner, M. A., Vachet, C., Botteron, K. N., Dager, S. R., et al. (2017) · Molecular Autism · doi:10.1186/s13229-017-0126-z · Cited by 142 · see citing works
“This adds to previous reports of disordinal interactions in brain and behavior between infants who did and did not receive a diagnosis of ASD [4, 5].”
BackgroundResultSelf-citationNeural Signatures of Autism Spectrum Disorders: Insights into Brain Network Dynamics
Hernandez, L. M., Rudie, J. D., Green, S. A., Bookheimer, S. Y., & Dapretto, M. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.172 · Cited by 141 · see citing works
“The recent DTI findings of WM abnormalities found in infants at-risk for autism, in an age range that typically precedes diagnosis, suggests that such differences precede and thus may be causal for ASD (Elison et al, 2013; Wolff et al, 2012), although this is not a conclusive evidence.”
BackgroundThe journey to autism: Insights from neuroimaging studies of infants and toddlers
Wolff, J. J., Jacob, S., & Elison, J. T. (2017) · Development and Psychopathology · doi:10.1017/s0954579417000980 · Cited by 131 · see citing works
“In another study of children at low and high familial risk for ASD using both DTI and eye tracking, Elison et al. (2013) found that functional coupling between visual orienting and the splenium of the corpus callosum apparent among low-risk controls was not observed in 7-month-old infants who later…”
BackgroundInfluentialSelf-citationA developmental neuroscience perspective on affect-biased attention
Morales, S., Fu, X., & Pérez‐Edgar, K. E. (2016) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2016.08.001 · Cited by 130 · see citing works
“…childhood (Power et al., 2012; Van Dijk et al., 2012), there is clear consensus that the neural regions subserving orienting are in place in the first year of life (Elison et al., 2013; Posner et al., 2012) and functionally mature between 3 and 6 months of age (Colombo, 2001; Courage et al., 2006).”
The over‐pruning hypothesis of autism
Thomas, M. S. C., Davis, R., Karmiloff‐Smith, A., Knowland, V. C. P., & Charman, T. (2015) · Developmental Science · doi:10.1111/desc.12303 · Cited by 122 · see citing works
“…with ASD) have shown that behavioural and neural differences can be found by virtue of risk status itself, whether the infant goes on to receive a diagnosis of ASD or not (e.g., Elsabbagh et al., 2013), thereby supporting the view that some common inheritance alters trajectories of development.”
BackgroundNetwork inefficiencies in autism spectrum disorder at 24 months.
Lewis, J. D., Evans, A. C., Pruett, J. R., Botteron, K., Zwaigenbaum, L., Estes, A., Gerig, G., Collins, L., Kostopoulos, P., McKinstry, R., et al. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.24 · Cited by 110 · see citing works
Self-citationRepetitive Behavior in 12-Month-Olds Later Classified With Autism Spectrum Disorder
Elison, J. T., Wolff, J. J., Reznick, J. S., Botteron, K. N., Estes, A. M., Gu, H., Hazlett, H. C., Meadows, A. J., Paterson, S. J., Zwaigenbaum, L., et al. (2014) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2014.08.004 · Cited by 113 · see citing works
“Additional information on the study design is provided by Elison et al.26 and Wolff et al.27”
Self-citationOrekhova, E. V., & Stroganova, T. A. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00034 · Cited by 119 · see citing works
“Although novelty P3 and P3a are elicited by distinctly different stimuli during quite different task circumstances, they may reflect the output of a similar configuration of neural sources (Friedman et al., 2001).”
BackgroundInfluentialThe role of cerebellar circuitry alterations in the pathophysiology of autism spectrum disorders
Mosconi, M. W., Wang, Z., Schmitt, L. M., Tsai, P., & Sweeney, J. A. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00296 · Cited by 112 · see citing works
“…and while these deficits have been well studied during social interactions, it is possible that more fundamental and earlier emerging alterations of oculomotor control could contribute to atypical patterns of eye gaze coordination among affected children (Bryson et al., 2007; Elison et al., 2013).”
BackgroundJohnson, B. P., Lum, J. A. G., Rinehart, N., & Fielding, J. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.08.007 · Cited by 111 · see citing works
Sacrey, L.-A. R., Bryson, S. E., & Zwaigenbaum, L. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.08.028 · Cited by 108 · see citing works
Self-citationBrain and behavior development in autism from birth through infancy
Shen, M. D., & Piven, J. (2017) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2017.19.4/mshen · Cited by 108 · see citing works
Self-citationEarly Infant Development and Intervention for Autism Spectrum Disorder
Sacrey, L.-A. R., Bennett, J., & Zwaigenbaum, L. (2015) · Journal of Child Neurology · doi:10.1177/0883073815601500 · Cited by 109 · see citing works
Self-citationAtypical developmental of dorsal and ventral attention networks in autism
Farrant, K., & Uddin, L. Q. (2015) · Developmental Science · doi:10.1111/desc.12359 · Cited by 97 · see citing works
Studying Autism Spectrum Disorder with Structural and Diffusion Magnetic Resonance Imaging: A Survey
Ismail, M. M. T., Keynton, R. S., Mostapha, M., Eltanboly, A. H., Casanova, M. F., Gimel’farb, G., & El-Baz, A. S. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00211 · Cited by 100 · see citing works
Jin, Y., Chong-yaw Wee, A., Shi, F., Thung, K., Ni, D., Yap, P., & Shen, D. G. (2015) · Human Brain Mapping · doi:10.1002/hbm.22957 · Cited by 94 · see citing works
“For example, the failure of flexibly orienting gaze and visual attention to the most salient or biologically relevant information in the environment implied abnormal functional specialization of posterior cortical circuits in 7-month-old ASD infants [Elison et al., 2013].”
BackgroundMcKinnon, C., Eggebrecht, A. T., Todorov, A. A., Wolff, J. J., Elison, J. T., Adams, C. M., Snyder, A. Z., Estes, A. M., Zwaigenbaum, L., Botteron, K. N., et al. (2018) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2018.09.008 · Cited by 95 · see citing works
Self-citationthe BASIS Team, Hendry, A. J., Jones, E. J. H., Bedford, R., Gliga, T., Charman, T., & Johnson, M. H. (2018) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-017-9219-4 · Cited by 93 · see citing works
“There is already good evidence for disruption to the development of attentional control amongst HR infants: infants who later show clinical levels of ASD symptoms tend to show difficulties with exogenously driven disengagement compared with low-risk (LR) controls, with group differences apparent at around 12–14 months…”
BackgroundEarly development of attention to threat-related facial expressions
Leppänen, J. M., Cataldo, J. K., Enlow, M. B., & Nelson, C. A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197424 · Cited by 93 · see citing works
“Further, given that the infants were tested with a rather lengthy EEG/fNIRS paradigm before the eye-tracking tests (S3 File), the retention rate in the current analysis was only 35 to 54%, which is noticeably lower than the 82 to 100% in previous infant eye-tracking studies using similar paradigms [34, 42, 43].”
ResultCerebrospinal fluid and the early brain development of autism
Shen, M. D. (2018) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-018-9256-7 · Cited by 90 · see citing works
the EASE Team, Thorup, E., Nyström, P., Gredebäck, G., Bölte, S., & Falck‐Ytter, T. (2018) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-017-0388-0 · Cited by 91 · see citing works
“It has also been shown that infants with later ASD may have difficulties disengaging their attention from one stimulus to another (Elsabbagh et al. 2013; Elison et al. 2013; Zwaigenbaum et al. 2005), which could result in less alternating gaze.”
BackgroundResultPre-symptomatic intervention for autism spectrum disorder (ASD): defining a research agenda
Grzadzinski, R., Amso, D., Landa, R. J., Watson, L. R., Guralnick, M. J., Zwaigenbaum, L., Deák, G. O., Estes, A. M., Brian, J. A., Bath, K. G., et al. (2021) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-021-09393-y · Cited by 88 · see citing works
“For example, results from infant sibling studies reveal differences in the visual system including the middle occipital gyrus [8] and splenium [35, 102].”
BackgroundResultSelf-citationBilleci, L., Narzisi, A., Campatelli, G., Crifaci, G., Calderoni, S., Gagliano, A., Calzone, C., Colombi, C., Pioggia, G., Muratori, F., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.75 · Cited by 83 · see citing works
The Neurodevelopment of Autism from Infancy Through Toddlerhood
Girault, J. B., & Piven, J. (2019) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2019.09.009 · Cited by 84 · see citing works
Self-citationBottom-Up Attention Orienting in Young Children with Autism
Amso, D., Haas, S., Tenenbaum, E. J., Markant, J. C., & Sheinkopf, S. J. (2013) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-013-1925-5 · Cited by 79 · see citing works
“Previous work has shown that ASD groups have difficulty with disengagement of fixations (e.g., Elsabbagh et al. 2009; Elison et al. 2013).”
InfluentialAttitudes of the autism community to early autism research
Fletcher‐Watson, S., Apicella, F., Bonnie Auyeung, B., Beranová, Š., Bonnet‐Brilhault, F., Canal‐Bedia, R., Charman, T., Chericoni, N., Conceição, I. C., Davies, K., et al. (2016) · Autism · doi:10.1177/1362361315626577 · Cited by 79 · see citing works
“However, few of these findings have yet been unequivocally corroborated, with the exception of early attention switching atypicalities (Elison et al., 2013; Elsabbagh et al., 2013; Zwaigenbaum et al., 2005).”
BackgroundEarly Development of Visual Attention: Change, Stability, and Longitudinal Associations
Hendry, A. J., Johnson, M. H., & Holmboe, K. (2019) · Annual Review of Developmental Psychology · doi:10.1146/annurev-devpsych-121318-085114 · Cited by 78 · see citing works
Shen, M. D., Swanson, M. R., Wolff, J. J., Elison, J. T., Girault, J. B., Kim, S. H., Smith, R. G., Graves, M. M., Weisenfeld, L. A. H., Flake, L., et al. (2022) · American Journal of Psychiatry · doi:10.1176/appi.ajp.21090896 · Cited by 79 · see citing works
Self-citationJohnson, M. H., Charman, T., Pickles, A. R., & Jones, E. J. H. (2021) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.13372 · Cited by 73 · see citing works
“This was subsequently replicated in two eye-tracking studies (Elison et al., 2013; Elsabbagh et al., 2013); Elsabbagh and colleagues further showed that the change in disen-gagement speed between 7 and 14 months was particularly strongly associated with later ASD (Elsabbagh et al., 2013).”
InfluentialBilleci, L., Narzisi, A., Tonacci, A., Sbriscia-Fioretti, B., Serasini, L., Fulceri, F., Apicella, F., Sicca, F., Calderoni, S., & Muratori, F. (2017) · Scientific Reports · doi:10.1038/s41598-017-13053-4 · Cited by 71 · see citing works
Andrews, D. S., Lee, J. K., Solomon, M., Rogers, S. J., Amaral, D. G., & Nordahl, C. W. (2019) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-019-9291-z · Cited by 70 · see citing works
Eye-tracking-based assessment of cognitive function in low-resource settings
Forssman, L., Ashorn, P., Ashorn, U., Maleta, K. M., Matchado, A., Kortekangas, E., & Leppänen, J. M. (2016) · Archives of Disease in Childhood · doi:10.1136/archdischild-2016-310525 · Cited by 67 · see citing works
Is mere exposure enough? The effects of bilingual environments on infant cognitive development
D’Souza, D., Brady, D., Haensel, J. X., & D’Souza, H. (2020) · Royal Society Open Science · doi:10.1098/rsos.180191 · Cited by 67 · see citing works
“…processes and the development of corticospinal tracts connecting brain stem to cerebral cortex [35], the ability to disengage attention — reflected by saccadic reaction times in the overlap condition — is associated with development of the splenium, the thickest part of the corpus callosum [36].”
Pruett, J. R., Kandala, S., Hoertel, S., Snyder, A. Z., Elison, J. T., Nishino, T., Feczko, E., Dosenbach, N. U. F., Nardos, B., Power, J. D., et al. (2015) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2015.01.003 · Cited by 57 · see citing works
“…and the microstructure of the plenium of the corpus callosum in 7-month-old low-risk nfants (Elison et al., 2013b), and a correlation between ractional anisotropy in the right uncinate fasciculus at 6 onths and the infants’ response to joint attention bids at 9 onths (Elison et al., 2013a).”
InfluentialSelf-citationMastergeorge, A. M., Kahathuduwa, C. N., & Blume, J. (2020) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-020-04731-w · Cited by 64 · see citing works
Widely applicable MATLAB routines for automated analysis of saccadic reaction times
Leppänen, J. M., Forssman, L., Kaatiala, J., Yrttiaho, S., & Wass, S. V. (2014) · Behavior Research Methods · doi:10.3758/s13428-014-0473-z · Cited by 64 · see citing works
“In essence, eye tracking is a noninvasive technology that has the advantage over other techniques in that it offers the possibility for automated acquisition and analysis of eye movements at a high spatial and temporal resolution, is less labor intensive, and minimizes the possibility of human error or biases (Aslin,…”
BackgroundResultInfluentialWhite matter correlates of sensory processing in autism spectrum disorders
Pryweller, J. R., Schauder, K. B., Anderson, A. W., Heacock, J. L., Foss‐Feig, J. H., Newsom, C. R., Loring, W. A., & Cascio, C. J. (2014) · NeuroImage Clinical · doi:10.1016/j.nicl.2014.09.018 · Cited by 62 · see citing works
“The association between SPLEN FA and nonsocial orienting in ASD corroborates recent evidence that inefficient visual orienting and associated SPLEN white matter integrity reduction may be early markers of risk for ASD (Elison et al., 2013).”
Conti, E., Mitra, J., Calderoni, S., Pannek, K., Shen, K., Pagnozzi, A. M., Rose, S., Mazzotti, S., Scelfo, D., Tosetti, M., et al. (2017) · Human Brain Mapping · doi:10.1002/hbm.23520 · Cited by 62 · see citing works
Role of deep learning in infant brain MRI analysis
Mostapha, M., & Styner, M. A. (2019) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2019.06.009 · Cited by 60 · see citing works
“…example, in studying ASD, It was demonstrated that infants who will later develop ASD show a variety of age-specific, brain differences between 6–24 months, as well as demonstrating early brain changes that correlate with ASD outcome and related behaviors measured at 24 months [69, 70, 71, 72, 73].”
BackgroundSelf-citationSacrey, L.-A. R., Bryson, S. E., Zwaigenbaum, L., Brian, J. A., Smith, I. M., Roberts, W., Szatmári, P., Vaillancourt, T., Roncadin, C., & Garon, N. (2016) · Autism · doi:10.1177/1362361316675120 · Cited by 62 · see citing works
“such as atypical visual orienting and face processing, have been detected by electroencephalogram (EEG) and eye tracking by 6–8 months, yet such technology-based methods are expensive and time-consuming (Chawarska et al., 2013; Cohen et al., 2013; Elison et al., 2013; Elsabbagh et al., 2012; Jones and Klin, 2013).”
BackgroundSelf-citationSabatos‐DeVito, M., Schipul, S. E., Bulluck, J., Belger, A., & Baranek, G. T. (2016) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-015-2681-5 · Cited by 59 · see citing works
“Attention disengagement deficits are amongst the earliest markers in at-risk siblings of children with ASD (Bryson et al. 2007; Elison et al. 2013; Elsabbagh et al. 2009, 2013), and are predictive of a later diagnosis (Zwaigenbaum et al. 2005).”
BackgroundInfluentialFalck‐Ytter, T. (2015) · Research in Autism · doi:10.1016/j.rasd.2015.06.007 · Cited by 57 · see citing works
Díaz‐Caneja, C. M., State, M. W., Hagerman, R. J., Jacquemont, S., Marín, Ó., Bagni, C., Umbricht, D., Simonoff, E. A., Andres-Trelles, F., Kaale, A., et al. (2021) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2021.02.020 · Cited by 54 · see citing works
Eurosibs: Towards robust measurement of infant neurocognitive predictors of autism across Europe
Jones, E. J. H., Mason, L., Ali, J. B., van den Boomen, C., Braukmann, R., Cauvet, É., Demurie, E., Hessels, R. S., Ward, E. K., Hunnius, S., et al. (2019) · Infant Behavior and Development · doi:10.1016/j.infbeh.2019.03.007 · Cited by 53 · see citing works
Falck‐Ytter, T., Thorup, E., & Bölte, S. (2014) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-014-2278-4 · Cited by 53 · see citing works
“Some studies have indicated that young autistic children have problems disengaging their attention from visual stimuli (Elison et al. 2013; Elsabbagh et al. 2013).”
BackgroundMüller, N., Baumeister, S., Dziobek, I., Banaschewski, T., & Poustka, L. (2016) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-016-2828-z · Cited by 54 · see citing works
Analysis of cortical shape in children with simplex autism
Dierker, D. L., Feczko, E., Pruett, J. R., Petersen, S. E., Schlaggar, B. L., Constantino, J. N., Harwell, J. W., Coalson, T. S., & Van Essen, D. C. (2015) · Cerebral Cortex · doi:10.1093/cercor/bht294 · Cited by 50 · see citing works
Splenium development and early spoken language in human infants
Swanson, M. R., Wolff, J. J., Elison, J. T., Gu, H., Hazlett, H. C., Botteron, K. N., Styner, M. A., Paterson, S., Gerig, G., Constantino, J. N., et al. (2015) · Developmental Science · doi:10.1111/desc.12360 · Cited by 52 · see citing works
Self-citationInfant Visual Brain Development and Inherited Genetic Liability in Autism
Girault, J. B., Donovan, K., Hawks, Z., Talović, M., Forsen, E., Elison, J. T., Shen, M. D., Swanson, M. R., Wolff, J. J., Kim, S. H., et al. (2022) · American Journal of Psychiatry · doi:10.1176/appi.ajp.21101002 · Cited by 47 · see citing works
Self-citationClinical and Translational Implications of an Emerging Developmental Substructure for Autism
Constantino, J. N., Charman, T., & Jones, E. J. H. (2021) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-081219-110503 · Cited by 50 · see citing works
“Possible manifestations of this include slower shifting of attention to a novel stimulus when interest is already captured (Elison et al. 2013, Elsabbagh et al. 2013) and increased connectivity in the alpha range (suggestive of greater internal focus) while viewing dynamic videos (Haartsen et al.…”
BackgroundTunç, B., Yankowitz, L., Parker, D., Alappatt, J. A., Pandey, J., Schultz, R., & Verma, R. (2019) · Molecular Autism · doi:10.1186/s13229-019-0301-5 · Cited by 47 · see citing works
Self-citationZhang, S., Chen, D., Tang, Y., & Zhang, L. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.651349 · Cited by 49 · see citing works
“…of EEG & eye-tracking recordings for instance, studies have shown that eye-tracking recordings have strong correlation with EEG acquisitions making it possible for the comprehensive analysis between the behavioral characteristics (eye-tracking) and the brain dynamics (EEG) (Elison et al., 2013).”
BackgroundApplication of Eye Tracking Technology in Medicine: A Bibliometric Analysis
Zammarchi, G., & Conversano, C. (2021) · Vision · doi:10.3390/vision5040056 · Cited by 51 · see citing works
“Some of these studies combined eye tracking with additional techniques such as MRI in order to investigate whether the identified differences in gaze patterns were associated with neurobiological abnormalities [26,27,45].”
BackgroundGlobally weaker and topologically different: resting-state connectivity in youth with autism
Yerys, B. E., Herrington, J. D., Satterthwaite, T. D., Guy, L., Schultz, R. T., & Bassett, D. S. (2017) · Molecular Autism · doi:10.1186/s13229-017-0156-6 · Cited by 44 · see citing works
“These system-specific findings align with imaging studies of toddlers [57] and younger siblings at risk for ASD [58, 59] that demonstrate unusual growth of white matter tracts linking attention and motor systems.”
ResultSelf-citationFranchini, M., Armstrong, V. L., Schaer, M., & Smith, I. M. (2018) · Child Neuropsychology · doi:10.1080/09297049.2018.1490706 · Cited by 47 · see citing works
“…findings may be explained by methodological differences between studies, including in particular that whereas studies by the Bryson group used similar stimuli across trials (Landry & Bryson, 2004; Zwaigenbaum et al., 2005), stimuli changed across trials in the Elison et al. (2013) study.”
BackgroundResultInfluentialUnimpaired attentional disengagement in toddlers with autism spectrum disorder
Fischer, J., Smith, H., Martinez‐Pedraza, F., Carter, A. S., Kanwisher, N., & Káldy, Z. (2015) · Developmental Science · doi:10.1111/desc.12386 · Cited by 47 · see citing works
“Several other gap-overlap studies have required disengagement from social stimuli and reported slower disengagement in children with ASD (Elison et al., 2013; Elsabbagh et al., 2009, 2013; Kawakubo et al., 2007); it is not the case that including social stimuli reduces the ability to detect any Fischer et al.”
Macari, S. L., Milgramm, A., Reed, J., Shic, F., Powell, K. K., Macris, D. M., & Chawarska, K. (2020) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2019.12.012 · Cited by 46 · see citing works
BK Channels Mediate Synaptic Plasticity Underlying Habituation in Rats
Zaman, T., Oliveira, C. D., Smoka, M., Narla, C., Poulter, M. O., & Schmid, S. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3699-16.2017 · Cited by 45 · see citing works
“…impact on social interactions and daily functioning (Hirstein et al., 2001; Minshew et al., 2002; Zwaigenbaum et al., 2005; Leekam et al., 2007; Crane et al., 2009; Schoen et al., 2009; Elison et al., 2013; Elsabbagh et al., 2013; Stroganova et al., 2013; for review, see Sinclair et al., 2016).”
BackgroundAltered lateralization of dorsal language tracts in 6‐week‐old infants at risk for autism
Liu, J., Tsang, T., Jackson, L., Ponting, C., Jeste, S., Bookheimer, S. Y., & Dapretto, M. (2018) · Developmental Science · doi:10.1111/desc.12768 · Cited by 45 · see citing works
Topál, J., Román, V., & Turcsán, B. (2019) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.1495 · Cited by 43 · see citing works
Yurkovic‐Harding, J., Lisandrelli, G., Shaffer, R. C., Dominick, K. C., Pedapati, E. V., Erickson, C. A., Kennedy, D. P., & Yu, C. (2021) · Scientific Reports · doi:10.1038/s41598-021-81102-0 · Cited by 42 · see citing works
Telford, E. J., Cox, S. R., Fletcher‐Watson, S., Anblagan, D., Sparrow, S. A., Pataky, R., Quigley, A. J., Semple, S. I. K., Bastin, M. E., & Boardman, J. P. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1455-6 · Cited by 39 · see citing works
“In addition, eye-movement recordings in response to social stimuli have been used to identify early behavioral trajectories associated with autism (Jones and Klin 2013), to link emergent social cognition with white matter microstructure in specific tracts (Elison et al. 2013), and to distinguish between the social cog…”
BackgroundCan Autism Be Diagnosed with Artificial Intelligence? A Narrative Review
Chaddad, A., Li, J., Lu, Q., Li, Y., Okuwobi, I. P., Tanougast, C., Desrosiers, C., & Niazi, T. M. (2021) · Diagnostics · doi:10.3390/diagnostics11112032 · Cited by 43 · see citing works
“This atypical expansion leads to problems such as visual receptivity deficits and neglect of social cues [42].”
BackgroundEye-Tracking Biomarkers and Autism Diagnosis in Primary Care
Keehn, B., Monahan, P. O., Enneking, B. A., Ryan, T., Swigonski, N. L., & Keehn, R. M. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.11190 · Cited by 40 · see citing works
Reducing age of autism diagnosis: developmental social neuroscience meets public health challenge.
Klin, A., Klaiman, C., & Jones, W. (2015) · PubMed · Cited by 39 · see citing works
Reduced visual disengagement but intact phasic alerting in young children with autism
Kleberg, J. L., Thorup, E., & Falck‐Ytter, T. (2016) · Autism Research · doi:10.1002/aur.1675 · Cited by 38 · see citing works
- Authors
- Elison, J. T., Paterson, S. J., Wolff, J. J., Reznick, J. S., Sasson, N. J., Gu, H., Botteron, K. N., Dager, S. R., Estes, A. M., Evans, A. C., Gerig, G., Hazlett, H. C., Schultz, R. T., Styner, M., Zwaigenbaum, L., Piven, J., & for the IBIS Network
- Affiliations
- University of North Carolina at Chapel Hill (US)
- ORCID
- Venue
- American Journal of Psychiatry
- Published
- 2013-08
- Volume
- 170
- Issue
- 8
- Pages
- 899-908
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- PMC
- PMC3863364
- OpenAlex
- W2133015692
- Cited by
- 277
- References
- 46
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 11 · 2023: 9 · 2022: 14 · 2021: 21 · 2020: 53 · 2019: 26 · 2018: 15 · 2017: 21 · 2016: 30 · 2015: 23 · 2014: 25 · 2013: 11
- FWCI
- 16.21
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Funders
- Autism Speaks
- Pfizer
- National Institutes of Health (HD 03110, EB005149)
- Intellectual and Developmental Disabilities Research Center (T32 HD40127, P30 HD03110)
- National Institute of Mental Health (R01MH091645)
- National Institute of Biomedical Imaging and Bioengineering (U54EB005149)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32-HD-40127, HD055741-S1, P30-HD03110, P30HD003110, T32HD007376, T32HD040127, R01HD055741)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Developmental and Educational Psychology › Child and Animal Learning Development
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, visual orienting, white matter microstructure, radial diffusivity, splenium of corpus callosum, saccade latency, oculomotor development, familial risk, corticospinal tract, eye tracking, diffusion-weighted imaging, infant development
- MeSH terms
- Attention, Brain, Brain Mapping, Cerebral Cortex, Child Development Disorders, Pervasive, Cognition Disorders, Corpus Callosum, Female, Follow-Up Studies, Humans, Image Interpretation, Computer-Assisted, Infant, Male, Nerve Fibers, Neurons, Orientation, Pyramidal Tracts, Reaction Time, Reference Values, Reticular Formation, Saccades, Superior Colliculi, Visual Pathways, Genetic Predisposition to Disease, Diffusion Magnetic Resonance Imaging, Emotional Intelligence, Leukoencephalopathies
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