Reciprocal effects of antidepressant treatment on activity and connectivity of the mood regulating circuit: an fMRI study
Open accessAbstract
It has been hypothesized that one of the effects of antidepressants is to increase functional connectivity between the cortical mood-regulating and the limbic mood-generating regions.One consequence of this antidepressant effect is thought to be decreased limbic activation in response to negative emotional stimuli.Twelve unmedicated unipolar depressed patients and 11 closely matched healthy comparison subjects completed two magnetic resonance imaging (MRI) scanning sessions at baseline and after 6 weeks.Depressed patients received treatment with sertraline between the two sessions.During each MRI session, subjects completed a resting state functional connectivity scan and a conventional block-design negative vs. neutral pictures regional brain activation scan.After 6 weeks of sertraline treatment resting state, functional connectivity between the ACC and limbic regions increased while limbic activation in response to negative versus neutral pictures decreased.The results of this study are consistent with the hypothesis that antidepressant treatment has reciprocal effects on corticolimbic functional connectivity and limbic activation in response to emotional stimuli.Recent neuroscience research has provided great insights into the mechanisms of antidepressants.Most antidepressants seem to work by inhibiting uptake of the monoamines -serotonin (5-HT), norepinephrine, and/or dopamine-thereby increasing their synaptic availability.However, the neurophysiological correlates of these neurochemical effects on the brain's mood regulating circuit 1 are not well understood.
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Pregenual ACC-amygdala coupling increases with pharmacological antidepressant treatment.
“the strength of coupling between pregenual ACC and AMY has been shown to increase as a function of treatment with pharmacological antidepressants (Anand et al., 2007; Anand et al., 2005b; Chen et al., 2008)”
From Neural correlates of emotional processing in depression: Changes with cognitive behavioral therapy and predictors of treatment response (2011) · cites this paper as Anand et al., 2007
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- Authors
- Anand, A., Li, Y., Wang, Y., Gardner, K., & Lowe, M. J.
- Affiliations
- Indiana University Indianapolis (US)
- Indiana University – Purdue University Indianapolis (US)
- Cleveland Clinic (US)
- Venue
- The Journal of Neuropsychiatry and Clinical Neurosciences
- Published
- 2007-07
- Volume
- 19
- Issue
- 3
- Pages
- 274-282
- ISSN
- 0895-0172 (ISSN-L)
- 1545-7222
- PMC
- PMC3465666
- OpenAlex
- W2126437271
- Cited by
- 215
- References
- 47
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 4 · 2023: 10 · 2022: 12 · 2021: 31 · 2020: 7 · 2019: 10 · 2018: 5 · 2017: 10 · 2016: 15 · 2015: 15 · 2014: 18 · 2013: 11 · 2012: 9
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neuropsychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- Funders
- Pfizer
- National Institute of Mental Health (R01MH075025)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- antidepressant treatment, sertraline, major depressive disorder, resting-state functional connectivity, anterior cingulate cortex, limbic system, mood regulation, emotional face processing, negative emotional stimuli, corticolimbic circuits
- MeSH terms
- Adolescent, Adult, Analysis of Variance, Antidepressive Agents, Brain Mapping, Depression, Emotions, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Limbic System, Magnetic Resonance Imaging, Middle Aged, Oxygen, Photic Stimulation, Case-Control Studies, Sertraline
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