Cited by 343Stress Responses and CortisolChild and Adolescent Psychosocial and Emotional DevelopmentNeural and Behavioral Psychology Studies

The Teenage Brain: The Stress Response and the Adolescent Brain

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Romeo, Russell D.·2013·Current Directions in Psychological Science

Abstract

Adolescence is a time of many psychosocial and physiological changes. One such change is how an individual responds to stressors. Specifically, adolescence is marked by significant shifts in hypothalamic-pituitary-adrenal (HPA) axis reactivity, resulting in heightened stress-induced hormonal responses. It is presently unclear what mediates these changes in stress reactivity and what impacts they may have on an adolescent individual. However, stress-sensitive limbic and cortical brain areas that continue to mature during adolescence may be particularly vulnerable to these shifts in responsiveness. Consequently, perturbations of the maturing adolescent brain may contribute to the increase in stress-related psychological dysfunctions, such as anxiety, depression, and drug abuse, often observed during this stage of development. The purpose of this review is to describe the changes that occur in HPA function during adolescence, as well as to briefly discuss the possible ramifications of these changes on the developing brain and psychological health.

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  1. McEwen, B. S. (2007). (See References). A thorough review on HPA physiology and the influence of stress on the structure and function of the brain.
  2. Romeo, R. D. (2010b). (See References). This review provides greater detail of HPA changes during pubertal and adolescent maturation.

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Authors
Romeo, R. D.
Affiliations
Columbia University (US)
Corresponding author
Romeo, Russell D.
Venue
Current Directions in Psychological Science
Published
2013-04
Volume
22
Issue
2
Pages
140-145
ISSN
  • 0963-7214 (ISSN-L)
  • 1467-8721
OpenAlex
W2103027336
Cited by
343
References
28
Citations by year
2026: 43 · 2025: 29 · 2024: 35 · 2023: 39 · 2022: 39 · 2021: 43 · 2020: 23 · 2019: 19 · 2018: 26 · 2017: 11 · 2016: 15 · 2015: 11 · 2014: 7 · 2013: 3
FWCI
5.47
Type
journal article
Language
en
Open access
Locations
  • Current Directions in Psychological Science (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (R03MH090224)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
adolescence, hypothalamic-pituitary-adrenal axis, stress reactivity, adolescent brain development, cortical maturation, anxiety, depression, drug abuse

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