Tissue and circulating microRNA influence reproductive function in endometrial disease
Abstract
microRNA (miRNA) have emerged as important epigenetic modulators of gene expression in diverse pathological and physiological processes. In the endometrium, miRNA appear to have a role in the dynamic changes associated with the menstrual cycle, in implantation and in the pathophysiology associated with reproductive disorders such as recurrent miscarriage and endometriosis. This review explores the role of miRNA in endometrial physiology and endometrial disorders of reproduction and also raises the prospect that circulating miRNA may modulate endometrial function or reflect disordered endometrial activity. The clinical potential to use miRNA in diagnostic tests of endometrial function or in the treatment of endometrial disorders will also be discussed.
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Results of studies with heterogeneous designs apply only to the cohort of patients and control subjects selected for that study.
“As cautioned by Hull and Nisenblat, and echoed by the conclusions from Cochrane Database of Systematic Reviews, the interpretation of data can not be hindered by the heterogeneity of study designs, where the results apply only to the cohort of patients and control subjects selected for that study (87).”
From Biomarkers in endometriosis: Challenges and opportunities (2017) · cites this paper as [87]
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Petracco, R. G. (2014) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
- Authors
- Louise Hull, M., & Nisenblat, V.
- Affiliations
- Women's and Children's Hospital (AU)
- ORCID
- Nisenblat, Victoria
- Venue
- Reproductive BioMedicine Online
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 27
- Issue
- 5
- Pages
- 515-529
- ISSN
- 1472-6483 (ISSN-L)
- OpenAlex
- W2033570297
- Cited by
- 69
- References
- 114
- Citations by year
- 2024: 4 · 2023: 5 · 2022: 4 · 2021: 7 · 2020: 6 · 2019: 8 · 2018: 5 · 2017: 7 · 2016: 7 · 2015: 10 · 2014: 3 · 2013: 3
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Reproductive BioMedicine Online (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Keywords
- microRNA, endometrium, endometrial disease, recurrent pregnancy loss, endometriosis, implantation, circulating microRNAs, epigenetic regulation, menstrual cycle, endometrial function, biomarkers
- MeSH terms
- Abortion, Habitual, Endometriosis, Endometrium, Female, Fertility, Humans, Menstrual Cycle, Models, Biological, Embryo Implantation, Uterine Diseases, Biomarkers, MicroRNAs, Epigenesis, Genetic
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