The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9
Open accessAbstract
Natural interferon-producing cells (IPCs) specialize in the production of high levels of type 1 interferons (IFNs) in response to encapsulated DNA and RNA viruses. Here we demonstrate that the secretion of type 1 IFN in response to herpes simplex virus type 1 (HSV-1) in vitro is mediated by the toll-like receptor 9 (TLR9)/MyD88 pathway. Moreover, IPCs produce interleukin-12 (IL-12) in response to HSV-1 in vitro, which is also dependent on TLR9/ MyD88 signaling. Remarkably, though TLR9/MyD88-deficiency abrogates IPC responses to HSV-1 in vitro, mice lacking either MyD88 or TLR9 are capable of controlling HSV-1 replication in vivo after local infection, demonstrating that TLR9- and MyD88-independent pathways in cells other than IPCs can effectively compensate for defective IPC responses to HSV-1.
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Metadata
- Authors
- Krug, A., Luker, G. D., Barchet, W., Leib, D. A., Akira, S., & Colonna, M.
- Venue
- Blood
- Publisher
- American Society of Hematology
- Published
- 2004-02-15
- Volume
- 103
- Issue
- 4
- Pages
- 1433-1437
- ISSN
- 0006-4971 (ISSN-L)
- 1528-0020
- OpenAlex
- W1980768668
- Cited by
- 695
- References
- 4
- FWCI
- 17.16
- Type
- journal article
- Language
- en
- Open access
- bronze
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
