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Cited by 45Schizophrenia research and treatmentFamily Caregiving in Mental IllnessCounseling, Therapy, and Family Dynamics

Multifamily Group Psychoeducation and Cognitive Remediation for First-Episode Psychosis: A Randomized Controlled Trial

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Breitborde, Nicholas JK, Moreno, Francisco A, Mai-Dixon, Natalie, Peterson, Rachele, Durst, Linda, Bernstein, Beth, Byreddy, Seenaiah, McFarlane, William R·2011·BMC Psychiatry
DOI 10.1186/1471-244x-11-9PMC PMC3030530
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Abstract

BACKGROUND: Multifamily group psychoeducation (MFG) has been shown to reduce relapse rates among individuals with first-episode psychosis. However, given the cognitive demands associated with participating in this intervention (e.g., learning and applying a structured problem-solving activity), the cognitive deficits that accompany psychotic disorders may limit the ability of certain individuals to benefit from this intervention. Thus, the goal of this study is to examine whether individuals with first-episode psychosis who participate simultaneously in MFG and cognitive remediation--an intervention shown to improve cognitive functioning among individuals with psychotic disorders--will be less likely to experience a relapse than individuals who participate in MFG alone. METHODS/DESIGN: Forty individuals with first-episode psychosis and their caregiving relative will be recruited to participate in this study. Individuals with first-episode psychosis will be randomized to one of two conditions: (i) MFG with concurrent participation in cognitive remediation or (ii) MFG alone. The primary outcome for this study is relapse of psychotic symptoms. We will also examine secondary outcomes among both individuals with first-episode psychosis (i.e., social and vocational functioning, health-related quality of life, service utilization, independent living status, and cognitive functioning) and their caregiving relatives (i.e., caregiver burden, anxiety, and depression) DISCUSSION: Cognitive remediation offers the possibility of ameliorating a specific deficit (i.e., deficits in cognitive functioning) that often accompanies psychotic symptoms and may restrict the magnitude of the clinical benefits derived from MFG. TRIAL REGISTRATION: ClinicalTrials (NCT): NCT01196286.

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  • Only Breitborde et al. (2011) have proposed evaluating outcomes of multifamily psychoeducation groups on anxiety and depression of family caregivers, but there are no reports yet.

    “Sólo Breitborde et al. (2011) han planteado evaluar los resultados de los grupos de psicoeducación multifamiliar en la ansiedad y la depresión de los familiares cuidadores, pero aún no hay informes al respecto.”

    From Intervención psicológica grupal, basada en la aceptación y el entrenamiento en comunicación, con familiares de personas con trastorno mental grave (2015) · cites this paper as Breitborde et al., 2011

    The Methods/Design section proposes measuring caregivers’ depression and anxiety after multifamily group participation, and the paper reports no results from that planned analysis. It does not establish that Breitborde et al. were the only researchers to propose such an evaluation; the same section cites earlier research on caregiver distress after family psychoeducation. (LLM, conf=0.86)

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Research works printed but not linked: 4

  1. McGlashan TH A selective review of recent North American follow-up studies on schizophrenia Schizophrenia Bulletin 1998 14 515 542 3064280
  2. First MB Spitzer RL Gibbon M Williams JBW Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition with Psychotic Screen (SCID-I/P W/PSY SCREEN) 2002 New York: Biometrics Research, New York State Psychiatric Institute
  3. Perkins DO Leserman J Jarskog LF Graham K Kazmer J Lieberman JA Characterizing and dating the onset of symptoms in psychotic illness Schizophrenia Research 2002 44 1 10 10867307
  4. Hays RD Sherbourne CD Mazel RM The RAND 36-Item Health Survey Health Economics 1993 2 217 227 8275167

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Authors
Breitborde, N. J., Moreno, F. A., Mai-Dixon, N., Peterson, R., Durst, L., Bernstein, B., Byreddy, S., & McFarlane, W. R.
Affiliations
  • University of Arizona (US)
  • University of Rochester Medicine (US)
  • Maine Medical Center (US)
Corresponding author
Breitborde, Nicholas JK
ORCID
Venue
BMC Psychiatry
Publisher
Springer Science and Business Media LLC
Published
2011-01-12
Volume
11
Issue
1
Pages
9-9
ISSN
1471-244X (ISSN-L)
DOI
10.1186/1471-244x-11-9
PMC
PMC3030530
OpenAlex
W2068902942
Cited by
45
References
80
Citations by year
2026: 1 · 2024: 1 · 2021: 2 · 2020: 2 · 2019: 5 · 2017: 4 · 2016: 1 · 2015: 11 · 2014: 4 · 2013: 7 · 2012: 5
FWCI
3.74
Type
journal article
Language
en
Open access
Licence
Locations
  • BMC Psychiatry (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • UA Campus Repository (The University of Arizona) (acceptedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
University of Arizona
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Psychology › Clinical Psychology › Family Caregiving in Mental Illness
  • Social Sciences › Psychology › Clinical Psychology › Counseling, Therapy, and Family Dynamics
Keywords
first-episode psychosis, cognitive remediation, relapse prevention, cognitive impairment, caregivers, caregiver burden, social functioning, vocational functioning, health-related quality of life, independent living, service utilization
MeSH terms
Adolescent, Adult, Clinical Protocols, Cognition Disorders, Family Therapy, Female, Health Education, Humans, Male, Patient Education as Topic, Psychotic Disorders, Research Design, Schizophrenia, Schizophrenic Psychology, Cognitive Behavioral Therapy, Treatment Outcome, Caregivers, Outcome Assessment, Health Care, Secondary Prevention

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