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Cited by 1,394

The DOI matches its Crossref record.

Dose escalation of a curcuminoid formulation

Open access
Lao, Christopher D, Ruffin, Mack T, Normolle, Daniel, Heath, Dennis D, Murray, Sandra I, Bailey, Joanne M, Boggs, Martha E, Crowell, James, Rock, Cheryl L, Brenner, Dean E·2006·BMC Complementary and Alternative Medicine
DOI 10.1186/1472-6882-6-10
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Abstract

Background: Curcumin is the major yellow pigment extracted from turmeric, a commonly-used spice in India and Southeast Asia that has broad anticarcinogenic and cancer chemopreventive potential. However, few systematic studies of curcumin's pharmacology and toxicology in humans have been performed. Methods: A dose escalation study was conducted to determine the maximum tolerated dose and safety of a single dose of standardized powder extract, uniformly milled curcumin (C3Complex™, Sabinsa Corporation). Healthy volunteers were administered escalating doses from 500 to 12,000 mg. Results: Seven of twenty-four subjects (30%) experienced only minimal toxicity that did not appear to be dose-related. No curcumin was detected in the serum of subjects administered 500, 1,000, 2,000, 4,000, 6,000 or 8,000 mg. Low levels of curcumin were detected in two subjects administered 10,000 or 12,000 mg. Conclusion: The tolerance of curcumin in high single oral doses appears to be excellent. Given that achieving systemic bioavailability of curcumin or its metabolites may not be essential for colorectal cancer chemoprevention, these findings warrant further investigation for its utility as a long-term chemopreventive agent.

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Authors
Lao, C. D., Ruffin, M. T., Normolle, D., Heath, D. D., Murray, S. I., Bailey, J. M., Boggs, M. E., Crowell, J., Rock, C. L., & Brenner, D. E.
Venue
BMC Complementary and Alternative Medicine
Publisher
Springer Science and Business Media LLC
Published
2006-03-17
Volume
6
Issue
1
Pages
10-10
ISSN
1472-6882 (ISSN-L)
DOI
10.1186/1472-6882-6-10
OpenAlex
W1604068141
Cited by
1,394
References
0
FWCI
12.24
Type
journal article
Language
en
Open access
gold

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