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Cited by 902Physical Activity and HealthCardiovascular and exercise physiologyRecreational Sport and Physical Activity

The DOI matches its Crossref record; 378 of the 378 references it cites were found in a registry or an index.

A systematic review of the evidence for Canada's Physical Activity Guidelines for Adults

Open access
Warburton, Darren ER, Charlesworth, Sarah, Ivey, Adam, Nettlefold, Lindsay, Bredin, Shannon SD·2010·International Journal of Behavioral Nutrition and Physical Activity
DOI 10.1186/1479-5868-7-39PMC PMC3583166
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Abstract

This systematic review examines critically the scientific basis for Canada's Physical Activity Guide for Healthy Active Living for adults. Particular reference is given to the dose-response relationship between physical activity and premature all-cause mortality and seven chronic diseases (cardiovascular disease, stroke, hypertension, colon cancer, breast cancer, type 2 diabetes (diabetes mellitus) and osteoporosis). The strength of the relationship between physical activity and specific health outcomes is evaluated critically. Literature was obtained through searching electronic databases (e.g., MEDLINE, EMBASE), cross-referencing, and through the authors' knowledge of the area. For inclusion in our systematic review articles must have at least 3 levels of physical activity and the concomitant risk for each chronic disease. The quality of included studies was appraised using a modified Downs and Black tool. Through this search we identified a total of 254 articles that met the eligibility criteria related to premature all-cause mortality (N = 70), cardiovascular disease (N = 49), stroke (N = 25), hypertension (N = 12), colon cancer (N = 33), breast cancer (N = 43), type 2 diabetes (N = 20), and osteoporosis (N = 2). Overall, the current literature supports clearly the dose-response relationship between physical activity and the seven chronic conditions identified. Moreover, higher levels of physical activity reduce the risk for premature all-cause mortality. The current Canadian guidelines appear to be appropriate to reduce the risk for the seven chronic conditions identified above and all-cause mortality.

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Crossref · 10.1186/1479-5868-7-39

Cites

378 of 378 references verified0 citation errors · 0 not checkable

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Figures

Figure 1 Theoretical relationship between the risk for chronic disease and physical activity/fitness.
Figure 1 Theoretical relationship between the risk for chronic disease and physical activity/fitness.CC BY · PubMed Central
Figure 2 Results of the Literature Search for All-Cause Mortality.
Figure 2 Results of the Literature Search for All-Cause Mortality.CC BY · PubMed Central
Figure 3 Mean relative risk reduction in all-cause mortality across physical activity/fitness categories.
Figure 3 Mean relative risk reduction in all-cause mortality across physical activity/fitness categories.CC BY · PubMed Central
Figure 4 Results of the Literature Search for Cardiovascular Disease.
Figure 4 Results of the Literature Search for Cardiovascular Disease.CC BY · PubMed Central
Figure 5 Results of the Literature Search for Stroke.
Figure 5 Results of the Literature Search for Stroke.CC BY · PubMed Central
Figure 6 Results of the Literature Search for Hypertension.
Figure 6 Results of the Literature Search for Hypertension.CC BY · PubMed Central
Figure 7 Results of the Literature Search for Colon Cancer.
Figure 7 Results of the Literature Search for Colon Cancer.CC BY · PubMed Central
Figure 8 Results of the Literature Search for Breast Cancer.
Figure 8 Results of the Literature Search for Breast Cancer.CC BY · PubMed Central
Figure 9 Results of the Literature Search for Diabetes.
Figure 9 Results of the Literature Search for Diabetes.CC BY · PubMed Central
Figure 10 Results of the Literature Search for Osteoporosis.
Figure 10 Results of the Literature Search for Osteoporosis.CC BY · PubMed Central

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Research works printed but not linked: 1

  1. Heart and Stroke Foundation of Canada Press Releases - Canadian leads effort to raise awareness of stroke as a global health epidemic 2007 Ottawa: Heart and Stroke Foundation of Canada

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Metadata

Authors
Warburton, D. E., Charlesworth, S., Ivey, A., Nettlefold, L., & Bredin, S. S.
Affiliations
University of British Columbia (CA)
Corresponding author
Warburton, Darren ER
ORCID
Venue
International Journal of Behavioral Nutrition and Physical Activity
Publisher
Springer Science and Business Media LLC
Published
2010
Volume
7
Issue
1
Pages
39
ISSN
1479-5868 (ISSN-L)
DOI
10.1186/1479-5868-7-39
PMC
PMC3583166
OpenAlex
W2170267040
Cited by
902
References
378
Citations by year
2026: 13 · 2025: 25 · 2024: 34 · 2023: 43 · 2022: 47 · 2021: 68 · 2020: 81 · 2019: 69 · 2018: 83 · 2017: 77 · 2016: 75 · 2015: 70 · 2014: 80 · 2013: 64 · 2012: 43
FWCI
4.41
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • International Journal of Behavioral Nutrition and Physical Activity (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • cIRcle (University of British Columbia) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Public Health Agency of Canada
  • Michael Smith Health Research BC
  • Public Health Agency
  • Canadian Institutes of Health Research
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Social Sciences › Life-span and Life-course Studies › Recreational Sport and Physical Activity
Keywords
physical activity guidelines, dose-response relationship, physical activity, all-cause mortality, cardiovascular disease, stroke, hypertension, colon cancer, breast cancer, type 2 diabetes, osteoporosis, chronic disease risk

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