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Cited by 717

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Environmental/lifestyle factors in the pathogenesis and prevention of type 2 diabetes

Open access
Kolb, Hubert, Martin, Stephan·2017·BMC Medicine

Abstract

BACKGROUND: Environmental and lifestyle changes, in addition to the ageing of populations, are generally believed to account for the rapid global increase in type 2 diabetes prevalence and incidence in recent decades. DISCUSSION: In this review, we present a comprehensive overview of factors contributing to diabetes risk, including aspects of diet quality and quantity, little physical activity, increased monitor viewing time or sitting in general, exposure to noise or fine dust, short or disturbed sleep, smoking, stress and depression, and a low socioeconomic status. In general, these factors promote an increase in body mass index. Since loss of β-cell function is the ultimate cause of developing overt type 2 diabetes, environmental and lifestyle changes must have resulted in a higher risk of β-cell damage in those at genetic risk. Multiple mechanistic pathways may come into play. CONCLUSIONS: Strategies of diabetes prevention should aim at promoting a 'diabetes-protective lifestyle' whilst simultaneously enhancing the resistance of the human organism to pro-diabetic environmental and lifestyle factors. More research on diabetes-protective mechanisms seems warranted.

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Metadata

Authors
Kolb, H., & Martin, S.
Venue
BMC Medicine
Published
2017-07-19
Volume
15
Issue
1
Pages
131-131
ISSN
1741-7015 (ISSN-L)
OpenAlex
W2724768241
Cited by
717
References
37
FWCI
23.94
Type
journal article
Language
en
Open access
gold

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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