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Amygdala activation in maltreated children during pre-attentive emotional processing
Open accessAbstract
Background: Childhood adversity is associated with significantly increased risk of psychiatric disorder. To date, functional magnetic resonance imaging (fMRI) studies of children have mainly focused on institutionalisation and investigated conscious processing of affect. Aims: To investigate neural response to pre-attentively presented affect cues in a community sample of children with documented experiences of maltreatment in the home. Method: A masked dot-probe paradigm involving pre-attentive presentation of angry, happy and neutral facial expressions was employed. Eighteen maltreated children were compared with 23 carefully matched non-maltreated peers. Results: Increased neural response was observed in the right amygdala for pre-attentively presented angry and happy faces in maltreated v. non-maltreated children. Level of amygdala activation was negatively associated with age at onset for several abuse subtypes. Conclusions: Maltreatment is associated with heightened neural response to positive and negative facial affect, even to stimuli outside awareness. This may represent a latent neural risk factor for future psychiatric disorder.
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“In this connection, it is relevant to note that studies of children exposed to maltreatment have reported alterations in amygdala reactivity, including increased amygdala reactivity in response to angry faces62 and during pre-attentive emotional processing63 while hypoactivation to social rejection cues64.”
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“…in the amygdala and other nodes of the salience network (e.g., anterior insula, putamen, thalamus) to a wide range of negative emotional stimuli (McCrory et al., 2013; McCrory et al., 2011; McLaughlin, Peverill, Gold, Alves, & Sheridan, 2015), suggesting heightened salience of information that…”
Background
Metadata
- Authors
- McCrory, E. J., De Brito, S. A., Kelly, P. A., Bird, G., Sebastian, C. L., Mechelli, A., Samuel, S., & Viding, E.
- Affiliations
- Anna Freud Centre (GB)
- University College London (GB)
- King's College London (GB)
- Corresponding author
- McCrory, Eamon J.
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2013-04
- Volume
- 202
- Issue
- 4
- Pages
- 269-276
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2117502124
- Cited by
- 215
- References
- 41
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 12 · 2023: 19 · 2022: 18 · 2021: 19 · 2020: 17 · 2019: 17 · 2018: 13 · 2017: 23 · 2016: 21 · 2015: 22 · 2014: 13 · 2013: 1
- FWCI
- 21.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- BIROn (Birkbeck, University of London) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Funders
- Economic and Social Research Council (ES/G000131/1)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Sociology and Political Science › Child Welfare and Adoption
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- child abuse, amygdala activation, facial expressions, dot-probe task, childhood adversity, psychiatric risk
- MeSH terms
- Age Factors, Amygdala, Attention, Child, Child Abuse, Cues, Emotions, Humans, Functional Laterality, Male, Psychiatric Status Rating Scales, Psychomotor Performance, Case-Control Studies, Functional Neuroimaging
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