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The recycling of apolipoprotein E and its amino-terminal 22 kDa fragment

Farkas, Monica H., Weisgraber, Karl H., Shepherd, Virginia L., Linton, MacRae F., Fazio, Sergio, Swift, Larry L.·2004·Journal of Lipid Research
DOI 10.1194/jlr.m400104-jlr200
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  • Secreted ApoE is taken back up and transits through the recycling endosome pathway in multiple cell types, including astrocytes.

    “However, this interpretation is complicated by the fact that secreted ApoE is taken back up and transits through the recycling endosome pathway in multiple cell types, including astrocytes [32–36].”

    From ApoE lipoproteins in the central nervous system under homeostasis and role in Alzheimer’s disease and related disorders (2026) · cites this paper as [35]

    The paper reports uptake and recycling of apoE in hepatocytes and notes recycling in macrophages, fibroblasts, and hepatoma cell lines (Abstract; page unavailable). It does not report recycling in astrocytes, and its Discussion (page unavailable) proposes endosomal routes as possibilities rather than establishing that apoE transits through a recycling endosome pathway. (LLM, conf=0.88)

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Research works printed but not linked: 58

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Metadata

Authors
Farkas, M. H., Weisgraber, K. H., Shepherd, V. L., Linton, M. F., Fazio, S., & Swift, L. L.
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
2004-08
Volume
45
Issue
8
Pages
1546-1554
ISSN
0022-2275
DOI
10.1194/jlr.m400104-jlr200
Cited by
23
References
4
Language
en
Licence

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