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Cited by 165Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesMemory and Neural Mechanisms

The DOI matches its Crossref record; 124 of the 124 references it cites were found in a registry or an index.

Striatal Contributions to Reward and Decision Making: Making Sense of Regional Variations in a Reiterated Processing Matrix

WICKENS, JEFFERY R., BUDD, CHRISTOPHER S., HYLAND, BRIAN I., ARBUTHNOTT, GORDON W.·2007·Annals of the New York Academy of Sciences
DOI 10.1196/annals.1390.016
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Abstract

The striatum is the major input nucleus of the basal ganglia. It is thought to play a key role in learning on the basis of positive reinforcement and in action selection. One view of the striatum conceives it as comprising a reiterated matrix of processing units that perform common operations in different striatal regions, namely synaptic plasticity according to a three-factor rule, and lateral inhibition. These operations are required for reinforcement learning and selection of previously reinforced actions. Analysis of the behavioral effects of circumscribed lesions of the striatum, however, suggests regional specialization of learning and decision-making operations. We consider how a basic processing unit may be modified by regional variations in neurochemical parameters, for example, by the gradient in density of dopamine terminals from dorsal to ventral striatum. These variations suggest subtle differences between dorsolateral and ventromedial striatal regions in the temporal properties of dopamine signaling, which are superimposed on regional differences in connectivity. We propose that these variations make sense in relation to the temporal structure of activity in striatal inputs from different regions, and the requirements of different learning operations. Dorsolateral striatal (DLS) regions may be subject to brief, precisely timed pulses of dopamine, whereas ventromedial striatal regions integrate dopamine signals over a longer time course. These differences may be important for understanding regional variations in the contribution to reinforcement of habits, versus incentive processes that are sensitive to the value of expected rewards.

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Crossref · 10.1196/annals.1390.016

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Citations

Cites

Research works printed but not linked: 5

  1. Brockhaus H., 1942, Zur feineren Anatomie des Septum und des Striatum, J. Psychol. Neurol. (Leipzig), 51, 1
  2. 10.1038/311461a0 · DOI
  3. Lindvall O., 1974, The organisation of the ascending catecholamine neuron systems in the rat brain: as revealed by the glyoxylic acid flourescence method, Acta Physiol. Scand. Suppl., 412, 1
  4. 10.1111/j.1365-201X.1971.tb10998.x · DOI · Paper page
  5. Garris P.A., 1995, Neuromethods, 179

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Metadata

Authors
WICKENS, J. R., BUDD, C. S., HYLAND, B. I., & ARBUTHNOTT, G. W.
Affiliations
  • Okinawa Institute of Science and Technology Graduate University (JP)
  • University of Otago (NZ)
Corresponding author
WICKENS, JEFFERY R.
ORCID
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2007-05
Volume
1104
Issue
1
Pages
192-212
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
DOI
10.1196/annals.1390.016
OpenAlex
W2001576766
Cited by
165
References
124
Citations by year
2026: 2 · 2025: 2 · 2024: 6 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 1 · 2019: 9 · 2018: 9 · 2017: 5 · 2016: 9 · 2015: 9 · 2014: 15 · 2013: 9 · 2012: 13
FWCI
1.27
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 50 d)
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
striatum, reward, decision-making, reinforcement learning, action selection, dopamine signaling, dorsolateral striatum, ventromedial striatum, basal ganglia, synaptic plasticity, lateral inhibition, regional specialization, habit formation, striatal connectivity
MeSH terms
Animals, Basal Ganglia, Behavior, Corpus Striatum, Decision Making, Dopamine, Humans, Learning, Models, Anatomic, Models, Neurological, Neural Pathways, Nucleus Accumbens, Reinforcement, Psychology, Reward, Time Factors

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