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Cited by 237

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels

Open access
Swerdloff, Ronald S., Dudley, Robert E., Page, Stephanie T., Wang, Christina, Salameh, Wael A.·2017·Endocrine Reviews
DOI 10.1210/er.2016-1067
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Abstract

Benefits associated with lowered serum DHT levels after 5α-reductase inhibitor (5AR-I) therapy in men have contributed to a misconception that circulating DHT levels are an important stimulus for androgenic action in target tissues (e.g., prostate). Yet evidence from clinical studies indicates that intracellular concentrations of androgens (particularly in androgen-sensitive tissues) are essentially independent of circulating levels. To assess the clinical significance of modest elevations in serum DHT and the DHT/testosterone (T) ratio observed in response to common T replacement therapy, a comprehensive review of the published literature was performed to identify relevant data. Although the primary focus of this review is about DHT in men, we also provide a brief overview of DHT in women. The available published data are limited by the lack of large, well-controlled studies of long duration that are sufficiently powered to expose subtle safety signals. Nonetheless, the preponderance of available clinical data indicates that modest elevations in circulating levels of DHT in response to androgen therapy should not be of concern in clinical practice. Elevated DHT has not been associated with increased risk of prostate disease (e.g., cancer or benign hyperplasia) nor does it appear to have any systemic effects on cardiovascular disease safety parameters (including increased risk of polycythemia) beyond those commonly observed with available T preparations. Well-controlled, long-term studies of transdermal DHT preparations have failed to identify safety signals unique to markedly elevated circulating DHT concentrations or signals materially different from T.

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Metadata

Authors
Swerdloff, R. S., Dudley, R. E., Page, S. T., Wang, C., & Salameh, W. A.
Venue
Endocrine Reviews
Publisher
The Endocrine Society
Published
2017-05-02
Volume
38
Issue
3
Pages
220-254
ISSN
  • 0163-769X (ISSN-L)
  • 1945-7189
DOI
10.1210/er.2016-1067
OpenAlex
W2610994046
Cited by
237
References
39
FWCI
8.72
Type
journal article
Language
en
Open access
hybrid

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