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Cited by 602

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Sunscreens Suppress Cutaneous Vitamin D3Synthesis*

MATSUOKA, LOIS Y., IDE, LORRAINE, WORTSMAN, JACOBO, MACLAUGHLIN, JULIA A., HOLICK, MICHAEL F.·1987·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem-64-6-1165
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Abstract

Sunscreens block the cutaneous absorption of UV-B radiation and prevent sunburning, premature aging, and cancer of the skin. Inasmuch as UV-B radiation is also responsible for the photosynthesis of vitamin D3, we investigated the effect of sunscreens on the cutaneous formation of vitamin D3 in vivo and in vitro. Eight normal subjects, four of whom had been protected with the sunscreen para-aminobenzoic acid (sun protection factor 8), were exposed to one minimal erythema dose of UV radiation. The mean serum vitamin D3 concentration increased from 1.5 +/- 1.0 (+/- SEM) to 25.6 +/- 6.7 ng/mL in unprotected subjects, whereas it was 5.6 +/- 3.0 and 4.4 +/- 2.4 ng/mL at these times in the subjects who were protected with para-aminobenzoic acid. Para-aminobenzoic acid also prevented the photoisomerization of 7-dehydrocholesterol to previtamin D3 in human skin slices in vitro. These results indicate that the sunscreen interferred with the cutaneous production of vitamin D3.

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Metadata

Authors
MATSUOKA, L. Y., IDE, L., WORTSMAN, J., MACLAUGHLIN, J. A., & HOLICK, M. F.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1987-06
Volume
64
Issue
6
Pages
1165-1168
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem-64-6-1165
OpenAlex
W2162463371
Cited by
602
References
1
FWCI
4.91
Type
journal article
Language
en
Open access
closed

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